Exposure to conflict and disaster: A national survey on the prevalence of psychotic experiences in Sri Lanka.

Abstract:

:Recent research conducted in high-income countries suggests psychotic experiences are common in the general population, but evidence from low- and middle-income countries (LMIC) remains limited. Sri Lanka is a LMIC affected by three decades of civil conflict and, in 2004, a devastating tsunami. This study aimed to investigate the prevalence of psychotic experiences in a general population sample in Sri Lanka and associations with conflict- and tsunami-related trauma. This is a first National Mental Health Survey conducted in Sri Lanka. A cross-sectional, multi-stage, cluster sampling design was used to estimate the prevalence of psychotic symptoms. Data on socio-demographic characteristics, conflict- and tsunami-related trauma, and psychotic experiences were collected using culturally validated measures in a sample of 5927 participants. The weighted prevalence of psychotic symptoms was 9.7%. Exposure to one or more conflict-related events (adj. OR 1.79, 95% CI 1.40-2.31, p<0.001) and loss or injury of a family member or friend through conflict (adj. OR, 1.83, 95% CI 1.42-2.37, p<0.001) were associated with increased odds of reporting psychotic experiences. Psychotic experiences were more common in individuals directly exposed to tsunami disaster (adj. OR, 1.68, 95% CI 1.04-2.73, P=0.035) and in those who had a family member who died or was injured as result of tsunami (adj. OR, 1.42, 95% CI 1.04-1.94, p=0.029). Our findings suggest that psychotic experiences are common in the Sri Lankan population. Exposure to traumatic events in armed conflicts and natural disasters may be important socio-environmental factors in the development of psychotic experiences.

journal_name

Schizophr Res

journal_title

Schizophrenia research

authors

Keraite A,Sumathipala A,Siriwardhana C,Morgan C,Reininghaus U

doi

10.1016/j.schres.2016.01.026

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

79-85

issue

1-3

eissn

0920-9964

issn

1573-2509

pii

S0920-9964(16)30032-9

journal_volume

171

pub_type

杂志文章
  • A randomized controlled trial of cognitive-behavior therapy for persistent symptoms in schizophrenia: a five-year follow-up.

    abstract::Meta-analyses of randomized controlled trials support the efficacy of cognitive behavioral therapy (CBT) in the treatment of symptoms of schizophrenia refractory to antipsychotic medication. This article addresses the issue of medium term durability. A five-year follow-up was undertaken of a sample of 90 subjects who ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.schres.2007.09.026

    authors: Turkington D,Sensky T,Scott J,Barnes TR,Nur U,Siddle R,Hammond K,Samarasekara N,Kingdon D

    更新日期:2008-01-01 00:00:00

  • Somatosensory evoked potentials during a rubber-hand illusion in schizophrenia.

    abstract::The rubber-hand illusion (RHI), an illusion in which tactile sensations are referred to a synthetic alien limb, is enhanced in schizophrenia patients. Somatosensory evoked responses of the illusion were compared between schizophrenia patients and normal control subjects. Schizophrenia patients had significant alterati...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/s0920-9964(03)00057-4

    authors: Peled A,Pressman A,Geva AB,Modai I

    更新日期:2003-11-15 00:00:00

  • Relationships between smartphone social behavior and relapse in schizophrenia: A preliminary report.

    abstract::Social dysfunction is a hallmark of schizophrenia. Social isolation may increase individuals' risk for psychotic symptom exacerbation and relapse. Monitoring and timely detection of shifts in social functioning are hampered by the limitations of traditional clinic-based assessment strategies. Ubiquitous mobile technol...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.schres.2019.03.014

    authors: Buck B,Scherer E,Brian R,Wang R,Wang W,Campbell A,Choudhury T,Hauser M,Kane JM,Ben-Zeev D

    更新日期:2019-06-01 00:00:00

  • The status of spectral EEG abnormality as a diagnostic test for schizophrenia.

