Characteristics of youth with reported family history of psychosis spectrum symptoms in the Philadelphia Neurodevelopmental Cohort.


:Little is known about the impact of family history of psychosis on youth from community samples. To fill this gap, we compared youth with a first-degree relative with psychosis spectrum symptoms (i.e. family history of psychosis spectrum symptoms, FHPS) to youth without FHPS in a cross-sectional analysis of the Philadelphia Neurodevelopmental Cohort (PNC). The PNC is a racially diverse community sample of 9498 youth ages 8-21 years old, of whom 8928 completed the Family Interview for Genetic Studies to determine FHPS status. Polygenic risk score for schizophrenia (PRSS) was available for a subsample of 4433 European Americans. FHPS youth (n = 489) constituted 5.5% of the analytic sample. After adjusting for environmental risk factors (sociodemographic variables and traumatic stressful events), FHPS youth had lower functioning on the Children's Global Assessment Scale and elevated psychosis spectrum, mood, externalizing, and fear symptoms compared to non-FHPS youth (all p < .001). In the European-American subsample, FHPS status was associated with poorer functioning and greater symptom burden in all four psychopathology domains (all p < .001), even after covarying for PRSS. Thus, ascertaining FHPS is important because it is uniquely associated with symptoms and functional impairment in community youth beyond PRS-S and the environmental risk factors we investigated. Future research identifying environmental causes of FHPS-associated impairment could inform the development of interventions for the broad array of symptoms observed in FHPS youth.


Schizophr Res


Schizophrenia research


Taylor JH,Asabere N,Calkins ME,Moore TM,Tang SX,Xavier RM,Merikangas AK,Wolf DH,Almasy L,Gur RC,Gur RE




Has Abstract


2020-02-01 00:00:00












  • Insight in paranoia: The role of experiential avoidance and internalized stigma.

    abstract::Evidence suggests that insight in psychosis has been related to treatment adherence, recovery and good prognosis, but also to depression, low self-esteem, and diminished quality of life. Thus, insight might not be advantageous under all circumstances. Internalized-stigma (i.e. self-acceptance of stigmatizing images of...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Valiente C,Provencio M,Espinosa R,Duque A,Everts F

    更新日期:2015-05-01 00:00:00

  • Latent class analysis of discordance between results of drug use assessments in the CATIE data.

    abstract:OBJECTIVE:The primary aim is to examine concordant/discordant results of drug use assessments in adults with schizophrenia. METHODS:Latent class analysis and multinomial logistic regression were used to examine concordance/discordance between drug use measures and identify characteristics differentiating participants ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,随机对照试验


    authors: Johnson KL,Desmarais SL,Swartz MS,Van Dorn RA

    更新日期:2015-02-01 00:00:00

  • Schizophrenia and the retina: Towards a 2020 perspective.

    abstract:BACKGROUND:Differences between people with schizophrenia and psychiatrically healthy controls have been consistently demonstrated on measures of retinal function such as electroretinography (ERG), and measures of retinal structure such as optical coherence tomography (OCT). Since our 2015 review of this literature, mul...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Silverstein SM,Fradkin SI,Demmin DL

    更新日期:2020-05-01 00:00:00

  • Application of cognitive scales to medical records of schizophrenia inpatients.

    abstract::The Scales of Cognitive Impairment Rated From Institutional Records (SCIRFIR), a battery based on commonly used dementia rating instruments, was tested on the records of 26 chronically institutionalized, elderly schizophrenia patients, for the purpose of retrospectively evaluating the long-term course of cognitive cha...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Ortakov V,Mancevski B,Keilp J,Oppenheim S,Dwork AJ

    更新日期:1999-01-11 00:00:00

  • Unitary construct of generalized cognitive ability underlying BACS performance across psychotic disorders and in their first-degree relatives.

    abstract::Despite robust evidence of neurocognitive dysfunction in psychotic patients, the degree of similarity in cognitive architecture across psychotic disorders and among their respective first-degree relatives is not well delineated. The present study examined the latent factor structure of the Brief Assessment of Cognitio...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Hochberger WC,Hill SK,Nelson CL,Reilly JL,Keefe RS,Pearlson GD,Keshavan MS,Tamminga CA,Clementz BA,Sweeney JA

    更新日期:2016-01-01 00:00:00

  • If patients with schizophrenia have small brains, why don't they have small heads?

