Altered gyrification in schizophrenia and its relation to other morphometric markers.

abstract：INTRODUCTION:This study investigates the effect of exposure to "The Troubles" (the period of civil unrest from 1968 onwards) in Northern Ireland on symptomatology in people with schizophrenia. METHOD:Eighty-two participants were assessed on a number of psychiatric rating scales and on measures of trauma, including an ...

journal_title：Schizophrenia research

authors： Mulholland C,Boyle C,Shannon C,Huda U,Clarke L,Meenagh C,Dempster M

更新日期：2008-07-01 00:00:00

abstract：:There is controversy over whether the incidence rates of schizophrenia and psychotic disorders have changed in recent decades. To detect deviations from trends in incidence, we analysed admission data of patients with an ICD-8/9/10 diagnosis of psychotic disorders in the Canton Zurich / Switzerland, for the period 197...

journal_title：Schizophrenia research

authors： Ajdacic-Gross V,Lauber C,Warnke I,Haker H,Murray RM,Rössler W

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:Corpus callosum (CC) size and interhemispheric communication differences have been reported between patients with schizophrenia and normal controls. Childhood-onset schizophrenia (COS) is a severe form of the disorder that is continuous with later-onset disorder. Corpus callosal area was examined for COS at i...

journal_title：Schizophrenia research

authors： Keller A,Jeffries NO,Blumenthal J,Clasen LS,Liu H,Giedd JN,Rapoport JL

更新日期：2003-07-01 00:00:00

abstract：:Genetic epidemiological studies have demonstrated markedly reduced rates in reproduction among schizophrenic patients. According to evolutionary theory, behavioral and psychological phenotypes are selected based on ecological "fit". Where differential survival or reproductive success exists, genotype frequencies are a...

journal_title：Schizophrenia research

authors： Avila M,Thaker G,Adami H

更新日期：2001-03-01 00:00:00

abstract：:Though negative symptoms in schizophrenia are associated with a host of deleterious outcomes (e.g., White et al., 2009), not all individuals with schizophrenia suffer from negative symptoms (e.g., Blanchard et al., 2005). Thus, methods to quickly screen and identify patients for more intensive clinical interview asses...

journal_title：Schizophrenia research

authors： Park SG,Llerena K,McCarthy JM,Couture SM,Bennett ME,Blanchard JJ

更新日期：2012-03-01 00:00:00

abstract：:Neuropsychological performance in 20 chronic schizophrenic patients was contrasted to 25 Parkinson's disease, 12 Huntington's disease patients and 26 normal controls on measures shown to be sensitive to subcortical dysfunction. Some overlap was observed in the performance of the schizophrenic and basal ganglia groups ...

journal_title：Schizophrenia research

authors： Hanes KR,Andrewes DG,Pantelis C,Chiu E

更新日期：1996-05-01 00:00:00

abstract：:Psychotic-like experiences (PLEs) are part of a continuum of psychosis. Previous longitudinal studies highlighted a relationship between peripheral inflammation during childhood and onset of PLEs in adulthood. In this study, we tested if this association is mediated by internalising and externalising symptoms experien...

journal_title：Schizophrenia research

authors： Francesconi M,Minichino A,Khandaker GM,Midouhas E,Lewis G,Flouri E

更新日期：2020-12-01 00:00:00

abstract：:Although the concept of remission has been widely accepted and utilized in depression and anxiety disorders, there has been much less emphasis on defining remission in schizophrenia. Recently, an expert consensus definition of remission in schizophrenia was proposed along specific operational criteria for the attainme...

journal_title：Schizophrenia research

authors： Lasser RA,Nasrallah H,Helldin L,Peuskens J,Kane J,Docherty J,Tronco AT

更新日期：2007-11-01 00:00:00

abstract：:Jumping to conclusions and bias against disconfirmatory evidence are two cognitive biases common in people with psychotic-like experiences and psychosis. However, many participants show comprehension problems doing traditional tasks; new paradigms with additional applied scenarios are thus needed. A large MTurk commun...

journal_title：Schizophrenia research

authors： Scheunemann J,Gawęda Ł,Reininger KM,Jelinek L,Hildebrandt H,Moritz S

更新日期：2020-02-01 00:00:00

abstract：:Psychotic disorders are characterized by auditory verbal hallucinations (AVHs), and research has shown that AVHs are linked to deficits in working memory. Our understanding of AVHs across the psychosis continuum is limited. To date, little research has tested whether hallucination proneness (HP) is linked with abnorma...

