Genetic susceptibility to tardive dyskinesia in chronic schizophrenia subjects: III. Lack of association of CYP3A4 and CYP2D6 gene polymorphisms.

abstract：BACKGROUND:The Discrimination and Stigma Scale (DISC-12) was specifically developed to measure experienced and anticipated discrimination reported by people with mental health problems. However, the length of the DISC-12 may represent a disadvantage especially in country settings with limited human capacity and infrast...

journal_title：Schizophrenia research

authors： Bakolis I,Thornicroft G,Vitoratou S,Rüsch N,Bonetto C,Lasalvia A,Evans-Lacko S

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Severity of negative symptoms has been associated with poor functioning, cognitive deficits, and defeatist beliefs in schizophrenia patients. However, one area that remains understudied is persistent negative symptoms (PNS). Negative symptoms, including PNS, have been observed in those at clinical high-risk ...

journal_title：Schizophrenia research

authors： Devoe DJ,Lu L,Cannon TD,Cadenhead KS,Cornblatt BA,McGlashan TH,Perkins DO,Seidman LJ,Tsuang MT,Woods SW,Walker EF,Mathalon DH,Bearden CE,Addington J

更新日期：2020-04-30 00:00:00

abstract：BACKGROUND:Second-generation antipsychotics (SGAs) increase the risk of type 2 diabetes. The mechanism is thought to center on drug-induced weight gain, which starts the dysmetabolic cascade of insulin resistance, increased insulin production and pancreatic beta-cell failure. An independent effect of SGAs on insulin se...

journal_title：Schizophrenia research

authors： Manu P,Correll CU,Wampers M,van Winkel R,Yu W,Shiffeldrim D,Kane JM,De Hert M

更新日期：2013-02-01 00:00:00

abstract：:Because previous studies have shown deficits in olfactory identification for male patients with schizophrenia, either withdrawn from or receiving neuroleptic medication, the purpose of the current study was to determine if such deficits occurred in male patients who had never received neuroleptics. A sample of male (n...

journal_title：Schizophrenia research

authors： Kopala LC,Clark C,Hurwitz T

更新日期：1993-01-01 00:00:00

abstract：:Self-determination theory (SDT) provides a model for understanding motivation deficits in schizophrenia, and recent research has focused on problems with intrinsic motivation. However, SDT emphasizes that motivated behavior results from three different factors: intrinsic motivators (facilitated by needs for autonomy, ...

journal_title：Schizophrenia research

authors： Gard DE,Sanchez AH,Starr J,Cooper S,Fisher M,Rowlands A,Vinogradov S

更新日期：2014-07-01 00:00:00

abstract：:We employed a simple and relatively undemanding task of monotone counting for the assessment of sustained attention in schizophrenic patients. The monotone counting task has been validated neuropsychologically and is particularly sensitive to right prefrontal lesions. We compared the performance of schizophrenic patie...

journal_title：Schizophrenia research

authors： Chen EY,Lam LC,Chen RY,Nguyen DG,Chan CK,Wilkins AJ

更新日期：1997-04-11 00:00:00

abstract：:Antipsychotic drugs (APDs) are the standard treatment for schizophrenia. The therapeutic effect of these drugs is dependent upon the dopaminergic D2 blockade, but they also modulate other neurotransmitter pathways. The exact mechanisms underlying the clinical response to APDs are not fully understood. In this study, w...

journal_title：Schizophrenia research

authors： Santoro ML,Ota VK,Stilhano RS,Silva PN,Santos CM,Diana MC,Gadelha A,Bressan RA,Melaragno MI,Han SW,Abílio VC,Belangero SI

更新日期：2014-08-01 00:00:00

abstract：:The effects of gut microbiota on the central nervous system, along its possible role in mental disorders, have received increasing attention. Here we investigated differences in fecal microbiota between 28 patients with first-episode psychosis (FEP) and 16 healthy matched controls and explored whether such differences...

journal_title：Schizophrenia research

authors： Schwarz E,Maukonen J,Hyytiäinen T,Kieseppä T,Orešič M,Sabunciyan S,Mantere O,Saarela M,Yolken R,Suvisaari J

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Executive Functioning (EF) is an important factor for community functioning for people with severe mental illness. Cognitive remediation programs often improve EF, but do so by using multiple therapeutic techniques. Little is known regarding how individual treatment elements promote cognitive improvement. Os...

journal_title：Schizophrenia research

authors： Best MW,Gale D,Tran T,Haque MK,Bowie CR

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Noncompliance is common in patients with schizophrenia and can have serious consequences; therefore research of the variables associated with noncompliance is a priority. Although the MEMS device is regarded as the "reference standard" for evaluating compliance, it has been used in very few published studies...