    abstract:OBJECTIVE:A literature review was conducted to ascertain whether or not EEG spectral abnormalities are consistent enough to warrant additional effort towards developing them into a clinical diagnostic test for schizophrenia. METHODS:Fifty three papers met criteria for inclusion into the review and 15 were included in ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.schres.2007.11.020

    authors: Boutros NN,Arfken C,Galderisi S,Warrick J,Pratt G,Iacono W

    更新日期:2008-02-01 00:00:00

  • Health-related quality of life in acute schizophrenia patients treated with RBP-7000 once monthly risperidone: An 8-week, randomized, double-blind, placebo-controlled, multicenter phase 3 study.

    abstract:BACKGROUND:There is increased interest in the impact of new long-acting treatments on health-related quality of life (HRQoL) in patients with schizophrenia. The aim of this study was to evaluate the impact of treatment with subcutaneous injections of RBP-7000, a new sustained-release formulation of risperidone, compare...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.schres.2016.03.020

    authors: Isitt JJ,Nadipelli VR,Kouassi A,Fava M,Heidbreder C

    更新日期:2016-07-01 00:00:00

  • Revisiting the International Physical Activity Questionnaire (IPAQ): Assessing physical activity among individuals with schizophrenia.

    abstract:BACKGROUND:Individuals with schizophrenia tend to have low levels of physical activity (PA) which contributes to high rates of physical comorbidities. Valid and reliable methods of assessing PA are essential for advancing health research. Ten years after initial validation of the Short-Form International Physical Activ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2016.09.010

    authors: Duncan MJ,Arbour-Nicitopoulos K,Subramanieapillai M,Remington G,Faulkner G

    更新日期:2017-01-01 00:00:00

  • Maternal infection leads to abnormal gene regulation and brain atrophy in mouse offspring: implications for genesis of neurodevelopmental disorders.

    abstract::Prenatal viral infection has been associated with development of schizophrenia and autism. Our laboratory has previously shown that viral infection causes deleterious effects on brain structure and function in mouse offspring following late first trimester (E9) administration of influenza virus. We hypothesized that l...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2007.11.018

    authors: Fatemi SH,Reutiman TJ,Folsom TD,Huang H,Oishi K,Mori S,Smee DF,Pearce DA,Winter C,Sohr R,Juckel G

    更新日期:2008-02-01 00:00:00

  • Neuroimaging predictors of functional outcomes in schizophrenia at baseline and 6-month follow-up.

    abstract:PURPOSE:Studies show that deficit syndrome schizophrenia patients, characterized by primary negative symptoms and poor functional outcome, have impairment in specific neural circuits. We assessed whether these same neural circuits are directly linked to functional outcomes across schizophrenia patients. METHODS:T1- an...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2015.10.023

    authors: Behdinan T,Foussias G,Wheeler AL,Stefanik L,Felsky D,Remington G,Rajji TK,Mallar Chakravarty M,Voineskos AN

    更新日期:2015-12-01 00:00:00

  • Inhibitory processing in visuospatial attention in healthy adults and schizophrenic patients.

    abstract::This study assessed visuospatial attention in healthy adults and medicated schizophrenic patients. Participants performed a visual orientation task in which a peripheral cue was followed. at different intervals, by a target presented either at valid or invalid locations. When the long stimulus onset asynchrony (SOA) w...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/s0920-9964(99)00044-4

    authors: Fuentes LJ,Boucart M,Alvarez R,Vivas AB,Zimmerman MA

    更新日期:1999-11-09 00:00:00

  • Brain volumes as predictor of outcome in recent-onset schizophrenia: a multi-center MRI study.

    abstract::Gray matter brain volume decreases have been found in patients with schizophrenia as compared to healthy control subjects measured by using Magnetic Resonance Imaging (MRI). An association has been suggested between decreased gray matter volume and poor outcome in chronically ill patients with schizophrenia. The prese...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,多中心研究

    doi:10.1016/s0920-9964(03)00018-5

    authors: van Haren NE,Cahn W,Hulshoff Pol HE,Schnack HG,Caspers E,Lemstra A,Sitskoorn MM,Wiersma D,van den Bosch RJ,Dingemans PM,Schene AH,Kahn RS

