Abstract：
OBJECTIVE:We recently reported that the type-2 cytokine response is increased in schizophrenia. The aim of this study was to analyse the effects of antipsychotic drugs on the serum levels of type-1 (TNF-α, IFN-γ), type-2 (IL-4, IL-10), type-17 (IL-17) and regulatory cytokines (TGF-β, IL-27 and IL-6). METHODS:Cytokine measurements in the patients were performed on day 0 and day 30 of the treatment using standard ELISA assays. Three groups of subjects were studied: patients that were unmedicated with First Episode Psychosis (FEP; n=88), patients that were treated with antipsychotics with Schizophrenia in relapse (SC in relapse; n=45) and healthy controls (n=36). RESULTS:TGF-β levels were increased in both patient groups and were further enhanced after treatment in the FEP group (p=0.014) but not in the SC relapse group. Antipsychotic treatment was correlated with lower levels of IL-4, IL-6 and IL-27 (p<0.005) in the FEP group. Finally, the serum levels of IL-17 were not significantly altered between the two measurements but were significantly lower in the FEP group (p<0.001) when compared with healthy controls. After therapy, patients with SC who were in relapse had decreased serum levels of IL-4 (p=0.006) and IL-6 (p=0.007). We also observed a weak negative correlation between the IFN-γ/TGF-β ratio and the total PANSS score and between the IL-17/TGF-β ratio and the negative and general psychopathology subscales. CONCLUSION:The increased type-2 cytokine serum levels in schizophrenia appear to be downregulated by antipsychotic treatment.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Borovcanin M,Jovanovic I,Radosavljevic G,Djukic Dejanovic S,Stefanovic V,Arsenijevic N,Lukic MLdoi
10.1016/j.schres.2013.03.027subject
Has Abstractpub_date
2013-06-01 00:00:00pages
103-109issue
1eissn
0920-9964issn
1573-2509pii
S0920-9964(13)00173-4journal_volume
147pub_type
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