Abstract:
:The present study determined the minimal exposure time (i.e., critical stimulus duration (CSD) necessary for feature registration and recognition by normals and chronic schizophrenics. Our interest was whether the longer exposure times required by schizophrenics than by normals could be attributed to an inability of schizophrenics to maintain attention when the task criteria were stringent as opposed to 'loose'. The present findings support previous findings of impaired feature recognition by chronic schizophrenics. Chronic schizophrenics' and normals' CSDs were not affected by task criterion. The consistent performance by these groups on the 'loose' and 'rigid' task criteria suggest that if attentional lapses occur then they are as likely to occur for chronic schizophrenics as for normals and they are independent of the task's criterion. It is concluded that impaired feature registration for chronic schizophrenics is a consequence of a deficit at the earliest stage of encoding.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Schwartz BD,Evans WJ,Sautter F,Winstead DKdoi
10.1016/0920-9964(92)90049-bsubject
Has Abstractpub_date
1992-07-01 00:00:00pages
185-9issue
2eissn
0920-9964issn
1573-2509pii
0920-9964(92)90049-Bjournal_volume
7pub_type
杂志文章abstract::Patients with schizophrenia did not take significantly more trials than normal controls to learn to use a visual warning signal to avoid a non-aversive stimulus on a simple computer-administered avoidance learning task. When the stimulus to be avoided was aversive (i.e., a loud buzzer), however, the schizophrenic grou...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(98)00181-9
更新日期:1999-07-27 00:00:00
abstract:BACKGROUND:All currently available antipsychotic medications bind to both the dopamine-2 (D2) and dopamine-3 (D3) receptors in vitro. However, there is conflicting evidence from in vivo studies about whether or not antipsychotic medications bind to the D3 receptor (D3R). The purpose of this study was to determine wheth...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.06.027
更新日期:2015-10-01 00:00:00
abstract::Schizophrenia is a heterogeneous spectrum disorder often associated with detrimental negative symptoms. In recent years, computational approaches to psychiatry have attracted growing attention. Negative symptoms have shown some overlap with general cognitive impairments and were also linked to impaired motivational pr...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2016.10.004
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:We aimed to examine the association between illicit substance use and age at onset in psychotic disorders in an Australian cohort. METHODS:Retrospectively acquired information on substance use during the year prior to illness onset was collected from 1642 participants enrolled in the Australian National 201...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.04.003
更新日期:2014-07-01 00:00:00
abstract::A literature review and power analysis of longitudinal studies published since 1997 investigating the trajectory of neurocognitive deficits across time in patients with schizophrenia was conducted. Ten studies were identified, evaluating a total of 834 patients with mean ages of 24.0-77.8 years at study entry. Power e...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2004.07.005
更新日期:2005-04-01 00:00:00
abstract::Large studies investigating the psychosocial effects of lifestyle interventions in patients with a severe mental illness (SMI) are scarce, especially in residential patients. This large, randomized controlled, multicentre pragmatic trial assessed the psychosocial effects of a combined diet-and-exercise lifestyle inter...
journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.schres.2018.02.053
更新日期:2018-09-01 00:00:00
abstract::Healthy siblings of schizophrenia patients have an almost 9-fold higher risk for developing the illness than the general population. Disruption of white matter (WM) integrity as indicated by reduced fractional anisotropy (FA) derived from diffusion tensor imaging (DTI), is believed to be the key substrate of schizophr...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.07.001
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Targeting glutamatergic dysfunction provides an exciting opportunity to improve cognitive impairment in schizophrenia. One treatment approach has targeted inadequate antioxidant defenses at glutamatergic synapses. Animal and human data suggest NMDA antagonists worsen executive cognitive controls--e.g. increa...
journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.schres.2012.10.001
更新日期:2012-12-01 00:00:00
abstract::Abnormality of P300 waveforms of event-related potentials (ERPs) has been suggested to represent an aspect of the pathophysiology of schizophrenia. Previous work points to the contribution of altered neural function in discrete brain regions in the left hemisphere to psychotic symptoms and cognitive deficits of schizo...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.01.020
更新日期:2008-04-01 00:00:00
abstract::Vulnerability-stress models suggest that training in specific stress management techniques should yield benefits to those suffering from schizophrenia and related disorders. In this paper, we describe an evaluation of the impact of adding a stress management program to other medical and psychosocial interventions for ...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0920-9964(01)00371-1
更新日期:2002-12-01 00:00:00
abstract::We developed and validated a self-administered questionnaire (Subjective Quality of Life Analysis, S.QUA.L.A.) to measure subjective quality of life. S.QUA.L.A. is a multidimensional instrument. This scale includes 22 domains of life. It covers traditional areas (food, family relation etc)., and more abstract aspects ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2004.09.017
更新日期:2005-07-01 00:00:00
abstract::The memory profile of acute and chronic schizophrenic patients was examined according to the information processing model, with which encoding, retention and retrieval processes of these patients were compared. The effects of an external organizational strategy on their verbal learning and memory were also examined. T...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(99)00078-x
更新日期:2000-02-14 00:00:00
abstract::Early intervention strategies in psychosis would significantly benefit from the identification of reliable prognostic biomarkers. Pattern classification methods have shown the feasibility of an early diagnosis of psychosis onset both in clinical and familial high-risk populations. Here we were interested in replicatin...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.08.061
更新日期:2019-12-01 00:00:00
abstract::The study of the mechanisms involved in cognition is of paramount importance for the understanding of the neurobiological substrates in psychiatric disorders. Hence, this research is aimed at exploring the brain network dynamics during a cognitive task. Specifically, we analyze the predictive capability of the pre-sti...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.04.043
