Effects of omega-3 PUFA on immune markers in adolescent individuals at ultra-high risk for psychosis - Results of the randomized controlled Vienna omega-3 study.

abstract：BACKGROUND:Despite the upsurge of research regarding cognitive impairment in schizophrenia we still lack adequate understanding of the executive functioning of patients in symptomatic remission. Moreover, the cognitive functioning of patients in partial remission has not been studied previously although they comprise a...

journal_title：Schizophrenia research

authors： Braw Y,Benozio A,Levkovitz Y

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:Deficits in the mediodorsal and anterior nuclei of the thalamus may contribute to the psychopathological symptoms of schizophrenia. These thalamic nuclei have been found to be abnormal in schizophrenia and have close connections with other brain structures implicated in the disorder. We therefore examined sch...

journal_title：Schizophrenia research

authors： Jakary A,Vinogradov S,Feiwell R,Deicken RF

更新日期：2005-07-15 00:00:00

abstract：BACKGROUND:Anomalies in visual and auditory perception represent an important aspect of the symptomatic manifestation of schizophrenia (ScZ). However, there are currently no instruments available that allow the assessment of the full range of auditory and visual abnormalities using a self-report measure. METHODS:We de...

journal_title：Schizophrenia research

authors： Nikitova N,Keane BP,Demmin D,Silverstein SM,Uhlhaas PJ

更新日期：2019-07-01 00:00:00

abstract：:Schizophrenia is associated with premature mortality and a high rate of sudden, unexpected deaths. Autopsy data are scant, and in studies using death certificates or root cause assessments, a majority of sudden deaths remained unexplained. In the community, post-mortem data indicate that the most common cause of sudde...

journal_title：Schizophrenia research

authors： Ifteni P,Correll CU,Burtea V,Kane JM,Manu P

更新日期：2014-05-01 00:00:00

abstract：:Social skill and role functioning were assessed in matched groups of patients with DSM-III-R schizoaffective disorder, bipolar disorder, and schizophrenia. Schizophrenics were categorized as negative syndrome or non-negative on the basis of the SANS. The negative schizophrenics were significantly more impaired on almo...

journal_title：Schizophrenia research

authors： Bellack AS,Morrison RL,Mueser KT,Wade J

更新日期：1989-07-01 00:00:00

abstract：:CACNA1C (12p13.3) has been implicated as a susceptibility gene for schizophrenia by several replicated genome wide association studies. While these results have been consistent among studies in European populations, the findings in East Asian populations have varied. To test whether CACNA1C is a risk gene for schizoph...

journal_title：Schizophrenia research

authors： Zheng F,Zhang Y,Xie W,Li W,Jin C,Mi W,Wang F,Ma W,Ma C,Yang Y,Du B,Li K,Liu C,Wang L,Lu T,Zhang H,Wang Y,Lu L,Lv L,Zhang D,Yue W

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Recent research has identified impairment in processing speed, measured by the digit-symbol substitution task, as central to the cognitive deficit in schizophrenia. However, the underlying cognitive correlates of this impairment remain unknown. METHODS:A sample of cases (N=125) meeting DSM-IV criteria for s...

journal_title：Schizophrenia research

authors： Knowles EE,Weiser M,David AS,Dickinson D,Glahn D,Gold J,Davidson M,Reichenberg A

更新日期：2012-12-01 00:00:00

abstract：:Cognitive impairments have been shown to predict impairments in adaptive functioning in patients with chronic schizophrenia and to be more predictive of overall outcome than positive or negative symptoms of the illness. Both adaptive and cognitive impairments are multidimensional, and it is possible that correlations ...

journal_title：Schizophrenia research

authors： Harvey PD,Sukhodolsky D,Parrella M,White L,Davidson M

更新日期：1997-10-30 00:00:00

abstract：:Despite the notion that increases in functioning should be associated with increases in life satisfaction in schizophrenia, research has often found no association between the two. Dual change models of global and domain-specific life satisfaction and functioning were examined in 145 individuals with schizophrenia rec...

journal_title：Schizophrenia research

authors： Edmondson M,Pahwa R,Lee KK,Hoe M,Brekke JS

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:All currently available antipsychotic medications bind to both the dopamine-2 (D2) and dopamine-3 (D3) receptors in vitro. However, there is conflicting evidence from in vivo studies about whether or not antipsychotic medications bind to the D3 receptor (D3R). The purpose of this study was to determine wheth...

journal_title：Schizophrenia research

authors： Girgis RR,Xu X,Gil RB,Hackett E,Ojeil N,Lieberman JA,Slifstein M,Abi-Dargham A

