Insight into illness in patients and caregivers during early psychosis: a pilot study.


BACKGROUND:Impaired insight into illness is common during early psychosis and has been associated with treatment delays and poorer long-term outcomes. The relationship between patients' insight into illness and their caregivers' knowledge about psychosis is putatively associated with treatment outcome but there is limited research about this. This pilot study was designed to test the hypothesis that caregivers' levels of insight into illness is associated with patients' insight into illness in early psychosis and would be related to caregivers' levels of critical, rejecting attitudes toward patients. METHODS:Patients with schizophrenia or schizoaffective disorder within 5 years of psychosis onset (n=14) and caregivers (n=14) of the patients' choosing were studied. Insight into illness was assessed in patients using the Scale to assess Unawareness of Mental Disorder (SUMD). Caregiver insight into illness was assessed with a modified version of the SUMD with questions rephrased to probe caregivers' understanding of the patients' illness. Caregivers' critical attitudes toward patients were assessed with the Patient Rejection Scale (PRS). RESULTS:Significant correlations were found between patients' and caregivers' awareness of need for treatment (r=.55, p=.02), awareness of symptoms (r=.48, p=.04) and between caregivers' awareness of illness and critical attitudes toward patients (r=.65, p=.01). CONCLUSIONS:These findings suggest that caregivers' emotional characteristics and levels of insight into illness may be related to insight into illness in patients. Implications for family psychoeducational approaches to impairments of insight into illness during early psychosis are discussed.


Schizophr Res


Schizophrenia research


Brent BK,Giuliano AJ,Zimmet SV,Keshavan MS,Seidman LJ




Has Abstract


2011-04-01 00:00:00














  • Stress and arousability in schizophrenia.

    abstract::This paper examines trait arousability (TA), a temperament characteristic, in 47 stable outpatients with schizophrenia and 50 non-psychiatric controls. Self-reported levels of stress were obtained during a negative and positive memory speech task. Levels of TA, and the association of TA scores with reported stress dur...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Dinzeo TJ,Cohen AS,Nienow TM,Docherty NM

    更新日期:2004-11-01 00:00:00

  • A case-control association study between the GRID1 gene and schizophrenia in the Chinese Northern Han population.

    abstract::The glutamatergic dysfunction hypothesis of schizophrenia implicates the genes involved in glutamatergic transmission as strong candidates for schizophrenia-susceptibility. Recent linkage and association studies have identified the glutamate receptor, ionotropic, delta 1 gene GRID1 on 10q22 as a strong candidate for s...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Guo SZ,Huang K,Shi YY,Tang W,Zhou J,Feng GY,Zhu SM,Liu HJ,Chen Y,Sun XD,He L

    更新日期:2007-07-01 00:00:00

  • Autoimmune diseases, gastrointestinal disorders and the microbiome in schizophrenia: more than a gut feeling.

    abstract::Autoimmunity, gastrointestinal (GI) disorders and schizophrenia have been associated with one another for a long time. This paper reviews these connections and provides a context by which multiple risk factors for schizophrenia may be related. Epidemiological studies strongly link schizophrenia with autoimmune disorde...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,评审


    authors: Severance EG,Yolken RH,Eaton WW

    更新日期:2016-09-01 00:00:00

  • Effect of parental age on treatment response in adolescents with schizophrenia.

    abstract:BACKGROUND:Advanced paternal age (APA) is associated with increased risk for schizophrenia, but its effect on treatment response has not been longitudinally studied. METHODS:Association of parental ages at the time of the child's birth with age of onset, initial symptom severity and treatment response (to placebo and ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,随机对照试验


    authors: Opler M,Malaspina D,Gopal S,Nuamah I,Savitz AJ,Singh J,Hough D

    更新日期:2013-12-01 00:00:00

  • The neurocognitive underpinnings of diminished expressivity in schizotypy: what the voice reveals.

    abstract::Diminished expressivity is a characteristic feature of schizophrenia-spectrum pathology. However, attempts to elucidate the neurobiological underpinnings of diminished expressivity have yielded limited information. The present study posited that diminished expressivity was associated with a right, but not left-hemisph...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Cohen AS,Iglesias B,Minor KS

    更新日期:2009-04-01 00:00:00

  • Febrile seizures and risk of schizophrenia.

    abstract:BACKGROUND:Febrile seizure is a benign condition for most children, but experiments in animals and neuroimaging studies in humans suggest that some febrile seizures may damage the hippocampus, a brain area of possible importance in schizophrenia. METHODS:A population-based cohort of all children born in Denmark betwee...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Vestergaard M,Pedersen CB,Christensen J,Madsen KM,Olsen J,Mortensen PB

