Abstract:
:Grey matter brain networks are disrupted in schizophrenia, but it is still unclear at which point during the development of the illness these disruptions arise and whether these can be associated with behavioural predictors of schizophrenia. We investigated if single-subject grey matter networks were disrupted in a sample of people at familial risk of schizophrenia. Single-subject grey matter networks were extracted from structural MRI scans of 144 high risk subjects, 32 recent-onset patients and 36 healthy controls. The following network properties were calculated: size, connectivity density, degree, path length, clustering coefficient, betweenness centrality and small world properties. People at risk of schizophrenia showed decreased path length and clustering in mostly prefrontal and temporal areas. Within the high risk sample, the path length of the posterior cingulate cortex and the betweenness centrality of the left inferior frontal operculum explained 81% of the variance in schizotypal cognitions, which was previously shown to be the strongest behavioural predictor of schizophrenia in the study. In contrast, local grey matter volume measurements explained 48% of variance in schizotypy. The present results suggest that single-subject grey matter networks can quantify behaviourally relevant biological alterations in people at increased risk for schizophrenia before disease onset.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Tijms BM,Sprooten E,Job D,Johnstone EC,Owens DG,Willshaw D,Seriès P,Lawrie SMdoi
10.1016/j.schres.2015.08.025subject
Has Abstractpub_date
2015-10-01 00:00:00pages
1-8issue
1-2eissn
0920-9964issn
1573-2509pii
S0920-9964(15)00454-5journal_volume
168pub_type
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