Patterns of emotional experience in schizophrenia: differences in emotional response to visual stimuli are associated with clinical presentation and functional outcome.

Abstract:

:The current study examined whether patterns of emotional response are differentially associated with symptom presentation and functional outcome in individuals with schizophrenia. Participants included 49 outpatients with schizophrenia and 50 demographically matched controls. All participants rated their emotional response to 131 images from the International Affective Picture Systems (IAPS) library on both arousal and valence scales. Stimuli were split into categories of positive versus negatively valenced stimuli based on control subject ratings. Cluster analysis was used to assess whether there were reliably distinct patterns of emotional response within the patient sample. Follow-up discriminant function analysis indicated that these groups were adequately separated. Sixty percent of the individuals with schizophrenia rated valence and arousal similarly to healthy subjects, while 40% displayed an atypical profile. Schizophrenia sub-groups classified by these two emotional response styles significantly differed on measures of functional outcome, severity of negative symptoms, and self-reported anhedonia. Findings are discussed in relation to current theories of emotional experience in schizophrenia.

journal_name

Schizophr Res

journal_title

Schizophrenia research

authors

Strauss GP,Herbener ES

doi

10.1016/j.schres.2011.01.010

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

117-23

issue

1-3

eissn

0920-9964

issn

1573-2509

pii

S0920-9964(11)00023-5

journal_volume

128

pub_type

杂志文章
  • Abnormal GABAergic function and face processing in schizophrenia: A pharmacologic-fMRI study.

    abstract::The involvement of the gamma-aminobutyric acid (GABA) system in schizophrenia is suggested by postmortem studies and the common use of GABA receptor-potentiating agents in treatment. In a recent study, we used a benzodiazepine challenge to demonstrate abnormal GABAergic function during processing of negative visual st...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2015.08.022

    authors: Tso IF,Fang Y,Phan KL,Welsh RC,Taylor SF

    更新日期:2015-10-01 00:00:00

  • Reproducibility of fMRI activations during a story listening task in patients with schizophrenia.

    abstract::A prerequisite to longitudinal fMRI studies in schizophrenia is the knowledge on fMRI signal reliability in schizophrenia patients. We assessed the reproducibility of activations elicited by two fMRI sessions, which were 21 months apart, of a story listening paradigm in 10 schizophrenia patients and 10 healthy subject...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2011.01.025

    authors: Maïza O,Mazoyer B,Hervé PY,Razafimandimby A,Dollfus S,Tzourio-Mazoyer N

    更新日期:2011-05-01 00:00:00

  • Latent class analysis of discordance between results of drug use assessments in the CATIE data.

    abstract:OBJECTIVE:The primary aim is to examine concordant/discordant results of drug use assessments in adults with schizophrenia. METHODS:Latent class analysis and multinomial logistic regression were used to examine concordance/discordance between drug use measures and identify characteristics differentiating participants ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.schres.2014.11.016

    authors: Johnson KL,Desmarais SL,Swartz MS,Van Dorn RA

    更新日期:2015-02-01 00:00:00

  • Do we need oxytocin to treat schizophrenia? A randomized clinical trial.

    abstract:BACKGROUND:Schizophrenia is a disabling complex mental disorder and despite all available treatment, many patients unfortunately remain partial- or non-responders. A large body of research has shown that oxytocin is an important prosocial peptide and there is initial evidence that the central oxytocin system is altered...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.schres.2016.02.011

    authors: Dagani J,Sisti D,Abelli M,Di Paolo L,Pini S,Raimondi S,Rocchi MB,Saviotti FM,Scocco P,Totaro S,Balestrieri M,de Girolamo G

    更新日期:2016-04-01 00:00:00

  • The Audio-Visual Abnormalities Questionnaire (AVAQ): Development and validation of a new instrument for assessing anomalies in sensory perception in schizophrenia spectrum disorders.

    abstract:BACKGROUND:Anomalies in visual and auditory perception represent an important aspect of the symptomatic manifestation of schizophrenia (ScZ). However, there are currently no instruments available that allow the assessment of the full range of auditory and visual abnormalities using a self-report measure. METHODS:We de...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2019.03.016

    authors: Nikitova N,Keane BP,Demmin D,Silverstein SM,Uhlhaas PJ

    更新日期:2019-07-01 00:00:00

  • Gender differences in premorbid, entry, treatment, and outcome characteristics in a treated epidemiological sample of 661 patients with first episode psychosis.

