当前位置： SCI文献检索 > SCHIZOPHRENIA RESEARCH期刊下所有文献 > BDNF Val66Met and spontaneous dyskinesias in non-clinical psychosis.

BDNF Val66Met and spontaneous dyskinesias in non-clinical psychosis.

Abstract：

BACKGROUND:Evidence indicating that symptoms of non-clinical psychosis (NCP) occur in 6-8% of the general population suggests that psychosis may occur across a continuum. Although a number of studies have examined environmental contributors, to date there have been few investigations of biological/genetic factors in this integral population. A recent study observed spontaneous dyskinetic movements (reflecting an innervated striatal system) in individuals reporting NCP. The present investigation is designed to replicate this finding and determine if brain-derived neurotrophic factor (BDNF) (implicated in striatal dopamine function) is associated with dyskinesias. METHOD:A total of 68 young-adult participants reporting High and Low-NCP were assessed for dyskinetic movements using a sensitive instrumental measure of force variability. Saliva from the participants was genotyped for val66met (rs6265), a common functional polymorphism of the BDNF gene (the Met allele is associated with lower activity-dependent release of BDNF). RESULTS:Participants in the High-NCP group showed significantly elevated levels of force variability. Met allele carriers exhibited significantly higher levels of force variability when compared with the Val homozygotes. Logistic regression indicated that the odds of membership in the High-NCP group were significantly higher given the presence of dyskinesias (OR=2.32; CI: 1.25-4.28). CONCLUSION:Findings of elevated force variability suggest that individuals with NCP exhibit subtle signs of striatal vulnerability, reflected more dramatically as jerking and hyperkinetic movements in patients with formal psychosis. The results are consistent with a larger literature implicating BDNF as a critical factor underlying abnormal movements, and suggest that specific candidate genes underlie putative markers across a psychosis continuum.

journal_name

Schizophr Res

journal_title

Schizophrenia research

authors

Mittal VA,Smolen A,Dean DJ,Pelletier AL,Lunsford-Avery J,Smith A

doi

10.1016/j.schres.2012.06.018

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

65-70

issue

1-3

eissn

0920-9964

issn

1573-2509

pii

S0920-9964(12)00335-0

journal_volume

140

pub_type

杂志文章

相关文献

SCHIZOPHRENIA RESEARCH文献大全
  • Predictors of antipsychotic medication adherence in patients recovering from a first psychotic episode.

    abstract：BACKGROUND:Many patients recovering from a first psychotic episode will discontinue medication against medical advice, even before a 1-year treatment course is completed. Factors associated with treatment adherence in patients with chronic schizophrenia include beliefs about severity of illness and need for treatment, ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2005.10.016

    authors： Perkins DO,Johnson JL,Hamer RM,Zipursky RB,Keefe RS,Centorrhino F,Green AI,Glick IB,Kahn RS,Sharma T,Tohen M,McEvoy JP,Weiden PJ,Lieberman JA,HGDH Research Group.

    更新日期：2006-03-01 00:00:00

  • No association of complexin1 and complexin2 genes with schizophrenia in a Japanese population.

    abstract：:Several investigations suggest that complexin may be a schizophrenia-susceptibility factor. We conducted a genetic association analysis between complexin genes (CPLX1 and CPLX2) and schizophrenia in Japanese patients (377 cases and 341 controls). Ten and eleven haplotype-tagging (ht)SNPs in CPLX1 and CPLX2, respective...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2005.12.842

    authors： Kishi T,Ikeda M,Suzuki T,Kitajima T,Yamanouchi Y,Kinoshita Y,Ozaki N,Iwata N

    更新日期：2006-02-28 00:00:00

  • The relationship between symptomatic remission and neuropsychological improvement in schizophrenia patients switched to treatment with ziprasidone.

