Abstract：
BACKGROUND:Tumor necrosis factor alpha (TNFalpha), a cytokine involved in inflammatory processes, has been implicated in the pathophysiology of schizophrenia. The chromosomal location in the major histocompatibility complex (MHC) region on 6p21.1-21.3, a region with evidence for linkage, suggests a role in susceptibility to schizophrenia. Association of the minor (A) allele of the -G308A TNFalpha gene polymorphism with schizophrenia has been reported [Mol. Psychiatry 6 (2001) 79]. METHODS:Association of the -G308A TNFalpha gene and the lymphotoxin alpha (LTalpha)+A252G gene polymorphisms with schizophrenia was studied in 79 sib pair families with linkage in the MHC region and in 128 trio families using the transmission disequilibrium test (TDT). RESULTS:Weak association of the common G allele was detected for TNFalpha -G308A in both samples independently with borderline significance in the sib pair families (0.064) and with a nominally significant value of P=0.022 in the trio families. Combining both samples produced P=0.003, while LTalpha+A252G, located approximately 2-3 kb distally, revealed P=0.03 and the two locus haplotype yielded a P value of 0.001. CONCLUSION:Our data suggests association of the common G allele of the -G308A TNFalpha gene polymorphism with schizophrenia in a sample of 207 families. However, linkage disequilibrium with a different allele of the TNFalpha gene or another gene in the MHC region cannot be excluded.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Schwab SG,Mondabon S,Knapp M,Albus M,Hallmayer J,Borrmann-Hassenbach M,Trixler M,Gross M,Schulze TG,Rietschel M,Lerer B,Maier W,Wildenauer DBdoi
10.1016/s0920-9964(02)00534-0subject
Has Abstractpub_date
2003-12-01 00:00:00pages
19-25issue
1eissn
0920-9964issn
1573-2509pii
S0920996402005340journal_volume
65pub_type
杂志文章abstract：BACKGROUND:The intrusion of associations into the utterances of schizophrenic individuals typically disrupts the coherence of the patient's utterances. Recent theoretical formulations of these phenomena have emphasized the hyperactivity) of associational networks in such language disturbance (e.g., Maher, B.A. 2003 Sch...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2005.05.017
更新日期：2005-10-15 00:00:00
abstract：BACKGROUND:Findings from the WHO sponsored multicenter studies done a few decades ago, which reported favorable outcome of schizophrenia in developing countries both in 2 and 5 year follow-up studies, dominated the world view until recently. Emerging evidence from Low and Middle Income countries (LAMIC) started to chal...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.schres.2011.10.021
更新日期：2012-04-01 00:00:00
abstract：:Patients with schizophrenia demonstrate a generalized deficit across multiple cognitive domains. However, it is unknown whether this deficit is largely due to lower intelligence, or if there is an impact of schizophrenia which cannot be accounted for by measures of general intellectual ability (GIA). We created four I...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.04.016
更新日期：2013-07-01 00:00:00
abstract：:A review of 65 studies of individuals with schizophrenia who had never been treated with antipsychotic medications indicates significant abnormalities in brain structure and function. Neurological and neuropsychological measures show the most consistent and largest group differences between those affected and normal c...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/s0920-9964(02)00381-x
更新日期：2002-12-01 00:00:00
abstract：:The intracellular enzyme phospholipase A2 (PLA2) plays an essential role in the breakdown of membrane phospholipids, which regulate the physicochemical properties of the cell membrane. In the brain PLA2 has been reported to influence receptor function and signal transduction. Regarding dopaminergic neurons, data from ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(94)00060-l
更新日期：1995-07-01 00:00:00
abstract：:A disturbance of "minimal self," - of the immediate sense of mine-ness inherent in experience-is hypothesized to be the core disturbance in schizophrenia. Research with the Examination of Anomalous Self Experience (EASE) has demonstrated the selective aggregation of anomalous self-experiences in the schizophrenia spec...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.07.001
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVE:We recently reported that the type-2 cytokine response is increased in schizophrenia. The aim of this study was to analyse the effects of antipsychotic drugs on the serum levels of type-1 (TNF-α, IFN-γ), type-2 (IL-4, IL-10), type-17 (IL-17) and regulatory cytokines (TGF-β, IL-27 and IL-6). METHODS:Cytokine ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.03.027
更新日期：2013-06-01 00:00:00