    abstract:OBJECTIVES:Gender differences in psychotic disorder have been observed in terms of illness onset and course; however, past research has been limited by inconsistencies between studies and the lack of epidemiological representative of samples assessed. Thus, the aim of this study was to elucidate gender differences in a...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2009.07.002

    authors: Cotton SM,Lambert M,Schimmelmann BG,Foley DL,Morley KI,McGorry PD,Conus P

    更新日期:2009-10-01 00:00:00

  • Measuring theory of mind in schizophrenia research: Cross-cultural validation.

    abstract::Theory of mind (ToM) is the ability to understand mental states of others and it is crucial for building sensitivity to other persons or events. Measuring ToM is important for understanding and rehabilitating social cognitive impairments in persons with schizophrenia. The Social Attribution Task-Multiple Choice (SAT-M...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2018.06.022

    authors: Lee HS,Corbera S,Poltorak A,Park K,Assaf M,Bell MD,Wexler BE,Cho YI,Jung S,Brocke S,Choi KH

    更新日期:2018-11-01 00:00:00

  • The impact of a family history of psychosis on age-at-onset and positive and negative symptoms of schizophrenia: a meta-analysis.

    abstract::The results of research on the relation of family history (FH) of psychosis with clinical presentation in schizophrenia have been mixed. To date, there have been no comprehensive reviews that have examined this body of research. The current review quantitatively evaluates research on the relation of FH with two aspect...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.schres.2010.01.011

    authors: Esterberg ML,Trotman HD,Holtzman C,Compton MT,Walker EF

    更新日期:2010-07-01 00:00:00

  • The role of family work in early psychosis.

    abstract::In keeping with the current clinical and research focus on early intervention and the rapid increase worldwide of programs for those experiencing a first episode of psychosis, the development of services for families has to be an integral part of any comprehensive program. Families can and do play a major role in the ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,评审

    doi:10.1016/j.schres.2005.01.013

    authors: Addington J,Collins A,McCleery A,Addington D

    更新日期:2005-11-01 00:00:00

  • Effects of repeated electroconvulsive shocks on dopamine supersensitivity psychosis model rats.

    abstract::While the long-term administration of antipsychotics is known to cause dopamine supersensitivity psychosis (DSP), recent studies revealed that DSP helps form the foundation of treatment resistance. Electroconvulsive shock (ES) is one of the more effective treatments for treatment-resistant schizophrenia. The objective...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2020.11.062

    authors: Kimura M,Oda Y,Oishi K,Yoshino K,Kimura H,Niitsu T,Kanahara N,Shirayama Y,Hashimoto K,Iyo M

    更新日期:2021-01-08 00:00:00

  • Reprint of: Internalising symptoms mediate the longitudinal association between childhood inflammation and psychotic-like experiences in adulthood.

    abstract::Psychotic-like experiences (PLEs) are part of a continuum of psychosis. Previous longitudinal studies highlighted a relationship between peripheral inflammation during childhood and onset of PLEs in adulthood. In this study, we tested if this association is mediated by internalising and externalising symptoms experien...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2020.11.009

    authors: Francesconi M,Minichino A,Khandaker GM,Midouhas E,Lewis G,Flouri E

    更新日期:2020-12-01 00:00:00

  • Genetic inactivation of GSK3α rescues spine deficits in Disc1-L100P mutant mice.

    abstract::Disrupted-in-Schizophrenia 1 (DISC1), a strong candidate gene for schizophrenia and other mental disorders, regulates neurodevelopmental processes including neurogenesis, neuronal migration, neurite outgrowth and spine development. Glycogen synthase kinase-3 (GSK3) directly interacts with DISC1 and also plays a role i...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2011.03.032

    authors: Lee FH,Kaidanovich-Beilin O,Roder JC,Woodgett JR,Wong AH

    更新日期:2011-06-01 00:00:00

  • Neurocognitive deficits and neurological signs in schizophrenia.

    abstract:OBJECTIVE:This is a comprehensive study designed to examine the association between specific clusters of neurological abnormalities and several clinically relevant aspects of schizophrenia such as positive and negative symptoms, neurocognitive deficits and psychosocial performance. METHODS:Thirty-seven clinically stab...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/S0920-9964(96)00095-3

    authors: Wong AH,Voruganti LN,Heslegrave RJ,Awad AG

    更新日期:1997-02-07 00:00:00

  • Neighborhood-level predictors of age at onset and duration of untreated psychosis in first-episode psychotic disorders.

    abstract:OBJECTIVE:Recent years have witnessed growing interest in the role of the social environment in the development and outcomes of schizophrenia. We investigated whether neighborhood characteristics are associated with two important prognostic factors in early-course psychosis, age at onset of psychosis (AOP) and duration...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2019.12.036

    authors: Ku BS,Pauselli L,Manseau M,Compton MT

    更新日期:2020-04-01 00:00:00

  • Cytokines in cerebrospinal fluid of patients with schizophrenia spectrum disorders: New data and an updated meta-analysis.