    更新日期:2005-03-01 00:00:00

  • Can disorganisation of semantic memory account for the abnormalities of thought in schizophrenia-a controlled experimental study.

    abstract:BACKGROUND:Disorganisation of semantic memory could provide a cognitive explanation for the disturbances of thinking and reasoning in schizophrenia. In this study, we directly test this explanation by identifying patients with disorganised semantic categories and then examine how they use their knowledge about these sa...

    journal_title:Schizophrenia research

    pub_type: 临床试验,杂志文章


    authors: Green NE,Done DJ,Anthony SH,McKenna PJ,Ochocki M

    更新日期:2004-10-01 00:00:00

  • Course of psychotic symptoms, depression and global functioning in persons at clinical high risk of psychosis: Results of a longitudinal observation study over three years focusing on both converters and non-converters.

    abstract::The aim of this study was to test the validity of the CHR state by focusing on the course of psychosis spectrum symptoms, depression and global functioning in converters and non-converters. A total of 188 CHR-positive subjects (60.2% men) aged between 13 and 35years (mean=20.5) at study outset were assessed five times...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Hengartner MP,Heekeren K,Dvorsky D,Walitza S,Rössler W,Theodoridou A

    更新日期:2017-11-01 00:00:00

  • Cognitive decline in schizophrenia from childhood to midlife: a 33-year longitudinal birth cohort study.

    abstract:BACKGROUND:We examined cognitive deficits before and after onset of schizophrenia in a longitudinal study that: 1) covers a long time interval; 2) minimizes test unreliability by including the identical measure at both childhood and post-onset cognitive assessments; and 3) minimizes bias by utilizing a population-based...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Kremen WS,Vinogradov S,Poole JH,Schaefer CA,Deicken RF,Factor-Litvak P,Brown AS

    更新日期:2010-05-01 00:00:00

  • 1-year follow-up study of cognitive function in first-episode non-affective psychosis.

    abstract::The longitudinal course of primary cognitive dysfunction seen in schizophrenia has yet to be fully clarified. Whereas some studies in chronic patients have revealed a progressive decline in cognitive abilities, those studies with first-episode patients have indicated that initial cognitive deficits might remain stable...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Rodríguez-Sánchez JM,Pérez-Iglesias R,González-Blanch C,Pelayo-Terán JM,Mata I,Martínez O,Sánchez-Cubillo I,Vázquez-Barquero JL,Crespo-Facorro B

    更新日期:2008-09-01 00:00:00

  • Differentiating patients with schizophrenia from healthy controls by hippocampal subfields using radiomics.

    abstract:BACKGROUND:Accurately diagnosing schizophrenia is still challenging due to the lack of validated biomarkers. Here, we aimed to investigate whether radiomic features in bilateral hippocampal subfields from magnetic resonance images (MRIs) can differentiate patients with schizophrenia from healthy controls (HCs). METHOD...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Park YW,Choi D,Lee J,Ahn SS,Lee SK,Lee SH,Bang M

    更新日期:2020-09-01 00:00:00

  • Cardiovascular risk in a first-episode psychosis sample: a 'critical period' for prevention?

    abstract:OBJECTIVE:Studies in first episode psychosis samples about status of cardiovascular risk factors have shown discordant results. We aimed to determine the 10-year risk of developing coronary heart disease in a sample of first episode psychosis patients referred to an early intervention clinic and compared the same with ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Phutane VH,Tek C,Chwastiak L,Ratliff JC,Ozyuksel B,Woods SW,Srihari VH

    更新日期:2011-04-01 00:00:00

  • Adolescent developmental change in topography of EEG amplitude.

    abstract::EEGs were recorded from 32 channels in 30 normal males, ages 16-22. Delta activity decreased throughout this age range. This decrease was greatest in the left frontal and temporal regions; no occipital lead showed this pattern. Relative EEG amplitude analysis, based on normalized maps, revealed decreases with age acro...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Buchsbaum MS,Mansour CS,Teng DG,Zia AD,Siegel BV Jr,Rice DM

    更新日期:1992-07-01 00:00:00

  • Risk factors and confounders in the geographical clustering of schizophrenia.

    abstract::In response to previous reports of geographical clustering of individuals with psychosis, a study was carried out in Denmark utilizing the national case register. Two-thousand one-hundred and ninety-nine (2199) individuals with schizophrenia were divided by place of birth into 217 geographical areas and analyzed by ag...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Torrey EF,Mortensen PB,Pedersen CB,Wohlfahrt J,Melbye M

    更新日期:2001-04-30 00:00:00

  • Abstract and experiential thinking differentially account for anomalous perception of reality in people with or without schizophrenia.

