Abstract:
:Recovery from psychotic disorders includes both symptomatic and functional components. Progress in understanding recovery requires careful replication and extension of findings using comparable measures. In the current paper, we present a study of five year recovery rates in an early intervention program in London, Canada with the same operational criteria as those used in a previous report from the OPUS cohort in Denmark. Our analysis extends the OPUS reports by including additional potential predictors of overall recovery, such as cognitive functioning, adherence to medication and early social support, and examining rates and predictors of individual components of recovery at five year follow-up. Consistent with reports from OPUS, we found younger age of onset and lower initial severity of negative symptoms to predict greater likelihood of overall recovery. Different patterns of predictors emerge when we examine individual components of recovery. Adherence to medication during the first year was the sole independent predictor of remission of positive symptoms, while early social adjustment and social support were more likely to predict negative symptom and functional aspects of recovery at five years. Cognitive functioning, as represented by IQ, did not predict any aspects of recovery. Our findings suggest the importance of examining the predictors of individual components in the quest to improve overall recovery.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Norman RMG,MacDougall A,Manchanda R,Harricharan Rdoi
10.1016/j.schres.2017.08.054subject
Has Abstractpub_date
2018-05-01 00:00:00pages
469-474eissn
0920-9964issn
1573-2509pii
S0920-9964(17)30531-5journal_volume
195pub_type
杂志文章abstract::Poor insight into the neurocognitive deficits in schizophrenia-spectrum disorders may have significant clinical implications for treatment. The purpose of this study was to replicate and extend the psychometric findings initially reported on the Measure of Insight into Cognition Clinician-Rated (MIC-CR) and Self-Repor...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2011.10.002
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:The presence of a psychosis continuum is suggested by studies showing that schizophrenia and non-clinical psychotic symptoms in the general population share the same risk factors. However, to our knowledge no large-scale studies have been conducted which examine the specificity of these risk factors in the g...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.03.033
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:The intrusion of associations into the utterances of schizophrenic individuals typically disrupts the coherence of the patient's utterances. Recent theoretical formulations of these phenomena have emphasized the hyperactivity) of associational networks in such language disturbance (e.g., Maher, B.A. 2003 Sch...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2005.05.017
更新日期:2005-10-15 00:00:00
abstract::Studying Klinefelter syndrome (47,XXY), a genetically defined disorder characterized by the presence of an additional X chromosome, can reveal insights into genotype-phenotype associations. Increased vulnerability to psychiatric disorders characterized by difficulties in social interactions, such as schizophrenia and ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2006.02.020
更新日期:2006-06-01 00:00:00
abstract::Second generation antipsychotics cause derangements in glucose metabolism that are often interpreted as insulin resistance. In previous studies we have shown that this is not classical insulin resistance but the drugs were actually inducing a hyperglycaemic state associated with elevated hepatic glucose output (HGO) a...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.05.003
更新日期:2014-08-01 00:00:00
abstract::Primary motor abnormalities (PMA), as found in patients with schizophrenia, are quantitatively and qualitatively distinct markers of motor system abnormalities. PMA have been often referred to phenomena that are present across schizophrenia-spectrum disorders. A dysfunction of frontoparietal and subcortical networks h...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2017.10.007
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Proton magnetic resonance spectroscopy (1H-MRS) studies of schizophrenia suggest an effect of the disease or of antipsychotic medications on brain N-acetyl aspartate (NAA), a marker of neuronal viability. We studied in the rat the effect of antipsychotic drugs on NAA in several brain regions where NAA reduct...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(02)00528-5
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Older paternal age predicts schizophrenia diagnosis in offspring. If this relationship reflects a pathogenic process, paternal age should predict the expression of subclinical schizophrenia liability (schizotypy). We hypothesized that paternal and maternal ages predict positive, negative, and disorganized fe...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.09.018
更新日期:2015-12-01 00:00:00
abstract::A role for immune processes in the pathogenesis of schizophrenia has been suggested by genetic and epidemiological studies, as well as cross-sectional studies on blood and brain samples. However, results are heterogeneous, which is likely caused by low samples sizes, insufficient control of confounders that influence ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.05.028
更新日期:2020-03-01 00:00:00
abstract::Patients with schizophrenia often exhibit structural brain abnormalities, as well as neurological soft signs (NSS), consistent with its conceptualization as a neurodevelopmental disorder. NSS are mild, presumably nonlocalizing, neurological impairments that are inferred from performance deficits in domains such as sen...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.06.018
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:Self-rated attenuated psychotic-like experiences (APLEs) are increasingly used to screen for ultra-high-risk (UHR) across all ages. However, self-rated psychotic-like experiences (PLEs), in particular perception-related ones, were more frequent in children and adolescents, in which they possessed less clinica...
journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.schres.2014.10.005
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:To assess the prevalence and correlates of antipsychotic polypharmacy (APP) across decades and regions. METHODS:Electronic PubMed/Google Scholar search for studies reporting on APP, published from 1970 to 05/2009. Median rates and interquartile ranges (IQR) were calculated and compared using non-parametric t...
journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.schres.2012.03.018
更新日期:2012-06-01 00:00:00
abstract::Schizophrenia is associated with subtle developmental compromise, but the degree to which this is also associated with heritability and genetic risk is uncertain. The goal of the current study was to investigate the childhood, adolescent, and early adulthood social and academic function of patients with schizophrenia,...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.04.007
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:In many natural audiovisual events (e.g., the sight of a face articulating the syllable /ba/), the visual signal precedes the sound and thus allows observers to predict the onset and the content of the sound. In healthy adults, the N1 component of the event-related brain potential (ERP), reflecting neural ac...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.04.038
更新日期:2013-07-01 00:00:00
abstract::Earlier studies suggest that social competence has a higher predictive value for vocational outcome than psychopathology. These studies, however, show methodological shortcomings, including the fact that the instruments used for assessing social competence, psychopathology and work performance are strongly interrelate...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/S0920-9964(96)00082-5
更新日期:1997-01-17 00:00:00
abstract:INTRODUCTION:Progressive atrophy occurs in brain regions involved in the working memory network along the schizophrenia's course, but without parallel evolution of working memory impairment. We investigated the functional organization inside this network at different stages of the disease. METHODS:Twenty-eight patient...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.10.023
更新日期:2013-12-01 00:00:00
abstract::Previous transcriptome analyses of brain samples provided several insights into the pathophysiology of schizophrenia. In this study, we aimed to re-investigate gene expression datasets from seven brain regions of patients with schizophrenia and healthy controls by adopting a unified approach. After adjustment for conf...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2020.06.032
更新日期:2020-09-01 00:00:00
abstract::MicroRNAs (miRNAs) are small non-coding RNAs that mainly function as negative regulators of gene expression (Lai, 2002) and have been shown to be involved in schizophrenia etiology through genetic and expression studies (Burmistrova et al., 2007; Hansen et al., 2007a; Perkins et al., 2007; Beveridge et al., 2010; Kim ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2012.06.038
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Advanced paternal age (APA) is associated with increased risk for schizophrenia, but its effect on treatment response has not been longitudinally studied. METHODS:Association of parental ages at the time of the child's birth with age of onset, initial symptom severity and treatment response (to placebo and ...
journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2013.10.001
更新日期:2013-12-01 00:00:00
abstract::Cortical thickness may be useful as a treatment response predictor in first-episode (FE) patients with schizophrenia, although this possibility has been scarcely assessed. In this study we assessed the possible relation between cortical thickness in regions of interest selected because of previously reported structura...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.06.042
更新日期:2014-09-01 00:00:00
abstract::Executive dysfunction and language impairment are the most prominent neuropsychological models of formal thought disorder (FTD) in schizophrenia. However, available studies have provided contradictory findings regarding the accuracy of these models. Furthermore, specific neurocognitive underpinnings of positive FTD (P...
journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.schres.2019.05.025
更新日期:2019-07-01 00:00:00
abstract::Schizophrenia is associated with poor quality of life (QOL). Whereas the effects of neurocognitive deficits and psychopathology on QOL of schizophrenia patients have recently been elucidated, little is known about social cognitive deficits in this regard. This study investigated the influence of social cognition on QO...
journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.schres.2012.02.017
更新日期:2012-05-01 00:00:00
abstract::This paper examines trait arousability (TA), a temperament characteristic, in 47 stable outpatients with schizophrenia and 50 non-psychiatric controls. Self-reported levels of stress were obtained during a negative and positive memory speech task. Levels of TA, and the association of TA scores with reported stress dur...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2004.01.008
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE:Attentional deficits represent a core cognitive impairment in schizophrenia. The distractor condition Sustained Attention Task (dSAT) has been identified by the Cognitive Neuroscience Treatment to Improve Cognition in Schizophrenia (CNTRICS) initiative as a promising translational task for assessing schizophr...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.01.003
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Pharmaceutical companies conduct clinical trials to show the efficacy and safety of new medications for the treatment of schizophrenia. After the new medications are marketed, clinicians treating patients with schizophrenia discover that a considerable number of patients do not respond to these new medicatio...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2017.03.020
更新日期:2017-12-01 00:00:00
abstract::Psychiatric case records from Eaton and Weil's 1950-53 study of the Hutterites were rediagnosed using DSM-III-R criteria. The results confirmed that the Hutterites have a very low prevalence of both schizophrenia (0.9 per 1000) and bipolar disorder (0.6 per 1000). Genetic and/or environmental explanations are both pos...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/0920-9964(95)00042-k
更新日期:1995-08-01 00:00:00
abstract::The effects of gut microbiota on the central nervous system, along its possible role in mental disorders, have received increasing attention. Here we investigated differences in fecal microbiota between 28 patients with first-episode psychosis (FEP) and 16 healthy matched controls and explored whether such differences...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.04.017
更新日期:2018-02-01 00:00:00
abstract::The aim of this study is to compare the neurocognitive functions in individuals with clinical or genetic risk for psychosis, in patients with first-episode schizophrenia (FES) and in healthy controls. We compared cognitive functions of 52 individuals at ultra high risk (UHR) for psychosis, 53 patients with FES, their ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.10.030
更新日期:2013-12-01 00:00:00
abstract::Early intervention strategies in psychosis would significantly benefit from the identification of reliable prognostic biomarkers. Pattern classification methods have shown the feasibility of an early diagnosis of psychosis onset both in clinical and familial high-risk populations. Here we were interested in replicatin...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.08.061
更新日期:2019-12-01 00:00:00
abstract::Given the morbidity and difficulty of treating psychotic disorders, including schizophrenia, there has been a move toward identifying and treating adolescents and young adults who appear to be clinically at risk or "prodromal" to psychosis. The field now has greater specificity in identification, with rates of 40-50% ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2004.05.021
更新日期:2005-03-01 00:00:00