Abstract：
:The dot pattern expectancy (DPX) task has been strongly recommended as a measure of goal maintenance, which is impaired in schizophrenia patients. The current event-related potential (ERP) study was designed mainly to identify the ERP component that could represent the goal maintenance process of the DPX task as indexed by the error rate of the BX vs. AY (EBX-AY). We focused our analysis on the cue-phased contingent negative variation (CNV) and found a significant association between the EBX-AY and the amplitude of the difference wave of cue B vs. cue A (CNVB-A) (for CP3, β=-0.262, P=0.001; for CPZ, β=-0.184, P=0.025; for CP4, β=-0.201, P=0.015). Lower EBX-AY (better goal maintenance) was correlated with larger CNVB-A. Further analysis found a significant association between the error rate of AY condition (EAY) and the amplitude of CNVA (for CP3, β=-0.180, P=0.029; for CPZ, β=-0.184, P=0.024; for CP4, β=-0.208, P=0.011) and a significant association between the error rate of BX condition (EBX) and the amplitude of CNVB-A (for CP3, β=-0.198, P=0.016; for CPZ, β=-0.165, P=0.043; for CP4, β=-0.151, P=0.066), but not the amplitude of the CNVB (all P>0.05). All these results together suggested that the cue-phased CNV could be used to represent the goal maintenance process. Future research needs to verify these results with schizophrenia patients.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Shen A,Zhao W,Han B,Zhang Q,Zhang Z,Chen X,Zhai J,Chen M,Du B,Deng X,Ji F,Wang C,Xiang YT,Wu H,Dong Q,Chen C,Li Jdoi
10.1016/j.schres.2017.09.038subject
Has Abstractpub_date
2018-05-01 00:00:00pages
372-377eissn
0920-9964issn
1573-2509pii
S0920-9964(17)30600-Xjournal_volume
195pub_type
杂志文章abstract：:Brain abnormalities have been identified in patients with schizophrenia, but what is unclear is whether these changes are progressive over the course of the disorder. In this longitudinal study, hippocampal and temporal lobe volumes were measured at two time points in 30 patients with first episode psychosis (mean fol...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00175-x
更新日期：2001-10-01 00:00:00
abstract：OBJECTIVE:Self-rated attenuated psychotic-like experiences (APLEs) are increasingly used to screen for ultra-high-risk (UHR) across all ages. However, self-rated psychotic-like experiences (PLEs), in particular perception-related ones, were more frequent in children and adolescents, in which they possessed less clinica...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.schres.2014.10.005
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:Clozapine is the drug of choice for patients with unsatisfactory response to routine antipsychotic treatment. Polypharmacy is widely used among patients having clozapine-resistant schizophrenia, although no solid evidence exists for any effective augmentation therapy for this patient population. We aimed to ...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.schres.2009.01.002
更新日期：2009-04-01 00:00:00
abstract：:Around 1 in 5 children under 13 years old experience sub-clinical psychotic experiences (PEs) like hallucinations and delusions. While PEs in childhood are a significant risk factor for adult psychotic disorders, the majority of those experiencing childhood PEs do not develop a psychotic disorder. Individual differenc...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.08.022
更新日期：2020-01-01 00:00:00
abstract：:The purpose of the present study was to investigate the patterns of interregional correlations of serotonin transporter (SERT) availability with glucose metabolism using 7-Tesla magnetic resonance imaging (MRI) and high-resolution positron emission tomography (PET) with 11C-3-amino-4-(2-dimethylaminomethylphenylthio)b...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.10.020
更新日期：2017-04-01 00:00:00
abstract：:Results of first-episode psychosis studies have shown that the diagnosis of schizophrenia is more stable across time than other diagnoses within the psychosis spectrum disorders. The objective of this study was to determine the diagnostic stability in a sample of first-episode patients and to determine the factors tha...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2006.04.018
更新日期：2006-09-01 00:00:00
abstract：BACKGROUND:Recovery is the ultimate goal of psychosis treatment. Basic self-disturbances (BSDs) are non-psychotic phenomena associated with clinical outcome, present in prodromal, psychotic and residual phases of psychotic disorders. AIM:To investigate the relationship between BSDs and recovery seven years after first...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.08.009
更新日期：2019-10-01 00:00:00
