Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population.

Abstract:

:It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant association with schizophrenia was observed to one SNP marker, rs9658635 (p=0.0269), and with a 2 marker haplotype (p=0.0016). Significant association of rs9658635 was then replicated in a second independent cohort (377 schizophrenia and 338 control samples) (p=0.007). These results suggest that the CHGA gene is associated with the risk of developing schizophrenia in the Japanese population.

journal_name

Schizophr Res

journal_title

Schizophrenia research

authors

Takahashi N,Ishihara R,Saito S,Maemo N,Aoyama N,Ji X,Miura H,Ikeda M,Iwata N,Suzuki T,Kitajima T,Yamanouchi Y,Kinoshita Y,Ozaki N,Inada T

doi

10.1016/j.schres.2005.12.854

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

179-83

issue

2-3

eissn

0920-9964

issn

1573-2509

pii

S0920-9964(06)00004-1

journal_volume

83

pub_type

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