abstract：:Schizophrenia has generally been viewed as having a unique preschizophrenia personality or destructive to the personality post-onset. This view is reflected in the scarcity of studies of personality in schizophrenia with the exception of schizotypal personality considered by many as an endophenotype of schizophrenia. ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.02.015
更新日期：2017-11-01 00:00:00
abstract：:Converging lines of evidence implicate structural and functional abnormalities in the cerebellum in schizophrenia (SCZ). The cerebellar vermis is of particular interest given its association with clinical symptoms and cognitive deficits in SCZ and its known connections with cortical regions such as the prefrontal cort...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.06.028
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:Many patients with schizophrenia suffer from metabolic symptoms and weight gain in which predispose them to obesity, diabetes, and cardiovascular problems. This trial examines the efficacy and safety of zonisamide on weight and body mass index in patients with schizophrenia being administered with atypical a...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2013.03.021
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND:Auditory verbal hallucinations (AVH) do not have uniform pathological significance. They affect patients with different brain disorders, and vary along multiple phenomenological dimensions. Evidence indicates that some of the phenomenological variables have specific neural substrates. Therefore, a comprehens...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(03)00013-6
更新日期：2003-06-01 00:00:00
abstract：:Verbal dichotic listening performance was examined in 42 right-handed men and women with DSM-IV-defined schizotypal personality disorder (SPD) and 68 right-handed controls. As expected, both male and female control groups showed a right ear advantage on a verbal dichotic listening task. Although SPD subjects in genera...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.04.028
更新日期：2009-12-01 00:00:00
abstract：INTRODUCTION:Progressive atrophy occurs in brain regions involved in the working memory network along the schizophrenia's course, but without parallel evolution of working memory impairment. We investigated the functional organization inside this network at different stages of the disease. METHODS:Twenty-eight patient...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.10.023
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:Genetic factors are important in the aetiology of psychotic disorders, but it is unclear how far they influence aspects of illness history within psychoses. AIMS:To investigate the extent, and type of familial aggregation for a range of illness history variables in psychosis. METHODS:Two-hundred-and-twenty...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.09.002
更新日期：2009-12-01 00:00:00
abstract：:While the "clinical high-risk state" for psychosis has demonstrated good reliability and fair predictive validity for psychotic disorders, over 50% of identified subjects do not progress to psychosis. Despite the benefits that early detection and treatment might offer, debate concerning the official inclusion of a "ps...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2010.03.012
更新日期：2010-07-01 00:00:00
abstract：:The right shift (RS) theory (Annett, M., 1972. The distribution of manual asymmetry. Br. J. Psychol. 63, 343-358; Annett, M., 1985. Left, Right, Hand and Brain: The Right Shift Theory. Lawrence Erlbaum, London) suggests that the typical pattern of human cerebral and manual asymmetries depends on a single gene (RS+) wh...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(99)00072-9
更新日期：1999-10-19 00:00:00
abstract：:Neurodevelopmental pathogenesis of schizophrenia might be mediated by abnormalities in Insulin-like Growth Factor-1 (IGF-1). Developmental disturbances like obstetric complications, by themselves, as well as through the resultant hypercortisolemia due to hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, can lea...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2010.01.033
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVE:We examined the relationship between cerebral gray matter (GM) volume and severity of delusions and hallucinations in adults with schizophrenia. METHOD:MRI scans in 43 patients with schizophrenia were acquired. Correlations were computed between GM volume and clinician ratings of hallucinations and delusions...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2011.08.004
更新日期：2011-12-01 00:00:00
abstract：:Insight and hopelessness have been reported to be associated with suicidality in schizophrenia. In addition, there is evidence that diminished insight is correlated with impairment in some domains of cognitive function in schizophrenia. The purpose of this study was to clarify the relative importance for suicidality i...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(02)00310-9
