Abstract：
:Although the concept of remission has been widely accepted and utilized in depression and anxiety disorders, there has been much less emphasis on defining remission in schizophrenia. Recently, an expert consensus definition of remission in schizophrenia was proposed along specific operational criteria for the attainment of remission focusing on the three core dimensions of psychopathology identified within schizophrenia: psychoticism, disorganization and negative symptoms. To date, the criteria have been applied retrospectively to several clinical studies, and these have demonstrated that the proposed definition of remission correlates significantly with established measures of symptom severity, functioning and quality of life, and appears achievable for a significant proportion of patients receiving at least 3 months of pharmacotherapy. In this article we extend the notion of remission to include an examination of the possible association of several modifiable and unmodifiable factors and co-morbidities on remission status. We also propose an investigation into the likelihood of different patient populations in achieving remission as well as assessing the impact of remission on health care costs and family burden. Since cognitive dysfunction and negative symptoms may be strongly correlated with a lower likelihood of achieving remission, we recommend retrospective and/or prospective studies to determine the relationship between neurocognitive status and the predominance of negative symptoms at treatment start and the probability of achieving remission. Taken together, these studies should help identify key predictors of remission, further define the remitted state, reduce therapeutic pessimism, raise treatment expectations and chart a strategy for further research in this important area.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Lasser RA,Nasrallah H,Helldin L,Peuskens J,Kane J,Docherty J,Tronco ATdoi
10.1016/j.schres.2007.05.003subject
Has Abstractpub_date
2007-11-01 00:00:00pages
223-31issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(07)00201-0journal_volume
96pub_type
杂志文章abstract：BACKGROUND:Previous studies have found increased prolactin concentrations in antipsychotic-naïve patients with schizophrenia. However, the roles of other hormones, and of potentially confounding variables such as gender and smoking, have not been considered. METHODS:Blood from newly diagnosed, antipsychotic-naïve pati...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2011.07.025
更新日期：2012-01-01 00:00:00
abstract：:The objective of this study was to compare the efficacy and reliability of sertraline versus imipramine in the treatment of postpsychotic depressive disorder of schizophrenia. The diagnosis was based on DSM-IV research criteria. The Sympson-Angus Scale and SANS were performed in order to discriminate between depressiv...
journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0920-9964(98)00054-1
更新日期：1998-09-07 00:00:00
abstract：BACKGROUND:Higher cognitive dysfunction, lower perceptual disturbance and its relation to the structures that implicate such processes have been considered as key features in patients with schizophrenia. However, little is known about the relationship between perceptual processing and structural deficits in ultra-high-...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.06.014
更新日期：2012-09-01 00:00:00
abstract：OBJECTIVE:Blockade of dopamine D₂ receptors with antipsychotics above 65% is associated with optimal chance of clinical response although recent data suggest a lower threshold for the maintenance treatment of schizophrenia. The objective of this study was to prospectively examine whether such continuous high blockade w...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2015.03.025
更新日期：2015-05-01 00:00:00
abstract：:Autoimmunity, gastrointestinal (GI) disorders and schizophrenia have been associated with one another for a long time. This paper reviews these connections and provides a context by which multiple risk factors for schizophrenia may be related. Epidemiological studies strongly link schizophrenia with autoimmune disorde...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2014.06.027
更新日期：2016-09-01 00:00:00
abstract：:Studies of neurocognitive function in patients with schizophrenia use widely variable assessment techniques. Clinical trials assessing the cognitive enhancing effect of new medications have used neurocognitive assessment batteries that differed in content, length and administration procedures. The Brief Assessment of ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2003.09.011
更新日期：2004-06-01 00:00:00
abstract：:Schizophrenia (SZ) is a mental illness characterized by psychosis, negative symptoms, and cognitive deficits. The anterior cingulate cortex (ACC), a structurally and functionally diverse region, is one of several brain regions that is abnormal in SZ. The present study compared synaptic organization and mitochondrial n...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.07.016