    abstract::Although patients with schizophrenia have reduced brain size, there is no conclusive evidence that they have reduced head size. This begs the question: 'What is the precise relationship between head size and brain size?' We used a unique osteological collection to explore the relationship between external head measure...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Friedman L,Wiechers IR,Cerny CA,Schulz SC,Buckley P

    更新日期:2000-03-16 00:00:00

  • Investigation of metamemory dysfunctions in first-episode schizophrenia.

    abstract::A number of recent studies have suggested that schizophrenia patients share metamemory deficits, particularly, a decreased ability to distinguish between errors and correct responses in terms of response confidence (i.e., decreased confidence gap): patients are over-confident in errors while at the same time being und...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Moritz S,Woodward TS,Chen E

    更新日期:2006-01-31 00:00:00

  • The contribution of the contingent negative variation (CNV) to goal maintenance.

    abstract::The dot pattern expectancy (DPX) task has been strongly recommended as a measure of goal maintenance, which is impaired in schizophrenia patients. The current event-related potential (ERP) study was designed mainly to identify the ERP component that could represent the goal maintenance process of the DPX task as index...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Shen A,Zhao W,Han B,Zhang Q,Zhang Z,Chen X,Zhai J,Chen M,Du B,Deng X,Ji F,Wang C,Xiang YT,Wu H,Dong Q,Chen C,Li J

    更新日期:2018-05-01 00:00:00

  • Identification of antibodies to heat shock proteins 90 kDa and 70 kDa in patients with schizophrenia.

    abstract:OBJECTIVES:Recent reports of antibodies to heat shock proteins 60kDa (HSP60) and HSP70 suggested that antibodies to the heat shock protein that plays a protective role against environmental stresses in a cell might be related to the pathogenesis of schizophrenia, although the antibody to HSP90 had not yet been identifi...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Kim JJ,Lee SJ,Toh KY,Lee CU,Lee C,Paik IH

    更新日期:2001-10-01 00:00:00

  • Family load estimates of schizophrenia and associated risk factors in a nation-wide population study of former child and adolescent patients up to forty years of age.

    abstract:OBJECTIVES:This nation-wide register-based study investigates the family load of schizophrenia (SZ) across three generations in affected families compared to control families. Furthermore the study compares the family load in case vs. control families considering the age of onset of the disorder in the cases. In additi...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Helenius D,Munk-Jørgensen P,Steinhausen HC

    更新日期:2012-08-01 00:00:00

  • The nuts and bolts of Cognitive Remediation: Exploring how different training components relate to cognitive and functional gains.

    abstract:BACKGROUND:Cognitive Remediation (CR) is an evidence based treatment targeting cognitive and functional difficulties in people with psychosis. Despite the large number of effectiveness studies, only limited evidence exists for the active ingredients of this therapy. This study begins to fill this gap by exploring the r...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,随机对照试验


    authors: Cella M,Wykes T

    更新日期:2019-01-01 00:00:00

  • Chronic psychotropic drug treatment causes differential expression of connexin 43 and GFAP in frontal cortex of rats.

    abstract::Astrocytic markers glial fibrillary acidic protein (GFAP) and connexin 43 (CX43) are known to have altered expression in brains of subjects with psychiatric disorders including autism and major depression. The current study investigated whether GFAP and CX43 expressions are affected by several commonly used psychotrop...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Fatemi SH,Folsom TD,Reutiman TJ,Pandian T,Braun NN,Haug K

    更新日期:2008-09-01 00:00:00

  • The meaning of childhood attention-deficit hyperactivity symptoms in patients with a first-episode of schizophrenia-spectrum psychosis.

    abstract:OBJECTIVE:To examine childhood ADHD symptoms in regard to their association with a number of illness-related variables including risk factors, early neurodevelopment, premorbid functioning and clinical characteristics in patients with schizophrenia-spectrum psychoses. METHODS:One-hundred and twenty-two first-episode p...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Peralta V,de Jalón EG,Campos MS,Zandio M,Sanchez-Torres A,Cuesta MJ

    更新日期:2011-03-01 00:00:00

  • Prolactin concentrations in newly diagnosed, antipsychotic-naïve patients with nonaffective psychosis.

    abstract:BACKGROUND:Previous studies have found increased prolactin concentrations in antipsychotic-naïve patients with schizophrenia. However, the roles of other hormones, and of potentially confounding variables such as gender and smoking, have not been considered. METHODS:Blood from newly diagnosed, antipsychotic-naïve pati...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Garcia-Rizo C,Fernandez-Egea E,Oliveira C,Justicia A,Parellada E,Bernardo M,Kirkpatrick B

