Switch and maintenance of task set in schizophrenia.

abstract：BACKGROUND:Executive Functioning (EF) is an important factor for community functioning for people with severe mental illness. Cognitive remediation programs often improve EF, but do so by using multiple therapeutic techniques. Little is known regarding how individual treatment elements promote cognitive improvement. Os...

journal_title：Schizophrenia research

authors： Best MW,Gale D,Tran T,Haque MK,Bowie CR

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Functional remission (FR) is an intermediate and necessary step toward recovery, but is understudied in first-episode psychosis (FEP). We aimed to examine the rate and predictors of FR in FEP patients in the context of a randomized-controlled trial (RCT) comparing a 1-year extension of early intervention (Ex...

journal_title：Schizophrenia research

authors： Chang WC,Kwong VW,Chan GH,Jim OT,Lau ES,Hui CL,Chan SK,Lee EH,Chen EY

更新日期：2016-05-01 00:00:00

abstract：:A disturbance of "minimal self," - of the immediate sense of mine-ness inherent in experience-is hypothesized to be the core disturbance in schizophrenia. Research with the Examination of Anomalous Self Experience (EASE) has demonstrated the selective aggregation of anomalous self-experiences in the schizophrenia spec...

journal_title：Schizophrenia research

authors： Madeira L,Pienkos E,Filipe T,Melo M,Queiroz G,Eira J,Costa C,Figueira ML,Sass L

更新日期：2019-09-01 00:00:00

abstract：:We tested the hypothesis that the expression of schizophrenic psychopathology is dependent on the stage of adolescent development. The study had a retrospective design, using high-quality case-note material of cases of schizophrenia at first admission. Patients with onset of illness between the age of 11 and 21 years ...

journal_title：Schizophrenia research

authors： Galdos P,van Os J

更新日期：1995-01-01 00:00:00

abstract：:To clarify the molecular mechanism of phencyclidine (PCP)-induced schizophreniform psychosis in humans and of behavioral abnormalities in experimental animals, we used differential screening of a cDNA library from the cerebral cortex of rats treated with PCP. We identified a PCP-induced cDNA clone as the gene encoding...

journal_title：Schizophrenia research

authors： Shimizu E,Shirasawa H,Kodama K,Kuroyanagi H,Shirasawa T,Sato T,Simizu B

更新日期：1997-06-20 00:00:00

abstract：OBJECTIVE:While "dual diagnosis" involving both psychiatric and substance use disorders has long been a focus of schizophrenia research, recent studies have advocated for a shift of focus to multimorbidity, addressing comorbidity from both additional psychiatric disorders and substance use disorders. We hypothesized th...

journal_title：Schizophrenia research

authors： Bhalla IP,Stefanovics EA,Rosenheck RA

更新日期：2018-11-01 00:00:00

abstract：INTRODUCTION:Emotion perception (EP) is impaired in schizophrenia, is stable across clinical state, resistant to antipsychotic treatment and linked to symptom severity. Given its pervasive nature, there is a need to quantitatively examine whether this dysfunction impacts functional outcomes. We used a meta-analytic str...

journal_title：Schizophrenia research

authors： Irani F,Seligman S,Kamath V,Kohler C,Gur RC

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Project produced a battery of tests, the MATRICS Consensus Cognitive Battery (MCCB), designed to assess cognitive treatment effects in clinical trials of patients with schizophrenia. In validation studies, the MCCB demonstr...

journal_title：Schizophrenia research

authors： Keefe RS,Fox KH,Harvey PD,Cucchiaro J,Siu C,Loebel A

更新日期：2011-02-01 00:00:00

abstract：:Schizophrenia is associated with poor quality of life (QOL). Whereas the effects of neurocognitive deficits and psychopathology on QOL of schizophrenia patients have recently been elucidated, little is known about social cognitive deficits in this regard. This study investigated the influence of social cognition on QO...

journal_title：Schizophrenia research

authors： Maat A,Fett AK,Derks E,GROUP Investigators.

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Targeting glutamatergic dysfunction provides an exciting opportunity to improve cognitive impairment in schizophrenia. One treatment approach has targeted inadequate antioxidant defenses at glutamatergic synapses. Animal and human data suggest NMDA antagonists worsen executive cognitive controls--e.g. increa...

journal_title：Schizophrenia research

authors： Chengappa KN,Turkin SR,DeSanti S,Bowie CR,Brar JS,Schlicht PJ,Murphy SL,Hetrick ML,Bilder R,Fleet D

更新日期：2012-12-01 00:00:00

abstract：:Phencyclidine (PCP), ketamine and other N-methyl-D-aspartate (NMDA) antagonists induce schizophrenia-like symptoms in normal volunteers, suggesting that endogenous dysfunction or dysregulation of NMDA receptors may contribute to the pathophysiology of schizophrenia. Glycine and D-cycloserine are potential treatments f...