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND:Many studies have identified urban-rural differences in the occurrence of schizophrenia. Though unknown, the underlying causes responsible for these differences have been hypothesized to include urban-rural differences in toxic exposures, diet, infections, stress, or an artifact due to selective migration. F...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.08.028
更新日期：2015-10-01 00:00:00
abstract：:In 1990 a satellite session of the American College of Neuropsychopharmacology (ACNP) Annual Meeting was held that focused on the question of whether progressive changes in brain structure occur in schizophrenia and this session raised considerable controversy. Eighteen years later, on December 12, 2008, after much da...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.04.025
更新日期：2009-07-01 00:00:00
abstract：:In this study we use high resolution Magnetic Resonance imaging (MRI) and apply rigorous manual tracing criteria in order to assess volumetrically the prefrontal cortex (PFC) in schizophrenia. Previous MRI studies suggested PFC is included in neural systems necessary for emotional processing and cognition, and regiona...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.10.026
更新日期：2014-01-01 00:00:00
abstract：:In the last 25 years, the Positive and Negative Syndrome Scale (PANSS) has been largely used to assess schizophrenia symptom intensity, but little information is available on how this scale was generally applied when evaluating the efficacy of schizophrenia therapies in randomized clinical trials. In the attempt to ad...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2015.04.006
更新日期：2015-07-01 00:00:00
abstract：:While the "clinical high-risk state" for psychosis has demonstrated good reliability and fair predictive validity for psychotic disorders, over 50% of identified subjects do not progress to psychosis. Despite the benefits that early detection and treatment might offer, debate concerning the official inclusion of a "ps...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2010.03.012
更新日期：2010-07-01 00:00:00
abstract：:There is some evidence that memory for temporal order is a process that may be impaired independently of other forms of memory. For example, patients with Korsakoff's syndrome have been shown to have poorer temporal-order memory than other amnesic patients, despite item memory being equivalent. Patients with schizophr...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(00)00014-1
更新日期：2000-12-15 00:00:00
abstract：:The aim of the study was to assess changes in cortical thickness related to the use of n-3 polyunsaturated fatty acids (PUFA) as add-on therapy in patients with first episode schizophrenia. A double-blind randomized controlled study was conducted using a 26-week intervention composed of concentrated fish oil containin...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2017.10.013
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:Numerous studies have examined a wide range of risk factors associated with violence among patients with schizophrenia. However, risk factors linked to different socio-cultural backgrounds remain unclear. OBJECTIVE:The objectives were to investigate factors associated with violence among Japanese patients w...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.10.016
更新日期：2014-12-01 00:00:00
abstract：:Levels of the histamine metabolites, tele-methylhistamine (t-MH) and tele-methylimidazoleacetic acid (t-MIAA), and metabolites of other aminergic transmitters and of norepinephrine were measured in cerebrospinal fluid of 36 inpatients with chronic schizophrenia and eight controls. The mean t-MH level from controls was...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(94)00034-6
更新日期：1995-01-01 00:00:00
abstract：:Schizophrenia is a multifactorial disease in both clinical and molecular terms. Thus, depicting the molecular aspects of the disease will contribute to the understanding of its biochemical mechanisms and consequently may lead to the development of new treatment strategies. The protein phosphorylation/dephosphorylation...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.03.022
更新日期：2016-11-01 00:00:00
abstract：OBJECTIVE:Psychotic disorders in childhood and early adolescence often progress to chronic schizophrenia, but in many cases there are diagnosable medical and genetic causes or risk factors. We reviewed our clinical experience and the relevant literature to identify these factors and to define their clinical features, a...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2017.05.011
更新日期：2018-02-01 00:00:00