    更新日期:2012-01-01 00:00:00

  • Reproducibility of fMRI activations during a story listening task in patients with schizophrenia.

    abstract::A prerequisite to longitudinal fMRI studies in schizophrenia is the knowledge on fMRI signal reliability in schizophrenia patients. We assessed the reproducibility of activations elicited by two fMRI sessions, which were 21 months apart, of a story listening paradigm in 10 schizophrenia patients and 10 healthy subject...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Maïza O,Mazoyer B,Hervé PY,Razafimandimby A,Dollfus S,Tzourio-Mazoyer N

    更新日期:2011-05-01 00:00:00

  • Patterns of emotional experience in schizophrenia: differences in emotional response to visual stimuli are associated with clinical presentation and functional outcome.

    abstract::The current study examined whether patterns of emotional response are differentially associated with symptom presentation and functional outcome in individuals with schizophrenia. Participants included 49 outpatients with schizophrenia and 50 demographically matched controls. All participants rated their emotional res...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Strauss GP,Herbener ES

    更新日期:2011-05-01 00:00:00

  • Proteomic systems evaluation of the molecular validity of preclinical psychosis models compared to schizophrenia brain pathology.

    abstract::Pharmacological and genetic rodent models of schizophrenia play an important role in the drug discovery pipeline, but quantifying the molecular similarity of such models with the underlying human pathophysiology has proved difficult. We developed a novel systems biology methodology for the direct comparison of anterio...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Cox DA,Gottschalk MG,Wesseling H,Ernst A,Cooper JD,Bahn S

    更新日期:2016-11-01 00:00:00

  • Genetic epidemiology and schizophrenia: a study of reproductive fitness.

    abstract::Genetic epidemiological studies have demonstrated markedly reduced rates in reproduction among schizophrenic patients. According to evolutionary theory, behavioral and psychological phenotypes are selected based on ecological "fit". Where differential survival or reproductive success exists, genotype frequencies are a...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Avila M,Thaker G,Adami H

    更新日期:2001-03-01 00:00:00

  • Schizophrenia patients with polydipsia and water intoxication are characterized by greater severity of psychotic illness and a more frequent history of alcohol abuse.

    abstract::Polydipsia and water intoxication (PWI) are relatively frequent among schizophrenic subjects, particularly in institutional settings and may lead to severe complications. However, little is known on their association with other characteristics of psychosis. Hence, we took advantage of a cohort of 114 subjects extensiv...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Poirier S,Legris G,Tremblay P,Michea R,Viau-Guay L,Mérette C,Bouchard RH,Maziade M,Roy MA

    更新日期:2010-05-01 00:00:00

  • Procedural learning in schizophrenia: a functional magnetic resonance imaging investigation.

    abstract::Procedural learning (PL) is a type of rule-based learning in which performance facilitation occurs with practice on task without the need for conscious awareness. Schizophrenic patients have often (though not invariably) been found to show impaired PL. We performed functional magnetic resonance imaging (fMRI) during a...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Kumari V,Gray JA,Honey GD,Soni W,Bullmore ET,Williams SC,Ng VW,Vythelingum GN,Simmons A,Suckling J,Corr PJ,Sharma T

    更新日期:2002-09-01 00:00:00

  • Relationships between depression and psychotic symptoms of schizophrenia during an acute episode and stable period.

    abstract::The aim of the present study is to explore the relationship between depression and psychotic symptoms of schizophrenia over the course of illness. Sixty-eight patients meeting DSM-IV criteria for schizophrenia were enrolled, 27 in an acute episode, 41 when stable. Assessments were performed using the Calgary Depressio...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Lançon C,Auquier P,Reine G,Bernard D,Addington D

    更新日期:2001-03-01 00:00:00

  • Testing a modification of cognitive adaptation training: streamlining the model for broader implementation.

    abstract::Cognitive adaptation training (CAT) is a home-based, manualized treatment that utilizes environmental supports to improve target behaviors and functional outcomes in persons with schizophrenia. Although clinical trials have shown CAT to be effective across functional, clinical, and treatment adherence domains, when th...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,随机对照试验


    authors: Kidd SA,Herman Y,Barbic S,Ganguli R,George TP,Hassan S,McKenzie K,Maples N,Velligan D

    更新日期:2014-06-01 00:00:00

  • Decomposing P300 into correlates of genetic risk and current symptoms in schizophrenia: An inter-trial variability analysis.

