Abstract：
:Schizophrenia is a complex disorder that is diagnosed mainly with clinical observation and evaluation. Recent studies suggest that many people with schizophrenia have abnormalities in the function of the N-methyl-d-aspartate receptor (NMDAR). The retina is part of the central nervous system and expresses the NMDAR, raising the possibility of the early detection of NMDAR-related schizophrenia by detecting differences in retinal function. As a first-step, we used two non-invasive outpatient tests of retinal function, the photopic negative response (PhNR) of the light-adapted flash-electroretinogram (PhNR-fERG) and the pattern ERG (PERG), to test individuals with schizophrenia and controls to determine if there were measurable differences between the two populations. The PhNR-fERG showed that males with schizophrenia had a significant increase in the variability of the overall response, which was not seen in the females with schizophrenia. Additionally at the brightest flash strength, there were significant increases in the PhNR amplitude in people with schizophrenia that were maximal in controls. Our results show measurable dysfunction of retinal ganglion cells (RGCs) in schizophrenia using the PhNR-fERG, with a good deal of variability in the retinal responses of people with schizophrenia. The PhNR-fERG holds promise as a method to identify individuals more at risk for developing schizophrenia, and may help understand heterogeneity in etiology and response to treatment.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Moghimi P,Torres Jimenez N,McLoon LK,Netoff TI,Lee MS,MacDonald A 3rd,Miller RFdoi
10.1016/j.schres.2019.09.005subject
Has Abstractpub_date
2020-05-01 00:00:00pages
34-46eissn
0920-9964issn
1573-2509pii
S0920-9964(19)30414-1journal_volume
219pub_type
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journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.04.026
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journal_title：Schizophrenia research
pub_type： 杂志文章
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更新日期：2013-05-01 00:00:00
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更新日期：1988-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.schres.2014.07.044
更新日期：2014-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.schres.2014.10.034
更新日期：2015-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.schres.2006.08.015
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更新日期：2018-07-01 00:00:00
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