Abstract:
:Schizophrenia is associated with structural brain abnormalities that are likely to be present before disease onset. It remains unclear to what extent these represent general vulnerability indicators or are associated with the developing clinical state itself. It also remains unclear whether such state or trait alterations may be evident at any given time-point, or whether they progress over time. To investigate this, structural brain scans were acquired at two time-points (mean scan-interval 1.87years) in a cohort of young unaffected individuals at high familial risk of schizophrenia (baseline, n=142; follow-up, n=64) and healthy controls (baseline, n=36; follow-up, n=18). Sub-cortical reconstructions of the hippocampus and amygdala were generated using the longitudinal pipeline available with Freesurfer. The high risk cohort was subdivided into individuals that remained well during the study (HR[well], baseline, n=68; follow-up, n=30), transient and/or partial symptoms that were insufficient to support a formal diagnosis (HR[symp], baseline, n=57; follow-up, n=26) and individuals that subsequently developed schizophrenia according to ICD-10 criteria (HR[ill], baseline, n=17; follow-up, n=8). Longitudinal change in the hippocampus and amygdala was compared, focusing first on overall differences between high-risk individuals and controls and then on sub-group differences within the high-risk cohort. We found a significantly altered developmental trajectory for all high risk individuals compared to controls, with controls showing a significant increase in hippocampal volume over time compared to those at high risk. We did not find evidence of altered longitudinal trajectories based on clinical outcome within the high risk cohort. These results suggest that an altered developmental trajectory of hippocampal volume is associated with a general familial predisposition to develop schizophrenia, as this alteration was not related to subsequent clinical outcome.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Bois C,Levita L,Ripp I,Owens DCG,Johnstone EC,Whalley HC,Lawrie SMdoi
10.1016/j.schres.2014.12.003subject
Has Abstractpub_date
2016-06-01 00:00:00pages
146-151issue
3eissn
0920-9964issn
1573-2509pii
S0920-9964(14)00713-0journal_volume
173pub_type
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更新日期:2018-02-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2014.04.032
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pub_type: 杂志文章
doi:10.1016/0920-9964(95)00023-2
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pub_type: 杂志文章
doi:10.1016/j.schres.2007.05.003
更新日期:2007-11-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/s0920-9964(98)00065-6
更新日期:1998-09-07 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2007.12.468
更新日期:2008-03-01 00:00:00
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pub_type: 杂志文章,meta分析
doi:10.1016/j.schres.2017.01.005
更新日期:2017-07-01 00:00:00
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更新日期:2020-01-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.03.003
更新日期:2014-05-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.03.010
更新日期:2015-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0920-9964(96)00065-5
更新日期:1996-11-15 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2020-03-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2017-05-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2017-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.05.020
更新日期:2018-11-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.02.008
更新日期:2017-11-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/0920-9964(92)90039-8
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND:Neuropsychological impairment is common in schizophrenia and psychotic bipolar disorder. It has been hypothesized that the pathways leading to impairment differ between disorders. Cognitive impairment in schizophrenia is believed to result largely from atypical neurodevelopment, whereas bipolar disorder is i...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.10.009
更新日期:2019-04-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0920-9964(95)00024-g
更新日期:1995-09-01 00:00:00