更新日期:2018-11-01 00:00:00
abstract::Previous studies have indicated that schizophrenic patients have olfactory deficits. The question as to whether olfactory deficits are due to chronic effects of medication has not been addressed. This is the first paper to report that never-medicated schizophrenic patients also have olfactory deficits. Twenty four nor...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/0920-9964(93)90008-7
更新日期:1993-03-01 00:00:00
abstract::Affect perception has frequently been shown to be impaired in patients suffering from schizophrenia or bipolar disorder (BD), but it remains unclear whether these impairments exist during symptomatic remission and whether the two disorders differ from each other in this regard. Most previous studies have investigated ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.07.019
更新日期:2014-09-01 00:00:00
abstract::Postmortem studies have suggested that there is abnormal GABAergic activity in the hippocampus in schizophrenia (SZ). In micro-dissected human hippocampal slices, a loss of interneurons and a compensatory upregulation of GABAA receptor binding activity on interneurons, but not PNs, has suggested that disinhibitory GAB...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2015.01.014
更新日期:2015-09-01 00:00:00
abstract::Affective impairments were examined in patients with and without deficit syndrome schizophrenia. Two Emotional Stroop tasks designed to measure automatic processing of emotional information were administered to deficit (n=15) and non-deficit syndrome (n=26) schizophrenia patients classified according to the Schedule f...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.01.014
更新日期:2008-07-01 00:00:00
abstract::There is controversy over whether the incidence rates of schizophrenia and psychotic disorders have changed in recent decades. To detect deviations from trends in incidence, we analysed admission data of patients with an ICD-8/9/10 diagnosis of psychotic disorders in the Canton Zurich / Switzerland, for the period 197...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.06.001
更新日期:2007-09-01 00:00:00
abstract::Meta-analyses of randomized controlled trials support the efficacy of cognitive behavioral therapy (CBT) in the treatment of symptoms of schizophrenia refractory to antipsychotic medication. This article addresses the issue of medium term durability. A five-year follow-up was undertaken of a sample of 90 subjects who ...
journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2007.09.026
更新日期:2008-01-01 00:00:00
abstract::The dopamine hypothesis of schizophrenia was formulated 30 years ago and postulates that the symptoms of schizophrenia are related to an increased central dopaminergic neurotransmission. The two fundamental assumptions that underlay the dopamine hypothesis of schizophrenia have received support from brain imaging stud...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(97)00121-7
更新日期:1997-12-19 00:00:00
abstract:BACKGROUND:The presence of a psychosis continuum is suggested by studies showing that schizophrenia and non-clinical psychotic symptoms in the general population share the same risk factors. However, to our knowledge no large-scale studies have been conducted which examine the specificity of these risk factors in the g...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.03.033
更新日期:2010-07-01 00:00:00
abstract::The goal of this study was to determine if family burden experienced by the families of individuals with a recent-onset of schizophrenia is associated with whether the individual is able to work or attend school during the first year of treatment. Forty-one participants with a recent first episode of schizophrenia and...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.06.068
更新日期:2018-12-01 00:00:00
abstract::Systematic linkage disequilibrium (LD) mapping of 8p12-21 in the Icelandic population identified neuregulin 1 (NRG1) as a prime candidate gene for schizophrenia. However, results of replication studies have been inconsistent, and no large sample analyses have been reported. Therefore, we designed this study with the a...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.01.010
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:Family studies have suggested that schizophrenia and bipolar disorders share some susceptibility factors. Schizotypal personality disorder (SPD) may be an intermediate phenotype common both to schizophrenia and bipolar disorders. We explored the familiality of schizotypal dimensions by comparing the magnitud...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2005.07.009
更新日期:2005-12-15 00:00:00
abstract:OBJECTIVE:Amoxapine is marketed as an antidepressant. However, its receptor occupancy, in vitro and in vivo, and its effects in pre-clinical models are very similar to atypical antipsychotics. To examine if this leads to an atypical antipsychotic effect in the clinical context, the authors examined the antipsychotic an...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章
doi:10.1016/s0920-9964(01)00342-5
更新日期:2003-01-01 00:00:00
abstract::Recovery from psychotic disorders includes both symptomatic and functional components. Progress in understanding recovery requires careful replication and extension of findings using comparable measures. In the current paper, we present a study of five year recovery rates in an early intervention program in London, Ca...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.08.054
更新日期:2018-05-01 00:00:00
abstract::Previous studies (including genome-wide association study (GWAS) and candidate gene studies) have revealed the important roles of genetic risk factors in schizophrenia, and RELN has been identified as a risk gene for this illness. We recently found that the low-density lipoprotein receptor-related protein 8 (LRP8), a ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.05.002
更新日期:2020-01-01 00:00:00
abstract::The current study sought to expand on prior reports of the validity and reliability of the CAINS (CAINS) by examining its performance across diverse non-academic clinical settings as employed by raters not affiliated with the scale's developers and across a longer test-retest follow-up period. The properties of the CA...
journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.schres.2017.01.011
更新日期:2017-07-01 00:00:00
abstract::Speech deficits, notably those involved in psychomotor retardation, blunted affect, alogia and poverty of content of speech, are pronounced in a wide range of serious mental illnesses (e.g., schizophrenia, unipolar depression, bipolar disorders). The present project evaluated the degree to which these deficits manifes...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.10.032
更新日期:2014-12-01 00:00:00