journal_title：Schizophrenia research

authors： Heresco-Levy U,Javitt DC

更新日期：2004-02-01 00:00:00

abstract：:Thirty-six subjects aged 16 years or older judged at risk for a first episode of psychosis within a North American multi-site study of the schizophrenia prodrome [McGlashan et al., Schizophr. Res. (2003); Miller et al., Schizophr. Res. (2003)] performed at levels intermediate to population norms and data reported for ...

journal_title：Schizophrenia research

authors： Hawkins KA,Addington J,Keefe RS,Christensen B,Perkins DO,Zipurksy R,Woods SW,Miller TJ,Marquez E,Breier A,McGlashan TH

更新日期：2004-04-01 00:00:00

abstract：:In recent years, early intervention services have attempted to identify people with a first episode of psychosis as early as possible, reducing the duration of untreated psychosis and changing the timing of delivery of interventions. The logic of early intervention is based partly on accessing people in a more treatme...

journal_title：Schizophrenia research

authors： Francey SM,Nelson B,Thompson A,Parker AG,Kerr M,Macneil C,Fraser R,Hughes F,Crisp K,Harrigan S,Wood SJ,Berk M,McGorry PD

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:Self-rated attenuated psychotic-like experiences (APLEs) are increasingly used to screen for ultra-high-risk (UHR) across all ages. However, self-rated psychotic-like experiences (PLEs), in particular perception-related ones, were more frequent in children and adolescents, in which they possessed less clinica...

journal_title：Schizophrenia research

authors： Brandizzi M,Schultze-Lutter F,Masillo A,Lanna A,Curto M,Lindau JF,Solfanelli A,Listanti G,Patanè M,Kotzalidis G,Gebhardt E,Meyer N,Di Pietro D,Leccisi D,Girardi P,Fiori Nastro P

更新日期：2014-12-01 00:00:00

abstract：:Early intervention strategies in psychosis would significantly benefit from the identification of reliable prognostic biomarkers. Pattern classification methods have shown the feasibility of an early diagnosis of psychosis onset both in clinical and familial high-risk populations. Here we were interested in replicatin...

journal_title：Schizophrenia research

authors： Zarogianni E,Storkey AJ,Borgwardt S,Smieskova R,Studerus E,Riecher-Rössler A,Lawrie SM

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Schizophrenia is a disabling complex mental disorder and despite all available treatment, many patients unfortunately remain partial- or non-responders. A large body of research has shown that oxytocin is an important prosocial peptide and there is initial evidence that the central oxytocin system is altered...

journal_title：Schizophrenia research

authors： Dagani J,Sisti D,Abelli M,Di Paolo L,Pini S,Raimondi S,Rocchi MB,Saviotti FM,Scocco P,Totaro S,Balestrieri M,de Girolamo G

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:Following encouraging results in the early detection of psychotic disorders, interest in the early detection of affective, especially bipolar disorders, has recently been renewed. However, the differentiation between affective disorders with and without psychotic features is often missing, although it has bee...

journal_title：Schizophrenia research

authors： Schultze-Lutter F,Schimmelmann BG,Klosterkötter J,Ruhrmann S

更新日期：2012-07-01 00:00:00

abstract：:The 24-h profiles of plasma melatonin and cortisol were evaluated in 7 drug-free male paranoid schizophrenics and in 7 healthy subjects matched to the patients for age, sex, body weight, height and season of testing. Blood samples were obtained at 20.00, 22.00, 24.00, 01.00, 02.00, 06.00, 08.00 and 12.00 h. Light was ...

journal_title：Schizophrenia research

authors： Monteleone P,Maj M,Fusco M,Kemali D,Reiter RJ

更新日期：1992-04-01 00:00:00

abstract：:This study reports findings of the Edinburgh High Risk Study four years after it began. This study is designed to explore the pathogenesis of schizophrenia by examining a large sample of young adults aged 16-25 years who are at enhanced risk of developing schizophrenia by having two close relatives with the disorder, ...

journal_title：Schizophrenia research

authors： Johnstone EC,Abukmeil SS,Byrne M,Clafferty R,Grant E,Hodges A,Lawrie SM,Owens DG

更新日期：2000-11-30 00:00:00

abstract：:Recent preclinical and clinical evidence suggests that the stearoyl-CoA desaturase-1 (Scd1) enzyme plays a key role in the regulation of triglyceride (TG) biosynthesis and insulin sensitivity, and in vitro studies have found that antipsychotic medications up-regulate Scd1 mRNA expression. To investigate these effects ...

