Abstract：
OBJECTIVES:In the present study, we used Activation Likelihood Estimation (ALE) meta-analysis to quantitatively examine brain grey matter reduction in schizophrenia patients with persistent negative symptoms (PNS). METHOD:A total of 12 voxel-based morphometry (VBM) studies were included in ALE meta-analysis using more stringent criterion of PNS. RESULTS:Significant grey matter reduction in the PNS group relative to controls was observed in the left caudate nucleus, the left precentral region, the left middle frontal region, the bilateral parahippocampal region, the left anterior cingulate region, the bilateral medial frontal gyrus, the thalamus and the insula. CONCLUSION:Our results suggest that brain regions in the reward network may be specifically related to PNS, especially the left caudate nucleus. It is possible that abnormality in reward processing may constitute the neural basis of PNS.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Li Y,Li WX,Xie DJ,Wang Y,Cheung EFC,Chan RCKdoi
10.1016/j.schres.2017.04.005subject
Has Abstractpub_date
2018-02-01 00:00:00pages
9-15eissn
0920-9964issn
1573-2509pii
S0920-9964(17)30192-5journal_volume
192pub_type
杂志文章,meta分析,评审abstract：:Childhood trauma is a risk factor for the onset of schizophrenic psychosis. Because the psychosis phenotype can be described as a continuum with varying levels of severity and persistence, childhood trauma might likewise increase the risk for psychotic experiences below the diagnostic threshold. But the impact of stre...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.02.006
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND:Clinical guidelines recommend maintenance treatment with antipsychotic medication for one to two years following remission of symptoms after a first episode of psychosis. However, recent research has suggested that this may not be indicated. Consistent predictors of outcome would be beneficial to guide clini...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.11.010
更新日期：2018-07-01 00:00:00
abstract：OBJECTIVE:Amoxapine is marketed as an antidepressant. However, its receptor occupancy, in vitro and in vivo, and its effects in pre-clinical models are very similar to atypical antipsychotics. To examine if this leads to an atypical antipsychotic effect in the clinical context, the authors examined the antipsychotic an...
journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章
doi：10.1016/s0920-9964(01)00342-5
更新日期：2003-01-01 00:00:00
abstract：:Executive functioning (EF) impairments are common in schizophrenia. There are two propositions regarding the causes of these impairments: (1) executive impairments are the result of the compounding effects of deficits in lower order cognitive skills (e.g. processing speed, attention) or (2) EF impairments exist in the...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.07.034
更新日期：2013-10-01 00:00:00
abstract：:The frontal and temporal lobes have been implicated as pathogenic sites for schizophrenia, although there is a marked heterogeneity of brain function and structure between individual patients. It is currently unclear whether some patients with schizophrenia exhibit primarily frontal lobe dysfunction, while others exhi...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(00)00115-8
更新日期：2001-03-01 00:00:00
abstract：:Verbal fluency deficits in schizophrenia are difficult to interpret because the tasks are multi-factorial and groups differ in total words generated. We manipulated retrieval and switching demands by requiring alternation between over-learned sequences in which retrieval is relatively automatic (OS) and semantic categ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.11.017
更新日期：2008-02-01 00:00:00
abstract：:The extent of age-related changes in glutamate and other neurometabolites in the anterior cingulate cortex (ACC) in individuals with schizophrenia remain unclear. Magnetic resonance spectroscopy (MRS) at 7 T, which yields precise measurements of various metabolites and can distinguish glutamate from glutamine, was use...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.02.017
更新日期：2016-04-01 00:00:00
abstract：:Genetic and environmental models of neuropsychiatric disease have grown exponentially over the last 20years. One measure that is often used to evaluate the translational relevance of these models to human neuropsychiatric disease is prepulse inhibition of startle (PPI), an operational measure of sensorimotor gating. D...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2017.10.009
更新日期：2018-08-01 00:00:00
abstract：:Individuals diagnosed with schizophrenia spectrum disorders have significant neuropsychological deficits that have been linked to poor functional outcome. As more treatments are developed and implemented for cognitive impairments, it will be important to consider whether people with schizophrenia have insight into the...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2008.07.007
更新日期：2008-10-01 00:00:00
abstract：:We found previously that a subgroup of schizophrenic patients who passed screening tests of attentional competence showed memory deficits on word memory tasks, but were comparable with controls on tone memory tasks. To better understand the nature of language-specific memory deficits in this subgroup of patients, the ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00194-3
更新日期：2002-01-15 00:00:00
abstract：:Numerous studies have described attenuated event-related potential (ERP) component amplitudes in schizophrenia (e.g., P300, Mismatch Negativity (MMN), Error Negativity/Error-Related Negativity (Ne/ERN)). Functional magnetic resonance imaging (fMRI) studies have typically shown decreased recruitment of diverse brain ar...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.09.036
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:Executive Functioning (EF) is an important factor for community functioning for people with severe mental illness. Cognitive remediation programs often improve EF, but do so by using multiple therapeutic techniques. Little is known regarding how individual treatment elements promote cognitive improvement. Os...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2017.08.052
更新日期：2019-01-01 00:00:00
abstract：:The rubber-hand illusion (RHI), an illusion in which tactile sensations are referred to a synthetic alien limb, is enhanced in schizophrenia patients. Somatosensory evoked responses of the illusion were compared between schizophrenia patients and normal control subjects. Schizophrenia patients had significant alterati...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(03)00057-4
更新日期：2003-11-15 00:00:00
abstract：:Gray matter brain volume decreases have been found in patients with schizophrenia as compared to healthy control subjects measured by using Magnetic Resonance Imaging (MRI). An association has been suggested between decreased gray matter volume and poor outcome in chronically ill patients with schizophrenia. The prese...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/s0920-9964(03)00018-5
