Abnormal expression of glutamate transporter and transporter interacting molecules in prefrontal cortex in elderly patients with schizophrenia.

abstract：:Forensic patients with schizophrenia who had carried out a homicide scored higher on a measure of moral cognition (MFQ-30) than other violent patients. Neurocognitive impairment was associated with homicide by mediation via higher scores for in-group loyalty. ...

journal_title：Schizophrenia research

authors： O'Reilly K,O'Connell P,Corvin A,O'Sullivan D,Coyle C,Mullaney R,O'Flynn P,Grogan K,Richter M,Kennedy H

更新日期：2018-03-01 00:00:00

abstract：:It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant ...

journal_title：Schizophrenia research

authors： Takahashi N,Ishihara R,Saito S,Maemo N,Aoyama N,Ji X,Miura H,Ikeda M,Iwata N,Suzuki T,Kitajima T,Yamanouchi Y,Kinoshita Y,Ozaki N,Inada T

更新日期：2006-04-01 00:00:00

abstract：:We found previously that a subgroup of schizophrenic patients who passed screening tests of attentional competence showed memory deficits on word memory tasks, but were comparable with controls on tone memory tasks. To better understand the nature of language-specific memory deficits in this subgroup of patients, the ...

journal_title：Schizophrenia research

authors： Wexler BE,Donegan N,Stevens AA,Jacob SA

更新日期：2002-01-15 00:00:00

abstract：INTRODUCTION:Since the early description of paranoia, the nosology of delusional disorder has always been controversial. The old idea of unitary psychosis has now gained some renewed value from the dimensional continuum model of psychotic symptoms. AIMS:1. To study the psychopathological dimensions of the psychosis sp...

journal_title：Schizophrenia research

authors： Muñoz-Negro JE,Ibanez-Casas I,de Portugal E,Ochoa S,Dolz M,Haro JM,Ruiz-Veguilla M,de Dios Luna Del Castillo J,Cervilla JA

更新日期：2015-12-01 00:00:00

abstract：:Social skill and role functioning were assessed in matched groups of patients with DSM-III-R schizoaffective disorder, bipolar disorder, and schizophrenia. Schizophrenics were categorized as negative syndrome or non-negative on the basis of the SANS. The negative schizophrenics were significantly more impaired on almo...

journal_title：Schizophrenia research

authors： Bellack AS,Morrison RL,Mueser KT,Wade J

更新日期：1989-07-01 00:00:00

abstract：:Sustained attention deficits and high rates of smoking are often observed in patients with schizophrenia. This has led to the hypothesis that patients may smoke as an attempt to ameliorate cognitive deficits related to abnormal nicotinic structure and function. Continuous performance tasks (CPT) are often used to inde...

journal_title：Schizophrenia research

authors： Roth M,Hong LE,McMahon RP,Fuller RL

更新日期：2013-08-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs that mainly function as negative regulators of gene expression (Lai, 2002) and have been shown to be involved in schizophrenia etiology through genetic and expression studies (Burmistrova et al., 2007; Hansen et al., 2007a; Perkins et al., 2007; Beveridge et al., 2010; Kim ...

journal_title：Schizophrenia research

authors： Kim AH,Parker EK,Williamson V,McMichael GO,Fanous AH,Vladimirov VI

更新日期：2012-10-01 00:00:00

abstract：:Biomarkers which predict response to atypical antipsychotic drugs (AAPDs) increases their benefit/risk ratio. We sought to identify common variants in genes which predict response to lurasidone, an AAPD, by associating genome-wide association study (GWAS) data and changes (Δ) in Positive And Negative Syndrome Scale (P...

journal_title：Schizophrenia research

authors： Li J,Yoshikawa A,Brennan MD,Ramsey TL,Meltzer HY

更新日期：2018-02-01 00:00:00

abstract：:Although patients with schizophrenia have reduced brain size, there is no conclusive evidence that they have reduced head size. This begs the question: 'What is the precise relationship between head size and brain size?' We used a unique osteological collection to explore the relationship between external head measure...

journal_title：Schizophrenia research

authors： Friedman L,Wiechers IR,Cerny CA,Schulz SC,Buckley P

更新日期：2000-03-16 00:00:00

abstract：BACKGROUND:Little is known about the effects of antipsychotic medications on gray matter (GM) in schizophrenia. Although clozapine remains the most effective antipsychotic medication in treatment-refractory cases, it is unknown whether it has a differential effect on GM development. METHODS:In an exploratory analysis,...

journal_title：Schizophrenia research

authors： Mattai A,Chavez A,Greenstein D,Clasen L,Bakalar J,Stidd R,Rapoport J,Gogtay N