    abstract::repetitive thinking is often increased in various psychopathological conditions. However, evidence for its possible contribution to psychotic symptoms relies only on correlational analysis and has not been experimentally tested within the psychotic continuum. This research aims to examine whether repetitive thinking a...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Ricarte JJ,Del Rey F,Ros L,Latorre JM,Berna F

    更新日期:2018-03-01 00:00:00

  • Subjective quality of life in first-episode psychosis. A ten year follow-up study.

    abstract:UNLABELLED:Subjective quality of life (S-QoL) is an important outcome measure in first episode psychosis (FEP). The aims of this study were to describe S-QoL-development the first 10-years in FEP patients and to identify predictors of this development. METHODS:A representative sample of 272 patients with a first episo...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Gardsjord ES,Romm KL,Friis S,Barder HE,Evensen J,Haahr U,ten Velden Hegelstad W,Joa I,Johannessen JO,Langeveld J,Larsen TK,Opjordsmoen S,Rund BR,Simonsen E,Vaglum P,McGlashan T,Melle I,Røssberg JI

    更新日期:2016-04-01 00:00:00

  • Developing models of how cognitive improvements change functioning: mediation, moderation and moderated mediation.

    abstract:BACKGROUND:Cognitive remediation (CRT) affects functioning but the extent and type of cognitive improvements necessary are unknown. AIM:To develop and test models of how cognitive improvement transfers to work behaviour using the data from a current service. METHOD:Participants (N49) with a support worker and a paid ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Wykes T,Reeder C,Huddy V,Taylor R,Wood H,Ghirasim N,Kontis D,Landau S

    更新日期:2012-06-01 00:00:00

  • Deficit of entropy modulation of the EEG in schizophrenia associated to cognitive performance and symptoms. A replication study.

    abstract::Spectral entropy (SE) is a measurement from information theory field that provides an estimation of EEG regularity and may be useful as a summary of its spectral properties. Previous studies using small samples reported a deficit of EEG entropy modulation in schizophrenia during cognitive activity. The present study i...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Molina V,Bachiller A,Gomez-Pilar J,Lubeiro A,Hornero R,Cea-Cañas B,Valcárcel C,Haidar MK,Poza J

    更新日期:2018-05-01 00:00:00

  • Neuregulin-1 and the P300 waveform--a preliminary association study using a psychosis endophenotype.

    abstract:OBJECTIVE:Neuregulin-1 (NRG1) has been put forward as a susceptibility gene for schizophrenia. We investigated the association between Neuregulin-1 and the P300 wave, a schizophrenia endophenotype. METHODS:Participants were 64 patients with DSM-IV schizophrenia or schizoaffective disorder, 97 of their non psychotic re...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Bramon E,Dempster E,Frangou S,Shaikh M,Walshe M,Filbey FM,McDonald C,Sham P,Collier DA,Murray R

    更新日期:2008-08-01 00:00:00

  • Abnormal prefrontal cortical activity and connectivity during response selection in first episode psychosis, chronic schizophrenia, and unaffected siblings of individuals with schizophrenia.

    abstract::The search for genes conferring liability for schizophrenia may be aided by the identification of endophenotypes. Response selection is a heritable cognitive function that is impaired in patients with schizophrenia and their unaffected siblings. The abnormalities in cerebral function that presumably underlie the defic...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Woodward ND,Waldie B,Rogers B,Tibbo P,Seres P,Purdon SE

    更新日期:2009-04-01 00:00:00

  • Variations in myelin and oligodendrocyte-related gene expression across multiple brain regions in schizophrenia: a gene ontology study.

    abstract::Large-scale gene expression studies in schizophrenia (SZ) have generally focused on the dorsolateral prefrontal cortex. Studies of other brain regions have been less frequent and have rarely been performed in the same subjects. We analyzed postmortem gene expression in multiple cortical regions (Brodmann areas 8, 10, ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Katsel P,Davis KL,Haroutunian V

    更新日期:2005-11-15 00:00:00

  • Th17 and MAIT cell mediated inflammation in antipsychotic free schizophrenia patients.

    abstract::The immune hypothesis of schizophrenia has gained significant popularity in recent years in schizophrenia research. Evidence suggests that the peripheral immune system communicates with central nervous system and the effect propagates through microglial and lymphocyte crosstalk, especially during neuro-inflammation. A...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Varun CN,Venkataswamy MM,Ravikumar R,Nagaraju R,Debnath M,Varambally S,Venkatasubramanian G,Ravi V

    更新日期:2019-10-01 00:00:00

  • Altered interregional correlations between serotonin transporter availability and cerebral glucose metabolism in schizophrenia: A high-resolution PET study using [11C]DASB and [18F]FDG.

