Abstract：
INTRODUCTION:Progressive atrophy occurs in brain regions involved in the working memory network along the schizophrenia's course, but without parallel evolution of working memory impairment. We investigated the functional organization inside this network at different stages of the disease. METHODS:Twenty-eight patients with schizophrenia (16 with long disease duration (>60 months) and 12 with short disease duration (<60 months)) and eleven healthy controls underwent structural and functional MRI during an n-back task to determine atrophy and activation patterns. RESULTS:At similar n-back performances and relative to short disease duration patients, long disease duration patients activated more frontal temporal parietal and frontal network during 0-back and 1-back tasks respectively. n-back scores were correlated to atrophy in the frontal-temporal areas. DISCUSSION:Functional reorganization in the working memory network may play a compensatory role during the first ten years of schizophrenia.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Faget-Agius C,Boyer L,Lançon C,Richieri R,Fassio E,Soulier E,Chanoine V,Auquier P,Ranjeva JP,Guye Mdoi
10.1016/j.schres.2013.10.023subject
Has Abstractpub_date
2013-12-01 00:00:00pages
48-60issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(13)00570-7journal_volume
151pub_type
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