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Schizophrenia risk factors constitute general risk factors for psychiatric symptoms in the population.

Abstract：

BACKGROUND:The presence of a psychosis continuum is suggested by studies showing that schizophrenia and non-clinical psychotic symptoms in the general population share the same risk factors. However, to our knowledge no large-scale studies have been conducted which examine the specificity of these risk factors in the general population. AIM:To investigate whether socio-demographic characteristics associated with non-clinical psychotic symptoms are also associated with other psychiatric symptoms. And secondly, to examine to what extent concomitant psychiatric symptoms explain the relationship between socio-demographic characteristics and non-clinical psychotic symptoms. METHODS:In a general population sample of 4894 subjects (mean age 39 years, 45% men) from the Utrecht Health Project we investigated the associations of socio-demographical characteristics with non-clinical psychotic symptoms and other psychiatric symptoms by using the SCL-90. We examined these associations using multivariable logistic regression analyses with and without controlling for the presence of other psychiatric symptoms. RESULTS:Participants with non-clinical psychotic symptoms had an 89% probability of concomitant depressive, anxiety or phobic anxiety symptoms, compared to 11% in participants without psychotic symptoms. The risk profiles for non-clinical psychotic symptoms and other psychiatric symptoms were largely similar. Non-Dutch ethnicity was most strongly associated with non-clinical psychotic symptoms. Adjusting for other psychiatric symptoms did not increase the specificity of the risk factors. CONCLUSION:Socio-demographic risk factors for non-clinical psychotic symptoms in the general population are also risk factors for other psychiatric symptoms. The relationship between these risk factors and psychotic symptoms are for a substantial part explained by an increase in other psychiatric symptoms.

journal_name

Schizophr Res

journal_title

Schizophrenia research

authors

Breetvelt EJ,Boks MP,Numans ME,Selten JP,Sommer IE,Grobbee DE,Kahn RS,Geerlings MI

doi

10.1016/j.schres.2010.03.033

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

184-90

issue

1-3

eissn

0920-9964

issn

1573-2509

pii

S0920-9964(10)01204-1

journal_volume

120

pub_type

杂志文章

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