Abstract:
:Systematic linkage disequilibrium (LD) mapping of 8p12-21 in the Icelandic population identified neuregulin 1 (NRG1) as a prime candidate gene for schizophrenia. However, results of replication studies have been inconsistent, and no large sample analyses have been reported. Therefore, we designed this study with the aim of assessing this putative association between schizophrenia and NRG1 (especially HAP(ICE) region and exon region) using a gene-based association approach in the Japanese population. This study was a two-stage association analysis with a different panel of samples, in which the significant association found in the first-set screening samples (1126 cases and 1022 controls) was further assessed in the confirmation samples (1262 cases and 1172 controls, and 166 trio samples). In the first-set scan, 60 SNPs (49 tagging SNPs from HapMap database, four SNPs from other papers, and seven SNPs detected in the mutation scan) were examined. One haplotype showed a significant association in the first-set screening samples (Global P-value=0.0244, uncorrected). However, we could not replicate this association in the following independent confirmation samples. Moreover, we could not find sufficient evidence for association of the haplotype identified as being significant in the first-set samples by imputing ungenotyped SNPs from HapMap database. These results indicate that the positionally and functionally attractive regions of NRG1 are unlikely to contribute to susceptibility to schizophrenia in the Japanese population. Moreover, the nature of our results support that two-stage analysis with large sample size is appropriate to examine the susceptibility genes for common diseases.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Ikeda M,Takahashi N,Saito S,Aleksic B,Watanabe Y,Nunokawa A,Yamanouchi Y,Kitajima T,Kinoshita Y,Kishi T,Kawashima K,Hashimoto R,Ujike H,Inada T,Someya T,Takeda M,Ozaki N,Iwata Ndoi
10.1016/j.schres.2008.01.010subject
Has Abstractpub_date
2008-04-01 00:00:00pages
1-8issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(08)00055-8journal_volume
101pub_type
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journal_title:Schizophrenia research
pub_type: 杂志文章
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更新日期:2018-10-01 00:00:00
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journal_title:Schizophrenia research
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更新日期:2013-01-01 00:00:00
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更新日期:2007-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2012.09.016
更新日期:2012-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
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journal_title:Schizophrenia research
pub_type: 杂志文章
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更新日期:2005-03-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析
doi:10.1016/j.schres.2014.07.014
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:To develop a pharmacokinetic-pharmacodynamic (PK-PD) model using individual-level data of Positive and Negative Syndrome Scale (PANSS) total score to characterize the antipsychotic drug effect taking into account the placebo effect and dropout rate. In addition, a clinical utility (CU) criterion that describ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.02.011
更新日期:2013-05-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:1993-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0920-9964(02)00295-5
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abstract:OBJECTIVE:While "dual diagnosis" involving both psychiatric and substance use disorders has long been a focus of schizophrenia research, recent studies have advocated for a shift of focus to multimorbidity, addressing comorbidity from both additional psychiatric disorders and substance use disorders. We hypothesized th...
journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2018.04.035
更新日期:2018-11-01 00:00:00
abstract::Past studies have shown that schizophrenic men tend to be impaired on the olfactory identification task. We examined individual differences in the olfactory function in relation to schizotypy. Healthy individuals who might carry latent liability for schizophrenia participated in olfactory identification and acuity tas...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(97)00045-5
更新日期:1997-08-29 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.10.017
更新日期:2020-01-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(98)00113-3
更新日期:1999-01-04 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.05.034
更新日期:2010-08-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.12.005
更新日期:2018-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(99)00068-7
更新日期:2000-01-21 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.08.001
更新日期:2010-05-01 00:00:00
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doi:10.1016/j.schres.2018.10.012
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pub_type: 杂志文章,随机对照试验
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更新日期:2014-06-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.04.027
更新日期:2015-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:1995-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析
doi:10.1016/j.schres.2004.08.022
更新日期:2005-06-15 00:00:00
abstract::Second generation antipsychotics cause derangements in glucose metabolism that are often interpreted as insulin resistance. In previous studies we have shown that this is not classical insulin resistance but the drugs were actually inducing a hyperglycaemic state associated with elevated hepatic glucose output (HGO) a...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.05.003
更新日期:2014-08-01 00:00:00
abstract:INTRODUCTION:This study investigates the effect of exposure to "The Troubles" (the period of civil unrest from 1968 onwards) in Northern Ireland on symptomatology in people with schizophrenia. METHOD:Eighty-two participants were assessed on a number of psychiatric rating scales and on measures of trauma, including an ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.02.012
更新日期:2008-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2014.10.044
更新日期:2016-09-01 00:00:00
abstract::High nailfold plexus visibility (NPV) is a trait identifying a putative endophenotype for schizophrenia. We describe a new method of NPV assessment using computer storage of digital photomicrographs. We performed a reliability study of this method using 40 subjects. The intraclass correlation between two blinded rater...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.08.017
更新日期:2010-09-01 00:00:00
abstract::Schizophrenia and affective disorders are relatively common neuropsychiatric diseases with a complex genetic etiology. A multigenic inheritance with variable influence of unknown environmental factors may be involved. Family studies have demonstrated the existence of both phenotypes in the same kindreds, and in certai...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/s0920-9964(99)00108-5
更新日期:1999-09-29 00:00:00