更新日期：2010-01-01 00:00:00

abstract：:The MATRICS Consensus Cognitive Battery (MCCB) was developed to assess cognitive treatment effects in schizophrenia clinical trials, and is considered the FDA gold standard outcome measure for that purpose. The aim of the present study was to establish pre-treatment psychometric characteristics of the MCCB in a large ...

journal_title：Schizophrenia research

authors： Georgiades A,Davis VG,Atkins AS,Khan A,Walker TW,Loebel A,Haig G,Hilt DC,Dunayevich E,Umbricht D,Sand M,Keefe RSE

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Higher cognitive dysfunction, lower perceptual disturbance and its relation to the structures that implicate such processes have been considered as key features in patients with schizophrenia. However, little is known about the relationship between perceptual processing and structural deficits in ultra-high-...

journal_title：Schizophrenia research

authors： Shin KS,Jung WH,Kim JS,Jang JH,Hwang JY,Chung CK,Kwon JS

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:The study aimed to assess the construct validity, internal consistency and factor structure of the Specific Levels of Functioning Scale (SLOF), a multidimensional instrument assessing real life functioning. METHODS:The study was carried out in 895 Italian people with schizophrenia, all living in the communi...

journal_title：Schizophrenia research

authors： Mucci A,Rucci P,Rocca P,Bucci P,Gibertoni D,Merlotti E,Galderisi S,Maj M,Italian Network for Research on Psychoses.

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Loneliness is common in people with psychotic disorders and associated with reduced health and well-being. The relationship between loneliness in psychosis and health service use is unclear. This study examined whether loneliness predicts increased health care utilization in this population, independently of...

journal_title：Schizophrenia research

authors： Badcock JC,Di Prinzio P,Waterreus A,Neil AL,Morgan VA

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Depressive symptoms frequently accompany schizophrenia. Older patients constitute the fastest growing segment of the schizophrenia population. With regard to the risk factors associated with depression, it is uncertain to which extent older schizophrenia patients differ from their age peers in the community....

journal_title：Schizophrenia research

authors： Meesters PD,Comijs HC,Sonnenberg CM,Hoogendoorn AW,de Haan L,Eikelenboom P,Beekman AT,Stek ML

更新日期：2014-08-01 00:00:00

abstract：:Mitochondria have been linked to the etiology of schizophrenia (SZ). However, studies of mitochondria in SZ might be confounded by the effects of pharmacological treatment with antipsychotic drugs (APDs) and other common medications. This review summarizes findings on relevant mitochondria mechanisms underlying SZ, an...

journal_title：Schizophrenia research

authors： Chan ST,McCarthy MJ,Vawter MP

更新日期：2020-03-01 00:00:00

abstract：:In 200 inpatients on regular neuroleptics, point prevalence of extrapyramidal syndromes, including Parkinson syndrome, akathisia and tardive dyskinesia (TD), was studied and found to be 20, 11 and 22%, respectively. A total of 46 patients have currently, and for a longer time, (average about 3years, median over 1year)...

journal_title：Schizophrenia research

authors： Modestin J,Stephan PL,Erni T,Umari T

更新日期：2000-05-05 00:00:00

abstract：:The aim of the study was to assess changes in cortical thickness related to the use of n-3 polyunsaturated fatty acids (PUFA) as add-on therapy in patients with first episode schizophrenia. A double-blind randomized controlled study was conducted using a 26-week intervention composed of concentrated fish oil containin...

journal_title：Schizophrenia research

authors： Pawełczyk T,Piątkowska-Janko E,Bogorodzki P,Gębski P,Grancow-Grabka M,Trafalska E,Żurner N,Pawełczyk A

更新日期：2018-05-01 00:00:00

abstract：:Cognitive impairments have been shown to predict impairments in adaptive functioning in patients with chronic schizophrenia and to be more predictive of overall outcome than positive or negative symptoms of the illness. Both adaptive and cognitive impairments are multidimensional, and it is possible that correlations ...

journal_title：Schizophrenia research

authors： Harvey PD,Sukhodolsky D,Parrella M,White L,Davidson M

更新日期：1997-10-30 00:00:00

abstract：OBJECTIVE:Executive dysfunction is a common feature of schizophrenia and bipolar disorder (BP). While deficits in social cognitive abilities, including theory of mind (ToM), have been suggested to be specific to schizophrenia, available evidence suggests that there is also a significant overlap in social cognitive perf...

