Abstract：
:Impaired fiber bundle connectivity between brain regions is a key neuropathological finding in schizophrenia. Symptom dimensions in schizophrenia can be clustered into factor models. Single syndromes have been related to grey and white matter brain structure alterations. We associated all core syndromes of schizophrenia in a single patient group with changes in white matter integrity. Diffusion weighted images (3T MRI) and SAPS/SANS scores were measured in 26 male patients and 26 healthy controls. First, group differences in fractional anisotropy (FA) were calculated with TBSS. Second, core symptom dimensions of schizophrenia were correlated with FA within these altered tracts. We found differences between groups in nine white matter tracts. Hallucinations were positively correlated with FA in the left uncinate fasciculus and left corticospinal tract. Ego-disturbances (passivity phenomena) showed a positive correlation with FA in the right anterior thalamic radiation. Positive formal thought disorders (FTD) corresponded negatively with FA in the right cingulum bundle. Negative symptoms were positively associated with the right anterior thalamic radiation and negatively with the right ventral cingulum bundle. For the first time, we analyzed the whole range of psychopathological factors in one schizophrenia patient group. We could validate our novel results for positive FTD and passivity phenomena by replicating findings for hallucinations and negative symptoms. Only those brain circuits which are most vulnerable at a given time during neurodevelopment are affected by a particular pathological impact (genetic, environmental). This scenario could explain the predominance of particular psychopathological syndromes related to specific white matter anomalies.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Bopp MHA,Zöllner R,Jansen A,Dietsche B,Krug A,Kircher TTJdoi
10.1016/j.schres.2016.11.045subject
Has Abstractpub_date
2017-06-01 00:00:00pages
59-68eissn
0920-9964issn
1573-2509pii
S0920-9964(16)30556-4journal_volume
184pub_type
杂志文章abstract：:It is now well established that the utilization of standardized clinical criteria can enhance prediction of psychosis. These criteria are primarily concerned with the presence and severity of attenuated positive symptoms. Because these symptom criteria are used to derive algorithms for designating clinical high risk (...
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pub_type： 临床试验,杂志文章
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.02.008
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pub_type： 杂志文章
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pub_type： 杂志文章,meta分析
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pub_type： 杂志文章
doi：10.1016/j.schres.2014.07.021
更新日期：2014-09-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2016-06-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1016/j.schres.2013.10.009
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pub_type： 杂志文章
doi：10.1016/j.schres.2012.06.038
更新日期：2012-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0920-9964(98)00106-6
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pub_type： 杂志文章
doi：10.1016/j.schres.2010.05.034
更新日期：2010-08-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2015-05-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2008.06.002
更新日期：2008-09-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
doi：10.1016/j.schres.2013.12.002
更新日期：2014-02-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.08.022
更新日期：2016-12-01 00:00:00
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pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.schres.2016.02.013
更新日期：2016-05-01 00:00:00
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pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2017.01.026
更新日期：2017-10-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.06.007
更新日期：2016-10-01 00:00:00
abstract：:Brain abnormalities have been identified in patients with schizophrenia, but what is unclear is whether these changes are progressive over the course of the disorder. In this longitudinal study, hippocampal and temporal lobe volumes were measured at two time points in 30 patients with first episode psychosis (mean fol...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00175-x
更新日期：2001-10-01 00:00:00