    abstract：BACKGROUND:A definition of clinical remission in schizophrenia has recently been proposed. However, it is also known that neuropsychological (NP) impairments may be better predictors of functional outcomes than clinical symptoms. Understanding the relationship between clinical remission and cognitive improvement may be...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2006.12.032

    authors： Buckley PF,Harvey PD,Bowie CR,Loebel A

    更新日期：2007-08-01 00:00:00

  • Longitudinal study of symptoms and cognitive function in chronic schizophrenia.

    abstract：:There is conflicting evidence of a relationship between changes in symptoms and cognitive functioning in schizophrenia. This study investigated longitudinal changes in psychopathology and cognitive functioning in chronic schizophrenia utilising three different dimensional models of symptomatology. Sixty-two patients d...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/s0920-9964(01)00393-0

    authors： Hughes C,Kumari V,Soni W,Das M,Binneman B,Drozd S,O'Neil S,Mathew V,Sharma T

    更新日期：2003-02-01 00:00:00

  • Psychometric properties of the recovery measurement in homeless people with severe mental illness.

    abstract：OBJECTIVE:The Recovery Assessment Scale (RAS) is one of the most widely used measurements of recovery in mental health research. To date, no data have been available concerning the psychometric characteristics of the RAS in homeless people with severe mental illness. The aim of this study was to provide new data regard...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2015.10.007

    authors： Girard V,Tinland A,Mohamed EH,French Housing First Study Group.,Boyer L,Auquier P

    更新日期：2015-12-01 00:00:00

  • Exposure to conflict and disaster: A national survey on the prevalence of psychotic experiences in Sri Lanka.

    abstract：:Recent research conducted in high-income countries suggests psychotic experiences are common in the general population, but evidence from low- and middle-income countries (LMIC) remains limited. Sri Lanka is a LMIC affected by three decades of civil conflict and, in 2004, a devastating tsunami. This study aimed to inv...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2016.01.026

    authors： Keraite A,Sumathipala A,Siriwardhana C,Morgan C,Reininghaus U

    更新日期：2016-03-01 00:00:00

  • Delay discounting and affective priming in individuals with negative schizotypy.

    abstract：:Previous studies have demonstrated that patients with schizophrenia and individuals with schizotypy experience decreased anticipatory pleasure. However, it is unclear whether this decrease is contributed by altered reward processing at the proximal or distal future. In order to investigate the preference for receiving...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2018.12.040

    authors： Cai XL,Weigl M,Liu BH,Cheung EFC,Ding JH,Chan RCK

    更新日期：2019-08-01 00:00:00

  • Abnormal involuntary movements are linked to psychosis-risk in children and adolescents: Results of a population-based study.

    abstract：BACKGROUND:Altered motor behavior has consistently been reported in medication-naive adult patients with schizophrenia and first episode psychosis and adults at clinical high risk for psychosis (CHR). This study is the first to evaluate the prevalence of abnormal involuntary movements in a community sample of children ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2016.04.032

    authors： Kindler J,Schultze-Lutter F,Michel C,Martz-Irngartinger A,Linder C,Schmidt SJ,Stegmayer K,Schimmelmann BG,Walther S

    更新日期：2016-07-01 00:00:00

  • The Premorbid Adjustment Scale as a measure of developmental compromise in patients with schizophrenia and their healthy siblings.

    abstract：:Schizophrenia is associated with subtle developmental compromise, but the degree to which this is also associated with heritability and genetic risk is uncertain. The goal of the current study was to investigate the childhood, adolescent, and early adulthood social and academic function of patients with schizophrenia,...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2009.04.007

    authors： Shapiro DI,Marenco S,Spoor EH,Egan MF,Weinberger DR,Gold JM

    更新日期：2009-07-01 00:00:00

  • Dissociable contributions of MRI volume reductions of superior temporal and fusiform gyri to symptoms and neuropsychology in schizophrenia.

    abstract：:We sought to identify the functional correlates of reduced magnetic resonance imaging (MRI) volumes of the superior temporal gyrus (STG) and the fusiform gyrus (FG) in patients with chronic schizophrenia. MRI volumes, positive/negative symptoms, and neuropsychological tests of facial memory and executive functioning w...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2006.11.025

    authors： Nestor PG,Onitsuka T,Gurrera RJ,Niznikiewicz M,Frumin M,Shenton ME,McCarley RW

