Transient and executive function working memory in schizophrenia.

Abstract:

:Transient working memory requires attention and temporary storage of information, whereas executive function working memory requires additional mental manipulation of that information. Working memory impairment is common in schizophrenia patients, but only some studies have found differential impairment in executive function working memory compared to transient working memory. We measured both types of working memory using the Digit Span forward (DF) and backward (DB) tasks in a large sample of schizophrenia patients (n=267) and normal comparison subjects (n=82); in the patients, we also examined associations between performance on the Digit Span tasks and Letter-Number Sequencing (LNS), a putative executive function working memory test. Compared to healthy subjects, the schizophrenia patients showed impairment in the medium effect size range on both DF (d=-0.55) and DB (d=-0.68). DB scores predicted LNS performance, whereas DF scores did not. Worse negative symptoms were associated with worse performance on DF, DB and LNS. These results do not reflect differential executive function working memory dysfunction in schizophrenia, but appear to support transient and executive function working memory as separable constructs.

journal_name

Schizophr Res

journal_title

Schizophrenia research

authors

Twamley EW,Palmer BW,Jeste DV,Taylor MJ,Heaton RK

doi

10.1016/j.schres.2006.04.013

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

185-90

issue

1-3

eissn

0920-9964

issn

1573-2509

pii

S0920-9964(06)00200-3

journal_volume

87

pub_type

杂志文章
  • Differential patterns of premorbid social and academic deterioration in deficit and nondeficit schizophrenia.

    abstract::Numerous studies indicate that social dysfunction is associated with negative symptoms of schizophrenia during the chronic phase of illness. However, it is unclear whether social abnormalities exist during the premorbid phase in people who later develop schizophrenia with prominent negative symptoms, or whether social...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2011.11.007

    authors: Strauss GP,Allen DN,Miski P,Buchanan RW,Kirkpatrick B,Carpenter WT Jr

    更新日期:2012-03-01 00:00:00

  • Elevated GRIA1 mRNA expression in Layer II/III and V pyramidal cells of the DLPFC in schizophrenia.

    abstract::The functional integrity of the dorsolateral prefrontal cortex (DLPFC) is altered in schizophrenia leading to profound deficits in working memory and cognition. Growing evidence indicates that dysregulation of glutamate signaling may be a significant contributor to the pathophysiology mediating these effects; however,...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2007.09.022

    authors: O'Connor JA,Hemby SE

    更新日期:2007-12-01 00:00:00

  • Sexual dimorphism of the cerebellar vermis in schizophrenia.

    abstract::Converging lines of evidence implicate structural and functional abnormalities in the cerebellum in schizophrenia (SCZ). The cerebellar vermis is of particular interest given its association with clinical symptoms and cognitive deficits in SCZ and its known connections with cortical regions such as the prefrontal cort...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2016.06.028

    authors: Womer FY,Tang Y,Harms MP,Bai C,Chang M,Jiang X,Wei S,Wang F,Barch DM

    更新日期:2016-10-01 00:00:00

  • A dimensional comparison between delusional disorder, schizophrenia and schizoaffective disorder.

    abstract:INTRODUCTION:Since the early description of paranoia, the nosology of delusional disorder has always been controversial. The old idea of unitary psychosis has now gained some renewed value from the dimensional continuum model of psychotic symptoms. AIMS:1. To study the psychopathological dimensions of the psychosis sp...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2015.10.039

    authors: Muñoz-Negro JE,Ibanez-Casas I,de Portugal E,Ochoa S,Dolz M,Haro JM,Ruiz-Veguilla M,de Dios Luna Del Castillo J,Cervilla JA

    更新日期:2015-12-01 00:00:00

  • Developing models of how cognitive improvements change functioning: mediation, moderation and moderated mediation.

    abstract:BACKGROUND:Cognitive remediation (CRT) affects functioning but the extent and type of cognitive improvements necessary are unknown. AIM:To develop and test models of how cognitive improvement transfers to work behaviour using the data from a current service. METHOD:Participants (N49) with a support worker and a paid ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2012.03.020

    authors: Wykes T,Reeder C,Huddy V,Taylor R,Wood H,Ghirasim N,Kontis D,Landau S

    更新日期:2012-06-01 00:00:00

  • Effects of cannabis use on age at onset in schizophrenia and bipolar disorder.

    abstract:BACKGROUND:Cannabis use may decrease age at onset in both schizophrenia and bipolar disorder, given the evidence for substantial phenotypic and genetic overlap between both disorders. METHODS:766 patients, aged 16 to 65 years, were assessed with the Composite International Diagnostic Interview (CIDI) for substance abu...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2010.07.003

    authors: De Hert M,Wampers M,Jendricko T,Franic T,Vidovic D,De Vriendt N,Sweers K,Peuskens J,van Winkel R