journal_title：Schizophrenia research

authors： Acosta FJ,Bosch E,Sarmiento G,Juanes N,Caballero-Hidalgo A,Mayans T

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Formal thought disorder (FTD) is a core feature of psychosis, however there are gaps in our knowledge about its prevalence and factor structure. We had two aims: first, to establish the factor structure of FTD; second, to explore the clinical utility of dimensions of FTD in order to further the understanding...

journal_title：Schizophrenia research

authors： Roche E,Lyne JP,O'Donoghue B,Segurado R,Kinsella A,Hannigan A,Kelly BD,Malone K,Clarke M

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Despite the upsurge of research regarding cognitive impairment in schizophrenia we still lack adequate understanding of the executive functioning of patients in symptomatic remission. Moreover, the cognitive functioning of patients in partial remission has not been studied previously although they comprise a...

journal_title：Schizophrenia research

authors： Braw Y,Benozio A,Levkovitz Y

更新日期：2012-12-01 00:00:00

abstract：:Sustained attention deficits and high rates of smoking are often observed in patients with schizophrenia. This has led to the hypothesis that patients may smoke as an attempt to ameliorate cognitive deficits related to abnormal nicotinic structure and function. Continuous performance tasks (CPT) are often used to inde...

journal_title：Schizophrenia research

authors： Roth M,Hong LE,McMahon RP,Fuller RL

更新日期：2013-08-01 00:00:00

abstract：:Synapsin II is a synaptic vesicle-associated phosphoprotein that has been implicated in the pathophysiology of schizophrenia. Researchers have demonstrated reductions in synapsin II mRNA and protein in post-mortem prefrontal cortex and hippocampus samples from patients with schizophrenia. Synapsin II protein expressio...

journal_title：Schizophrenia research

authors： Dyck BA,Tan ML,Daya RP,Basu D,Sookram CD,Thomas N,Mishra RK

更新日期：2012-05-01 00:00:00

abstract：:Morphologic abnormalities of the insular cortex have been described in psychotic disorders such as schizophrenia, but it remains unclear whether these changes predate the onset of psychosis or develop progressively over the course of illness. In this study, we used magnetic resonance imaging to investigate the gray ma...

journal_title：Schizophrenia research

authors： Takahashi T,Wood SJ,Yung AR,Phillips LJ,Soulsby B,McGorry PD,Tanino R,Zhou SY,Suzuki M,Velakoulis D,Pantelis C

更新日期：2009-06-01 00:00:00

abstract：:Meta-analyses of randomized controlled trials support the efficacy of cognitive behavioral therapy (CBT) in the treatment of symptoms of schizophrenia refractory to antipsychotic medication. This article addresses the issue of medium term durability. A five-year follow-up was undertaken of a sample of 90 subjects who ...

journal_title：Schizophrenia research

authors： Turkington D,Sensky T,Scott J,Barnes TR,Nur U,Siddle R,Hammond K,Samarasekara N,Kingdon D

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Accurately diagnosing schizophrenia is still challenging due to the lack of validated biomarkers. Here, we aimed to investigate whether radiomic features in bilateral hippocampal subfields from magnetic resonance images (MRIs) can differentiate patients with schizophrenia from healthy controls (HCs). METHOD...

journal_title：Schizophrenia research

authors： Park YW,Choi D,Lee J,Ahn SS,Lee SK,Lee SH,Bang M

更新日期：2020-09-01 00:00:00

abstract：:Insight was investigated in 180 individuals consecutively admitted to a comprehensive early psychosis treatment program. Insight was assessed on admission and after 3, 6 and 12 months. Insight improved significantly over 12 months, and was negatively correlated with both positive and negative symptoms, and positively ...

journal_title：Schizophrenia research

authors： Mintz AR,Addington J,Addington D

更新日期：2004-04-01 00:00:00

abstract：:The dopamine (DA) hypothesis of schizophrenia stated that increased DA activity is the primary cause of schizophrenia. Recently, even though increased DA activity is in fact involved in psychotic symptoms and antipsychotic drug response, it has become clear that decreased DA activity is present in remitted and chronic...

journal_title：Schizophrenia research

authors： van Kammen DP,Kelley M

更新日期：1991-03-01 00:00:00

abstract：:Despite robust evidence of neurocognitive dysfunction in psychotic patients, the degree of similarity in cognitive architecture across psychotic disorders and among their respective first-degree relatives is not well delineated. The present study examined the latent factor structure of the Brief Assessment of Cognitio...