    更新日期：2007-03-01 00:00:00

  • On the boundaries of blunt affect/alogia across severe mental illness: implications for Research Domain Criteria.

    abstract：:There is growing awareness that reduced expressive behaviors (e.g., blunt affect, alogia, psychomotor retardation) are characteristic of a range of psychiatric conditions, including mood and schizophrenia-spectrum disorders. From a Research Domain Criteria (RDoC) perspective, it would be critical to determine whether ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2012.07.001

    authors： Cohen AS,Najolia GM,Kim Y,Dinzeo TJ

    更新日期：2012-09-01 00:00:00

  • The neurocognitive underpinnings of diminished expressivity in schizotypy: what the voice reveals.

    abstract：:Diminished expressivity is a characteristic feature of schizophrenia-spectrum pathology. However, attempts to elucidate the neurobiological underpinnings of diminished expressivity have yielded limited information. The present study posited that diminished expressivity was associated with a right, but not left-hemisph...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2009.01.010

    authors： Cohen AS,Iglesias B,Minor KS

    更新日期：2009-04-01 00:00:00

  • Body weight and self-esteem in patients with schizophrenia evaluated with B-WISE.

    abstract：BACKGROUND:Metabolic abnormalities and weight gain are an important problem in patients with schizophrenia. An instrument to evaluate body image and self-esteem related to weight has recently been developed (B-WISE). The first objective was to evaluate whether the findings of the original validation study could be conf...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2006.07.025

    authors： De Hert M,Peuskens B,van Winkel R,Kalnicka D,Hanssens L,Van Eyck D,Wyckaert S,Peuskens J

    更新日期：2006-12-01 00:00:00

  • Hippocampal and orbital inferior frontal gray matter volume abnormalities and cognitive deficit in treatment-naive, first-episode patients with schizophrenia.

    abstract：BACKGROUND:Cognitive impairment is a core feature of schizophrenia. Some evidence suggests an association between cognition deficits and gray matter reductions. In this study, we investigated the relationship between cognitive performance and gray matter volumes in patients with treatment-naïve, first-episode schizophr...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2013.12.015

    authors： Guo X,Li J,Wang J,Fan X,Hu M,Shen Y,Chen H,Zhao J

    更新日期：2014-02-01 00:00:00

  • Wisconsin Card Sorting Test performance in schizophrenia: the role of working memory.

    abstract：:Schizophrenia typically results in reduced performance on the Wisconsin Card Sorting Test (WCST). In the current study, we used a variety of approaches to examine the role of working memory (WM) in this deficit. One approach was to examine patterns of perseverative and non-perseverative errors. A second approach invol...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/s0920-9964(02)00353-5

    authors： Hartman M,Steketee MC,Silva S,Lanning K,Andersson C

    更新日期：2003-10-01 00:00:00

  • Self-esteem moderates affective and psychotic responses to social stress in psychosis: A virtual reality study.

    abstract：BACKGROUND:Higher liability to psychosis is associated with low self-esteem and increased sensitivity to social stress. Recently, we reported a positive relation between liability to psychosis and affective and psychotic responses to social stress. This study investigated how self-esteem moderates paranoia, peak subjec...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2018.06.042

    authors： Jongeneel A,Pot-Kolder R,Counotte J,van der Gaag M,Veling W

    更新日期：2018-12-01 00:00:00

  • Cortical thinning and caudate abnormalities in first episode psychosis and their association with clinical outcome.

    abstract：:First episode psychosis (FEP) has been associated with structural brain changes, largely identified by volumetric analyses. Advances in neuroimaging processing have made it possible to measure geometric properties that may identify subtle structural changes not appreciated by a measure of volume alone. In this study w...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2014.07.030

    authors： Scanlon C,Anderson-Schmidt H,Kilmartin L,McInerney S,Kenney J,McFarland J,Waldron M,Ambati S,Fullard A,Logan S,Hallahan B,Barker GJ,Elliott MA,McCarthy P,Cannon DM,McDonald C