abstract：OBJECTIVE:The use of dopaminergic antagonist antipsychotics is associated with hyperprolactinemia, but some studies have found increased prolactin concentrations in antipsychotic-naive patients with schizophrenia and related disorders. We conducted a systematic review and meta-analysis of studies of prolactin in antips...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.schres.2016.03.018
更新日期：2016-07-01 00:00:00
abstract：INTRODUCTION:HTR2A gene has been the subject of numerous studies in psychiatric genetics because LSD, which resembles serotonin causes psychosis and atypical antipsychotic drugs target the HTR2A receptor. However, evidence for the role of HTR2A polymorphism(s) in schizophrenia (SCZ) and bipolar disorder (BD) has been e...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2011.04.007
更新日期：2011-07-01 00:00:00
abstract：BACKGROUND:Anomalies in visual and auditory perception represent an important aspect of the symptomatic manifestation of schizophrenia (ScZ). However, there are currently no instruments available that allow the assessment of the full range of auditory and visual abnormalities using a self-report measure. METHODS:We de...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.03.016
更新日期：2019-07-01 00:00:00
abstract：:Glutamate cycling is critically important for neurotransmission, and may be altered in schizophrenia. The excitatory amino acid transporters (EAATs) facilitate the reuptake of glutamate from the synaptic cleft and have a key role in glutamate cycling. We hypothesized that expression of the EAATs and the EAAT regulatin...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2008.06.012
更新日期：2008-09-01 00:00:00
abstract：:MicroRNAs (miRNAs) are small non-coding RNAs that mainly function as negative regulators of gene expression (Lai, 2002) and have been shown to be involved in schizophrenia etiology through genetic and expression studies (Burmistrova et al., 2007; Hansen et al., 2007a; Perkins et al., 2007; Beveridge et al., 2010; Kim ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.06.038
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:Patients with schizophrenia and comorbid drug use disorders (DUD) have a severe course of illness. Despite strong evidence that drug use can exacerbate psychotic symptoms, we have limited knowledge of how specific drugs may increase risk of schizophrenia readmission in this group. This study aimed to assess ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.09.026
更新日期：2018-05-01 00:00:00
abstract：:Unemployment rates for schizophrenia are high across all age groups compared to the general population. Past studies have focused on neurocognition as a key determinant of unemployment and poor work outcome in schizophrenia. However, several recent studies suggest that clinical symptoms may be equally or more importan...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.06.001
更新日期：2018-02-01 00:00:00
abstract：:Cognitive adaptation training (CAT) is a home-based, manualized treatment that utilizes environmental supports to improve target behaviors and functional outcomes in persons with schizophrenia. Although clinical trials have shown CAT to be effective across functional, clinical, and treatment adherence domains, when th...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2014.03.026
更新日期：2014-06-01 00:00:00
abstract：:Recent studies have proposed that difficulty with accessing the lexical-semantic memory store may underpin some of the specific linguistic problems associated with formal thought disorder (FTD). We examined the consistency of name retrieval as an indicator of the ability to access lexical-semantic knowledge in patient...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2006.07.005
更新日期：2006-12-01 00:00:00
abstract：:Several investigations suggest that complexin may be a schizophrenia-susceptibility factor. We conducted a genetic association analysis between complexin genes (CPLX1 and CPLX2) and schizophrenia in Japanese patients (377 cases and 341 controls). Ten and eleven haplotype-tagging (ht)SNPs in CPLX1 and CPLX2, respective...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2005.12.842
更新日期：2006-02-28 00:00:00
abstract：:Vulnerability for schizophrenia is related, in part, to genetic predisposition. The identification of pathophysiological abnormalities associated with the disorder that are also present in unaffected family members of individuals with schizophrenia may assist in delineating the genetic contributions to vulnerability f...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.04.026
更新日期：2007-08-01 00:00:00
abstract：:A number of recent studies have suggested that schizophrenia patients share metamemory deficits, particularly, a decreased ability to distinguish between errors and correct responses in terms of response confidence (i.e., decreased confidence gap): patients are over-confident in errors while at the same time being und...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2005.09.004
