Abstract：
:Converging lines of evidence implicate structural and functional abnormalities in the cerebellum in schizophrenia (SCZ). The cerebellar vermis is of particular interest given its association with clinical symptoms and cognitive deficits in SCZ and its known connections with cortical regions such as the prefrontal cortex. Prior neuroimaging studies have shown structural and functional abnormalities in the vermis in SCZ. In this study, we examined the cerebellar vermis in 50 individuals with SCZ and 54 healthy controls (HC) using a quantitative volumetric approach. All participants underwent high-resolution structural magnetic resonance imaging (MRI). The vermis was manually traced for each participant, and vermis volumes were computed using semiautomated methods. Volumes for total vermis and vermis subregions (anterior and posterior vermis) were analyzed in the SCZ and HC groups. Significant diagnosis-by-sex interaction effects were found in total vermis and vermis subregion analyses. These effects appeared to be driven by significantly decreased posterior vermis volumes in males with SCZ. Exploratory analyses did not reveal significant effects of clinical variables (FEP status, illness duration, and BPRS total score and subscores) on vermis volumes. The findings herein highlight the presence of neural sex differences in SCZ and the need for considering sex-related factors in studying the disorder.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Womer FY,Tang Y,Harms MP,Bai C,Chang M,Jiang X,Wei S,Wang F,Barch DMdoi
10.1016/j.schres.2016.06.028subject
Has Abstractpub_date
2016-10-01 00:00:00pages
164-170issue
2-3eissn
0920-9964issn
1573-2509pii
S0920-9964(16)30310-3journal_volume
176pub_type
杂志文章abstract：:Recovery from psychotic disorders includes both symptomatic and functional components. Progress in understanding recovery requires careful replication and extension of findings using comparable measures. In the current paper, we present a study of five year recovery rates in an early intervention program in London, Ca...
journal_title：Schizophrenia research
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abstract：:Schizophrenia is an illness characterized by positive symptoms, negative symptoms, and cognitive impairments. Cognitive impairments occur before the onset of psychosis and could reflect glutamatergic dysregulation. Thus, identifying associations between genetic variations in genes coding for glutamatergic receptors an...
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.07.044
更新日期：2013-10-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.04.043
更新日期：2018-11-01 00:00:00
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pub_type： 临床试验,杂志文章,多中心研究
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pub_type： 杂志文章,评审
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journal_title：Schizophrenia research
pub_type： 杂志文章
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更新日期：2020-08-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2003.07.005
更新日期：2004-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.schres.2012.10.003
更新日期：2012-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：1993-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.schres.2017.04.001
更新日期：2018-02-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.schres.2004.05.002
更新日期：2005-05-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.04.007
更新日期：2014-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0920-9964(94)90051-5
更新日期：1994-10-01 00:00:00
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更新日期：2020-01-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00244-4
更新日期：2001-08-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2010.04.015
更新日期：2010-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0920-9964(92)90028-4
更新日期：1992-12-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.08.027
更新日期：2008-02-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.04.050
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pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2011.03.016
更新日期：2011-06-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(96)00065-5
更新日期：1996-11-15 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0920-9964(99)00063-8
更新日期：1999-12-21 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.04.024
更新日期：2018-09-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2010.07.023
更新日期：2010-11-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2015-05-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.schres.2009.01.002
更新日期：2009-04-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.08.029
更新日期：2015-10-01 00:00:00
