Abstract:
:Poor insight into the neurocognitive deficits in schizophrenia-spectrum disorders may have significant clinical implications for treatment. The purpose of this study was to replicate and extend the psychometric findings initially reported on the Measure of Insight into Cognition Clinician-Rated (MIC-CR) and Self-Report (MIC-SR) which assess awareness, attribution, and frequency of neurocognitive deficits. Assessments conducted one week apart allowed for internal consistency, test-retest reliability, concurrent validity, and administration order effects to be determined. In this study sample (N=80), 73 demonstrated significant neurocognitive impairment, yet on the MIC-CR, the average awareness and attribution scores indicated only partial awareness and attribution of neurocognitive deficits. The average MIC-SR score indicated rare frequency of cognitive difficulty in everyday life. Cronbach's alphas for the MIC-CR (0.83) and MIC-SR (0.93) were consistent with the initial validation study; test-retest reliability for both MIC assessments was significant (p<0.001). In new analyses, concurrent validity was demonstrated by significant correlations between the MIC-CR and MIC-SR in the first validation sample: r=-0.75 (p<0.001) and the current replication sample: r=-0.70 (p<0.001). Effect sizes were large when frequencies of neurocognitive complaints (MIC-SR) were compared between subjects with good versus poor awareness on the MIC-CR. Reliability and concurrent validity results were similar and significant regardless of order of MIC-CR and MIC-SR administration. The MIC-CR and MIC-SR are thus reliable and valid complementary instruments to assess neurocognitive insight in people with schizophrenia spectrum disorders.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Saperstein AM,Thysen J,Medalia Adoi
10.1016/j.schres.2011.10.002subject
Has Abstractpub_date
2012-01-01 00:00:00pages
54-8issue
1eissn
0920-9964issn
1573-2509pii
S0920-9964(11)00514-7journal_volume
134pub_type
杂志文章abstract::In previous studies of self-monitoring in schizophrenia, patients have exhibited reductions in the amplitude of the error-related negativity (ERN), a component of the event-related brain potential (ERP) elicited most prominently immediately following the execution of incorrect responses. In the current study, we exami...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.08.027
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:Persistent formal thought disorder (FTD) is one of the most characteristic features of schizophrenia. Several neuroimaging studies report spatially distinct neuroanatomical changes in association with FTD. Given that most studies so far have employed a univariate localisation approach that obscures the study...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.07.022
更新日期:2015-10-01 00:00:00
abstract::The current study sought to expand on prior reports of the validity and reliability of the CAINS (CAINS) by examining its performance across diverse non-academic clinical settings as employed by raters not affiliated with the scale's developers and across a longer test-retest follow-up period. The properties of the CA...
journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.schres.2017.01.011
更新日期:2017-07-01 00:00:00
abstract::Speech deficits, notably those involved in psychomotor retardation, blunted affect, alogia and poverty of content of speech, are pronounced in a wide range of serious mental illnesses (e.g., schizophrenia, unipolar depression, bipolar disorders). The present project evaluated the degree to which these deficits manifes...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.10.032
更新日期:2014-12-01 00:00:00
abstract::Currently, little is known about the pharmacological effects of the new generation of antipsychotic medications on perception of emotion in schizophrenia. The present study was designed to compare the effects of risperidone versus haloperidol on the ability to perceive emotion in 20 treatment-resistant schizophrenia p...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0920-9964(98)00026-7
更新日期:1998-05-25 00:00:00
abstract:INTRODUCTION:Since the early description of paranoia, the nosology of delusional disorder has always been controversial. The old idea of unitary psychosis has now gained some renewed value from the dimensional continuum model of psychotic symptoms. AIMS:1. To study the psychopathological dimensions of the psychosis sp...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.10.039
更新日期:2015-12-01 00:00:00
abstract::Prior studies of mRNA expression, protein expression, and pathway metabolite levels have implicated dysregulation of the kynurenine pathway in the etiology of schizophrenia and bipolar disorder. Here we investigate whether genes involved in kynurenine pathway regulation might interact with genes that respond to kynure...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.05.014
更新日期:2009-09-01 00:00:00
abstract::[(3)H]ketanserin binding to 5HT(2A) receptors was measured in the left planum temporale (sensory speech cortex) from schizophrenic and non-schizophrenic (control) subjects using both particulate membranes and tissue sections. There was a significant decrease in the affinity of [(3)H]ketanserin binding to particulate m...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(99)00150-4
更新日期:2000-07-07 00:00:00
abstract:OBJECTIVE:Internalized stigma can lead to pervasive negative effects among people with severe mental illness (SMI). Although prevalence of internalized stigma is high, there is a dearth of interventions and meanwhile a lack of evidence as to their effectiveness. This study aims at unraveling the existence of different ...
journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.schres.2016.02.013
更新日期:2016-05-01 00:00:00
abstract::Childhood trauma is a risk factor for the onset of schizophrenic psychosis. Because the psychosis phenotype can be described as a continuum with varying levels of severity and persistence, childhood trauma might likewise increase the risk for psychotic experiences below the diagnostic threshold. But the impact of stre...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2016.02.006
更新日期:2016-04-01 00:00:00
abstract::Autism and schizophrenia share multiple phenotypic and genotypic markers, and there is ongoing debate regarding the relationship of these two disorders. To examine whether cortical dynamics are similar across these disorders, we directly compared fMRI responses to visual, somatosensory and auditory stimuli in adults w...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2016.03.036
更新日期:2016-08-01 00:00:00
abstract::Diminished expressivity is a characteristic feature of schizophrenia-spectrum pathology. However, attempts to elucidate the neurobiological underpinnings of diminished expressivity have yielded limited information. The present study posited that diminished expressivity was associated with a right, but not left-hemisph...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.01.010
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:The diagnosis of psychotic disorder is associated with a risk of violence. Psychotic-like experiences (PLEs) in the general population may share an etiological background with psychotic disorders. The present study has evaluated the association between PLEs and violent behavior in adolescents. METHODS:PLEs a...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.08.028
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Auditory verbal hallucinations (AVH) do not have uniform pathological significance. They affect patients with different brain disorders, and vary along multiple phenomenological dimensions. Evidence indicates that some of the phenomenological variables have specific neural substrates. Therefore, a comprehens...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(03)00013-6
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVE:Supported employment is the evidence-based treatment of choice for assisting individuals with severe mental illness to achieve competitive employment, but few supported employment programs specifically target older clients with psychiatric illness. The purpose of this study was to evaluate the efficacy of sup...
journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2011.11.036
更新日期:2012-03-01 00:00:00
abstract::In keeping with the current clinical and research focus on early intervention and the rapid increase worldwide of programs for those experiencing a first episode of psychosis, the development of services for families has to be an integral part of any comprehensive program. Families can and do play a major role in the ...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2005.01.013
更新日期:2005-11-01 00:00:00
abstract::Studies of the risk of schizophrenia and related non-affective psychoses among individuals exposed to head injury have reported conflicting findings. The diagnostic specificity of reported associations remains unclear and the effects of sex, genetic vulnerability and timing of exposures are also uncertain. The authors...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2006.07.001
更新日期:2006-12-01 00:00:00
abstract::Mismatch negativity (MMN) and P3a are auditory event-related potential (ERP) components that show robust deficits in schizophrenia (SZ) patients and exhibit qualities of endophenotypes, including substantial heritability, test-retest reliability, and trait-like stability. These measures also fulfill criteria for use a...
journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.schres.2014.09.042
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Self-referential processing (i.e. linking internal and external stimuli to one's own self) has received scant attention thus far in schizophrenia. This type of processing is a key component of social cognition and thought to be important for adaptive social functioning. Memory studies in healthy subjects hav...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.11.011
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Biochemical, physiological and genetic evidence suggests dysregulation of central nicotinic acetylcholine receptor (nAChR) systems in schizophrenia, which may contribute to neuropsychological dysfunction and the high rates of smoking in this disorder. To evaluate the effects of nAChR blockade on neuropsychol...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章
doi:10.1016/j.schres.2006.03.025
更新日期:2006-07-01 00:00:00
abstract::The effects of stereotype suppression on psychiatric stigma were investigated in two studies. In experiment 1, 52 participants were presented with a photograph of someone labeled with schizophrenia and instructed to write a passage describing a day in that person's life. Half of the participants were instructed to avo...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0920-9964(01)00207-9
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:A definition of clinical remission in schizophrenia has recently been proposed. However, it is also known that neuropsychological (NP) impairments may be better predictors of functional outcomes than clinical symptoms. Understanding the relationship between clinical remission and cognitive improvement may be...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2006.12.032
更新日期:2007-08-01 00:00:00
abstract::Though negative symptoms in schizophrenia are associated with a host of deleterious outcomes (e.g., White et al., 2009), not all individuals with schizophrenia suffer from negative symptoms (e.g., Blanchard et al., 2005). Thus, methods to quickly screen and identify patients for more intensive clinical interview asses...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2011.12.007
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Executive Functioning (EF) is an important factor for community functioning for people with severe mental illness. Cognitive remediation programs often improve EF, but do so by using multiple therapeutic techniques. Little is known regarding how individual treatment elements promote cognitive improvement. Os...
journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2017.08.052
更新日期:2019-01-01 00:00:00
abstract::Social anhedonia is an important feature of schizophrenia and it is a promising indicator of schizotypy. Although social anhedonia is defined as an affective construct (less pleasure derived from social encounters), little is known about the emotional responsivity and expressivity of individuals with high levels of so...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.06.012
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Targeting glutamatergic dysfunction provides an exciting opportunity to improve cognitive impairment in schizophrenia. One treatment approach has targeted inadequate antioxidant defenses at glutamatergic synapses. Animal and human data suggest NMDA antagonists worsen executive cognitive controls--e.g. increa...
journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.schres.2012.10.001
更新日期:2012-12-01 00:00:00
abstract::Schizophrenia is associated with significant impairments in both higher and lower order social cognitive performance and these impairments contribute to poor social functioning. People with schizophrenia report poor social functioning to be one of their greatest unmet treatment needs. Recent studies have suggested the...
journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2015.06.005
更新日期:2015-11-01 00:00:00
abstract::Previous studies (including genome-wide association study (GWAS) and candidate gene studies) have revealed the important roles of genetic risk factors in schizophrenia, and RELN has been identified as a risk gene for this illness. We recently found that the low-density lipoprotein receptor-related protein 8 (LRP8), a ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.05.002
更新日期:2020-01-01 00:00:00
abstract::The aim of this paper is to provide a brief review of mitochondrial structure as it relates to function and then present abnormalities in mitochondria in postmortem schizophrenia with a focus on ultrastructure. Function, morphology, fusion, fission, motility, ΔΨmem, ATP production, mitochondrial derived vesicles, and ...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2017.01.056
更新日期:2017-09-01 00:00:00
abstract::Schizophrenia constitutes a complex disease. Negative and cognitive symptoms are enduring and debilitating components of the disorder, highly associated to disability and burden. Disrupted neurotransmission circuits in dorsolateral prefrontal cortex (DLPFC) have been related to these symptoms. To identify candidates a...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2016.04.050
更新日期:2016-11-01 00:00:00