Abstract：
:Cognitive impairments have been shown to predict impairments in adaptive functioning in patients with chronic schizophrenia and to be more predictive of overall outcome than positive or negative symptoms of the illness. Both adaptive and cognitive impairments are multidimensional, and it is possible that correlations between these domains may be limited to certain aspects of these functions. In this study, 208 geriatric patients with chronic schizophrenia were examined with a cognitive battery and assessed with a structured scale to determine the extent of their adaptive functions. Instrumental and social skills deficits were more strongly correlated with cognitive impairments than with the severity of undercontrolled behavior. Each of the cognitive measures was correlated with global social-adaptive deficits, with minimal variation in the magnitude of correlations. These results suggest that interventions should be individually targeted to cognitive-adaptive impairments and undercontrolled behavior.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Harvey PD,Sukhodolsky D,Parrella M,White L,Davidson Mdoi
10.1016/S0920-9964(97)00068-6subject
Has Abstractpub_date
1997-10-30 00:00:00pages
211-8issue
2-3eissn
0920-9964issn
1573-2509pii
S0920-9964(97)00068-6journal_volume
27pub_type
杂志文章abstract：:Auditory-verbal hallucinations (AVHs) are associated with an impaired connectivity of large-scale networks. To examine the relationship between white-matter integrity and AVHs, we conducted a meta-analysis of diffusion-tensor-imaging studies that compared patients with schizophrenia and AVHs with matched healthy contr...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析
doi：10.1016/j.schres.2014.07.014
更新日期：2014-10-01 00:00:00
abstract：:We conducted data-mining analyses of genome wide association (GWA) studies of the CATIE and MGS-GAIN datasets, and found 13 markers in the two physically linked genes, PTPN21 and EML5, showing nominally significant association with schizophrenia. Linkage disequilibrium (LD) analysis indicated that all 7 markers from P...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2011.06.023
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:Bullying victimisation has been suggested to contribute to paranoid ideation in general population samples and recent evidence found that individuals with an ultra high risk (UHR) for psychosis are twice as likely to have been bullied than controls. AIMS:This study sought to examine whether a history of bul...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.08.029
更新日期：2015-10-01 00:00:00
abstract：:To investigate relationships between birth season and biological family history in schizophrenia, this study used a sample of schizophrenics that had the advantages of (a) particularly thorough diagnostic assessments of schizophrenics' relatives, including information from direct interviews as well as chart reviews, a...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/S0920-9964(99)00162-0
更新日期：2000-08-03 00:00:00
abstract：:Recent transcriptomic, proteomic and metabolomics studies have highlighted an abnormal cerebral glucose and energy metabolism as one of the potential pathophysiological mechanisms of schizophrenia. This raises the possibility that a metabolically-based intervention might have therapeutic value in the management of sch...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.11.011
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVES:Recent reports of antibodies to heat shock proteins 60kDa (HSP60) and HSP70 suggested that antibodies to the heat shock protein that plays a protective role against environmental stresses in a cell might be related to the pathogenesis of schizophrenia, although the antibody to HSP90 had not yet been identifi...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(00)00091-8
更新日期：2001-10-01 00:00:00
abstract：:T1 and T2 relaxation times were measured in ten brain regions on the right and left side in a sample of 27 schizophrenic patients and 37 normal controls. The schizophrenic patients showed a prolongation of T2 relaxation time, and to a lesser extent of T1 relaxation time, which was more predominantly localized in the r...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(91)90080-b
更新日期：1991-10-01 00:00:00
abstract：:It has been proposed that certain psychotic symptoms associated with schizophrenia reflect a deficit in the ability to appreciate other people's mental states (Frith, 1992). This notion is tested using a newly devised task examining the capacity to infer intentions behind indirect speech. The findings support the noti...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(95)00024-g
更新日期：1995-09-01 00:00:00
abstract：OBJECTIVE:Individuals with both physical and mental health problems may have elevated levels of emergency department (ED) service utilization either for index conditions or for associated comorbidities. This study examines the use of ED services by Medicaid beneficiaries with comorbid diabetes and schizophrenia, a dyad...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.12.002
更新日期：2014-02-01 00:00:00
abstract：:Dopamine's proposed role in psychosis proved a starting point in our understanding of the neurobiology of relapse, fitting given the central role positive symptoms play. This link is reflected in early work examining neurotransmitter metabolite and drug (e.g. amphetamine, methylphenidate) challenge studies as a means ...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2013.10.009
更新日期：2014-02-01 00:00:00
abstract：:Second generation antipsychotics cause derangements in glucose metabolism that are often interpreted as insulin resistance. In previous studies we have shown that this is not classical insulin resistance but the drugs were actually inducing a hyperglycaemic state associated with elevated hepatic glucose output (HGO) a...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.05.003
更新日期：2014-08-01 00:00:00
abstract：:Here, we used data from large genome-wide association studies to test the presence of causal relationships, conducting a Mendelian randomization analysis; and shared molecular mechanisms, calculating the genetic correlation, among schizophrenia, type 2 diabetes (T2D), and impaired glucose homeostasis. Although our Men...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.10.033
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:Alterations in the inhibitory circuitry of the dorsolateral prefrontal cortex (DLPFC) in schizophrenia include reduced expression of the messenger RNA (mRNA) for somatostatin (SST), a neuropeptide present in a subpopulation of gamma-aminobutyric acid (GABA) neurons. Neuropeptide Y (NPY) is expressed in a sub...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.09.014
更新日期：2009-12-01 00:00:00
