Abstract:
:Recent transcriptomic, proteomic and metabolomics studies have highlighted an abnormal cerebral glucose and energy metabolism as one of the potential pathophysiological mechanisms of schizophrenia. This raises the possibility that a metabolically-based intervention might have therapeutic value in the management of schizophrenia, a notion supported by our recent results that a low carbohydrate/high-fat therapeutic ketogenic diet (KD) prevented a variety of behavioural abnormalities induced by pharmacological inhibition of NMDA glutamate receptors. Here we asked if the beneficial effects of KD can be generalised to impaired prepulse inhibition of startle (PPI), a translationally validated endophenotype of schizophrenia, in a pharmacological model in mice. Furthermore, we addressed the issue of whether the effect of KD is linked to the calorie-restricted state typical of the initial phase of KD. We fed male C57BL/6 mice a KD for 7 weeks and tested PPI at 3 and 7 weeks, in the presence and absence of a significant digestible energy deficit, respectively. We used an NMDA receptor hypo-function model of schizophrenia induced by acute injection of dizocilpine (MK-801). We found that KD effectively prevented MK-801-induced PPI impairments at both 3 and 7 weeks, irrespective of the presence or absence of digestible energy deficit. Furthermore, there was a lack of correlation between PPI and body weight changes. These results support the efficacy of the therapeutic KD in a translational model of schizophrenia and furthermore provide evidence against the role of calorie restriction in its mechanism of action.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Kraeuter AK,van den Buuse M,Sarnyai Zdoi
10.1016/j.schres.2018.11.011subject
Has Abstractpub_date
2019-04-01 00:00:00pages
244-250eissn
0920-9964issn
1573-2509pii
S0920-9964(18)30662-5journal_volume
206pub_type
杂志文章abstract::Schizophrenia is associated with structural brain abnormalities that are likely to be present before disease onset. It remains unclear to what extent these represent general vulnerability indicators or are associated with the developing clinical state itself. It also remains unclear whether such state or trait alterat...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.12.003
更新日期:2016-06-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2006.04.001
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journal_title:Schizophrenia research
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doi:10.1016/s0920-9964(96)00060-6
更新日期:1996-12-15 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2011.03.016
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journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析
doi:10.1016/j.schres.2006.08.021
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.06.002
更新日期:2008-09-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2019-06-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.03.012
更新日期:2010-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.10.017
更新日期:2020-01-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2020.03.048
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.04.032
更新日期:2014-08-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(02)00534-0
更新日期:2003-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.schres.2016.02.013
更新日期:2016-05-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/S0920-9964(03)00086-0
更新日期:2004-05-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2005.01.013
更新日期:2005-11-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.02.015
更新日期:2019-06-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(96)00065-5
更新日期:1996-11-15 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2012.09.016
更新日期:2012-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.10.012
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pub_type: 杂志文章
doi:10.1016/j.schres.2016.09.014
更新日期:2016-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2020.04.004
更新日期:2020-04-30 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,评审
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更新日期:1999-03-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.06.009
更新日期:2015-08-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.03.017
更新日期:2009-06-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.01.019
更新日期:2015-03-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2016.01.048
更新日期:2016-04-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.06.009
更新日期:2007-09-01 00:00:00