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:To explore the impact of the introduction of newer antipsychotic long-acting injections (LAIs) on trends in LAI prescribing and characteristics associated with initiation of LAIs in naturalistic conditions. METHODS:The study was performed using reimbursement data from the French Insurance Healthcare system. ...

journal_title：Schizophrenia research

authors： Verdoux H,Pambrun E,Tournier M,Bezin J,Pariente A

更新日期：2016-12-01 00:00:00

abstract：:Patients with schizophrenia demonstrate a variety of attentional impairments which have proven difficult to relate to specific neural systems. Posner et al. (1988) reported an asymmetric slowing of right visual field orienting in schizophrenia similar to that observed in patients with parietal lesions. We examined the...

journal_title：Schizophrenia research

authors： Gold JM,Randolph C,Coppola R,Carpenter CJ,Goldberg TE,Weinberger DR

更新日期：1992-09-01 00:00:00

abstract：:Previous transcriptome analyses of brain samples provided several insights into the pathophysiology of schizophrenia. In this study, we aimed to re-investigate gene expression datasets from seven brain regions of patients with schizophrenia and healthy controls by adopting a unified approach. After adjustment for conf...

journal_title：Schizophrenia research

authors： Karpiński P,Samochowiec J,Sąsiadek MM,Łaczmański Ł,Misiak B

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Second-generation antipsychotics (SGAs) increase the risk of type 2 diabetes. The mechanism is thought to center on drug-induced weight gain, which starts the dysmetabolic cascade of insulin resistance, increased insulin production and pancreatic beta-cell failure. An independent effect of SGAs on insulin se...

journal_title：Schizophrenia research

authors： Manu P,Correll CU,Wampers M,van Winkel R,Yu W,Shiffeldrim D,Kane JM,De Hert M

更新日期：2013-02-01 00:00:00

abstract：:Task set maintenance and switching deficits are robust in schizophrenia. However, little is known about how these constructs are related to one another. The development of an improved understanding of set switching and maintenance deficits in schizophrenia requires that these constructs be explicated in terms of eleme...

journal_title：Schizophrenia research

authors： Kieffaber PD,Kappenman ES,Bodkins M,Shekhar A,O'Donnell BF,Hetrick WP

更新日期：2006-06-01 00:00:00

abstract：:Because previous studies have shown deficits in olfactory identification for male patients with schizophrenia, either withdrawn from or receiving neuroleptic medication, the purpose of the current study was to determine if such deficits occurred in male patients who had never received neuroleptics. A sample of male (n...

journal_title：Schizophrenia research

authors： Kopala LC,Clark C,Hurwitz T

更新日期：1993-01-01 00:00:00

abstract：:Fragile X mental retardation protein (FMRP) is an RNA binding protein with 842 target mRNAs in mammalian brain. Silencing of the fragile X mental retardation 1 (FMR1) gene leads to loss of expression of FMRP and upregulated metabotropic glutamate receptor 5 (mGluR5) signaling resulting in the multiple physical and cog...

journal_title：Schizophrenia research

authors： Folsom TD,Thuras PD,Fatemi SH

更新日期：2015-07-01 00:00:00

abstract：:The current study examined the factor structure of the Brief Negative Symptom Scale (BNSS), a next-generation negative symptom rating instrument developed in response to the NIMH-sponsored Consensus Development Conference on Negative Symptoms. Participants included 146 individuals with a DSM-IV diagnosis of schizophre...

journal_title：Schizophrenia research

authors： Strauss GP,Hong LE,Gold JM,Buchanan RW,McMahon RP,Keller WR,Fischer BA,Catalano LT,Culbreth AJ,Carpenter WT,Kirkpatrick B

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Persistent formal thought disorder (FTD) is one of the most characteristic features of schizophrenia. Several neuroimaging studies report spatially distinct neuroanatomical changes in association with FTD. Given that most studies so far have employed a univariate localisation approach that obscures the study...

journal_title：Schizophrenia research

authors： Palaniyappan L,Mahmood J,Balain V,Mougin O,Gowland PA,Liddle PF

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Findings from the WHO sponsored multicenter studies done a few decades ago, which reported favorable outcome of schizophrenia in developing countries both in 2 and 5 year follow-up studies, dominated the world view until recently. Emerging evidence from Low and Middle Income countries (LAMIC) started to chal...

journal_title：Schizophrenia research

authors： Teferra S,Shibre T,Fekadu A,Medhin G,Wakwoya A,Alem A,Jacobsson L

更新日期：2012-04-01 00:00:00

abstract：:Stigma can be a major stressor for individuals with schizophrenia and other mental illnesses. It is unclear, however, why some stigmatized individuals appraise stigma as more stressful, while others feel they can cope with the potential harm posed by public prejudice. We tested the hypothesis that the level of perceiv...