更新日期：2003-11-01 00:00:00
abstract：BACKGROUND:Self-referential processing (i.e. linking internal and external stimuli to one's own self) has received scant attention thus far in schizophrenia. This type of processing is a key component of social cognition and thought to be important for adaptive social functioning. Memory studies in healthy subjects hav...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2010.11.011
更新日期：2011-04-01 00:00:00
abstract：:Although the concept of remission has been widely accepted and utilized in depression and anxiety disorders, there has been much less emphasis on defining remission in schizophrenia. Recently, an expert consensus definition of remission in schizophrenia was proposed along specific operational criteria for the attainme...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.05.003
更新日期：2007-11-01 00:00:00
abstract：OBJECTIVE:A literature review was conducted to ascertain whether or not EEG spectral abnormalities are consistent enough to warrant additional effort towards developing them into a clinical diagnostic test for schizophrenia. METHODS:Fifty three papers met criteria for inclusion into the review and 15 were included in ...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.schres.2007.11.020
更新日期：2008-02-01 00:00:00
abstract：:Left or mixed-handedness, footedness, and eye dominance are thought to indicate abnormalities in lateralization related to schizophrenia. Increased left or mixed-dominance in schizophrenia suggests possible hemispheric abnormalities associated with the disorder. A related body of research suggests that some indication...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2004.04.003
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:A potential link between increase in total cholesterol and triglycerides and clinical improvement has been observed during antipsychotic drug treatment in chronic schizophrenia patients, possibly due to drug related effects on lipid biosynthesis. We examined whether changes in serum lipids are associated wit...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.10.042
更新日期：2018-07-01 00:00:00
abstract：:Long-stay patients constitute a small proportion of all patients with schizophrenia, but in both VA and state psychiatric systems these patients account for a majority of the costs associated with treatment of the illness. VA and state patients would be expected to differ in several respects, including age at onset an...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(99)00182-6
更新日期：2000-05-25 00:00:00
abstract：BACKGROUND:Startle inhibition by weak prepulses (PPI) is studied to understand the biology of information processing in schizophrenia patients and healthy comparison subjects (HCS). The Consortium on the Genetics of Schizophrenia (COGS) identified associations between PPI and single nucleotide polymorphisms in schizoph...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.schres.2013.12.004
更新日期：2014-02-01 00:00:00
abstract：:We sought to identify the functional correlates of reduced magnetic resonance imaging (MRI) volumes of the superior temporal gyrus (STG) and the fusiform gyrus (FG) in patients with chronic schizophrenia. MRI volumes, positive/negative symptoms, and neuropsychological tests of facial memory and executive functioning w...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2006.11.025
更新日期：2007-03-01 00:00:00
abstract：:Schizophrenia is associated with structural brain abnormalities that are likely to be present before disease onset. It remains unclear to what extent these represent general vulnerability indicators or are associated with the developing clinical state itself. It also remains unclear whether such state or trait alterat...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.12.003
更新日期：2016-06-01 00:00:00
abstract：:Research on the effectiveness of treatment programs in early stages of severe mental illness raise significant ethical questions when conducted in industrialized countries that have adequate protections for the human subjects of biomedical and behavioral research. Before embarking on similar trials in developing count...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00244-4
更新日期：2001-08-01 00:00:00
abstract：BACKGROUND:Because risperidone and olanzapine have similar efficacy and tolerability in the treatment of schizophrenia, costs, physician experience, and preference become relevant considerations in making treatment decisions. The purpose of this paper is to compare daily treatment costs of risperidone and olanzapine, a...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(00)00036-0
更新日期：2000-12-15 00:00:00
abstract：:Schizophrenia may result from the concerted action of several pathophysiological factors. This pilot study compared the distribution of measurements of three such putative factors in 11 schizophrenics and their siblings: a neurophysiological deficit in auditory sensory gating, diminished hippocampal volume, and increa...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(94)90067-1
更新日期：1994-05-01 00:00:00
abstract：OBJECTIVE:Several risk factors of venous thromboembolism (VTE) and pulmonary embolism (PE) were found in patients with schizophrenia. Therefore, we hypothesize that the incidences of VTE and PE are relatively higher among schizophrenia patients in comparison with the general population. METHOD:For this population-base...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.01.012
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:There is increased interest in the impact of new long-acting treatments on health-related quality of life (HRQoL) in patients with schizophrenia. The aim of this study was to evaluate the impact of treatment with subcutaneous injections of RBP-7000, a new sustained-release formulation of risperidone, compare...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.schres.2016.03.020
更新日期：2016-07-01 00:00:00
abstract：:Affect perception has frequently been shown to be impaired in patients suffering from schizophrenia or bipolar disorder (BD), but it remains unclear whether these impairments exist during symptomatic remission and whether the two disorders differ from each other in this regard. Most previous studies have investigated ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.07.019
更新日期：2014-09-01 00:00:00
abstract：:Motion-induced blindness (MIB) occurs when target stimuli are presented together with a moving distractor pattern. Most observers experience the targets disappearing and reappearing repeatedly for periods of up to several seconds. MIB can be viewed as a striking marker for the organization of cognitive functioning. In...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2005.08.012
更新日期：2006-01-31 00:00:00
