Abstract：
:Catatonia is a severe psychomotor syndrome that frequently occurs in patients with schizophrenia spectrum disorders (SSD). Accumulating neuroimaging evidence suggests orbitofrontal, frontoparietal and cerebellar network dysfunction in catatonia. Very little is known about contributions of brainstem regions (as part of the dopaminergic-based subcortical-cortical motor circuit) to catatonia in SSD patients. Here, we used structural magnetic resonance imaging (MRI) at 3 T to examine volumes of brainstem regions in catatonic SSD patients compared to non-catatonic SSD patients. Catatonia severity was measured with the Northoff Catatonia Rating Scale (NCRS). The segmentation of the brainstem in order to investigate the volumes of medulla oblongata, pons, superior cerebellar pedunculus, and midbrain was carried out using FreeSurfer vers. 6.0. Catatonic patients (NCRS total score ≥ 3; at least 1 point in the three different symptom categories; i.e., motor, behavioral, and affective; n = 30) had significantly smaller midbrain volumes (p = 0.004, Bonferroni corr.) when compared to non-catatonic patients (NCRS total score = 0; n = 29). In catatonic patients, significant correlations were detected between NCRS motor scores and whole brainstem (p = 0.015, Bonferroni corr.) volumes. These results support a neuromechanistically important role of brainstem structures in catatonia in SSD, particularly in motor symptom expression.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Fritze S,Thieme CE,Kubera KM,Northoff G,Schmitgen MM,Wolf RC,Hirjak Ddoi
10.1016/j.schres.2020.09.025subject
Has Abstractpub_date
2020-10-01 00:00:00pages
82-87eissn
0920-9964issn
1573-2509pii
S0920-9964(20)30483-7journal_volume
224pub_type
杂志文章abstract：:There is growing awareness that reduced expressive behaviors (e.g., blunt affect, alogia, psychomotor retardation) are characteristic of a range of psychiatric conditions, including mood and schizophrenia-spectrum disorders. From a Research Domain Criteria (RDoC) perspective, it would be critical to determine whether ...
journal_title：Schizophrenia research
pub_type： 杂志文章
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更新日期：2012-09-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.03.020
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journal_title：Schizophrenia research
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2004.03.025
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journal_title：Schizophrenia research
pub_type： 杂志文章
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2006.04.018
更新日期：2006-09-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析,评审
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journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
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更新日期：2007-08-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章
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更新日期：2004-07-01 00:00:00
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更新日期：1994-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.schres.2011.08.004
更新日期：2011-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：1996-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.schres.2013.01.035
更新日期：2013-05-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章,评审
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更新日期：2012-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.schres.2015.05.017
更新日期：2015-08-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
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更新日期：2013-08-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：1996-07-05 00:00:00
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journal_title：Schizophrenia research
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pub_type： 杂志文章
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更新日期：1998-08-17 00:00:00
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pub_type：
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更新日期：2002-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2008-02-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
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更新日期：1996-10-18 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.05.002
更新日期：2014-08-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.06.022
更新日期：2018-11-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2002-06-01 00:00:00
abstract：BACKGROUND:While poor premorbid functioning is associated with poorer outcomes in psychotic illnesses, little is known about whether it is also a risk factor for suicide attempts. OBJECTIVE:The current study examined the association of premorbid functioning and suicide attempts in a county-wide cohort of first-admissi...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.11.005
更新日期：2010-02-01 00:00:00