    更新日期:2011-03-01 00:00:00

  • Caregiving processes and expressed emotion in psychosis, a cross-cultural, meta-analytic review.

    abstract::The construct of Expressed Emotion (EE) is a reliable predictor of relapse in psychotic disorders globally. However, cultural differences in the level and manifestation of EE have been reported. This review was conducted in line with PRISMA guidelines to demonstrate the distribution of EE and its domains cross-cultura...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.schres.2019.03.020

    authors: O'Driscoll C,Sener SB,Angmark A,Shaikh M

    更新日期:2019-06-01 00:00:00

  • Insight and white matter fractional anisotropy in first-episode schizophrenia.

    abstract::Impaired insight is a hallmark feature of schizophrenia. Structural studies implicate predominantly prefrontal, cingulate, cuneus/precuneus, and inferior temporal brain regions. The cortical midline structures (CMS) are also implicated in functional studies primarily through self-reflective processing tasks. However, ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2016.11.005

    authors: Asmal L,du Plessis S,Vink M,Fouche JP,Chiliza B,Emsley R

    更新日期:2017-05-01 00:00:00

  • Longitudinal investigation of the relationship between family history of psychosis and affective disorders and Child Behavior Checklist ratings in clinical high-risk adolescents.

    abstract::This is the first study to investigate whether positive family history (FH) of psychosis and affective disorders moderates the relationship between child diagnostic status and parent-reported social and behavioral problems on the Child Behavior Checklist (CBCL) in clinical high-risk adolescents. This longitudinal inve...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2015.04.027

    authors: Simeonova DI,Lee FJ,Walker EF

    更新日期:2015-08-01 00:00:00

  • High functioning individuals with schizophrenia have preserved social perception but not mentalizing abilities.

    abstract::Social perception and mentalizing are fundamental social cognitive abilities that are related to functioning and are impaired in schizophrenia. A novel approach to examine the relationship between social cognition and community functioning is to first functionally categorize individuals with schizophrenia and then eva...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2016.01.029

    authors: Karpouzian TM,Alden EC,Reilly JL,Smith MJ

    更新日期:2016-03-01 00:00:00

  • Amoxapine shows atypical antipsychotic effects in patients with schizophrenia: results from a prospective open-label study.

    abstract:OBJECTIVE:Amoxapine is marketed as an antidepressant. However, its receptor occupancy, in vitro and in vivo, and its effects in pre-clinical models are very similar to atypical antipsychotics. To examine if this leads to an atypical antipsychotic effect in the clinical context, the authors examined the antipsychotic an...

    journal_title:Schizophrenia research

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0920-9964(01)00342-5

    authors: Apiquian R,Ulloa E,Fresan A,Loyzaga C,Nicolini H,Kapur S

    更新日期:2003-01-01 00:00:00

  • Identification of antibodies to heat shock proteins 90 kDa and 70 kDa in patients with schizophrenia.

    abstract:OBJECTIVES:Recent reports of antibodies to heat shock proteins 60kDa (HSP60) and HSP70 suggested that antibodies to the heat shock protein that plays a protective role against environmental stresses in a cell might be related to the pathogenesis of schizophrenia, although the antibody to HSP90 had not yet been identifi...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/s0920-9964(00)00091-8

    authors: Kim JJ,Lee SJ,Toh KY,Lee CU,Lee C,Paik IH

    更新日期:2001-10-01 00:00:00

  • The Measure of Insight into Cognition: reliability and validity of clinician-rated and self-report scales of neurocognitive insight for schizophrenia.

    abstract::Poor insight into the neurocognitive deficits in schizophrenia-spectrum disorders may have significant clinical implications for treatment. The purpose of this study was to replicate and extend the psychometric findings initially reported on the Measure of Insight into Cognition Clinician-Rated (MIC-CR) and Self-Repor...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2011.10.002

    authors: Saperstein AM,Thysen J,Medalia A

    更新日期:2012-01-01 00:00:00

  • Cytokines in cerebrospinal fluid of patients with schizophrenia spectrum disorders: New data and an updated meta-analysis.

    abstract::Few studies have been conducted examining cytokines in cerebrospinal fluid of patients compared to healthy volunteers. The goals of this study were: 1) to report original data detailing cytokine levels in the cerebrospinal fluid (CSF) of 10 patients with a schizophrenia spectrum disorder (SSD) diagnosis and 10 healthy...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.schres.2018.07.019

    authors: Gallego JA,Blanco EA,Husain-Krautter S,Madeline Fagen E,Moreno-Merino P,Del Ojo-Jiménez JA,Ahmed A,Rothstein TL,Lencz T,Malhotra AK

    更新日期:2018-12-01 00:00:00

  • Prefrontal cortical sulcal widening associated with poor treatment response to clozapine.