journal_title：Schizophrenia research

authors： Hochberger WC,Hill SK,Nelson CL,Reilly JL,Keefe RS,Pearlson GD,Keshavan MS,Tamminga CA,Clementz BA,Sweeney JA

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:Executive dysfunction is a common feature of schizophrenia and bipolar disorder (BP). While deficits in social cognitive abilities, including theory of mind (ToM), have been suggested to be specific to schizophrenia, available evidence suggests that there is also a significant overlap in social cognitive perf...

journal_title：Schizophrenia research

authors： Bora E,Veznedaroğlu B,Vahip S

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:The primary aim is to examine concordant/discordant results of drug use assessments in adults with schizophrenia. METHODS:Latent class analysis and multinomial logistic regression were used to examine concordance/discordance between drug use measures and identify characteristics differentiating participants ...

journal_title：Schizophrenia research

authors： Johnson KL,Desmarais SL,Swartz MS,Van Dorn RA

更新日期：2015-02-01 00:00:00

abstract：:A number of recent studies have suggested that schizophrenia patients share metamemory deficits, particularly, a decreased ability to distinguish between errors and correct responses in terms of response confidence (i.e., decreased confidence gap): patients are over-confident in errors while at the same time being und...

journal_title：Schizophrenia research

authors： Moritz S,Woodward TS,Chen E

更新日期：2006-01-31 00:00:00

abstract：:Cognitive impairments have been shown to predict impairments in adaptive functioning in patients with chronic schizophrenia and to be more predictive of overall outcome than positive or negative symptoms of the illness. Both adaptive and cognitive impairments are multidimensional, and it is possible that correlations ...

journal_title：Schizophrenia research

authors： Harvey PD,Sukhodolsky D,Parrella M,White L,Davidson M

更新日期：1997-10-30 00:00:00

abstract：:Most individuals with schizophrenia will be confronted with some form of stigma. In recent years, clinicians and family members have increasingly contested the term "schizophrenia". Many of them discuss changing this name, as a means to fight stigma. Up until now, surprisingly, most research has been conducted using s...

journal_title：Schizophrenia research

authors： Rainteau N,Salesse RN,Macgregor A,Macioce V,Raffard S,Capdevielle D

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Cognitive remediation (CRT) affects functioning but the extent and type of cognitive improvements necessary are unknown. AIM:To develop and test models of how cognitive improvement transfers to work behaviour using the data from a current service. METHOD:Participants (N49) with a support worker and a paid ...

journal_title：Schizophrenia research

authors： Wykes T,Reeder C,Huddy V,Taylor R,Wood H,Ghirasim N,Kontis D,Landau S

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Self-referential processing (i.e. linking internal and external stimuli to one's own self) has received scant attention thus far in schizophrenia. This type of processing is a key component of social cognition and thought to be important for adaptive social functioning. Memory studies in healthy subjects hav...

journal_title：Schizophrenia research

authors： Harvey PO,Lee J,Horan WP,Ochsner K,Green MF

更新日期：2011-04-01 00:00:00

abstract：:Attention Deficit/Hyperactivity Disorder (ADHD) is the most common psychiatric disorder in childhood. It is unclear whether ADHD increases the risk of non-affective psychotic disorder (NAPD). The study included a matched cohort, drawn from all born in Sweden 1987-1991 (n = 548,852). ADHD was defined as ICD diagnosis a...

journal_title：Schizophrenia research

authors： Björkenstam E,Pierce M,Björkenstam C,Dalman C,Kosidou K

更新日期：2020-04-01 00:00:00

abstract：:We have previously reported aberrations in the striatal presynaptic dopamine function in neuroleptic-naive schizophrenic patients compared to healthy controls (Hietala, J., Syvälahti, E., Vuorio, K. et al., 1995. Lancet 346, 1130-1131). In this extended study we explore whether the altered presynaptic dopamine functio...

journal_title：Schizophrenia research

authors： Hietala J,Syvälahti E,Vilkman H,Vuorio K,Räkköläinen V,Bergman J,Haaparanta M,Solin O,Kuoppamäki M,Eronen E,Ruotsalainen U,Salokangas RK

更新日期：1999-01-04 00:00:00

abstract：:The distribution of schizophrenia in families supports the hypothesis of heritable risk factors in schizophrenia, but there is as yet no identification of an inherited neurobiological defect. Human embryonic brain tissue fragments, derived from first trimester abortions, can be transplanted into rat hosts, where they ...

journal_title：Schizophrenia research

authors： Freedman R,Strömberg I,Nordström AL,Seiger A,Olson L,Bygdeman M,Wiesel FA,Granholm AC,Hoffer BJ

更新日期：1994-10-01 00:00:00