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Associations of suicidality with cognitive ability and cognitive insight in outpatients with Schizophrenia.

Abstract：

BACKGROUND:Previous literature suggests that better cognitive ability and insight are associated with greater lifetime risk of suicide attempts in schizophrenia, counter to the direction of association in the general population. However, the conjoint association between distinct cognitive domains, insight, and suicidality has not been assessed. METHOD:In a cross-sectional study, 162 adults with schizophrenia or schizoaffective disorder completed cognitive testing via the MATRICS battery, symptom and cognitive insight assessments, along with the Columbia Suicide Severity Rating Scale. We then contrasted participants based on history of suicidality by cognitive domains and insight measures and conducted multivariate analyses. RESULTS:Although a history of any passive ideation was not associated with cognitive ability or insight, verbal learning was positively associated with a greater history of suicidal attempt and prior ideation with a plan and intent. Higher cognitive insight, and the self-reflectiveness subscale insight, was also associated with history of passive or active suicidal ideation. Cognitive insight and cognitive ability were independent from each other, and there were no moderating influences of insight on the effect of cognitive ability on suicide related history. Exploratory analyses revealed that history of planned attempts were associated with greater verbal learning, whereas histories of aborted attempts were associated with poorer reasoning and problem-solving. IMPLICATIONS:Although cross-sectional and retrospective, this study provides support that greater cognitive ability, specifically verbal learning, along with self-reflectiveness, may confer elevated risk for more severe suicidal ideation and behavior in an independent fashion. Interestingly, poorer problem-solving was associated with aborted suicide attempts.

journal_name

Schizophr Res

journal_title

Schizophrenia research

authors

Villa J,Choi J,Kangas JL,Kaufmann CN,Harvey PD,Depp CA

doi

10.1016/j.schres.2017.06.013

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

340-344

eissn

0920-9964

issn

1573-2509

pii

S0920-9964(17)30351-1

journal_volume

192

pub_type

杂志文章

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