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Motor abnormalities and cognitive impairment in first-episode psychosis patients, their unaffected siblings and healthy controls.

Abstract：

:Motor abnormalities (MAs) may be already evidenced long before the beginning of illness and are highly prevalent in psychosis. However, the extent to which the whole range of MAs are related to cognitive impairment in psychosis remains understudied. This study aimed to examine comparatively the relationships between the whole range of motor abnormalities and cognitive impairments in the first-episode of psychosis (FEP), their unaffected siblings and healthy control subjects. Fifty FEP patients, 21 of their healthy siblings and 24 age- and sex matched healthy controls were included. Motor assessment included catatonic, extrapyramidal and neurological soft signs (NSS) by means of standardized instruments. An exhaustive neuropsychological battery was also performed to extract the 7 cognitive dimensions of MATRICS initiative. Higher scores on NSS but not on extrapyramidal and catatonic signs showed significant associations with worse cognitive performance in the three study groups. However, the pattern of associations regarding specific cognitive functions was different among the three groups. Moreover, extrapyramidal signs showed significant associations with cognitive impairment only in FEP patients but not in their unaffected siblings and healthy controls. Catatonic signs did not show any significant association with cognitive functioning in the three study groups. These findings add evidence to the associations between motor abnormalities, particularly NSS and extrapyramidal signs, and cognitive impairment in first-episode psychosis patients. In addition, our results suggest that the specific pattern of associations between MAs and cognitive functioning is different in FEP patients from those of the unaffected siblings and healthy subjects.

journal_name

Schizophr Res

journal_title

Schizophrenia research

authors

Cuesta MJ,Moreno-Izco L,Ribeiro M,López-Ilundain JM,Lecumberri P,Cabada T,Lorente-Omeñaca R,Sánchez-Torres AM,Gómez MS,Peralta V

doi

10.1016/j.schres.2017.10.035

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

50-55

eissn

0920-9964

issn

1573-2509

pii

S0920-9964(17)30663-1

journal_volume

200

pub_type

杂志文章

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