    更新日期:2003-11-01 00:00:00

  • A pilot study of functional Cognitive Behavioral Therapy (fCBT) for schizophrenia.

    abstract:BACKGROUND:The feasibility and preliminary efficacy of a novel cognitive behavioral treatment for decreasing psychotic symptoms and improving social functioning was evaluated in a pilot study. This represents the first treatment outcome study of CBT for psychosis with a manualized, active comparison condition. METHODS...

    journal_title:Schizophrenia research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.schres.2004.05.002

    authors: Cather C,Penn D,Otto MW,Yovel I,Mueser KT,Goff DC

    更新日期:2005-05-01 00:00:00

  • Quantitative assessment of the frequency of normal associations in the utterances of schizophrenia patients and healthy controls.

    abstract:BACKGROUND:The intrusion of associations into the utterances of schizophrenic individuals typically disrupts the coherence of the patient's utterances. Recent theoretical formulations of these phenomena have emphasized the hyperactivity) of associational networks in such language disturbance (e.g., Maher, B.A. 2003 Sch...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2005.05.017

    authors: Maher BA,Manschreck TC,Linnet J,Candela S

    更新日期:2005-10-15 00:00:00

  • Spatial localization of retinal anomalies in regular cannabis users: The relevance of the multifocal electroretinogram.

    abstract::Widely used in industrialized countries, cannabis is a neuromodulator substance. The cannabinoid system is present at critical stages of retinal processing. We have recently shown a delay in bipolar and ganglion cell responses in regular cannabis users, as observed using flash (fERG) and pattern (PERG) electroretinogr...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2019.01.013

    authors: Schwitzer T,Henrion ML,Sarre D,Albuisson E,Angioi-Duprez K,Giersch A,Lalanne L,Schwan R,Laprevote V

    更新日期:2020-05-01 00:00:00

  • Cortical thinning and caudate abnormalities in first episode psychosis and their association with clinical outcome.

    abstract::First episode psychosis (FEP) has been associated with structural brain changes, largely identified by volumetric analyses. Advances in neuroimaging processing have made it possible to measure geometric properties that may identify subtle structural changes not appreciated by a measure of volume alone. In this study w...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2014.07.030

    authors: Scanlon C,Anderson-Schmidt H,Kilmartin L,McInerney S,Kenney J,McFarland J,Waldron M,Ambati S,Fullard A,Logan S,Hallahan B,Barker GJ,Elliott MA,McCarthy P,Cannon DM,McDonald C

    更新日期:2014-10-01 00:00:00

  • Grey matter networks in people at increased familial risk for schizophrenia.

    abstract::Grey matter brain networks are disrupted in schizophrenia, but it is still unclear at which point during the development of the illness these disruptions arise and whether these can be associated with behavioural predictors of schizophrenia. We investigated if single-subject grey matter networks were disrupted in a sa...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2015.08.025

    authors: Tijms BM,Sprooten E,Job D,Johnstone EC,Owens DG,Willshaw D,Seriès P,Lawrie SM

    更新日期:2015-10-01 00:00:00

  • Schizophrenia patients with polydipsia and water intoxication are characterized by greater severity of psychotic illness and a more frequent history of alcohol abuse.

    abstract::Polydipsia and water intoxication (PWI) are relatively frequent among schizophrenic subjects, particularly in institutional settings and may lead to severe complications. However, little is known on their association with other characteristics of psychosis. Hence, we took advantage of a cohort of 114 subjects extensiv...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2009.12.036

    authors: Poirier S,Legris G,Tremblay P,Michea R,Viau-Guay L,Mérette C,Bouchard RH,Maziade M,Roy MA

    更新日期:2010-05-01 00:00:00

  • The language of schizophrenia: an analysis of micro and macrolinguistic abilities and their neuropsychological correlates.

