当前位置： SCI文献检索 > SCHIZOPHRENIA RESEARCH期刊下所有文献 > Autoimmune diseases, gastrointestinal disorders and the microbiome in schizophrenia: more than a gut feeling.

Autoimmune diseases, gastrointestinal disorders and the microbiome in schizophrenia: more than a gut feeling.

Abstract：

:Autoimmunity, gastrointestinal (GI) disorders and schizophrenia have been associated with one another for a long time. This paper reviews these connections and provides a context by which multiple risk factors for schizophrenia may be related. Epidemiological studies strongly link schizophrenia with autoimmune disorders including enteropathic celiac disease. Exposure to wheat gluten and bovine milk casein also contribute to non-celiac food sensitivities in susceptible individuals. Co-morbid GI inflammation accompanies humoral immunity to food antigens, occurs early during the course of schizophrenia and appears to be independent from antipsychotic-generated motility effects. This inflammation impacts endothelial barrier permeability and can precipitate translocation of gut bacteria into systemic circulation. Infection by the neurotropic gut pathogen, Toxoplasma gondii, will elicit an inflammatory GI environment. Such processes trigger innate immunity, including activation of complement C1q, which also functions at synapses in the brain. The emerging field of microbiome research lies at the center of these interactions with evidence that the abundance and diversity of resident gut microbiota contribute to digestion, inflammation, gut permeability and behavior. Dietary modifications of core bacterial compositions may explain inefficient gluten digestion and how immigrant status in certain situations is a risk factor for schizophrenia. Gut microbiome research in schizophrenia is in its infancy, but data in related fields suggest disease-associated altered phylogenetic compositions. In summary, this review surveys associative and experimental data linking autoimmunity, GI activity and schizophrenia, and proposes that understanding of disrupted biological pathways outside of the brain can lend valuable information regarding pathogeneses of complex, polygenic brain disorders.

journal_name

Schizophr Res

journal_title

Schizophrenia research

authors

Severance EG,Yolken RH,Eaton WW

doi

10.1016/j.schres.2014.06.027

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

23-35

issue

1

eissn

0920-9964

issn

1573-2509

pii

S0920-9964(14)00319-3

journal_volume

176

pub_type

杂志文章,评审

相关文献

SCHIZOPHRENIA RESEARCH文献大全
  • Grey matter reduction in the caudate nucleus in patients with persistent negative symptoms: An ALE meta-analysis.

    abstract：OBJECTIVES:In the present study, we used Activation Likelihood Estimation (ALE) meta-analysis to quantitatively examine brain grey matter reduction in schizophrenia patients with persistent negative symptoms (PNS). METHOD:A total of 12 voxel-based morphometry (VBM) studies were included in ALE meta-analysis using more...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.schres.2017.04.005

    authors： Li Y,Li WX,Xie DJ,Wang Y,Cheung EFC,Chan RCK

    更新日期：2018-02-01 00:00:00

  • Predictors of antipsychotic medication adherence in patients recovering from a first psychotic episode.

    abstract：BACKGROUND:Many patients recovering from a first psychotic episode will discontinue medication against medical advice, even before a 1-year treatment course is completed. Factors associated with treatment adherence in patients with chronic schizophrenia include beliefs about severity of illness and need for treatment, ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2005.10.016

    authors： Perkins DO,Johnson JL,Hamer RM,Zipursky RB,Keefe RS,Centorrhino F,Green AI,Glick IB,Kahn RS,Sharma T,Tohen M,McEvoy JP,Weiden PJ,Lieberman JA,HGDH Research Group.