    更新日期：2014-10-01 00:00:00

  • Twin study of illness history variables in psychosis.

    abstract：BACKGROUND:Genetic factors are important in the aetiology of psychotic disorders, but it is unclear how far they influence aspects of illness history within psychoses. AIMS:To investigate the extent, and type of familial aggregation for a range of illness history variables in psychosis. METHODS:Two-hundred-and-twenty...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2009.09.002

    authors： Allan CL,Cardno AG,Rijsdijk FV,Kalidindi S,Farmer A,Murray RM,McGuffin P

    更新日期：2009-12-01 00:00:00

  • High-dose galantamine augmentation inferior to placebo on attention, inhibitory control and working memory performance in nonsmokers with schizophrenia.

    abstract：:Dysfunction in the neuronal nicotinic acetylcholine receptor (nAChR) system has been implicated in the pathophysiology of schizophrenia, and it has been postulated that treatments that increase nAChR activity may improve symptoms of the disorder. We investigated the effects of the acetylcholinesterase inhibitor and al...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.schres.2007.12.491

    authors： Dyer MA,Freudenreich O,Culhane MA,Pachas GN,Deckersbach T,Murphy E,Goff DC,Evins AE

    更新日期：2008-07-01 00:00:00

  • Why you can't be in sync with schizophrenia patients.

    abstract：:Most individuals with schizophrenia will be confronted with some form of stigma. In recent years, clinicians and family members have increasingly contested the term "schizophrenia". Many of them discuss changing this name, as a means to fight stigma. Up until now, surprisingly, most research has been conducted using s...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2019.11.054

    authors： Rainteau N,Salesse RN,Macgregor A,Macioce V,Raffard S,Capdevielle D

    更新日期：2020-02-01 00:00:00

  • Paternal and maternal ages have contrasting associations with self-reported schizophrenia liability.

    abstract：BACKGROUND:Older paternal age predicts schizophrenia diagnosis in offspring. If this relationship reflects a pathogenic process, paternal age should predict the expression of subclinical schizophrenia liability (schizotypy). We hypothesized that paternal and maternal ages predict positive, negative, and disorganized fe...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2015.09.018

    authors： Grattan RE,Morton SE,Warhurst ES,Parker TR,Nicolson MP,Maha JLK,Linscott RJ

    更新日期：2015-12-01 00:00:00

  • Behavioral sequelae of astrocyte dysfunction: focus on animal models of schizophrenia.

    abstract：:Astrocytes regulate multiple processes in the brain ranging from trophic support of developing neurons to modulation of synaptic neurotransmission and neuroinflammation in adulthood. It is, therefore, understandable that pathogenesis and pathophysiology of major psychiatric disorders involve astrocyte dysfunctions. Un...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,评审

    doi：10.1016/j.schres.2014.10.044

    authors： Xia M,Abazyan S,Jouroukhin Y,Pletnikov M

    更新日期：2016-09-01 00:00:00

  • Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder.

    abstract：:Prior studies of mRNA expression, protein expression, and pathway metabolite levels have implicated dysregulation of the kynurenine pathway in the etiology of schizophrenia and bipolar disorder. Here we investigate whether genes involved in kynurenine pathway regulation might interact with genes that respond to kynure...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2009.05.014

    authors： Miller CL,Murakami P,Ruczinski I,Ross RG,Sinkus M,Sullivan B,Leonard S

    更新日期：2009-09-01 00:00:00

  • The Italian version of the 92-item Prodromal Questionnaire: Concurrent validity with the SIPS and factor analysis in a sample of 258 outpatients aged 11-36years.