abstract：:Omega-3 treatment studies for multi-episode schizophrenia or clinical high risk for conversion to psychosis states have had variable, and often negative, results. To examine adjunctive omega-3 treatment for recent onset psychosis, participants aged 15-40 years with recent onset schizophrenia-spectrum (n = 46) or bipol...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2018.09.006
更新日期：2019-02-01 00:00:00
abstract：:Catatonia is a severe psychomotor syndrome that frequently occurs in patients with schizophrenia spectrum disorders (SSD). Accumulating neuroimaging evidence suggests orbitofrontal, frontoparietal and cerebellar network dysfunction in catatonia. Very little is known about contributions of brainstem regions (as part of...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2020.09.025
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:While insight in schizophrenia improves with treatment, significant impairments often persist. The degree of persistence is not well characterised. AIMS:We assessed patient and clinician-rated changes in insight in acutely ill, minimally treated first-episode schizophrenia spectrum disorder patients over 24...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.10.013
更新日期：2019-04-01 00:00:00
abstract：:Characterizing a pattern of cognitive dysfunction in early onset schizophrenic patients may illuminate neurodevelopmental contributions to the illness. A cohort of chronically institutionalized schizophrenic patients with a variable range of age of onset (range 7-29 years) was administered a comprehensive battery of n...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(95)00065-8
更新日期：1996-05-01 00:00:00
abstract：BACKGROUND:Working memory deficits represent a core feature of schizophrenia. These deficits have been associated with dysfunctional dorsolateral prefrontal cortex (DLPFC) cortical oscillations. Theta-gamma coupling describes the modulation of gamma oscillations by theta phasic activity that has been directly associate...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.01.044
更新日期：2017-11-01 00:00:00
abstract：:Schizophrenia and at-risk populations are suggested to exhibit referential cohesion deficits in language production (e.g., producing fewer pronouns or nouns that clearly link to concepts from previous sentences). Much of this work has focused on transcribed speech samples, while no work to our knowledge has examined r...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.04.025
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:Recovery is the ultimate goal of psychosis treatment. Basic self-disturbances (BSDs) are non-psychotic phenomena associated with clinical outcome, present in prodromal, psychotic and residual phases of psychotic disorders. AIM:To investigate the relationship between BSDs and recovery seven years after first...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.08.009
更新日期：2019-10-01 00:00:00
abstract：:Pro-inflammatory cytokines have been consistently reported to be elevated in schizophrenia patients. However, it is not known whether cytokines influence the presentation of psychotic symptoms. To address this issue, we evaluated the relationship between levels of inflammatory molecules and psychopathological paramete...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.10.019
更新日期：2013-12-01 00:00:00
abstract：:We have observed discreet subgroups of male patients with psychotic disorders who have unirhinal olfactory identification deficits (microsmia). The purpose of this study was to examine the relationship between left or right nostril microsmia and performance on literalised neuropsychological tests sensitive to lesions ...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/s0920-9964(01)00227-4
更新日期：2002-08-01 00:00:00
abstract：:Cognitive deficits have been recognized as a core feature of schizophrenia (SZ) and are present in most patients. Verbal memory (VM), working memory (WM), and executive function (EF) are domains commonly impaired in patients with SZ. These latter domains have been related to the genetic risk of the disorder characteri...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.08.019
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVE:Studies in first episode psychosis samples about status of cardiovascular risk factors have shown discordant results. We aimed to determine the 10-year risk of developing coronary heart disease in a sample of first episode psychosis patients referred to an early intervention clinic and compared the same with ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2010.12.008
更新日期：2011-04-01 00:00:00
abstract：:Variable levels of essential polyunsaturated fatty acids (EPUFAs) reported in schizophrenia are likely due to differences in age, sex, ethnicity, diet, life style and treatments. The present study examined the EPUFAs levels in plasma, RBC and CSF in never-medicated first-episode psychotic patients and normal controls ...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.schres.2007.09.036
更新日期：2008-01-01 00:00:00
abstract：PURPOSE:The excitatory neurotransmitter glutamate has become an important area of focus for schizophrenia researchers. Polymorphisms in the type-three metabotropic glutamate receptor gene (GRM3) have been associated with the pathogenesis of schizophrenia. The purpose of this study was to determine whether a pharmacogen...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2005.04.001
更新日期：2005-09-15 00:00:00
abstract：:This study assessed visuospatial attention in healthy adults and medicated schizophrenic patients. Participants performed a visual orientation task in which a peripheral cue was followed. at different intervals, by a target presented either at valid or invalid locations. When the long stimulus onset asynchrony (SOA) w...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(99)00044-4
更新日期：1999-11-09 00:00:00
abstract：OBJECTIVE:Reduced procreation among men with schizophrenia has been reported consistently when compared with female patients, but the cause is unknown. Reports on Caucasian individuals predominate in the published literature. Therefore, analyses were conducted concurrently among independent Indian and US samples in the...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2003.08.009
更新日期：2004-06-01 00:00:00
abstract：:Clinical improvement in psychotic symptoms is not immediate when neuroleptic treatment is commenced. Previous studies have demonstrated the development of biochemical tolerance to the effects of neuroleptics on the dopamine system. This study demonstrates a relationship between this biochemical change and the clinical...
journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0920-9964(90)90007-t
更新日期：1990-07-01 00:00:00
abstract：:Schizophrenia (SZ) is associated with broad burden. The clinical manifestations of SZ are related to pathophysiological alterations similar to what is seen in normal aging. Our aim was to evaluate the differences in telomere length (TL), a biomarker of cellular aging, in subjects with SZ (n=36), unaffected siblings (S...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.04.004
更新日期：2016-07-01 00:00:00