    更新日期：2006-03-01 00:00:00

  • Relative indices of treatment effect may be constant across different definitions of response in schizophrenia trials.

    abstract：BACKGROUND:In randomized controlled trials of antipsychotics, various cutoffs have been used to define response on continuous outcome measures. AIMS:To find a summary effect measure that remains constant across different definitions of response. METHOD:We conducted secondary analyses of individual patient data from 1...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.schres.2010.10.016

    authors： Furukawa TA,Akechi T,Wagenpfeil S,Leucht S

    更新日期：2011-03-01 00:00:00

  • An empirical conceptualization of the recovery orientation.

    abstract：OBJECTIVE:The recovery movement is having a growing impact on policy for people with severe mental illness. The empirical literature on the recovery orientation, however, is scant, and no empirical conceptualization of recovery has been published. METHOD:We identified items reflecting recovery themes and measuring asp...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2004.05.009

    authors： Resnick SG,Fontana A,Lehman AF,Rosenheck RA

    更新日期：2005-06-01 00:00:00

  • Brief executive function training for individuals with severe mental illness: Effects on EEG synchronization and executive functioning.

    abstract：BACKGROUND:Executive Functioning (EF) is an important factor for community functioning for people with severe mental illness. Cognitive remediation programs often improve EF, but do so by using multiple therapeutic techniques. Little is known regarding how individual treatment elements promote cognitive improvement. Os...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.schres.2017.08.052

    authors： Best MW,Gale D,Tran T,Haque MK,Bowie CR

    更新日期：2019-01-01 00:00:00

  • Red blood cell membrane dynamics in schizophrenia. I. Membrane fluidity.

    abstract：:Using the fluorescent probe DPH (1,6-diphenyl-1,3,5-hexatriene), steady-state anisotropy (rs) values were determined in red blood cell (RBC) ghost membranes of schizophrenic patients before (n = 26) and after (n = 16) haloperidol withdrawal, and age- and sex-matched normal controls (n = 22). Patients on haloperidol we...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/0920-9964(94)90014-0

    authors： Yao JK,van Kammen DP

    更新日期：1994-02-01 00:00:00

  • The Premorbid Adjustment Scale as a measure of developmental compromise in patients with schizophrenia and their healthy siblings.

    abstract：:Schizophrenia is associated with subtle developmental compromise, but the degree to which this is also associated with heritability and genetic risk is uncertain. The goal of the current study was to investigate the childhood, adolescent, and early adulthood social and academic function of patients with schizophrenia,...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2009.04.007

    authors： Shapiro DI,Marenco S,Spoor EH,Egan MF,Weinberger DR,Gold JM

    更新日期：2009-07-01 00:00:00

  • Schizophrenia, symptomatology and social inference: investigating "theory of mind" in people with schizophrenia.

    abstract：:It has been proposed that certain psychotic symptoms associated with schizophrenia reflect a deficit in the ability to appreciate other people's mental states (Frith, 1992). This notion is tested using a newly devised task examining the capacity to infer intentions behind indirect speech. The findings support the noti...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/0920-9964(95)00024-g

    authors： Corcoran R,Mercer G,Frith CD

    更新日期：1995-09-01 00:00:00

  • The Specific Level of Functioning Scale: construct validity, internal consistency and factor structure in a large Italian sample of people with schizophrenia living in the community.

    abstract：BACKGROUND:The study aimed to assess the construct validity, internal consistency and factor structure of the Specific Levels of Functioning Scale (SLOF), a multidimensional instrument assessing real life functioning. METHODS:The study was carried out in 895 Italian people with schizophrenia, all living in the communi...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2014.07.044

    authors： Mucci A,Rucci P,Rocca P,Bucci P,Gibertoni D,Merlotti E,Galderisi S,Maj M,Italian Network for Research on Psychoses.

    更新日期：2014-10-01 00:00:00

  • Depressive symptoms and presynaptic dopamine function in neuroleptic-naive schizophrenia.

    abstract：:We have previously reported aberrations in the striatal presynaptic dopamine function in neuroleptic-naive schizophrenic patients compared to healthy controls (Hietala, J., Syvälahti, E., Vuorio, K. et al., 1995. Lancet 346, 1130-1131). In this extended study we explore whether the altered presynaptic dopamine functio...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/s0920-9964(98)00113-3

    authors： Hietala J,Syvälahti E,Vilkman H,Vuorio K,Räkköläinen V,Bergman J,Haaparanta M,Solin O,Kuoppamäki M,Eronen E,Ruotsalainen U,Salokangas RK

