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Increase in serum HDL level is associated with less negative symptoms after one year of antipsychotic treatment in first-episode psychosis.

Abstract：

BACKGROUND:A potential link between increase in total cholesterol and triglycerides and clinical improvement has been observed during antipsychotic drug treatment in chronic schizophrenia patients, possibly due to drug related effects on lipid biosynthesis. We examined whether changes in serum lipids are associated with alleviation of psychosis symptoms after one year of antipsychotic drug treatment in a cohort of first-episode psychosis (FEP) patients. METHODS:A total of 132 non-affective antipsychotic-treated FEP patients were included through the Norwegian Thematically Organized Psychosis (TOP) project. Data on antipsychotic usage, serum lipids (total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol and triglycerides (TG)), body mass index (BMI) and clinical state were obtained at baseline and after 12months. The Positive and Negative Syndrome Scale (PANSS) was used to assess psychotic symptoms. Mixed-effects models were employed to examine the relationship between serum lipids and psychotic symptoms while controlling for potential confounders including BMI. RESULTS:An increase in HDL during one year of antipsychotic treatment was associated with reduction in PANSS negative subscores (B=-0.48, p=0.03). This relationship was not affected by concurrent change in BMI (adjusted HDL: B=-0.54, p=0.02). No significant associations were found between serum lipids, BMI and PANSS positive subscores. CONCLUSION:We found that an increase in HDL level during antipsychotic treatment is associated with improvement in negative symptoms in FEP. These findings warrant further investigation to clarify the interaction between lipid pathways and psychosis.

journal_name

Schizophr Res

journal_title

Schizophrenia research

authors

Gjerde PB,Dieset I,Simonsen C,Hoseth EZ,Iversen T,Lagerberg TV,Lyngstad SH,Mørch RH,Skrede S,Andreassen OA,Melle I,Steen VM

doi

10.1016/j.schres.2017.10.042

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

253-260

eissn

0920-9964

issn

1573-2509

pii

S0920-9964(17)30670-9

journal_volume

197

pub_type

杂志文章

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Increase in serum HDL level is associated with less negative symptoms after one year of antipsychotic treatment in first-episode psychosis.