    abstract::Few studies have been conducted examining cytokines in cerebrospinal fluid of patients compared to healthy volunteers. The goals of this study were: 1) to report original data detailing cytokine levels in the cerebrospinal fluid (CSF) of 10 patients with a schizophrenia spectrum disorder (SSD) diagnosis and 10 healthy...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.schres.2018.07.019

    authors: Gallego JA,Blanco EA,Husain-Krautter S,Madeline Fagen E,Moreno-Merino P,Del Ojo-Jiménez JA,Ahmed A,Rothstein TL,Lencz T,Malhotra AK

    更新日期:2018-12-01 00:00:00

  • Dopamine and norepinephrine activity in schizophrenia. An integrative perspective.

    abstract::The dopamine (DA) hypothesis of schizophrenia stated that increased DA activity is the primary cause of schizophrenia. Recently, even though increased DA activity is in fact involved in psychotic symptoms and antipsychotic drug response, it has become clear that decreased DA activity is present in remitted and chronic...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,评审

    doi:10.1016/0920-9964(91)90032-m

    authors: van Kammen DP,Kelley M

    更新日期:1991-03-01 00:00:00

  • Cognitive remediation therapy (CRT) for young early onset patients with schizophrenia: an exploratory randomized controlled trial.

    abstract:BACKGROUND:Schizophrenia with an onset in adolescence is known to be associated with a poorer outcome and cognitive difficulties. These impairments have an impact on quality of life and represent treatment targets. Cognitive remediation therapy (CRT) attempts to improve cognitive deficits by teaching information proces...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.schres.2007.03.030

    authors: Wykes T,Newton E,Landau S,Rice C,Thompson N,Frangou S

    更新日期:2007-08-01 00:00:00

  • Persistent negative symptoms after first episode schizophrenia: A 2-year follow-up study.

    abstract:BACKGROUND:The aim of this study is to determine the rate of persistent negative symptoms according to different criteria during two years of follow-up after first-episode schizophrenia. METHODS:The study sample consisted of 105 patients with first-episode schizophrenia who completed at least 12 months of follow-up pe...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2014.07.021

    authors: Üçok A,Ergül C

    更新日期:2014-09-01 00:00:00

  • Ketogenic diet prevents impaired prepulse inhibition of startle in an acute NMDA receptor hypofunction model of schizophrenia.

    abstract::Recent transcriptomic, proteomic and metabolomics studies have highlighted an abnormal cerebral glucose and energy metabolism as one of the potential pathophysiological mechanisms of schizophrenia. This raises the possibility that a metabolically-based intervention might have therapeutic value in the management of sch...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2018.11.011

    authors: Kraeuter AK,van den Buuse M,Sarnyai Z

    更新日期:2019-04-01 00:00:00

  • Shape distortion of the hippocampus: a possible explanation of the pyramidal cell disarray reported in schizophrenia.

    abstract::The finding of pyramidal cell disarray in the hippocampus of patients with schizophrenia has been disputed by several groups. Conflicting results have been attributed to differences in the subtype of patients used, staining method, the side of the hippocampus studied and the way cellular disarray has been measured. In...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/s0920-9964(01)00201-8

    authors: Casanova MF,Rothberg B

    更新日期:2002-05-01 00:00:00

  • Cognitive decline in schizophrenia from childhood to midlife: a 33-year longitudinal birth cohort study.

    abstract:BACKGROUND:We examined cognitive deficits before and after onset of schizophrenia in a longitudinal study that: 1) covers a long time interval; 2) minimizes test unreliability by including the identical measure at both childhood and post-onset cognitive assessments; and 3) minimizes bias by utilizing a population-based...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2010.01.009

    authors: Kremen WS,Vinogradov S,Poole JH,Schaefer CA,Deicken RF,Factor-Litvak P,Brown AS

    更新日期:2010-05-01 00:00:00

  • Memory for temporal order in patients with schizophrenia.

    abstract::There is some evidence that memory for temporal order is a process that may be impaired independently of other forms of memory. For example, patients with Korsakoff's syndrome have been shown to have poorer temporal-order memory than other amnesic patients, despite item memory being equivalent. Patients with schizophr...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/s0920-9964(00)00014-1

    authors: Elvevåg B,Egan MF,Goldberg TE

    更新日期:2000-12-15 00:00:00

  • Distinct alterations in resting-state electroencephalogram during eyes closed and eyes open and between morning and evening are present in first-episode psychosis patients.