    更新日期：1999-01-04 00:00:00

  • Maternal infection leads to abnormal gene regulation and brain atrophy in mouse offspring: implications for genesis of neurodevelopmental disorders.

    abstract：:Prenatal viral infection has been associated with development of schizophrenia and autism. Our laboratory has previously shown that viral infection causes deleterious effects on brain structure and function in mouse offspring following late first trimester (E9) administration of influenza virus. We hypothesized that l...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2007.11.018

    authors： Fatemi SH,Reutiman TJ,Folsom TD,Huang H,Oishi K,Mori S,Smee DF,Pearce DA,Winter C,Sohr R,Juckel G

    更新日期：2008-02-01 00:00:00

  • Further evidence for the association between LRP8 and schizophrenia.

    abstract：:Previous studies (including genome-wide association study (GWAS) and candidate gene studies) have revealed the important roles of genetic risk factors in schizophrenia, and RELN has been identified as a risk gene for this illness. We recently found that the low-density lipoprotein receptor-related protein 8 (LRP8), a ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2017.05.002

    authors： Xiao X,Yu H,Li J,Wang L,Li L,Chang H,Zhang D,Yue W,Li M

    更新日期：2020-01-01 00:00:00

  • The status of spectral EEG abnormality as a diagnostic test for schizophrenia.

    abstract：OBJECTIVE:A literature review was conducted to ascertain whether or not EEG spectral abnormalities are consistent enough to warrant additional effort towards developing them into a clinical diagnostic test for schizophrenia. METHODS:Fifty three papers met criteria for inclusion into the review and 15 were included in ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.schres.2007.11.020

    authors： Boutros NN,Arfken C,Galderisi S,Warrick J,Pratt G,Iacono W

    更新日期：2008-02-01 00:00:00

  • An Interleukin-1 beta (IL1B) haplotype linked with psychosis transition is associated with IL1B gene expression and brain structure.

    abstract：:We investigated IL1B genetic variation previously associated with risk for transition to psychosis for its association with gene expression in human post-mortem dorsolateral prefrontal cortex (DLPFC) from 74 (37 schizophrenia, 37 control) individuals and brain structure in 92 (44 schizophrenia, 48 control) living indi...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2018.09.008

    authors： Mostaid MS,Dimitrakopoulos S,Wannan C,Cropley V,Weickert CS,Everall IP,Pantelis C,Bousman CA

    更新日期：2019-02-01 00:00:00

  • Neurocognitive deficits and neurological signs in schizophrenia.

    abstract：OBJECTIVE:This is a comprehensive study designed to examine the association between specific clusters of neurological abnormalities and several clinically relevant aspects of schizophrenia such as positive and negative symptoms, neurocognitive deficits and psychosocial performance. METHODS:Thirty-seven clinically stab...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/S0920-9964(96)00095-3

    authors： Wong AH,Voruganti LN,Heslegrave RJ,Awad AG

    更新日期：1997-02-07 00:00:00

  • The theory of an agnosic right shift gene in schizophrenia and autism.

    abstract：:The right shift (RS) theory (Annett, M., 1972. The distribution of manual asymmetry. Br. J. Psychol. 63, 343-358; Annett, M., 1985. Left, Right, Hand and Brain: The Right Shift Theory. Lawrence Erlbaum, London) suggests that the typical pattern of human cerebral and manual asymmetries depends on a single gene (RS+) wh...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/s0920-9964(99)00072-9

    authors： Annett M

    更新日期：1999-10-19 00:00:00

  • Abnormal white matter integrity in antipsychotic-naïve first-episode psychosis patients assessed by a DTI principal component analysis.

    abstract：INTRODUCTION:Diffusion tensor imaging (DTI) studies in patients with schizophrenia have shown abnormalities in the microstructure of white matter tracts. Specifically, reduced fractional anisotropy (FA) has been described across multiple white matter tracts, in studies that have mainly included patients treated with an...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2015.01.019

    authors： Alvarado-Alanis P,León-Ortiz P,Reyes-Madrigal F,Favila R,Rodríguez-Mayoral O,Nicolini H,Azcárraga M,Graff-Guerrero A,Rowland LM,de la Fuente-Sandoval C