    abstract::Increased sulcal widening in the prefrontal cortex of patients with schizophrenia may be associated with a poor treatment response to clozapine. To further evaluate this, we examined data from patients treated with clozapine in our center. Patients with the greatest degree of improvement (n=26) and those with no impro...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/s0920-9964(00)00130-4

    authors: Konicki PE,Kwon KY,Steele V,White J,Fuller M,Jurjus GJ,Jaskiw GE

    更新日期:2001-03-30 00:00:00

  • Increased resting-state global functional connectivity density of default mode network in schizophrenia subjects treated with electroconvulsive therapy.

    abstract::Modified electroconvulsive therapy (MECT) has been widely applied to help treat schizophrenia patients who are treatment-resistant to pharmaceutical therapy. Although the technique is increasingly prevalent, the underlying neural mechanisms have not been well clarified. We conducted a longitudinal study to investigate...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2017.10.044

    authors: Huang H,Jiang Y,Xia M,Tang Y,Zhang T,Cui H,Wang J,Li Y,Xu L,Curtin A,Sheng J,Jia Y,Yao D,Li C,Luo C,Wang J

    更新日期:2018-07-01 00:00:00

  • Schizophrenic delusions: the detection of warning signals.

    abstract::Schizophrenic delusions are important target symptoms for treatment. This study aims to identify predictors of delusion formation. Two samples of schizophrenic patients (total n = 131) are examined prospectively every second week during a period of 6 months. In one sample (n = 60) delusion formation (n = 27; 45%) is c...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/s0920-9964(98)00033-4

    authors: Jørgensen P

    更新日期:1998-06-22 00:00:00

  • N-acetylaspartate reductions in the mediodorsal and anterior thalamus in men with schizophrenia verified by tissue volume corrected proton MRSI.

    abstract:OBJECTIVE:Deficits in the mediodorsal and anterior nuclei of the thalamus may contribute to the psychopathological symptoms of schizophrenia. These thalamic nuclei have been found to be abnormal in schizophrenia and have close connections with other brain structures implicated in the disorder. We therefore examined sch...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2005.02.012

    authors: Jakary A,Vinogradov S,Feiwell R,Deicken RF

    更新日期:2005-07-15 00:00:00

  • Testing a modification of cognitive adaptation training: streamlining the model for broader implementation.

    abstract::Cognitive adaptation training (CAT) is a home-based, manualized treatment that utilizes environmental supports to improve target behaviors and functional outcomes in persons with schizophrenia. Although clinical trials have shown CAT to be effective across functional, clinical, and treatment adherence domains, when th...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.schres.2014.03.026

    authors: Kidd SA,Herman Y,Barbic S,Ganguli R,George TP,Hassan S,McKenzie K,Maples N,Velligan D

    更新日期:2014-06-01 00:00:00

  • Cognitive decline in schizophrenia from childhood to midlife: a 33-year longitudinal birth cohort study.

    abstract:BACKGROUND:We examined cognitive deficits before and after onset of schizophrenia in a longitudinal study that: 1) covers a long time interval; 2) minimizes test unreliability by including the identical measure at both childhood and post-onset cognitive assessments; and 3) minimizes bias by utilizing a population-based...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2010.01.009

    authors: Kremen WS,Vinogradov S,Poole JH,Schaefer CA,Deicken RF,Factor-Litvak P,Brown AS

    更新日期:2010-05-01 00:00:00

  • Pronounced prefronto-temporal cortical thinning in schizophrenia: Neuroanatomical correlate of suicidal behavior?

    abstract::Schizophrenia is characterized by increased mortality for which suicidality is the decisive factor. An analysis of cortical thickness and folding to further elucidate neuroanatomical correlates of suicidality in schizophrenia has not yet been performed. We searched for relevant brain regions with such differences betw...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2016.08.010

    authors: Besteher B,Wagner G,Koch K,Schachtzabel C,Reichenbach JR,Schlösser R,Sauer H,Schultz CC

    更新日期:2016-10-01 00:00:00

  • Behavioral sequelae of astrocyte dysfunction: focus on animal models of schizophrenia.

    abstract::Astrocytes regulate multiple processes in the brain ranging from trophic support of developing neurons to modulation of synaptic neurotransmission and neuroinflammation in adulthood. It is, therefore, understandable that pathogenesis and pathophysiology of major psychiatric disorders involve astrocyte dysfunctions. Un...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,评审

    doi:10.1016/j.schres.2014.10.044

    authors: Xia M,Abazyan S,Jouroukhin Y,Pletnikov M

    更新日期:2016-09-01 00:00:00

  • Time-based but not event-based prospective memory remains impaired one year after the onset of schizophrenia: A prospective study.