journal_title：Schizophrenia research

authors： Bora E,Veznedaroğlu B,Vahip S

更新日期：2016-10-01 00:00:00

abstract：:Diffusion Tensor Imaging (DTI) investigations in schizophrenia have provided evidence of impairment in white matter as indicated by reduced fractional anisotropy (FA). However, the neuropathological implications of these findings remain unclear. In the current study, we conducted a voxelwise analysis of the constituen...

journal_title：Schizophrenia research

authors： Seal ML,Yücel M,Fornito A,Wood SJ,Harrison BJ,Walterfang M,Pell GS,Pantelis C

更新日期：2008-04-01 00:00:00

abstract：:Schizophrenia is a severe psychiatric disorder with lifetime prevalence of ~1% worldwide. A genotyping study was conducted using a custom panel of Illumina 1536 SNPs in 840 schizophrenia cases and 876 controls (351 patients and 385 controls from North India; and 436 patients, 401 controls and 143 familial samples with...

journal_title：Schizophrenia research

authors： Jajodia A,Kaur H,Kumari K,Gupta M,Baghel R,Srivastava A,Sood M,Chadda RK,Jain S,Kukreti R

更新日期：2015-03-01 00:00:00

abstract：:The study of the mechanisms involved in cognition is of paramount importance for the understanding of the neurobiological substrates in psychiatric disorders. Hence, this research is aimed at exploring the brain network dynamics during a cognitive task. Specifically, we analyze the predictive capability of the pre-sti...

journal_title：Schizophrenia research

authors： Gomez-Pilar J,Poza J,Gómez C,Northoff G,Lubeiro A,Cea-Cañas BB,Molina V,Hornero R

更新日期：2018-11-01 00:00:00

abstract：:In recent years, early intervention services have attempted to identify people with a first episode of psychosis as early as possible, reducing the duration of untreated psychosis and changing the timing of delivery of interventions. The logic of early intervention is based partly on accessing people in a more treatme...

journal_title：Schizophrenia research

authors： Francey SM,Nelson B,Thompson A,Parker AG,Kerr M,Macneil C,Fraser R,Hughes F,Crisp K,Harrigan S,Wood SJ,Berk M,McGorry PD

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:Supported employment is the evidence-based treatment of choice for assisting individuals with severe mental illness to achieve competitive employment, but few supported employment programs specifically target older clients with psychiatric illness. The purpose of this study was to evaluate the efficacy of sup...

journal_title：Schizophrenia research

authors： Twamley EW,Vella L,Burton CZ,Becker DR,Bell MD,Jeste DV

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Eye movement abnormalities have been identified in schizophrenia; however, their relevance to cognition is still unknown. In this study, we explored the general relationship between eye movements and cognitive function. METHODS:The three eye movement measures (scanpath length, horizontal position gain, and ...

journal_title：Schizophrenia research

authors： Morita K,Miura K,Fujimoto M,Yamamori H,Yasuda Y,Kudo N,Azechi H,Okada N,Koshiyama D,Ikeda M,Kasai K,Hashimoto R

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Formal thought disorder (FTD) is a core feature of psychosis, however there are gaps in our knowledge about its prevalence and factor structure. We had two aims: first, to establish the factor structure of FTD; second, to explore the clinical utility of dimensions of FTD in order to further the understanding...

journal_title：Schizophrenia research

authors： Roche E,Lyne JP,O'Donoghue B,Segurado R,Kinsella A,Hannigan A,Kelly BD,Malone K,Clarke M

更新日期：2015-10-01 00:00:00

abstract：:Psychotic experiences are far more common in the population than psychotic disorder. They are associated with a number of adverse outcomes but there has been little research on associations with functioning and distress. We wished to investigate functioning and distress in a community sample of adolescents with psycho...

journal_title：Schizophrenia research

authors： Kelleher I,Wigman JT,Harley M,O'Hanlon E,Coughlan H,Rawdon C,Murphy J,Power E,Higgins NM,Cannon M

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:Attentional deficits represent a core cognitive impairment in schizophrenia. The distractor condition Sustained Attention Task (dSAT) has been identified by the Cognitive Neuroscience Treatment to Improve Cognition in Schizophrenia (CNTRICS) initiative as a promising translational task for assessing schizophr...

journal_title：Schizophrenia research

authors： Demeter E,Guthrie SK,Taylor SF,Sarter M,Lustig C

更新日期：2013-03-01 00:00:00

abstract：:Research has demonstrated that individuals with schizophrenia fail to appropriately use negative feedback to guide learning. These learning deficits are thought to arise from abnormalities in midbrain dopamine activity. Primary and enduring negative symptoms are also associated with abnormal dopamine activity and are ...

journal_title：Schizophrenia research

authors： Vogel SJ,Strauss GP,Allen DN

更新日期：2013-12-01 00:00:00