    更新日期：2015-03-01 00:00:00

  • Effects of repeated electroconvulsive shocks on dopamine supersensitivity psychosis model rats.

    abstract：:While the long-term administration of antipsychotics is known to cause dopamine supersensitivity psychosis (DSP), recent studies revealed that DSP helps form the foundation of treatment resistance. Electroconvulsive shock (ES) is one of the more effective treatments for treatment-resistant schizophrenia. The objective...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2020.11.062

    authors： Kimura M,Oda Y,Oishi K,Yoshino K,Kimura H,Niitsu T,Kanahara N,Shirayama Y,Hashimoto K,Iyo M

    更新日期：2021-01-08 00:00:00

  • Comparison of cost, dosage and clinical preference for risperidone and olanzapine.

    abstract：BACKGROUND:Because risperidone and olanzapine have similar efficacy and tolerability in the treatment of schizophrenia, costs, physician experience, and preference become relevant considerations in making treatment decisions. The purpose of this paper is to compare daily treatment costs of risperidone and olanzapine, a...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/s0920-9964(00)00036-0

    authors： Rabinowitz J,Lichtenberg P,Kaplan Z

    更新日期：2000-12-15 00:00:00

  • Abnormal involuntary movements are linked to psychosis-risk in children and adolescents: Results of a population-based study.

    abstract：BACKGROUND:Altered motor behavior has consistently been reported in medication-naive adult patients with schizophrenia and first episode psychosis and adults at clinical high risk for psychosis (CHR). This study is the first to evaluate the prevalence of abnormal involuntary movements in a community sample of children ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2016.04.032

    authors： Kindler J,Schultze-Lutter F,Michel C,Martz-Irngartinger A,Linder C,Schmidt SJ,Stegmayer K,Schimmelmann BG,Walther S

    更新日期：2016-07-01 00:00:00

  • Symptomatic remission and associated factors in a catchment area based population of older patients with schizophrenia.

    abstract：BACKGROUND:Symptomatic remission and its associated factors have been evaluated in several studies of younger schizophrenic patients. Although the number of older individuals with schizophrenia is rapidly growing, evaluations of remission in elderly patients are scarce and limited to samples of convenience, questioning...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2010.09.003

    authors： Meesters PD,Comijs HC,de Haan L,Smit JH,Eikelenboom P,Beekman AT,Stek ML

    更新日期：2011-03-01 00:00:00

  • Childhood trauma as a risk factor for the onset of subclinical psychotic experiences: Exploring the mediating effect of stress sensitivity in a cross-sectional epidemiological community study.

    abstract：:Childhood trauma is a risk factor for the onset of schizophrenic psychosis. Because the psychosis phenotype can be described as a continuum with varying levels of severity and persistence, childhood trauma might likewise increase the risk for psychotic experiences below the diagnostic threshold. But the impact of stre...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2016.02.006

    authors： Rössler W,Ajdacic-Gross V,Rodgers S,Haker H,Müller M

    更新日期：2016-04-01 00:00:00

  • Prodromal interventions for schizophrenia vulnerability: the risks of being "at risk".

    abstract：:Given the morbidity and difficulty of treating psychotic disorders, including schizophrenia, there has been a move toward identifying and treating adolescents and young adults who appear to be clinically at risk or "prodromal" to psychosis. The field now has greater specificity in identification, with rates of 40-50% ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2004.05.021

    authors： Corcoran C,Malaspina D,Hercher L

    更新日期：2005-03-01 00:00:00

  • A reliable digital photomicroscopic method of nailfold plexus visibility assessment in schizophrenia.