    abstract::Language disturbance is one of the main diagnostic features in schizophrenia and abnormalities of brain language areas have been consistently found in schizophrenic patients. The main aim of this study was to describe the impairment of micro and macrolinguistic abilities in a group of twenty-nine schizophrenic patient...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2008.07.011

    authors: Marini A,Spoletini I,Rubino IA,Ciuffa M,Bria P,Martinotti G,Banfi G,Boccascino R,Strom P,Siracusano A,Caltagirone C,Spalletta G

    更新日期:2008-10-01 00:00:00

  • Insight in early psychosis: a 1-year follow-up.

    abstract::Insight was investigated in 180 individuals consecutively admitted to a comprehensive early psychosis treatment program. Insight was assessed on admission and after 3, 6 and 12 months. Insight improved significantly over 12 months, and was negatively correlated with both positive and negative symptoms, and positively ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/S0920-9964(03)00047-1

    authors: Mintz AR,Addington J,Addington D

    更新日期:2004-04-01 00:00:00

  • Longitudinal course of self-labeling, stigma stress and well-being among young people at risk of psychosis.

    abstract::Stigma may undermine the well-being of young people at risk of psychosis. We therefore measured self-labeling, stigma variables and well-being at baseline and again one year later among 77 at-risk participants. An increase in self-labeling during this period predicted heightened stigma stress after one year and a decr...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2014.07.016

    authors: Rüsch N,Müller M,Heekeren K,Theodoridou A,Metzler S,Dvorsky D,Corrigan PW,Walitza S,Rössler W

    更新日期:2014-09-01 00:00:00

  • Electoretinographic evidence of retinal ganglion cell-dependent function in schizophrenia.

    abstract::Schizophrenia is a complex disorder that is diagnosed mainly with clinical observation and evaluation. Recent studies suggest that many people with schizophrenia have abnormalities in the function of the N-methyl-d-aspartate receptor (NMDAR). The retina is part of the central nervous system and expresses the NMDAR, ra...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2019.09.005

    authors: Moghimi P,Torres Jimenez N,McLoon LK,Netoff TI,Lee MS,MacDonald A 3rd,Miller RF

    更新日期:2020-05-01 00:00:00

  • Evolution of neuroleptic-induced extrapyramidal syndromes under long-term neuroleptic treatment.

    abstract:BACKGROUND:The long-term evolution of neuroleptic-induced extrapyramidal syndromes (EPS) of Parkinsonism, akathisia and tardive dyskinesia (TD) is still a controversial issue worth exploring. METHOD:A total of 200 inpatients on regular typical neuroleptics (NL) and/or clozapine were assessed in 1995 with regard to the...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2007.10.018

    authors: Modestin J,Wehrli MV,Stephan PL,Agarwalla P

    更新日期:2008-03-01 00:00:00

  • Telomere length in subjects with schizophrenia, their unaffected siblings and healthy controls: Evidence of accelerated aging.

    abstract::Schizophrenia (SZ) is associated with broad burden. The clinical manifestations of SZ are related to pathophysiological alterations similar to what is seen in normal aging. Our aim was to evaluate the differences in telomere length (TL), a biomarker of cellular aging, in subjects with SZ (n=36), unaffected siblings (S...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2016.04.004

    authors: Czepielewski LS,Massuda R,Panizzutti B,da Rosa ED,de Lucena D,Macêdo D,Grun LK,Barbé-Tuana FM,Gama CS

    更新日期:2016-07-01 00:00:00

  • Caregiving processes and expressed emotion in psychosis, a cross-cultural, meta-analytic review.

    abstract::The construct of Expressed Emotion (EE) is a reliable predictor of relapse in psychotic disorders globally. However, cultural differences in the level and manifestation of EE have been reported. This review was conducted in line with PRISMA guidelines to demonstrate the distribution of EE and its domains cross-cultura...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.schres.2019.03.020

    authors: O'Driscoll C,Sener SB,Angmark A,Shaikh M

    更新日期:2019-06-01 00:00:00

  • Neither protein kinase C nor adenylate cyclase are altered in the striatum from subjects with schizophrenia.