更新日期：2003-03-01 00:00:00
abstract：:Normally, when two brief, non-startling auditory stimuli are presented 500 ms apart, with long (e.g., 10 s) interpair intervals, the positive potential occurring approx. 50 ms after the first stimulus (P50) is relatively large, and the P50 to the second stimulus is smaller. In schizophrenia patients, however, the P50 ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(97)00122-9
更新日期：1998-02-27 00:00:00
abstract：:Vulnerability for schizophrenia is related, in part, to genetic predisposition. The identification of pathophysiological abnormalities associated with the disorder that are also present in unaffected family members of individuals with schizophrenia may assist in delineating the genetic contributions to vulnerability f...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.04.026
更新日期：2007-08-01 00:00:00
abstract：:This study tested the hypothesis that maternal exposure to terror attacks during pregnancy is associated with the risk of schizophrenia in the offspring. A population-based study was conducted of Israeli children born between 1975 and 1995 and that were registered in the Ministry of Interior and followed up in the Min...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.04.024
更新日期：2018-09-01 00:00:00
abstract：:This study documents a severe picture naming impairment in a series of 22 chronically hospitalised schizophrenics. The pattern and level of naming impairment were comparable in degree and type to that seen neurological patients with left hemisphere lesions. This deficit was further examined to determine whether it con...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(99)00184-x
更新日期：2000-09-29 00:00:00
abstract：:Reduced glutamatergic activity and energy metabolism in the dorsolateral prefrontal cortex (DLPFC) have been described in schizophrenia. Glycogenolysis in astrocytes is responsible for providing neurons with lactate as a transient energy supply helping to couple glutamatergic neurotransmission and glucose utilization ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.04.024
更新日期：2016-11-01 00:00:00
abstract：:Impaired fiber bundle connectivity between brain regions is a key neuropathological finding in schizophrenia. Symptom dimensions in schizophrenia can be clustered into factor models. Single syndromes have been related to grey and white matter brain structure alterations. We associated all core syndromes of schizophren...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.11.045
更新日期：2017-06-01 00:00:00
abstract：:[(3)H]ketanserin binding to 5HT(2A) receptors was measured in the left planum temporale (sensory speech cortex) from schizophrenic and non-schizophrenic (control) subjects using both particulate membranes and tissue sections. There was a significant decrease in the affinity of [(3)H]ketanserin binding to particulate m...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(99)00150-4
更新日期：2000-07-07 00:00:00
abstract：:Social perception and mentalizing are fundamental social cognitive abilities that are related to functioning and are impaired in schizophrenia. A novel approach to examine the relationship between social cognition and community functioning is to first functionally categorize individuals with schizophrenia and then eva...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.01.029
更新日期：2016-03-01 00:00:00
abstract：PURPOSE:Studies show that deficit syndrome schizophrenia patients, characterized by primary negative symptoms and poor functional outcome, have impairment in specific neural circuits. We assessed whether these same neural circuits are directly linked to functional outcomes across schizophrenia patients. METHODS:T1- an...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.10.023
更新日期：2015-12-01 00:00:00
abstract：:Large studies investigating the psychosocial effects of lifestyle interventions in patients with a severe mental illness (SMI) are scarce, especially in residential patients. This large, randomized controlled, multicentre pragmatic trial assessed the psychosocial effects of a combined diet-and-exercise lifestyle inter...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.schres.2018.02.053
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND:Neurological soft signs (NSS) are intrinsic features of psychosis that appear years before beginning a drug treatment. However, whether NSS respond to antipsychotics and whether these changes are clinically reliable and significant remains to be seen. OBJECTIVE:We sought to determine the effect of antipsych...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.05.019
更新日期：2012-08-01 00:00:00