    abstract：:High nailfold plexus visibility (NPV) is a trait identifying a putative endophenotype for schizophrenia. We describe a new method of NPV assessment using computer storage of digital photomicrographs. We performed a reliability study of this method using 40 subjects. The intraclass correlation between two blinded rater...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2009.08.017

    authors： Miranowski SK,Vuchetich JP

    更新日期：2010-09-01 00:00:00

  • Altered CSNK1E, FABP4 and NEFH protein levels in the dorsolateral prefrontal cortex in schizophrenia.

    abstract：:Schizophrenia constitutes a complex disease. Negative and cognitive symptoms are enduring and debilitating components of the disorder, highly associated to disability and burden. Disrupted neurotransmission circuits in dorsolateral prefrontal cortex (DLPFC) have been related to these symptoms. To identify candidates a...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2016.04.050

    authors： Pinacho R,Villalmanzo N,Meana JJ,Ferrer I,Berengueras A,Haro JM,Villén J,Ramos B

    更新日期：2016-11-01 00:00:00

  • Atypical antipsychotic medications increase postprandial triglyceride and glucose levels in male rats: relationship with stearoyl-CoA desaturase activity.

    abstract：:Recent preclinical and clinical evidence suggests that the stearoyl-CoA desaturase-1 (Scd1) enzyme plays a key role in the regulation of triglyceride (TG) biosynthesis and insulin sensitivity, and in vitro studies have found that antipsychotic medications up-regulate Scd1 mRNA expression. To investigate these effects ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2011.03.016

    authors： McNamara RK,Jandacek R,Rider T,Tso P,Cole-Strauss A,Lipton JW

    更新日期：2011-06-01 00:00:00

  • Behavioral effects of non-viral mediated RNA interference of synapsin II in the medial prefrontal cortex of the rat.

    abstract：:Synapsin II is a synaptic vesicle-associated phosphoprotein that has been implicated in the pathophysiology of schizophrenia. Researchers have demonstrated reductions in synapsin II mRNA and protein in post-mortem prefrontal cortex and hippocampus samples from patients with schizophrenia. Synapsin II protein expressio...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2012.01.029

    authors： Dyck BA,Tan ML,Daya RP,Basu D,Sookram CD,Thomas N,Mishra RK

    更新日期：2012-05-01 00:00:00

  • The Italian version of the 92-item Prodromal Questionnaire: Concurrent validity with the SIPS and factor analysis in a sample of 258 outpatients aged 11-36years.

    abstract：BACKGROUND:Current early screeners for psychosis-risk states have still to prove ability in identifying at-risk individuals. Among screeners, the 92-item Prodromal Questionnaire (PQ-92) is often used. We aimed to assess the validity of its Italian translation in a large Italian adolescent and young adult help-seeking s...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2017.02.008

    authors： Kotzalidis GD,Solfanelli A,Piacentino D,Savoja V,Fiori Nastro P,Curto M,Lindau JF,Masillo A,Brandizzi M,Fagioli F,Raballo A,Gebhardt E,Preti A,D'Alema M,Fucci MR,Miletto R,Andropoli D,Leccisi D,Girardi P,Loewy RL,

    更新日期：2017-11-01 00:00:00

  • Gender and procreation among patients with schizophrenia.

    abstract：OBJECTIVE:Reduced procreation among men with schizophrenia has been reported consistently when compared with female patients, but the cause is unknown. Reports on Caucasian individuals predominate in the published literature. Therefore, analyses were conducted concurrently among independent Indian and US samples in the...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2003.08.009

    authors： Bhatia T,Franzos MA,Wood JA,Nimgaonkar VL,Deshpande SN

    更新日期：2004-06-01 00:00:00

  • Insight into illness in patients and caregivers during early psychosis: a pilot study.

    abstract：BACKGROUND:Impaired insight into illness is common during early psychosis and has been associated with treatment delays and poorer long-term outcomes. The relationship between patients' insight into illness and their caregivers' knowledge about psychosis is putatively associated with treatment outcome but there is limi...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2010.12.024

    authors： Brent BK,Giuliano AJ,Zimmet SV,Keshavan MS,Seidman LJ

    更新日期：2011-04-01 00:00:00