更新日期：2006-01-31 00:00:00
abstract：:The current study sought to expand on prior reports of the validity and reliability of the CAINS (CAINS) by examining its performance across diverse non-academic clinical settings as employed by raters not affiliated with the scale's developers and across a longer test-retest follow-up period. The properties of the CA...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.schres.2017.01.011
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:Mismatch negativity (MNN) and P3a are event related potential (ERP) measures of early sensory information processing. These components are usually conceptualized as being "pre-attentive" and therefore immune to changes with variations in attentional functioning. This study aimed to determine whether manipula...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.01.035
更新日期：2013-05-01 00:00:00
abstract：:Thirty-six subjects aged 16 years or older judged at risk for a first episode of psychosis within a North American multi-site study of the schizophrenia prodrome [McGlashan et al., Schizophr. Res. (2003); Miller et al., Schizophr. Res. (2003)] performed at levels intermediate to population norms and data reported for ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2003.08.007
更新日期：2004-04-01 00:00:00
abstract：OBJECTIVE:The relationship of religion and schizophrenia is widely acknowledged, but often minimized by practitioners and under investigated by researchers. In striving to help fill this gap, this paper focuses on examining four aims: 1) how research has investigated the association between religiosity and schizophreni...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2010.11.005
更新日期：2011-03-01 00:00:00
abstract：:Evidence from event-related-potential (ERP) studies has repeatedly shown differences in the perception and processing of auditory stimuli in children with dyslexia compared to control children. The mismatch negativity (MMN) - an ERP component reflecting passive auditory change detection ability - has been found to be ...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2017.07.010
更新日期：2018-01-01 00:00:00
abstract：:Non-compliance problems may rise to 50% among patients undergoing neuroleptic treatment. There are no direct measures available to predict compliance, if previous non-compliance is not taken into account. Attitudes towards neuroleptic treatment and insight into psychotic symptoms may vary during the course of the trea...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(99)00204-2
更新日期：2000-10-27 00:00:00
abstract：:Previous research demonstrates that people with schizophrenia have abnormally 'restricted' visual scanpaths to face and facial expression stimuli, which appear to be diagnostically specific to schizophrenia [Schizophr. Res. 55 (2002) 159; Biol. Psychiatry 52 (2002) 338]. This study examined the familial transmission o...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(03)00094-x
更新日期：2004-03-01 00:00:00
abstract：:Theory of mind (ToM) is the ability to understand mental states of others and it is crucial for building sensitivity to other persons or events. Measuring ToM is important for understanding and rehabilitating social cognitive impairments in persons with schizophrenia. The Social Attribution Task-Multiple Choice (SAT-M...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.06.022
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND:Cognitive deficits are prominent in schizophrenia and represent promising endophenotypes for genetic research. METHODS:The current study investigated the importance of two conceptually distinct genetic aggregates, one based on copy number variations (uncommon deletion burden), and one based on single nucleo...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.03.022
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:There remains a lack of agreement regarding criteria for treatment-resistant schizophrenia (TRS) and definition of response. METHOD:A literature search was conducted to identify clinical studies of antipsychotics in TRS using PubMed, EMBASE and PsycINFO (last search 31 July 2011). Psychopharmacological stud...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2011.09.016
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:A small but significant association between schizophrenia and violence is open to a number of explanations. Impaired empathy has been associated with schizophrenia, and with violence in the general population. Our aim was to conduct a systematic review of any research into relationships between schizophrenia...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2012.07.019
更新日期：2012-10-01 00:00:00
