The insula-claustrum region and delusions in schizophrenia.

Abstract:

OBJECTIVE:We examined the relationship between cerebral gray matter (GM) volume and severity of delusions and hallucinations in adults with schizophrenia. METHOD:MRI scans in 43 patients with schizophrenia were acquired. Correlations were computed between GM volume and clinician ratings of hallucinations and delusions. RESULTS:The analysis revealed significant inverse correlations between ratings of the severity of delusions and volumes of the left claustrum and right insula. Significant correlations were not observed between cerebral GM volume and ratings of hallucinations. CONCLUSION:The insula/claustrum region may be critical to the experience of delusions and more careful scrutiny of the claustrum in relation to schizophrenia appears warranted.

journal_name

Schizophr Res

journal_title

Schizophrenia research

authors

Cascella NG,Gerner GJ,Fieldstone SC,Sawa A,Schretlen DJ

doi

10.1016/j.schres.2011.08.004

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

77-81

issue

1-3

eissn

0920-9964

issn

1573-2509

pii

S0920-9964(11)00435-X

journal_volume

133

pub_type

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