Abstract:
:Schizophrenia is a severe psychiatric disorder with lifetime prevalence of ~1% worldwide. A genotyping study was conducted using a custom panel of Illumina 1536 SNPs in 840 schizophrenia cases and 876 controls (351 patients and 385 controls from North India; and 436 patients, 401 controls and 143 familial samples with 53 probands containing 37 complete and 16 incomplete trios from South India). Meta-analysis of this population of Indo-European and Dravidian ancestry identified three strongly associated variants with schizophrenia: STT3A (rs548181, p=1.47×10(-5)), NRG1 (rs17603876, p=8.66×10(-5)) and GRM7 (rs3864075, p=4.06×10(-3)). Finally, a meta-analysis was conducted comparing our data with data from the Schizophrenia Psychiatric Genome-Wide Association Study Consortium (PGC-SCZ) that supported rs548181 (p=1.39×10(-7)). In addition, combined analysis of sporadic case-control association and a transmission disequilibrium test in familial samples from South Indian population identified three associations: rs1062613 (p=3.12×10(-3)), a functional promoter variant of HTR3A; rs6710782 (p=3.50×10(-3)), an intronic variant of ERBB4; and rs891903 (p=1.05×10(-2)), an intronic variant of EBF1. The results support the risk variants observed in the earlier published work and suggest a potential role of neurodevelopmental genes in the schizophrenia pathogenesis.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Jajodia A,Kaur H,Kumari K,Gupta M,Baghel R,Srivastava A,Sood M,Chadda RK,Jain S,Kukreti Rdoi
10.1016/j.schres.2014.12.031subject
Has Abstractpub_date
2015-03-01 00:00:00pages
112-7issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(14)00764-6journal_volume
162pub_type
杂志文章,meta分析abstract::A prior study in a US state hospital suggested that schizophrenia is more closely associated with tobacco smoking when compared with other severe mental illnesses. This second study, in a neighborhood hospital, tries to (1) replicate that schizophrenia is associated with smoking and heavy smoking, and (2) rule out tha...
journal_title:Schizophrenia research
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journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.schres.2016.09.034
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.12.015
更新日期:2014-02-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.11.028
更新日期:2009-04-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.04.003
更新日期:2015-06-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.03.012
更新日期:2008-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2003.08.007
更新日期:2004-04-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/S0920-9964(99)00162-0
更新日期:2000-08-03 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.01.019
更新日期:2018-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.04.026
更新日期:2007-08-01 00:00:00
abstract::Social skill and role functioning were assessed in matched groups of patients with DSM-III-R schizoaffective disorder, bipolar disorder, and schizophrenia. Schizophrenics were categorized as negative syndrome or non-negative on the basis of the SANS. The negative schizophrenics were significantly more impaired on almo...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/0920-9964(89)90032-7
更新日期:1989-07-01 00:00:00
abstract::Deficits in emotion perception are common in people with schizophrenia and current research has focused on improving these deficits. In our previous research, we demonstrated that directing attention to salient facial features via attention shaping can improve these deficits among inpatients. In this study, we examine...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.05.011
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:The feasibility and preliminary efficacy of a novel cognitive behavioral treatment for decreasing psychotic symptoms and improving social functioning was evaluated in a pilot study. This represents the first treatment outcome study of CBT for psychosis with a manualized, active comparison condition. METHODS...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.schres.2004.05.002
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:Cannabis use may decrease age at onset in both schizophrenia and bipolar disorder, given the evidence for substantial phenotypic and genetic overlap between both disorders. METHODS:766 patients, aged 16 to 65 years, were assessed with the Composite International Diagnostic Interview (CIDI) for substance abu...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.07.003
更新日期:2011-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0920-9964(92)90002-m
更新日期:1992-03-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.schres.2012.02.017
更新日期:2012-05-01 00:00:00
abstract::Alterations of immune function have been reported in ultra-high risk (UHR) for psychosis patients causing expectations in terms of predictive meaningfulness and benefits of anti-inflammatory agents. According to a RCT in UHR-patients supplementation of omega-3 polyunsaturated fatty acids (PUFA) was effective in reduci...
journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2017.01.026
更新日期:2017-10-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.12.016
更新日期:2020-02-01 00:00:00
abstract:INTRODUCTION:Since the early description of paranoia, the nosology of delusional disorder has always been controversial. The old idea of unitary psychosis has now gained some renewed value from the dimensional continuum model of psychotic symptoms. AIMS:1. To study the psychopathological dimensions of the psychosis sp...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.10.039
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abstract:BACKGROUND:Advanced paternal age (APA) is associated with increased risk for schizophrenia, but its effect on treatment response has not been longitudinally studied. METHODS:Association of parental ages at the time of the child's birth with age of onset, initial symptom severity and treatment response (to placebo and ...
journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2013.10.001
更新日期:2013-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2019.11.025
更新日期:2020-11-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.12.002
更新日期:2014-02-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(02)00354-7
更新日期:2003-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2004.09.017
更新日期:2005-07-01 00:00:00
abstract::Schizoaffective disorder is a common diagnosis in clinical practice but its nosological status has been subject to debate ever since it was conceptualized. Although it is key that diagnostic reliability is sufficient, schizoaffective disorder has been reported to have low interrater reliability. Evidence based on syst...
journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.schres.2016.07.012
更新日期:2016-10-01 00:00:00
abstract::The way schizophrenia patients perceive the world is largely mysterious. Understanding and appreciating the visual world begins with the perception of basic visual features, which is altered in this mental disorder. Yet, the roles basic visual features play in functional activities such as appreciation of art are uncl...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.06.024
更新日期:2008-10-01 00:00:00
abstract::Previous transcriptome analyses of brain samples provided several insights into the pathophysiology of schizophrenia. In this study, we aimed to re-investigate gene expression datasets from seven brain regions of patients with schizophrenia and healthy controls by adopting a unified approach. After adjustment for conf...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2020.06.032
更新日期:2020-09-01 00:00:00
abstract::Arinami et al. (1994) reported an association between the Ser311/Cys311 variant of the DRD2 gene and schizophrenia in a Japanese population. We did not find statistically significant differences in the distribution of the allele frequencies between schizophrenics (103) and controls (97) in a case-control sample (chi 2...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/S0920-9964(97)00013-3
更新日期:1997-05-24 00:00:00
abstract:OBJECTIVE:To investigate the relationship between the four-facet model of PCL-R psychopathy and violence in a community-based sample of Australian men with schizophrenia-spectrum disorders. METHOD:A community sample of 94 males with schizophrenia-spectrum disorders was recruited from mental health services within Vict...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2011.09.010
更新日期:2012-04-01 00:00:00