    abstract::Dopamine (DA) D2 receptors which act by modulating second messenger pathways that include protein kinase C (PKC) and adenylate cyclase (AC) have been repeatedly shown to be increased in striatum from subjects with schizophrenia. Therefore it seemed possible that chronic up-regulation of DA-D2 receptors in the schizoph...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/s0920-9964(96)00065-5

    authors: Opeskin K,Dean B,Pavey G,Hill C,Keks N,Copolov D

    更新日期:1996-11-15 00:00:00

  • Schizophrenia spectrum disorders, substance misuse, and the four-facet model of psychopathy: the relationship to violence.

    abstract:OBJECTIVE:To investigate the relationship between the four-facet model of PCL-R psychopathy and violence in a community-based sample of Australian men with schizophrenia-spectrum disorders. METHOD:A community sample of 94 males with schizophrenia-spectrum disorders was recruited from mental health services within Vict...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2011.09.010

    authors: McGregor K,Castle D,Dolan M

    更新日期:2012-04-01 00:00:00

  • Clozapine-induced cardiomyopathy and myocarditis monitoring: A systematic review.

    abstract::The use of clozapine requires monitoring the absolute neutrophil count because of the risk of agranulocytosis, but other potentially fatal adverse events associated with clozapine (specifically, myocarditis and cardiomyopathy) do not have mandatory procedures. We performed a systematic review of English-language artic...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2018.03.006

    authors: Knoph KN,Morgan RJ 3rd,Palmer BA,Schak KM,Owen AC,Leloux MR,Patel M,Leung JG

    更新日期:2018-09-01 00:00:00

  • Exposure to "The Troubles" in Northern Ireland influences the clinical presentation of schizophrenia.

    abstract:INTRODUCTION:This study investigates the effect of exposure to "The Troubles" (the period of civil unrest from 1968 onwards) in Northern Ireland on symptomatology in people with schizophrenia. METHOD:Eighty-two participants were assessed on a number of psychiatric rating scales and on measures of trauma, including an ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2008.02.012

    authors: Mulholland C,Boyle C,Shannon C,Huda U,Clarke L,Meenagh C,Dempster M

    更新日期:2008-07-01 00:00:00

  • Can disorganisation of semantic memory account for the abnormalities of thought in schizophrenia-a controlled experimental study.

    abstract:BACKGROUND:Disorganisation of semantic memory could provide a cognitive explanation for the disturbances of thinking and reasoning in schizophrenia. In this study, we directly test this explanation by identifying patients with disorganised semantic categories and then examine how they use their knowledge about these sa...

    journal_title:Schizophrenia research

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.schres.2003.12.003

    authors: Green NE,Done DJ,Anthony SH,McKenna PJ,Ochocki M

    更新日期:2004-10-01 00:00:00

  • Hopelessness, neurocognitive function, and insight in schizophrenia: relationship to suicidal behavior.

    abstract::Insight and hopelessness have been reported to be associated with suicidality in schizophrenia. In addition, there is evidence that diminished insight is correlated with impairment in some domains of cognitive function in schizophrenia. The purpose of this study was to clarify the relative importance for suicidality i...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/s0920-9964(02)00310-9

    authors: Kim CH,Jayathilake K,Meltzer HY

    更新日期:2003-03-01 00:00:00

  • Effects of repeated electroconvulsive shocks on dopamine supersensitivity psychosis model rats.

    abstract::While the long-term administration of antipsychotics is known to cause dopamine supersensitivity psychosis (DSP), recent studies revealed that DSP helps form the foundation of treatment resistance. Electroconvulsive shock (ES) is one of the more effective treatments for treatment-resistant schizophrenia. The objective...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2020.11.062

    authors: Kimura M,Oda Y,Oishi K,Yoshino K,Kimura H,Niitsu T,Kanahara N,Shirayama Y,Hashimoto K,Iyo M

    更新日期:2021-01-08 00:00:00