abstract：:Accumulating evidence showed that interleukin-2 (IL-2) may be involved in the pathophysiology of schizophrenia. Increased IL-2 levels have been found in the serum of schizophrenia patients with mixed results. In the present study, we assessed serum IL-2 levels in a large group of 160 schizophrenia patients compared to...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.10.038
更新日期：2015-12-01 00:00:00
abstract：:Twenty-five schizophrenic patients diagnosed by DSM-III-R underwent event-related potentials and magnetic resonance imaging scans. Latency and amplitude of P300 waveform were measured using an auditory odd-ball paradigm. Anterior and posterior volumes of the superior temporal gyrus and medial temporal structure were m...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(97)00055-8
更新日期：1997-08-29 00:00:00
abstract：BACKGROUND:Some patients develop breakthrough psychotic symptoms on antipsychotic maintenance medication (BAMM), despite receiving therapeutic antipsychotic doses to which they previously responded. METHODS:We examined the occurrence of BAMM in previously minimally treated first-episode patients with schizophrenia-spe...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.11.025
更新日期：2020-11-01 00:00:00
abstract：:Research on the effectiveness of treatment programs in early stages of severe mental illness raise significant ethical questions when conducted in industrialized countries that have adequate protections for the human subjects of biomedical and behavioral research. Before embarking on similar trials in developing count...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00244-4
更新日期：2001-08-01 00:00:00
abstract：:Mitochondria have been linked to the etiology of schizophrenia (SZ). However, studies of mitochondria in SZ might be confounded by the effects of pharmacological treatment with antipsychotic drugs (APDs) and other common medications. This review summarizes findings on relevant mitochondria mechanisms underlying SZ, an...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.09.007
更新日期：2020-03-01 00:00:00
abstract：OBJECTIVES:Cognitive remediation therapy (CRT) has shown significant improvement in cognition in schizophrenia. However, effect sizes of CRT have been reported to be modest raising the issue how to augment the effects of CRT on neurocognition and social cognition. Our aim was to examine whether the addition of computer...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2018.06.012
更新日期：2018-11-01 00:00:00
abstract：:Non-compliance problems may rise to 50% among patients undergoing neuroleptic treatment. There are no direct measures available to predict compliance, if previous non-compliance is not taken into account. Attitudes towards neuroleptic treatment and insight into psychotic symptoms may vary during the course of the trea...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(99)00204-2
更新日期：2000-10-27 00:00:00
abstract：BACKGROUND:Previous literature suggests that better cognitive ability and insight are associated with greater lifetime risk of suicide attempts in schizophrenia, counter to the direction of association in the general population. However, the conjoint association between distinct cognitive domains, insight, and suicidal...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.06.013
更新日期：2018-02-01 00:00:00
abstract：:Cognitive adaptation training (CAT) is a home-based, manualized treatment that utilizes environmental supports to improve target behaviors and functional outcomes in persons with schizophrenia. Although clinical trials have shown CAT to be effective across functional, clinical, and treatment adherence domains, when th...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2014.03.026
更新日期：2014-06-01 00:00:00
abstract：:Natural killer cell activity was prospectively studied in 15 patients with chronic schizophrenia and in seven patients with schizoaffective disorder, depressed type. These patients were compared to individually matched normal controls. No mean differences in natural killer cell activity between the patient groups and ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(92)90028-4
更新日期：1992-12-01 00:00:00
abstract：BACKGROUND:Noncompliance is common in patients with schizophrenia and can have serious consequences; therefore research of the variables associated with noncompliance is a priority. Although the MEMS device is regarded as the "reference standard" for evaluating compliance, it has been used in very few published studies...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2008.09.007
更新日期：2009-02-01 00:00:00
abstract：:Schizophrenia may result from the concerted action of several pathophysiological factors. This pilot study compared the distribution of measurements of three such putative factors in 11 schizophrenics and their siblings: a neurophysiological deficit in auditory sensory gating, diminished hippocampal volume, and increa...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(94)90067-1
更新日期：1994-05-01 00:00:00