journal_title：Schizophrenia research

authors： Gupta T,DeVylder JE,Auerbach RP,Schiffman J,Mittal VA

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:Attentional deficits represent a core cognitive impairment in schizophrenia. The distractor condition Sustained Attention Task (dSAT) has been identified by the Cognitive Neuroscience Treatment to Improve Cognition in Schizophrenia (CNTRICS) initiative as a promising translational task for assessing schizophr...

journal_title：Schizophrenia research

authors： Demeter E,Guthrie SK,Taylor SF,Sarter M,Lustig C

更新日期：2013-03-01 00:00:00

abstract：:NRG1 is one of the most researched genes associated with schizophrenia. Although three meta-analyses in this area have been published, the results have been inconclusive and even conflicting. Family based studies can be problematical due to the difficulty of synthesizing them with case-control studies. Heterogeneity i...

journal_title：Schizophrenia research

authors： Gong YG,Wu CN,Xing QH,Zhao XZ,Zhu J,He L

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:While insight in schizophrenia improves with treatment, significant impairments often persist. The degree of persistence is not well characterised. AIMS:We assessed patient and clinician-rated changes in insight in acutely ill, minimally treated first-episode schizophrenia spectrum disorder patients over 24...

journal_title：Schizophrenia research

authors： Phahladira L,Asmal L,Kilian S,Chiliza B,Scheffler F,Luckhoff HK,du Plessis S,Emsley R

更新日期：2019-04-01 00:00:00

abstract：:CACNA1C gene polymorphism rs2007044 has been reported to be associated with schizophrenia, but its underlying brain mechanism is not clear. First, we conducted an exploratory functional magnetic resonance imaging (fMRI) study using an N-BACK task and a Stroop task in 194 subjects (55 schizophrenia patients and 139 hea...

journal_title：Schizophrenia research

authors： Zhang Z,Wang Y,Zhang Q,Zhao W,Chen X,Zhai J,Chen M,Du B,Deng X,Ji F,Wang C,Xiang Y,Li D,Wu H,Dong Q,Chen C,Li J

更新日期：2019-02-01 00:00:00

abstract：:Apolipoprotein D (apoD) is a member of the lipocalin superfamily of transporter proteins that bind small hydrophobic molecules, including arachidonic acid (AA). The ability of apoD to bind AA implicates it in pathways associated with membrane phospholipid signal transduction and metabolism. Recent findings of an incre...

journal_title：Schizophrenia research

authors： Yao JK,Thomas EA,Reddy RD,Keshavan MS

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Appropriate expression of emotions and correct perception of emotional expression in others are important social skills which may be impaired in schizophrenia and contribute to poor social adjustment. We examined the relationship between expression of emotions as measured by affective flattening and other ne...

journal_title：Schizophrenia research

authors： Silver H,Shlomo N

更新日期：2001-12-01 00:00:00

abstract：OBJECTIVE:Acoustic phonetic methods are useful in examining some symptoms of schizophrenia; we used such methods to understand the underpinnings of aprosody. We hypothesized that, compared to controls and patients without clinically rated aprosody, patients with aprosody would exhibit reduced variability in: pitch (F0)...

journal_title：Schizophrenia research

authors： Compton MT,Lunden A,Cleary SD,Pauselli L,Alolayan Y,Halpern B,Broussard B,Crisafio A,Capulong L,Balducci PM,Bernardini F,Covington MA

更新日期：2018-07-01 00:00:00

abstract：:Heterozygous reeler mouse has been used as an animal model for schizophrenia based on several neuropathological and behavioral abnormalities homologous to schizophrenia. Since some of these abnormalities are primarily associated with altered BDNF signaling we investigated BDNF signaling in the frontal cortex of reeler...

journal_title：Schizophrenia research

authors： Pillai A,Mahadik SP

更新日期：2008-03-01 00:00:00

abstract：:Neuroanatomical abnormalities are considered to be related to the pathogenesis of schizophrenia. Reversal or reduction of normal structural cerebral asymmetries in schizophrenia is particularly striking. The current study investigated the alteration of gray matter volume and cerebral asymmetry in early stage of first-...

journal_title：Schizophrenia research

authors： Sheng J,Zhu Y,Lu Z,Liu N,Huang N,Zhang Z,Tan L,Li C,Yu X

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:To develop a pharmacokinetic-pharmacodynamic (PK-PD) model using individual-level data of Positive and Negative Syndrome Scale (PANSS) total score to characterize the antipsychotic drug effect taking into account the placebo effect and dropout rate. In addition, a clinical utility (CU) criterion that describ...

journal_title：Schizophrenia research

authors： Pilla Reddy V,Kozielska M,Suleiman AA,Johnson M,Vermeulen A,Liu J,de Greef R,Groothuis GM,Danhof M,Proost JH

