Abstract:
:The degree of cortical atrophy as revealed by computed tomographic scans was assessed in 124 patients meeting the DSM III criteria for schizophrenia and in 45 age- and sex-matched healthy controls. 21 patients, i.e., 33% of the entire sample, showed moderate to severe atrophy. The presence of atrophy was not associated with such variables as patients' age, age at onset and duration of illness, diagnostic subtype of schizophrenia, family history of schizophrenia in first degree relatives, history of suicidal behavior, I.Q., employment status, clinical outcome on neuroleptic treatment and HLA antigens distribution. The only variables found to be associated with atrophy were: male sex and cerebral ventricular enlargement. The significance of the CT finding of cortical atrophy in schizophrenia is discussed in the light of these results.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Vita A,Sacchetti E,Calzeroni A,Cazzullo CLdoi
10.1016/0920-9964(88)90046-1subject
Has Abstractpub_date
1988-09-01 00:00:00pages
329-37issue
5eissn
0920-9964issn
1573-2509pii
0920-9964(88)90046-1journal_volume
1pub_type
杂志文章abstract:BACKGROUND:Some studies have suggested that antipsychotic-naïve patients with nonaffective psychosis (NAP) have glucose intolerance. AIMS:To conduct a systematic review and meta-analysis of fasting glucose (FG), two hour values in the oral glucose tolerance test (2HG), fasting insulin concentration (INS), and insulin ...
journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.schres.2016.09.026
更新日期:2017-01-01 00:00:00
abstract::Brain morphometry has been studied extensively in schizophrenic patients, and among the cortical differences identified two consistent findings are decreased cerebellar vermal volume and increased volume of the fourth ventricle; although contradictory findings are reported as well. Recent cognitive activation studies ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(98)00137-6
更新日期:1999-05-04 00:00:00
abstract::Stigma may undermine the well-being of young people at risk of psychosis. We therefore measured self-labeling, stigma variables and well-being at baseline and again one year later among 77 at-risk participants. An increase in self-labeling during this period predicted heightened stigma stress after one year and a decr...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.07.016
更新日期:2014-09-01 00:00:00
abstract::Little is known about the impact of family history of psychosis on youth from community samples. To fill this gap, we compared youth with a first-degree relative with psychosis spectrum symptoms (i.e. family history of psychosis spectrum symptoms, FHPS) to youth without FHPS in a cross-sectional analysis of the Philad...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.12.021
更新日期:2020-02-01 00:00:00
abstract::T1 and T2 relaxation times were measured in ten brain regions on the right and left side in a sample of 27 schizophrenic patients and 37 normal controls. The schizophrenic patients showed a prolongation of T2 relaxation time, and to a lesser extent of T1 relaxation time, which was more predominantly localized in the r...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/0920-9964(91)90080-b
更新日期:1991-10-01 00:00:00
abstract::The number of psychiatric beds has declined considerably in many countries over the past decades. Long-term studies on the impact of these health care changes for the severely mentally ill, however, are still scarce. This epidemiological study investigates the use of inpatient psychiatric services by people with schiz...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.07.006
更新日期:2007-12-01 00:00:00
abstract::There has been increasing interest in studying the impact of physical activity on the psychological and physical well-being and functioning in patients with first-episode psychosis. The exploration of factors which contribute to physical activity in psychosis may open up opportunities for improvement of functional out...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.08.034
更新日期:2013-11-01 00:00:00
abstract::Antipsychotic pharmacotherapy is the standard of care for the treatment of schizophrenia. Although pharmacotherapy effectively improves some symptoms, others can remain. Pharmacotherapy alone also tends to produce only limited improvement in social functioning and quality of life. Supportive psychosocial therapies hav...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2007.12.468
更新日期:2008-03-01 00:00:00
abstract::The minor neurological and cognitive deficits consistently reported in psychoses may reflect the same underlying brain dysfunction. Still, even in healthy individuals minor neurological abnormalities are associated with worse cognitive function. Therefore, establishing which neurological and cognitive deficits are spe...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2012.09.016
更新日期:2012-12-01 00:00:00
abstract::Past studies have demonstrated that the Brief Negative Symptom Scale (BNSS) has excellent psychometric properties in patients with schizophrenia. In the current study, we extended this literature by examining psychometric properties of the BNSS in outpatients diagnosed with bipolar disorder (n=46), outpatients with sc...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.12.014
更新日期:2016-02-01 00:00:00
abstract::Variable levels of essential polyunsaturated fatty acids (EPUFAs) reported in schizophrenia are likely due to differences in age, sex, ethnicity, diet, life style and treatments. The present study examined the EPUFAs levels in plasma, RBC and CSF in never-medicated first-episode psychotic patients and normal controls ...
journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.schres.2007.09.036
更新日期:2008-01-01 00:00:00
abstract::Here, we used data from large genome-wide association studies to test the presence of causal relationships, conducting a Mendelian randomization analysis; and shared molecular mechanisms, calculating the genetic correlation, among schizophrenia, type 2 diabetes (T2D), and impaired glucose homeostasis. Although our Men...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.10.033
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVES:Psychosis is associated with increased subjective and altered endocrine and autonomic nervous system stress-reactivity. Psychosis patients often experience auditory verbal hallucinations, with negative voice content being particularly associated with distress. The present study developed a voice-simulation p...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.07.019
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Although altered gamma-aminobutyric acid (GABA) neurotransmission has been implicated in the pathophysiology of schizophrenia, it is unclear whether the influence of GABA on working memory processes is confounded by nicotine use in this population. It is therefore crucial to evaluate working memory and its u...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2016.01.008
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:In randomized controlled trials of antipsychotics, various cutoffs have been used to define response on continuous outcome measures. AIMS:To find a summary effect measure that remains constant across different definitions of response. METHOD:We conducted secondary analyses of individual patient data from 1...
journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析
doi:10.1016/j.schres.2010.10.016
更新日期:2011-03-01 00:00:00
abstract::Evidence validating the influence of the cytochrome P450 (CYP) 2D6 and 2C19 enzymes genetic polymorphisms in the response to antipsychotics is scarce. We examined the hypothesis that a higher prevalence of CYP2D6 and/or CYP2C19 ultra rapid metabolizers might be found among refractory schizophrenia patients. Three grou...
journal_title:Schizophrenia research
pub_type: 信件
doi:10.1016/j.schres.2015.08.002
更新日期:2015-10-01 00:00:00
abstract::Cannabis use is highly prevalent worldwide and it is associated with psychosis, but its effects on brain structure and cognition are still controversial. The aim of this paper is to investigate cognitive functioning and brain structure in patients with their first episode of psychosis who used Cannabis. We examined gr...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.04.009
更新日期:2013-07-01 00:00:00
abstract::Minor physical anomalies (MPAs) are more prevalent amongst individuals with psychosis, supporting a neurodevelopmental model for psychotic disorders. The aim of this study was to investigate the possibility that neurodevelopmental adversity contributes to the excess of psychosis found in some ethnic groups in the UK. ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2006.08.019
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Schizophrenia with an onset in adolescence is known to be associated with a poorer outcome and cognitive difficulties. These impairments have an impact on quality of life and represent treatment targets. Cognitive remediation therapy (CRT) attempts to improve cognitive deficits by teaching information proces...
journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2007.03.030
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:Numerous studies have examined a wide range of risk factors associated with violence among patients with schizophrenia. However, risk factors linked to different socio-cultural backgrounds remain unclear. OBJECTIVE:The objectives were to investigate factors associated with violence among Japanese patients w...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.10.016
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:People with schizophrenia have an increased risk of premature mortality compared to the general population. We aimed to quantify which types of causes of death contributed to the excess mortality, and to examine whether there has been an increase in the excess mortality among persons with schizophrenia in th...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.11.003
更新日期:2019-04-01 00:00:00
abstract::Schizotypy is usually referred to as a "liability" to schizophrenia, but it could also be more generally referred to as nonspecific "psychosis-proneness". This study examined the structure of schizotypy in a normal sample and in a sample of schizophrenics through the administration of the Schizotypal Personality Quest...
journal_title:Schizophrenia research
pub_type:
doi:10.1016/s0920-9964(01)00353-x
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:In schizophrenic psychoses, the normal sexual dimorphism of the brain has been shown to be disrupted or even reversed. Little is known, however, at what time point in emerging psychosis this occurs. We have therefore examined, if these alterations are already present in the at-risk mental state (ARMS) for ps...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.03.034
更新日期:2018-09-01 00:00:00
abstract::Increased sulcal widening in the prefrontal cortex of patients with schizophrenia may be associated with a poor treatment response to clozapine. To further evaluate this, we examined data from patients treated with clozapine in our center. Patients with the greatest degree of improvement (n=26) and those with no impro...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(00)00130-4
更新日期:2001-03-30 00:00:00
abstract::Up to 50-90% of persons with schizophrenia smoke cigarettes. Limited data and theories suggest persons with schizophrenia may smoke for different reasons than persons without schizophrenia, making smoking cessation interventions particularly challenging in this population. Although health consequences of smoking are w...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2012.03.024
更新日期:2012-07-01 00:00:00
abstract::Schizophrenia is associated with premature mortality and a high rate of sudden, unexpected deaths. Autopsy data are scant, and in studies using death certificates or root cause assessments, a majority of sudden deaths remained unexplained. In the community, post-mortem data indicate that the most common cause of sudde...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.03.011
更新日期:2014-05-01 00:00:00
abstract::The role of mentalizing abilities (or theory of mind) and empathic abilities in violent behavior were studied in 24 hospitalized males with paranoid schizophrenia (ICD-10). Patients were divided into violent and nonviolent groups based on their history of committing violent acts against others. To examine these abilit...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章
doi:10.1016/S0920-9964(03)00049-5
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVE:To explore the impact of the introduction of newer antipsychotic long-acting injections (LAIs) on trends in LAI prescribing and characteristics associated with initiation of LAIs in naturalistic conditions. METHODS:The study was performed using reimbursement data from the French Insurance Healthcare system. ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2016.09.014
更新日期:2016-12-01 00:00:00
abstract::Gray matter brain volume decreases have been found in patients with schizophrenia as compared to healthy control subjects measured by using Magnetic Resonance Imaging (MRI). An association has been suggested between decreased gray matter volume and poor outcome in chronically ill patients with schizophrenia. The prese...
journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究
doi:10.1016/s0920-9964(03)00018-5
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:Stress has been associated with the onset of schizophrenia and exacerbation of psychotic symptoms. Patients with schizotypal personality disorder (SPD), the prototypic schizophrenia spectrum disorder, do not develop the frank psychosis of schizophrenia and appear clinically to be less reactive to stress than...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.schres.2003.10.008
更新日期:2004-09-01 00:00:00