    abstract::The purpose of the present study was to investigate the patterns of interregional correlations of serotonin transporter (SERT) availability with glucose metabolism using 7-Tesla magnetic resonance imaging (MRI) and high-resolution positron emission tomography (PET) with 11C-3-amino-4-(2-dimethylaminomethylphenylthio)b...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Kim JH,Kim JH,Son YD,Joo YH,Lee SY,Kim HK,Woo MK

    更新日期:2017-04-01 00:00:00

  • Building models for postmortem abnormalities in hippocampus of schizophrenics.

    abstract::Postmortem studies have suggested that there is abnormal GABAergic activity in the hippocampus in schizophrenia (SZ). In micro-dissected human hippocampal slices, a loss of interneurons and a compensatory upregulation of GABAA receptor binding activity on interneurons, but not PNs, has suggested that disinhibitory GAB...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,评审


    authors: Benes FM

    更新日期:2015-09-01 00:00:00

  • A multicenter, randomized, double-blind, controlled phase 3 trial of fixed-dose brexpiprazole for the treatment of adults with acute schizophrenia.

    abstract::The objective of this study was to evaluate the efficacy, safety and tolerability of brexpiprazole versus placebo in adults with acute schizophrenia. This was a 6-week, multicenter, placebo-controlled double-blind phase 3 study. Patients with acute schizophrenia were randomized to brexpiprazole 1, 2 or 4 mg, or placeb...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Kane JM,Skuban A,Ouyang J,Hobart M,Pfister S,McQuade RD,Nyilas M,Carson WH,Sanchez R,Eriksson H

    更新日期:2015-05-01 00:00:00

  • Unirhinal olfactory identification deficits in young male patients with schizophrenia and related disorders: association with impaired memory function.

    abstract::We have observed discreet subgroups of male patients with psychotic disorders who have unirhinal olfactory identification deficits (microsmia). The purpose of this study was to examine the relationship between left or right nostril microsmia and performance on literalised neuropsychological tests sensitive to lesions ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,多中心研究


    authors: Good KP,Martzke JS,Milliken HI,Honer WG,Kopala LC

    更新日期:2002-08-01 00:00:00

  • Social cognition and quality of life in schizophrenia.

    abstract::Schizophrenia is associated with poor quality of life (QOL). Whereas the effects of neurocognitive deficits and psychopathology on QOL of schizophrenia patients have recently been elucidated, little is known about social cognitive deficits in this regard. This study investigated the influence of social cognition on QO...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,多中心研究


    authors: Maat A,Fett AK,Derks E,GROUP Investigators.

    更新日期:2012-05-01 00:00:00

  • Natural surroundings in childhood are associated with lower schizophrenia rates.

    abstract::High exposure to green space and natural environments has previously been associated with lower schizophrenia rates possibly through low air pollution and improved psychological restoration. Exposure to natural environments could explain the negative urban-rural gradient of schizophrenia, but it is unclear if all natu...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Engemann K,Svenning JC,Arge L,Brandt J,Geels C,Mortensen PB,Plana-Ripoll O,Tsirogiannis C,Pedersen CB

    更新日期:2020-02-01 00:00:00

  • Cytokines in cerebrospinal fluid of patients with schizophrenia spectrum disorders: New data and an updated meta-analysis.

    abstract::Few studies have been conducted examining cytokines in cerebrospinal fluid of patients compared to healthy volunteers. The goals of this study were: 1) to report original data detailing cytokine levels in the cerebrospinal fluid (CSF) of 10 patients with a schizophrenia spectrum disorder (SSD) diagnosis and 10 healthy...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,meta分析


    authors: Gallego JA,Blanco EA,Husain-Krautter S,Madeline Fagen E,Moreno-Merino P,Del Ojo-Jiménez JA,Ahmed A,Rothstein TL,Lencz T,Malhotra AK

    更新日期:2018-12-01 00:00:00

  • Affective prosody perception in symptomatically remitted patients with schizophrenia and bipolar disorder.

    abstract::Affect perception has frequently been shown to be impaired in patients suffering from schizophrenia or bipolar disorder (BD), but it remains unclear whether these impairments exist during symptomatic remission and whether the two disorders differ from each other in this regard. Most previous studies have investigated ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Hoertnagl CM,Yalcin-Siedentopf N,Baumgartner S,Biedermann F,Deisenhammer EA,Hausmann A,Kaufmann A,Kemmler G,Mühlbacher M,Rauch AS,Fleischhacker WW,Hofer A

    更新日期:2014-09-01 00:00:00