Abstract:
:The serotonin and dopamine neurotransmitter systems are candidate pathways in the development of schizophrenia because of the assumed causal relationship with the observed symptoms as well as effective targeting of the corresponding receptors by antipsychotic drugs. However, genetic association studies have systematically focused on a limited set of genes and single nucleotide polymorphisms (SNPs), including T102C at HTR2A and Ser9Gly at DRD3. Meta-analyses of the associations between these two markers and schizophrenia revealed a true increase in risk, the magnitude of the effect being very low. In the present study we analyzed 260 schizophrenic patients and 354 control subjects from a homogeneous population, the Galician population, using an extensive linkage disequilibrium (LD) mapping approach, genotyping a total of 47 SNPs to test for the existence of additional variants that confer higher risk. We detected nominal significant association with schizophrenia for several haplotype tag SNPs (htSNPs) at HTR2A, although the significance was lost after multiple test corrections. In addition, haplotype analyses involving a sliding window approach, with window size 2 to 4 SNPs, revealed significant differences in frequencies of the DRD3 haplotypes at the 3' half of the gene region. This difference, which remains clearly significant after multiple test corrections (p=0.002, 0.0001, and 0.0025, for window sizes 2, 3, and 4, respectively), was mainly due to over-representation of several rare haplotypes in patients, at the expense of a single common haplotype; this represents interesting evidence of rare haplotypes for susceptibility detected using common htSNPs due to their strong effect.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Domínguez E,Loza MI,Padín F,Gesteira A,Paz E,Páramo M,Brenlla J,Pumar E,Iglesias F,Cibeira A,Castro M,Caruncho H,Carracedo A,Costas Jdoi
10.1016/j.schres.2006.09.022subject
Has Abstractpub_date
2007-02-01 00:00:00pages
123-9issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(06)00418-Xjournal_volume
90pub_type
杂志文章abstract::The construct of Expressed Emotion (EE) is a reliable predictor of relapse in psychotic disorders globally. However, cultural differences in the level and manifestation of EE have been reported. This review was conducted in line with PRISMA guidelines to demonstrate the distribution of EE and its domains cross-cultura...
journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章
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更新日期:2004-04-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1998-05-25 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(99)00182-6
更新日期:2000-05-25 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.08.013
更新日期:2008-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,评审
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.05.012
更新日期:2009-10-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.07.034
更新日期:2013-10-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.09.002
更新日期:2009-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2005.07.009
更新日期:2005-12-15 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0920-9964(01)00176-1
更新日期:2002-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2020.03.044
更新日期:2020-06-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(98)00113-3
更新日期:1999-01-04 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2019.03.007
更新日期:2020-03-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.03.011
更新日期:2014-05-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.11.030
更新日期:2008-03-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2016-05-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1994-09-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2006.08.015
更新日期:2007-01-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.05.034
更新日期:2010-08-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2016.04.022
更新日期:2016-08-01 00:00:00
abstract::Functional abnormalities in the interhemispheric transfer via the corpus callosum in schizophrenia may result in filtering problems and information processing problems, which may in turn be related to the synchronization of cortical event-related activity. To explore whether a relationship exists between corpus callos...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(00)00123-7
更新日期:2001-04-15 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/0920-9964(93)90007-6
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:The intrusion of associations into the utterances of schizophrenic individuals typically disrupts the coherence of the patient's utterances. Recent theoretical formulations of these phenomena have emphasized the hyperactivity) of associational networks in such language disturbance (e.g., Maher, B.A. 2003 Sch...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2005.05.017
更新日期:2005-10-15 00:00:00
abstract:BACKGROUND:There remains a lack of agreement regarding criteria for treatment-resistant schizophrenia (TRS) and definition of response. METHOD:A literature search was conducted to identify clinical studies of antipsychotics in TRS using PubMed, EMBASE and PsycINFO (last search 31 July 2011). Psychopharmacological stud...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2011.09.016
更新日期:2011-12-01 00:00:00