    abstract:BACKGROUND:Prospective memory (PM) deficits have been consistently found in people with schizophrenia. Although there is evidence to suggest that PM deficits may be putative markers for schizophrenia, no longitudinal study has investigated the persistence of PM deficits. AIMS:We examined whether PM deficits persist af...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2015.09.015

    authors: Cheung EFC,Lui SSY,Wang Y,Yang TX,Shum DHK,Chan RCK

    更新日期:2015-12-01 00:00:00

  • Quantitative assessment of the frequency of normal associations in the utterances of schizophrenia patients and healthy controls.

    abstract:BACKGROUND:The intrusion of associations into the utterances of schizophrenic individuals typically disrupts the coherence of the patient's utterances. Recent theoretical formulations of these phenomena have emphasized the hyperactivity) of associational networks in such language disturbance (e.g., Maher, B.A. 2003 Sch...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2005.05.017

    authors: Maher BA,Manschreck TC,Linnet J,Candela S

    更新日期:2005-10-15 00:00:00

  • Treatment of rats with antipsychotic drugs: lack of an effect on brain N-acetyl aspartate levels.

    abstract:BACKGROUND:Proton magnetic resonance spectroscopy (1H-MRS) studies of schizophrenia suggest an effect of the disease or of antipsychotic medications on brain N-acetyl aspartate (NAA), a marker of neuronal viability. We studied in the rat the effect of antipsychotic drugs on NAA in several brain regions where NAA reduct...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/s0920-9964(02)00528-5

    authors: Bustillo J,Wolff C,Myers-y-Gutierrez A,Dettmer TS,Cooper TB,Allan A,Lauriello J,Valenzuela CF

    更新日期:2004-01-01 00:00:00

  • Differential relationship between neurological and cognitive dysfunction in first episode psychosis patients and in healthy individuals.

    abstract::The minor neurological and cognitive deficits consistently reported in psychoses may reflect the same underlying brain dysfunction. Still, even in healthy individuals minor neurological abnormalities are associated with worse cognitive function. Therefore, establishing which neurological and cognitive deficits are spe...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2012.09.016

    authors: Mellacqua Z,Eyeson J,Orr KD,Morgan KD,Zanelli J,Lloyd T,Morgan C,Fearon P,Hutchinson G,Doody GA,Chan RC,Harrison G,Jones PB,Murray RM,Reichenberg A,Dazzan P

    更新日期:2012-12-01 00:00:00

  • Gender differences in living with schizophrenia. A cross-sectional European multi-site study.

    abstract::The EPSILON project (European Psychistric Services: Inputs Linked to Outcomes and Needs) is a cross-sectional study of the clinical and social characteristics, needs, satisfaction with services, quality of life, and service utilisation and costs for people with schizophrenia in five European sites (Amsterdam, Copenhag...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,多中心研究

    doi:10.1016/s0920-9964(01)00318-8

    authors: Thornicroft G,Leese M,Tansella M,Howard L,Toulmin H,Herran A,Schene A

    更新日期:2002-10-01 00:00:00

  • No association of complexin1 and complexin2 genes with schizophrenia in a Japanese population.

    abstract::Several investigations suggest that complexin may be a schizophrenia-susceptibility factor. We conducted a genetic association analysis between complexin genes (CPLX1 and CPLX2) and schizophrenia in Japanese patients (377 cases and 341 controls). Ten and eleven haplotype-tagging (ht)SNPs in CPLX1 and CPLX2, respective...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2005.12.842

    authors: Kishi T,Ikeda M,Suzuki T,Kitajima T,Yamanouchi Y,Kinoshita Y,Ozaki N,Iwata N

    更新日期:2006-02-28 00:00:00

  • Does a parent-report measure of behavioral problems enhance prediction of conversion to psychosis in clinical high-risk adolescents?

    abstract::Recent research on risk for psychosis has focused on youth who manifest subclinical signs that are often associated with the prodrome to psychosis. Standardized measures of prodromal symptoms have been shown to significantly enhance prediction of risk for conversion to an Axis I psychotic disorder. In the present stud...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2011.03.034

    authors: Simeonova DI,Attalla A,Trotman H,Esterberg M,Walker EF

    更新日期:2011-08-01 00:00:00

  • Attention deficits in schizophrenia--preliminary evidence of dissociable transient and sustained deficits.

    abstract::Attention deficits are considered to be fundamental in patients with schizophrenia. During attention tasks, patients with schizophrenia have been shown to display increased brain activity in some neuroimaging studies but reduced brain activity in others. These conflicting findings may be due to some study designs prim...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2010.03.019

    authors: Carter JD,Bizzell J,Kim C,Bellion C,Carpenter KL,Dichter G,Belger A

    更新日期:2010-09-01 00:00:00