更新日期：2013-05-01 00:00:00

abstract：:Schizophrenia has generally been viewed as having a unique preschizophrenia personality or destructive to the personality post-onset. This view is reflected in the scarcity of studies of personality in schizophrenia with the exception of schizotypal personality considered by many as an endophenotype of schizophrenia. ...

journal_title：Schizophrenia research

authors： Lewine R,Martin M,Hart M

更新日期：2017-11-01 00:00:00

abstract：:This paper describes an elementary deficit in sensory processing in people with schizophrenia. If paired sounds are presented to normal subjects, the response to the first sound, as measured by the P50 wave of the auditory-evoked potential, is much greater than the response to the second sound. The diminished response...

journal_title：Schizophrenia research

authors： Freedman R,Waldo M,Bickford-Wimer P,Nagamoto H

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Neurocognitive deficits have been well documented in patients with schizophrenia. Research has shown that a significant proportion of patients with schizophrenia have co-morbid obsessive-compulsive symptoms/disorder (OCS/OCD). However, the impact of OCS/OCD on various neurocognitive domains in patients with ...

journal_title：Schizophrenia research

authors： Sahoo S,Grover S,Nehra R

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Negative symptoms in schizophrenia are associated with deficits in executive function and frequently prove highly resistant to neuroleptic medication. Using repetitive transcranial magnetic stimulation (rTMS) to activate the prefrontal cortex has been suggested as a treatment for negative symptoms. METHODS:...

journal_title：Schizophrenia research

authors： Mogg A,Purvis R,Eranti S,Contell F,Taylor JP,Nicholson T,Brown RG,McLoughlin DM

更新日期：2007-07-01 00:00:00

abstract：:We have previously reported aberrations in the striatal presynaptic dopamine function in neuroleptic-naive schizophrenic patients compared to healthy controls (Hietala, J., Syvälahti, E., Vuorio, K. et al., 1995. Lancet 346, 1130-1131). In this extended study we explore whether the altered presynaptic dopamine functio...

journal_title：Schizophrenia research

authors： Hietala J,Syvälahti E,Vilkman H,Vuorio K,Räkköläinen V,Bergman J,Haaparanta M,Solin O,Kuoppamäki M,Eronen E,Ruotsalainen U,Salokangas RK

更新日期：1999-01-04 00:00:00

abstract：BACKGROUND:Psychotic-like experiences (PLEs) during adolescence are not uncommon and potentially represent a clinical and public health concern. A greater understanding of their aetiology and patterns of change over time is needed. We aimed to describe trajectories of PLEs during adolescence, and examine their associat...

journal_title：Schizophrenia research

authors： Thapar A,Heron J,Jones RB,Owen MJ,Lewis G,Zammit S

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Eye movement abnormalities have been identified in schizophrenia; however, their relevance to cognition is still unknown. In this study, we explored the general relationship between eye movements and cognitive function. METHODS:The three eye movement measures (scanpath length, horizontal position gain, and ...

journal_title：Schizophrenia research

authors： Morita K,Miura K,Fujimoto M,Yamamori H,Yasuda Y,Kudo N,Azechi H,Okada N,Koshiyama D,Ikeda M,Kasai K,Hashimoto R

更新日期：2019-07-01 00:00:00

abstract：:Recently, apolipoprotein D (apoD), a protein that is involved in the essential polyunsaturated fatty acid (EPUFA) transport and metabolism, and neuronal growth and regeneration was reported to have increased in the postmortem brain and decreased in the serum of schizophrenia patients. We studied the plasma apoD levels...

journal_title：Schizophrenia research

authors： Mahadik SP,Khan MM,Evans DR,Parikh VV

更新日期：2002-11-01 00:00:00

abstract：INTRODUCTION:Dysfunctional serotonin signaling has been linked to the pathogenesis of autism, obsessive compulsive disorder, mood disorders and schizophrenia. While the hypo-activity of serotonin signaling is involved in the pathogenesis of depression, anxiety and obsessive compulsive disorder; LSD, an agonist of serot...

journal_title：Schizophrenia research

authors： Abdolmaleky HM,Nohesara S,Ghadirivasfi M,Lambert AW,Ahmadkhaniha H,Ozturk S,Wong CK,Shafa R,Mostafavi A,Thiagalingam S

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Cannabis and cocaine are the most common illicit drugs for which people are treated in addiction services in Latin America. Much research has suggested that the use of cannabis increases the risk of schizophrenia; there is less evidence concerning cocaine. The aim of the present study was to establish the re...

journal_title：Schizophrenia research

authors： Libuy N,de Angel V,Ibáñez C,Murray RM,Mundt AP

更新日期：2018-04-01 00:00:00