    abstract:BACKGROUND:The P300 event-related potential (ERP) component, which reflects cognitive processing, is a candidate biomarker for schizophrenia. However, the role of P300 in the pathophysiology of schizophrenia remains unclear because averaged P300 amplitudes reflect both genetic predisposition and current clinical status...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Kim M,Lee TH,Kim JH,Hong H,Lee TY,Lee Y,Salisbury DF,Kwon JS

    更新日期:2018-02-01 00:00:00

  • Workshop on defining the significance of progressive brain change in schizophrenia: December 12, 2008 American College of Neuropsychopharmacology (ACNP) all-day satellite, Scottsdale, Arizona. The rapporteurs' report.

    abstract::In 1990 a satellite session of the American College of Neuropsychopharmacology (ACNP) Annual Meeting was held that focused on the question of whether progressive changes in brain structure occur in schizophrenia and this session raised considerable controversy. Eighteen years later, on December 12, 2008, after much da...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Borgwardt SJ,Dickey C,Hulshoff Pol H,Whitford TJ,DeLisi LE

    更新日期:2009-07-01 00:00:00

  • On the use of the Positive and Negative Syndrome Scale in randomized clinical trials.

    abstract::In the last 25 years, the Positive and Negative Syndrome Scale (PANSS) has been largely used to assess schizophrenia symptom intensity, but little information is available on how this scale was generally applied when evaluating the efficacy of schizophrenia therapies in randomized clinical trials. In the attempt to ad...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,评审


    authors: Nicotra E,Casu G,Piras S,Marchese G

    更新日期:2015-07-01 00:00:00

  • Antipsychotic binding to the dopamine-3 receptor in humans: A PET study with [(11)C]-(+)-PHNO.

    abstract:BACKGROUND:All currently available antipsychotic medications bind to both the dopamine-2 (D2) and dopamine-3 (D3) receptors in vitro. However, there is conflicting evidence from in vivo studies about whether or not antipsychotic medications bind to the D3 receptor (D3R). The purpose of this study was to determine wheth...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Girgis RR,Xu X,Gil RB,Hackett E,Ojeil N,Lieberman JA,Slifstein M,Abi-Dargham A

    更新日期:2015-10-01 00:00:00

  • Inverse correlation between hallucinations and serum prolactin in patients with non-affective psychoses.

    abstract::Serum prolactin (PRL) was correlated with clinical symptomatology in 17 drug-free patients suffering from non-affective psychoses. A clear-cut negative correlation was found between the Comprehensive Psychiatric Rating Scale (CPRS) items assessing hallucinations and serum PRL levels (r=-6.14, P=0.009). No correlation ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Appleberg B,Katila H,Rimón R

    更新日期:2000-09-01 00:00:00

  • Psychotic experiences in childhood are associated with increased structural integrity of the left arcuate fasciculus - A population-based case-control study.

    abstract::Around 1 in 5 children under 13 years old experience sub-clinical psychotic experiences (PEs) like hallucinations and delusions. While PEs in childhood are a significant risk factor for adult psychotic disorders, the majority of those experiencing childhood PEs do not develop a psychotic disorder. Individual differenc...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Dooley N,O'Hanlon E,Healy C,Adair A,McCandless C,Coppinger D,Kelleher I,Clarke M,Leemans A,Frodl T,Cannon M

    更新日期:2020-01-01 00:00:00

  • Prolonged haloperidol and reduced haloperidol plasma concentrations after decanoate withdrawal.

    abstract::Haloperidol and reduced haloperidol plasma concentrations were measured in twelve schizophrenic patients upon cessation of haloperidol decanoate (HLD) treatment. Each patient received HLD 100 mg every 4 weeks for five injections. After the fifth injection, HLD was discontinued. Haloperidol and reduced haloperidol plas...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Chang WH,Lin SK,Juang DJ,Chen LC,Yang CH,Hu WH,Chien CP,Lam YW,Jann MW

    更新日期:1993-03-01 00:00:00

  • Low maternal vitamin D as a risk factor for schizophrenia: a pilot study using banked sera.

    abstract:OBJECTIVE:Evidence from epidemiology suggests that low maternal vitamin D may be a risk factor for schizophrenia. METHOD:Based on sera taken during the third trimester, we compared the level of 25 hydroxyvitamin D3 in mothers of individuals with schizophrenia or schizoaffective disorders versus mothers of unaffected c...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: McGrath J,Eyles D,Mowry B,Yolken R,Buka S

    更新日期:2003-09-01 00:00:00