    abstract::Abnormalities in resting-state electroencephalogram (rs-EEG) activity have been previously reported in schizophrenia. While most rs-EEG recordings were performed in patients with chronic schizophrenia during eyes closed (EC), only a handful of studies have investigated rs-EEG activity during both EC and eyes open (EO)...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2020.12.014

    authors: Zhang Y,Geyfman A,Coffman B,Gill K,Ferrarelli F

    更新日期:2021-01-08 00:00:00

  • Uncovering the role of the nucleus accumbens in schizophrenia: A postmortem analysis of tyrosine hydroxylase and vesicular glutamate transporters.

    abstract::The nucleus accumbens (NAcc) is often implicated in schizophrenia (SZ) pathology, but with little evidence to support its role. This study examined postmortem human tissue to determine if abnormalities are present in the dopaminergic or glutamatergic systems in the NAcc in SZ. We compared the protein levels of tyrosin...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2015.08.041

    authors: McCollum LA,Roberts RC

    更新日期:2015-12-01 00:00:00

  • Adjunctive psychosocial therapies for the treatment of schizophrenia.

    abstract::Antipsychotic pharmacotherapy is the standard of care for the treatment of schizophrenia. Although pharmacotherapy effectively improves some symptoms, others can remain. Pharmacotherapy alone also tends to produce only limited improvement in social functioning and quality of life. Supportive psychosocial therapies hav...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,评审

    doi:10.1016/j.schres.2007.12.468

    authors: Patterson TL,Leeuwenkamp OR

    更新日期:2008-03-01 00:00:00

  • Pharmacokinetic-pharmacodynamic modeling of antipsychotic drugs in patients with schizophrenia Part I: the use of PANSS total score and clinical utility.

    abstract:BACKGROUND:To develop a pharmacokinetic-pharmacodynamic (PK-PD) model using individual-level data of Positive and Negative Syndrome Scale (PANSS) total score to characterize the antipsychotic drug effect taking into account the placebo effect and dropout rate. In addition, a clinical utility (CU) criterion that describ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2013.02.011

    authors: Pilla Reddy V,Kozielska M,Suleiman AA,Johnson M,Vermeulen A,Liu J,de Greef R,Groothuis GM,Danhof M,Proost JH

    更新日期:2013-05-01 00:00:00

  • Spatial localization of retinal anomalies in regular cannabis users: The relevance of the multifocal electroretinogram.

    abstract::Widely used in industrialized countries, cannabis is a neuromodulator substance. The cannabinoid system is present at critical stages of retinal processing. We have recently shown a delay in bipolar and ganglion cell responses in regular cannabis users, as observed using flash (fERG) and pattern (PERG) electroretinogr...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2019.01.013

    authors: Schwitzer T,Henrion ML,Sarre D,Albuisson E,Angioi-Duprez K,Giersch A,Lalanne L,Schwan R,Laprevote V

    更新日期:2020-05-01 00:00:00

  • An Interleukin-1 beta (IL1B) haplotype linked with psychosis transition is associated with IL1B gene expression and brain structure.

    abstract::We investigated IL1B genetic variation previously associated with risk for transition to psychosis for its association with gene expression in human post-mortem dorsolateral prefrontal cortex (DLPFC) from 74 (37 schizophrenia, 37 control) individuals and brain structure in 92 (44 schizophrenia, 48 control) living indi...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2018.09.008

    authors: Mostaid MS,Dimitrakopoulos S,Wannan C,Cropley V,Weickert CS,Everall IP,Pantelis C,Bousman CA

    更新日期:2019-02-01 00:00:00

  • Emotion recognition in psychosis: no evidence for an association with real world social functioning.

    abstract:BACKGROUND:Patients with psychotic disorders show impairments in the recognition of emotions in other people. These impairments have been associated with poor social functioning as measured by self-report questionnaires, clinical interviews and laboratory-based tests of social skills. The ecological validity of these t...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2012.10.003

    authors: Janssens M,Lataster T,Simons CJ,Oorschot M,Lardinois M,van Os J,Myin-Germeys I,GROUP.

    更新日期:2012-12-01 00:00:00

  • Schizophrenia and HLA: a review.

    abstract::A number of reports of genetic association of human leucocyte antigens (HLA) and alleles with schizophrenia have recently been published. A schizophrenia locus on chromosome 6p near the HLA region has also been reported, on the basis of linkage studies. We have therefore reviewed the investigations of association of H...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,评审

    doi:10.1016/s0920-9964(00)00022-0

    authors: Wright P,Nimgaonkar VL,Donaldson PT,Murray RM

    更新日期:2001-01-15 00:00:00