Limbic cortical injury sustained during adulthood leads to schizophrenia-like syndrome.

Abstract:

:Within 1 year of severe trauma to the left anterior temporal lobe and minor injury to the frontal lobes, a 35-year-old individual developed classic positive and negative symptoms of schizophrenia. His antipsychotic drug-induced parkinsonism was greater on the left side, suggesting increased left striatal dopaminergic transmission. The authors propose that even in adulthood, significant and selective disruption of fronto-temporal connectivity is sufficient to produce a phenocopy of schizophrenia.

journal_name

Schizophr Res

journal_title

Schizophrenia research

authors

Jaskiw GE,Kenny JF

doi

10.1016/s0920-9964(02)00152-4

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

205-12

issue

2-3

eissn

0920-9964

issn

1573-2509

pii

S0920996402001524

journal_volume

58

pub_type

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