Abstract:
:In 200 inpatients on regular neuroleptics, point prevalence of extrapyramidal syndromes, including Parkinson syndrome, akathisia and tardive dyskinesia (TD), was studied and found to be 20, 11 and 22%, respectively. A total of 46 patients have currently, and for a longer time, (average about 3years, median over 1year) been treated with clozapine, and 127 with typical neuroleptics (NLs). Comparing both groups, higher TD scores were found in the clozapine sample. Investigating the influence of a set of seven clinical variables on the TD score with the help of multiple regression analysis, the influence of the treatment modality disappeared, whereas the age proved to be the only significant variable. Studying the role of past clozapine therapy in patients currently on typical NLs and comparing 10 matched pairs of chronic patients with and without TD in whom a complete life-time cumulative dose of NLs was identified, a relationship between TD and length of current typical NL therapy and life-time typical NL dosage could be demonstrated. On the whole, long-term relatively extensive use of clozapine has not markedly reduced the prevalence of extrapyramidal syndromes in our psychiatric inpatient population. In particular, we failed to demonstrate a beneficial effect of clozapine on prevalence of TD. There are certainly patients who suffer from TD in spite of a long-term intensive clozapine treatment.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Modestin J,Stephan PL,Erni T,Umari Tdoi
10.1016/s0920-9964(99)00133-4subject
Has Abstractpub_date
2000-05-05 00:00:00pages
223-30issue
3eissn
0920-9964issn
1573-2509pii
S0920-9964(99)00133-4journal_volume
42pub_type
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pub_type: 杂志文章
doi:10.1016/j.schres.2011.03.032
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2005.03.020
更新日期:2005-09-15 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2020.12.014
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2012.06.014
更新日期:2012-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.12.014
更新日期:2016-02-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2016.06.028
更新日期:2016-10-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2020.06.032
更新日期:2020-09-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(99)00045-6
更新日期:1999-11-30 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/0920-9964(95)00069-0
更新日期:1996-05-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.07.049
更新日期:2015-10-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.schres.2012.03.018
更新日期:2012-06-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2006.12.032
更新日期:2007-08-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.07.002
更新日期:2009-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2014.12.003
更新日期:2016-06-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.10.014
更新日期:2019-04-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.08.041
更新日期:2015-12-01 00:00:00
abstract::Characterizing a pattern of cognitive dysfunction in early onset schizophrenic patients may illuminate neurodevelopmental contributions to the illness. A cohort of chronically institutionalized schizophrenic patients with a variable range of age of onset (range 7-29 years) was administered a comprehensive battery of n...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/0920-9964(95)00065-8
更新日期:1996-05-01 00:00:00
abstract:OBJECTIVE:Attentional deficits represent a core cognitive impairment in schizophrenia. The distractor condition Sustained Attention Task (dSAT) has been identified by the Cognitive Neuroscience Treatment to Improve Cognition in Schizophrenia (CNTRICS) initiative as a promising translational task for assessing schizophr...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.01.003
更新日期:2013-03-01 00:00:00
abstract::Systematic linkage disequilibrium (LD) mapping of 8p12-21 in the Icelandic population identified neuregulin 1 (NRG1) as a prime candidate gene for schizophrenia. However, results of replication studies have been inconsistent, and no large sample analyses have been reported. Therefore, we designed this study with the a...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.01.010
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVES:Cognitive remediation therapy (CRT) has shown significant improvement in cognition in schizophrenia. However, effect sizes of CRT have been reported to be modest raising the issue how to augment the effects of CRT on neurocognition and social cognition. Our aim was to examine whether the addition of computer...
journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2018.06.012
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Schizophrenia with an onset in adolescence is known to be associated with a poorer outcome and cognitive difficulties. These impairments have an impact on quality of life and represent treatment targets. Cognitive remediation therapy (CRT) attempts to improve cognitive deficits by teaching information proces...
journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2007.03.030
更新日期:2007-08-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2016.04.022
更新日期:2016-08-01 00:00:00
abstract::This study reports findings of the Edinburgh High Risk Study four years after it began. This study is designed to explore the pathogenesis of schizophrenia by examining a large sample of young adults aged 16-25 years who are at enhanced risk of developing schizophrenia by having two close relatives with the disorder, ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(99)00225-x
更新日期:2000-11-30 00:00:00