journal_title：Schizophrenia research

authors： Rüsch N,Corrigan PW,Wassel A,Michaels P,Olschewski M,Wilkniss S,Batia K

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:Several risk factors of venous thromboembolism (VTE) and pulmonary embolism (PE) were found in patients with schizophrenia. Therefore, we hypothesize that the incidences of VTE and PE are relatively higher among schizophrenia patients in comparison with the general population. METHOD:For this population-base...

journal_title：Schizophrenia research

authors： Hsu WY,Lane HY,Lin CL,Kao CH

更新日期：2015-03-01 00:00:00

abstract：:The involvement of the gamma-aminobutyric acid (GABA) system in schizophrenia is suggested by postmortem studies and the common use of GABA receptor-potentiating agents in treatment. In a recent study, we used a benzodiazepine challenge to demonstrate abnormal GABAergic function during processing of negative visual st...

journal_title：Schizophrenia research

authors： Tso IF,Fang Y,Phan KL,Welsh RC,Taylor SF

更新日期：2015-10-01 00:00:00

abstract：:Mismatch negativity (MMN) deficits in schizophrenia (SCZ) have been studied extensively since the early 1990s, with the vast majority of studies using simple auditory oddball task deviants that vary in a single acoustic dimension such as pitch or duration. There has been a growing interest in using more complex devian...

journal_title：Schizophrenia research

authors： Avissar M,Xie S,Vail B,Lopez-Calderon J,Wang Y,Javitt DC

更新日期：2018-01-01 00:00:00

abstract：:The frontal and temporal lobes have been implicated as pathogenic sites for schizophrenia, although there is a marked heterogeneity of brain function and structure between individual patients. It is currently unclear whether some patients with schizophrenia exhibit primarily frontal lobe dysfunction, while others exhi...

journal_title：Schizophrenia research

authors： Allen DN,Goldstein G,Weiner C

更新日期：2001-03-01 00:00:00

abstract：:First episode psychosis (FEP) has been associated with structural brain changes, largely identified by volumetric analyses. Advances in neuroimaging processing have made it possible to measure geometric properties that may identify subtle structural changes not appreciated by a measure of volume alone. In this study w...

journal_title：Schizophrenia research

authors： Scanlon C,Anderson-Schmidt H,Kilmartin L,McInerney S,Kenney J,McFarland J,Waldron M,Ambati S,Fullard A,Logan S,Hallahan B,Barker GJ,Elliott MA,McCarthy P,Cannon DM,McDonald C

更新日期：2014-10-01 00:00:00

abstract：:Jumping to conclusions and bias against disconfirmatory evidence are two cognitive biases common in people with psychotic-like experiences and psychosis. However, many participants show comprehension problems doing traditional tasks; new paradigms with additional applied scenarios are thus needed. A large MTurk commun...

journal_title：Schizophrenia research

authors： Scheunemann J,Gawęda Ł,Reininger KM,Jelinek L,Hildebrandt H,Moritz S

更新日期：2020-02-01 00:00:00

abstract：:Little is known about the impact of family history of psychosis on youth from community samples. To fill this gap, we compared youth with a first-degree relative with psychosis spectrum symptoms (i.e. family history of psychosis spectrum symptoms, FHPS) to youth without FHPS in a cross-sectional analysis of the Philad...

journal_title：Schizophrenia research

authors： Taylor JH,Asabere N,Calkins ME,Moore TM,Tang SX,Xavier RM,Merikangas AK,Wolf DH,Almasy L,Gur RC,Gur RE

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Cognitive deficits are prominent in schizophrenia and represent promising endophenotypes for genetic research. METHODS:The current study investigated the importance of two conceptually distinct genetic aggregates, one based on copy number variations (uncommon deletion burden), and one based on single nucleo...

journal_title：Schizophrenia research

authors： Yeo RA,Gangestad SW,Walton E,Ehrlich S,Pommy J,Turner JA,Liu J,Mayer AR,Schulz SC,Ho BC,Bustillo JR,Wassink TH,Sponheim SR,Morrow EM,Calhoun VD

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:To develop a pharmacokinetic-pharmacodynamic (PK-PD) model using individual-level data of Positive and Negative Syndrome Scale (PANSS) total score to characterize the antipsychotic drug effect taking into account the placebo effect and dropout rate. In addition, a clinical utility (CU) criterion that describ...

journal_title：Schizophrenia research

authors： Pilla Reddy V,Kozielska M,Suleiman AA,Johnson M,Vermeulen A,Liu J,de Greef R,Groothuis GM,Danhof M,Proost JH

更新日期：2013-05-01 00:00:00