Abstract:
:Patients with schizophrenia demonstrate a variety of attentional impairments which have proven difficult to relate to specific neural systems. Posner et al. (1988) reported an asymmetric slowing of right visual field orienting in schizophrenia similar to that observed in patients with parietal lesions. We examined the visual orienting performance of 19 patients and controls using two different versions of the Posner paradigm. In overall ANOVAs we found main effects of group, cue condition, and delay interval. However, we did not observe any main effect of visual field or interactions involving visual field. There was some evidence of an asymmetric cost of invalid cues similar to those reported by Posner et al. The bulk of data suggests bilateral attentional deficits.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Gold JM,Randolph C,Coppola R,Carpenter CJ,Goldberg TE,Weinberger DRdoi
10.1016/0920-9964(92)90013-usubject
Has Abstractpub_date
1992-09-01 00:00:00pages
203-9issue
3eissn
0920-9964issn
1573-2509pii
0920-9964(92)90013-Ujournal_volume
7pub_type
杂志文章abstract::The rubber-hand illusion (RHI), an illusion in which tactile sensations are referred to a synthetic alien limb, is enhanced in schizophrenia patients. Somatosensory evoked responses of the illusion were compared between schizophrenia patients and normal control subjects. Schizophrenia patients had significant alterati...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(03)00057-4
更新日期:2003-11-15 00:00:00
abstract::Recent trials support the hypothesis of the role of inflammation in the pathogenesis of schizophrenia. The overall therapeutic benefit of anti-inflammatory medication, in particular cyclo-oxygenase-2 (COX-2) inhibitors in schizophrenia, is still controversial. There are suggestions that therapy with COX-2 inhibitors m...
journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2010.04.015
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Executive Functioning (EF) is an important factor for community functioning for people with severe mental illness. Cognitive remediation programs often improve EF, but do so by using multiple therapeutic techniques. Little is known regarding how individual treatment elements promote cognitive improvement. Os...
journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2017.08.052
更新日期:2019-01-01 00:00:00
abstract::Astrocytic markers glial fibrillary acidic protein (GFAP) and connexin 43 (CX43) are known to have altered expression in brains of subjects with psychiatric disorders including autism and major depression. The current study investigated whether GFAP and CX43 expressions are affected by several commonly used psychotrop...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.05.016
更新日期:2008-09-01 00:00:00
abstract::Comorbid substance abuse disorders have emerged as one of the greatest obstacles to the effective treatment of persons with schizophrenia. Estimates of the prevalence of such comorbidity vary, but as many as half of persons with schizophrenia may suffer from a comorbid drug or alcohol disorder. Younger age, male gende...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/s0920-9964(98)00161-3
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND:Evidence indicating that symptoms of non-clinical psychosis (NCP) occur in 6-8% of the general population suggests that psychosis may occur across a continuum. Although a number of studies have examined environmental contributors, to date there have been few investigations of biological/genetic factors in th...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2012.06.018
更新日期:2012-09-01 00:00:00
abstract::Early intervention strategies in psychosis would significantly benefit from the identification of reliable prognostic biomarkers. Pattern classification methods have shown the feasibility of an early diagnosis of psychosis onset both in clinical and familial high-risk populations. Here we were interested in replicatin...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.08.061
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Individuals at ultra-high risk (UHR) for psychosis have significant cognitive deficits that can impede functional recovery. Applying cognitive remediation (CR) before the onset of frank psychosis may improve the cognitive and functional prognosis of UHR individuals, however, little is known about the feasibi...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2020.08.016
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:The main goal of the present study was to analyze levels of cytokines of the interleukin family (IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8 and IL-10), interferon-gamma (IFN-γ), monocyte chemoattractant protein-1 (MCP1), tumor necrosis factor-alpha (TNF-α), and vascular endothelial and endothelial growth factors (V...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.08.027
更新日期:2015-12-01 00:00:00
abstract::Recent molecular genetic studies have demonstrated X-chromosome abnormalities in the transmission of psychosis, a finding that may contribute to understanding sex differences in the disorder. Using our family high risk paradigm, we tested the hypothesis that there are sex-specific patterns of transmission of psychosis...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2011.01.019
更新日期:2011-05-01 00:00:00
abstract::First episode psychosis (FEP) has been associated with structural brain changes, largely identified by volumetric analyses. Advances in neuroimaging processing have made it possible to measure geometric properties that may identify subtle structural changes not appreciated by a measure of volume alone. In this study w...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.07.030
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Stress has been associated with the onset of schizophrenia and exacerbation of psychotic symptoms. Patients with schizotypal personality disorder (SPD), the prototypic schizophrenia spectrum disorder, do not develop the frank psychosis of schizophrenia and appear clinically to be less reactive to stress than...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.schres.2003.10.008
更新日期:2004-09-01 00:00:00
abstract::Little is known about the impact of family history of psychosis on youth from community samples. To fill this gap, we compared youth with a first-degree relative with psychosis spectrum symptoms (i.e. family history of psychosis spectrum symptoms, FHPS) to youth without FHPS in a cross-sectional analysis of the Philad...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.12.021
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Second-generation antipsychotics (SGAs) increase the risk of type 2 diabetes. The mechanism is thought to center on drug-induced weight gain, which starts the dysmetabolic cascade of insulin resistance, increased insulin production and pancreatic beta-cell failure. An independent effect of SGAs on insulin se...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2012.11.016
更新日期:2013-02-01 00:00:00
abstract::Patients with schizophrenia often exhibit structural brain abnormalities, as well as neurological soft signs (NSS), consistent with its conceptualization as a neurodevelopmental disorder. NSS are mild, presumably nonlocalizing, neurological impairments that are inferred from performance deficits in domains such as sen...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.06.018
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Many patients with schizophrenia suffer from metabolic symptoms and weight gain in which predispose them to obesity, diabetes, and cardiovascular problems. This trial examines the efficacy and safety of zonisamide on weight and body mass index in patients with schizophrenia being administered with atypical a...
journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2013.03.021
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Neuropsychological impairment is common in schizophrenia and psychotic bipolar disorder. It has been hypothesized that the pathways leading to impairment differ between disorders. Cognitive impairment in schizophrenia is believed to result largely from atypical neurodevelopment, whereas bipolar disorder is i...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.10.009
更新日期:2019-04-01 00:00:00
abstract::Previous diffusion tensor imaging (DTI) studies have shown structural abnormalities of the cingulum bundle (CB) in patients with schizophrenia. However, regional specificity and functional relevance of the pregenual and dorsal CB subdivisions has not been fully studied. In the current study, 31 patients with schizophr...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.05.012
更新日期:2009-10-01 00:00:00
abstract::Left or mixed-handedness, footedness, and eye dominance are thought to indicate abnormalities in lateralization related to schizophrenia. Increased left or mixed-dominance in schizophrenia suggests possible hemispheric abnormalities associated with the disorder. A related body of research suggests that some indication...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2004.04.003
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Patients with schizophrenia and comorbid drug use disorders (DUD) have a severe course of illness. Despite strong evidence that drug use can exacerbate psychotic symptoms, we have limited knowledge of how specific drugs may increase risk of schizophrenia readmission in this group. This study aimed to assess ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.09.026
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVES:Vesicular glutamate transporters (VGLUT1-3) package glutamate into vesicles in the presynaptic terminal and regulate the release of glutamate. In mesencephalic dopamine neuron culture, the majority of isolated dopamine neurons express VGLUT2, but not VGLUT1 or 3, have been demonstrated. As related to the dys...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.05.015
更新日期:2010-08-01 00:00:00
abstract::Minor physical anomalies (MPAs) are more prevalent amongst individuals with psychosis, supporting a neurodevelopmental model for psychotic disorders. The aim of this study was to investigate the possibility that neurodevelopmental adversity contributes to the excess of psychosis found in some ethnic groups in the UK. ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2006.08.019
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To examine the effect of diagnosis, mood state, and anxiety on subjective wellbeing in patients with affective and non-affective psychotic disorders treated with quetiapine IR. METHODS:2175 patients with schizophrenia-spectrum (SZ, n=1681), schizoaffective (SA, n=249), and bipolar disorder (BPD, n=245) were ...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章
doi:10.1016/j.schres.2009.03.004
更新日期:2009-05-01 00:00:00
abstract::Diffusion Tensor Imaging (DTI) investigations in schizophrenia have provided evidence of impairment in white matter as indicated by reduced fractional anisotropy (FA). However, the neuropathological implications of these findings remain unclear. In the current study, we conducted a voxelwise analysis of the constituen...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.12.489
更新日期:2008-04-01 00:00:00
abstract::Schizophrenia (SZ) is a mental illness characterized by psychosis, negative symptoms, and cognitive deficits. The anterior cingulate cortex (ACC), a structurally and functionally diverse region, is one of several brain regions that is abnormal in SZ. The present study compared synaptic organization and mitochondrial n...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.07.016
更新日期:2015-10-01 00:00:00
abstract::Disrupted-in-Schizophrenia 1 (DISC1), a strong candidate gene for schizophrenia and other mental disorders, regulates neurodevelopmental processes including neurogenesis, neuronal migration, neurite outgrowth and spine development. Glycogen synthase kinase-3 (GSK3) directly interacts with DISC1 and also plays a role i...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2011.03.032
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVES:Recent reports of antibodies to heat shock proteins 60kDa (HSP60) and HSP70 suggested that antibodies to the heat shock protein that plays a protective role against environmental stresses in a cell might be related to the pathogenesis of schizophrenia, although the antibody to HSP90 had not yet been identifi...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(00)00091-8
更新日期:2001-10-01 00:00:00
abstract::Autoimmunity, gastrointestinal (GI) disorders and schizophrenia have been associated with one another for a long time. This paper reviews these connections and provides a context by which multiple risk factors for schizophrenia may be related. Epidemiological studies strongly link schizophrenia with autoimmune disorde...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2014.06.027
更新日期:2016-09-01 00:00:00
abstract::There is considerable inconsistency in findings regarding the relationship between specific cognitive deficits and social impairment in patients with schizophrenia. This inconsistency may relate to variability across studies in how social functioning is measured and preliminary evidence suggests that different indices...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2005.09.007
更新日期:2006-01-31 00:00:00
abstract:OBJECTIVE:Studies in first episode psychosis samples about status of cardiovascular risk factors have shown discordant results. We aimed to determine the 10-year risk of developing coronary heart disease in a sample of first episode psychosis patients referred to an early intervention clinic and compared the same with ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.12.008
更新日期:2011-04-01 00:00:00