    abstract：BACKGROUND:Current early screeners for psychosis-risk states have still to prove ability in identifying at-risk individuals. Among screeners, the 92-item Prodromal Questionnaire (PQ-92) is often used. We aimed to assess the validity of its Italian translation in a large Italian adolescent and young adult help-seeking s...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2017.02.008

    authors： Kotzalidis GD,Solfanelli A,Piacentino D,Savoja V,Fiori Nastro P,Curto M,Lindau JF,Masillo A,Brandizzi M,Fagioli F,Raballo A,Gebhardt E,Preti A,D'Alema M,Fucci MR,Miletto R,Andropoli D,Leccisi D,Girardi P,Loewy RL,

    更新日期：2017-11-01 00:00:00

  • An examination of components of recovery after five years of treatment in an early intervention program for psychosis.

    abstract：:Recovery from psychotic disorders includes both symptomatic and functional components. Progress in understanding recovery requires careful replication and extension of findings using comparable measures. In the current paper, we present a study of five year recovery rates in an early intervention program in London, Ca...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2017.08.054

    authors： Norman RMG,MacDougall A,Manchanda R,Harricharan R

    更新日期：2018-05-01 00:00:00

  • Increasing mortality in schizophrenia: are women at particular risk? A follow-up of 1111 patients admitted during 1980-2006 in Northern Norway.

    abstract：:A study of mortality for all patients with schizophrenia admitted to the University Hospital of North Norway during 1980-2006 was performed, with a special focus on gender differences and changes in mortality during a period of transition from hospital-based to community-based care. A total of 1111 patients with schiz...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2011.07.021

    authors： Høye A,Jacobsen BK,Hansen V

    更新日期：2011-11-01 00:00:00

  • Novel rare variants in F-box protein 45 (FBXO45) in schizophrenia.

    abstract：:The ubiquitin ligase F-box protein 45 (FBXO45) is critical for synaptogenesis, neuronal migration, and synaptic transmission. FBXO45 is included in the 3q29 microdeletion region that confers a significant risk for schizophrenia, as shown by rare structural variant studies. Thus, FBXO45 is considered a prominent candid...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2014.04.032

    authors： Wang C,Koide T,Kimura H,Kunimoto S,Yoshimi A,Nakamura Y,Kushima I,Banno M,Kawano N,Takasaki Y,Xing J,Noda Y,Mouri A,Aleksic B,Ikeda M,Okada T,Iidaka T,Inada T,Iwata N,Ozaki N

    更新日期：2014-08-01 00:00:00

  • Increased phospholipase A2 activity in schizophrenia with absent response to niacin.

    abstract：:An absent response to the niacin skin test has been reported to occur in about 80% of schizophrenic patients, as compared to 20% of healthy individuals. Niacin provokes redness in skin caused by a capillary vasodilatation mediated by prostaglandins. The metabolism of prostaglandins is regulated by the enzyme phospholi...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/s0920-9964(02)00281-5

    authors： Tavares H,Yacubian J,Talib LL,Barbosa NR,Gattaz WF

    更新日期：2003-05-01 00:00:00

  • The relative prevalence of schizophrenia among cannabis and cocaine users attending addiction services.

    abstract：BACKGROUND:Cannabis and cocaine are the most common illicit drugs for which people are treated in addiction services in Latin America. Much research has suggested that the use of cannabis increases the risk of schizophrenia; there is less evidence concerning cocaine. The aim of the present study was to establish the re...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2017.04.010

    authors： Libuy N,de Angel V,Ibáñez C,Murray RM,Mundt AP

    更新日期：2018-04-01 00:00:00

  • On the use of the Positive and Negative Syndrome Scale in randomized clinical trials.

    abstract：:In the last 25 years, the Positive and Negative Syndrome Scale (PANSS) has been largely used to assess schizophrenia symptom intensity, but little information is available on how this scale was generally applied when evaluating the efficacy of schizophrenia therapies in randomized clinical trials. In the attempt to ad...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,评审

    doi：10.1016/j.schres.2015.04.006

    authors： Nicotra E,Casu G,Piras S,Marchese G

    更新日期：2015-07-01 00:00:00