Abstract：
OBJECTIVE:Following encouraging results in the early detection of psychotic disorders, interest in the early detection of affective, especially bipolar disorders, has recently been renewed. However, the differentiation between affective disorders with and without psychotic features is often missing, although it has been suggested that affective disorders with psychotic features may be distinct from those without psychotic features and closely linked to non-affective psychoses. METHODS:We compared the prodromal symptoms of patients who had sought help at an early detection center; had been assessed at baseline with the Structured Interview for Prodromal Syndromes (SIPS); and who, within 53 months on average, developed schizophrenia-spectrum psychosis (pre-SCZ; n=51), affective disorder with psychotic features (pre-AD-P; n=7), or affective disorder without psychotic features (pre-AD-noP; n=16). RESULTS:While pre-SCZ scored slightly higher on most positive symptoms than pre-AD, pre-AD-P and pre-SCZ scored comparably across the SIPS; moreover, pre-AD-noP and pre-SCZ differed on most subscales and items, particularly on the positive and negative dimensions. Furthermore, pre-AD-P scored higher on positive symptoms than pre-AD-noP. CONCLUSIONS:Our results suggest that, in the early detection of affective disorders, those that might take on a psychotic form and those with a non-psychotic course need to be considered separately. While the current at-risk criteria for psychosis function well in detecting those with a psychotic course, those with a non-psychotic course would benefit from the development and evaluation of new at-risk criteria and new early detection instruments.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Schultze-Lutter F,Schimmelmann BG,Klosterkötter J,Ruhrmann Sdoi
10.1016/j.schres.2012.04.001subject
Has Abstractpub_date
2012-07-01 00:00:00pages
218-22issue
2-3eissn
0920-9964issn
1573-2509pii
S0920-9964(12)00192-2journal_volume
138pub_type
杂志文章abstract：:A prerequisite to longitudinal fMRI studies in schizophrenia is the knowledge on fMRI signal reliability in schizophrenia patients. We assessed the reproducibility of activations elicited by two fMRI sessions, which were 21 months apart, of a story listening paradigm in 10 schizophrenia patients and 10 healthy subject...
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pub_type： 杂志文章,多中心研究
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更新日期：2012-09-01 00:00:00
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更新日期：2020-06-25 00:00:00
abstract：:Abnormalities in resting-state electroencephalogram (rs-EEG) activity have been previously reported in schizophrenia. While most rs-EEG recordings were performed in patients with chronic schizophrenia during eyes closed (EC), only a handful of studies have investigated rs-EEG activity during both EC and eyes open (EO)...
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更新日期：2021-01-08 00:00:00
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更新日期：2018-12-01 00:00:00
abstract：:Recent meta-analytic evidence suggests that clinical neuropsychological methods are not likely to uncover circumscribed cognitive impairments in the deficit syndrome of schizophrenia. To overcome this issue, we adapted a cognitive neuroscience perspective and used a new "chaining" habit learning task. Participants wer...
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更新日期：2008-02-01 00:00:00
abstract：:Neuropsychological performance in 20 chronic schizophrenic patients was contrasted to 25 Parkinson's disease, 12 Huntington's disease patients and 26 normal controls on measures shown to be sensitive to subcortical dysfunction. Some overlap was observed in the performance of the schizophrenic and basal ganglia groups ...
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