journal_title：Schizophrenia research

authors： McNamara RK,Jandacek R,Rider T,Tso P,Cole-Strauss A,Lipton JW

更新日期：2011-06-01 00:00:00

abstract：:Around 1 in 5 children under 13 years old experience sub-clinical psychotic experiences (PEs) like hallucinations and delusions. While PEs in childhood are a significant risk factor for adult psychotic disorders, the majority of those experiencing childhood PEs do not develop a psychotic disorder. Individual differenc...

journal_title：Schizophrenia research

authors： Dooley N,O'Hanlon E,Healy C,Adair A,McCandless C,Coppinger D,Kelleher I,Clarke M,Leemans A,Frodl T,Cannon M

更新日期：2020-01-01 00:00:00

abstract：:We examined the fractionation of executive functioning performance in ninety patients with schizophrenia, who were tested for initiation, sustained attention, switching/flexibility, attention allocation and impulsivity/disinhibition. The participants were also given tests of general intelligence and memory. We analyse...

journal_title：Schizophrenia research

authors： Chan RC,Chen EY,Cheung EF,Chen RY,Cheung HK

更新日期：2006-01-31 00:00:00

abstract：BACKGROUND:Many patients recovering from a first psychotic episode will discontinue medication against medical advice, even before a 1-year treatment course is completed. Factors associated with treatment adherence in patients with chronic schizophrenia include beliefs about severity of illness and need for treatment, ...

journal_title：Schizophrenia research

authors： Perkins DO,Johnson JL,Hamer RM,Zipursky RB,Keefe RS,Centorrhino F,Green AI,Glick IB,Kahn RS,Sharma T,Tohen M,McEvoy JP,Weiden PJ,Lieberman JA,HGDH Research Group.

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:The excitatory neurotransmitter glutamate has become an important area of focus for schizophrenia researchers. Polymorphisms in the type-three metabotropic glutamate receptor gene (GRM3) have been associated with the pathogenesis of schizophrenia. The purpose of this study was to determine whether a pharmacogen...

journal_title：Schizophrenia research

authors： Bishop JR,Ellingrod VL,Moline J,Miller D

更新日期：2005-09-15 00:00:00

abstract：:The number of psychiatric beds has declined considerably in many countries over the past decades. Long-term studies on the impact of these health care changes for the severely mentally ill, however, are still scarce. This epidemiological study investigates the use of inpatient psychiatric services by people with schiz...

journal_title：Schizophrenia research

authors： Lay B,Nordt C,Rössler W

更新日期：2007-12-01 00:00:00

abstract：:Variable levels of essential polyunsaturated fatty acids (EPUFAs) reported in schizophrenia are likely due to differences in age, sex, ethnicity, diet, life style and treatments. The present study examined the EPUFAs levels in plasma, RBC and CSF in never-medicated first-episode psychotic patients and normal controls ...

journal_title：Schizophrenia research

authors： Kale A,Joshi S,Naphade N,Sapkale S,Raju MS,Pillai A,Nasrallah H,Mahadik SP

更新日期：2008-01-01 00:00:00

abstract：:Diffusion Tensor Imaging (DTI) investigations in schizophrenia have provided evidence of impairment in white matter as indicated by reduced fractional anisotropy (FA). However, the neuropathological implications of these findings remain unclear. In the current study, we conducted a voxelwise analysis of the constituen...

journal_title：Schizophrenia research

authors： Seal ML,Yücel M,Fornito A,Wood SJ,Harrison BJ,Walterfang M,Pell GS,Pantelis C

更新日期：2008-04-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs that mainly function as negative regulators of gene expression (Lai, 2002) and have been shown to be involved in schizophrenia etiology through genetic and expression studies (Burmistrova et al., 2007; Hansen et al., 2007a; Perkins et al., 2007; Beveridge et al., 2010; Kim ...

journal_title：Schizophrenia research

authors： Kim AH,Parker EK,Williamson V,McMichael GO,Fanous AH,Vladimirov VI

更新日期：2012-10-01 00:00:00

abstract：:Dopamine's proposed role in psychosis proved a starting point in our understanding of the neurobiology of relapse, fitting given the central role positive symptoms play. This link is reflected in early work examining neurotransmitter metabolite and drug (e.g. amphetamine, methylphenidate) challenge studies as a means ...

journal_title：Schizophrenia research

authors： Remington G,Foussias G,Agid O,Fervaha G,Takeuchi H,Hahn M

更新日期：2014-02-01 00:00:00

abstract：:Elevated serum levels of Interleukin-3 (IL-3), a major component of the cytokines, have been observed in chronic and medicated patients with schizophrenia, but this elevation may reflect either or both medication and illness chronicity effects. Thus, we compared serum IL-3 levels in first-episode drug-naive (FEDN) to ...

journal_title：Schizophrenia research

authors： Fu YY,Zhang T,Xiu MH,Tang W,Han M,Yun LT,Chen DC,Chen S,Tan SP,Soares JC,Tang WJ,Zhang XY

更新日期：2016-10-01 00:00:00