当前位置： SCI文献检索 > SCHIZOPHRENIA RESEARCH期刊下所有文献 > High-dose galantamine augmentation inferior to placebo on attention, inhibitory control and working memory performance in nonsmokers with schizophrenia.

High-dose galantamine augmentation inferior to placebo on attention, inhibitory control and working memory performance in nonsmokers with schizophrenia.

Abstract：

:Dysfunction in the neuronal nicotinic acetylcholine receptor (nAChR) system has been implicated in the pathophysiology of schizophrenia, and it has been postulated that treatments that increase nAChR activity may improve symptoms of the disorder. We investigated the effects of the acetylcholinesterase inhibitor and allosteric nAChR modulator, galantamine, on cognitive performance and clinical symptoms when added to a stable antipsychotic medication regimen in nonsmoking outpatients with schizophrenia in a double-blind, placebo-controlled, parallel-group design. Participants were randomized to receive either galantamine (n=10) up to 32 mg/day or identical placebo (n=10) for 8 weeks and completed a cognitive battery at baseline and week 8 and clinical scales at baseline, week 4 and week 8. The primary outcome measure was attentional performance as measured by the d' measure in the Continuous Performance Test - Identical Pairs (CPT-IP) Version. Contrary to our hypothesis, galantamine treatment was associated with inferior performance on the CPT-IP, on the three-card Stroop task, and on the Letter-Number Span task without reordering. Galantamine had no effect on clinical symptoms. In summary, galantamine treatment, at a dose of 32 mg/day, was well tolerated but was not effective as an adjunctive treatment for cognitive deficits in stable nonsmokers with schizophrenia.

journal_name

Schizophr Res

journal_title

Schizophrenia research

authors

Dyer MA,Freudenreich O,Culhane MA,Pachas GN,Deckersbach T,Murphy E,Goff DC,Evins AE

doi

10.1016/j.schres.2007.12.491

subject

Has Abstract

pub_date

2008-07-01 00:00:00

pages

88-95

issue

1-3

eissn

0920-9964

issn

1573-2509

pii

S0920-9964(08)00061-3

journal_volume

102

pub_type

杂志文章,随机对照试验

相关文献

SCHIZOPHRENIA RESEARCH文献大全
  • Brain volumes as predictor of outcome in recent-onset schizophrenia: a multi-center MRI study.

    abstract：:Gray matter brain volume decreases have been found in patients with schizophrenia as compared to healthy control subjects measured by using Magnetic Resonance Imaging (MRI). An association has been suggested between decreased gray matter volume and poor outcome in chronically ill patients with schizophrenia. The prese...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,多中心研究

    doi：10.1016/s0920-9964(03)00018-5

    authors： van Haren NE,Cahn W,Hulshoff Pol HE,Schnack HG,Caspers E,Lemstra A,Sitskoorn MM,Wiersma D,van den Bosch RJ,Dingemans PM,Schene AH,Kahn RS

    更新日期：2003-11-01 00:00:00

  • A longitudinal study of hippocampal volume in first episode psychosis and chronic schizophrenia.

    abstract：:Brain abnormalities have been identified in patients with schizophrenia, but what is unclear is whether these changes are progressive over the course of the disorder. In this longitudinal study, hippocampal and temporal lobe volumes were measured at two time points in 30 patients with first episode psychosis (mean fol...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/s0920-9964(01)00175-x

    authors： Wood SJ,Velakoulis D,Smith DJ,Bond D,Stuart GW,McGorry PD,Brewer WJ,Bridle N,Eritaia J,Desmond P,Singh B,Copolov D,Pantelis C

    更新日期：2001-10-01 00:00:00

  • Effects of the Indianapolis Vocational Intervention Program (IVIP) on defeatist beliefs, work motivation, and work outcomes in serious mental illness.

    abstract：:Defeatist beliefs and amotivation are prominent obstacles in vocational rehabilitation for people with serious mental illnesses (SMI). The CBT-based Indianapolis Vocational Intervention Program (IVIP) was specifically designed to reduce defeatist beliefs related to work functioning. In the current study, we examined t...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2016.10.036

    authors： Mervis JE,Fiszdon JM,Lysaker PH,Nienow TM,Mathews L,Wardwell P,Petrik T,Thime W,Choi J

    更新日期：2017-04-01 00:00:00

  • Increased interleukin-2 serum levels were associated with psychopathological symptoms and cognitive deficits in treatment-resistant schizophrenia.

    abstract：:Accumulating evidence showed that interleukin-2 (IL-2) may be involved in the pathophysiology of schizophrenia. Increased IL-2 levels have been found in the serum of schizophrenia patients with mixed results. In the present study, we assessed serum IL-2 levels in a large group of 160 schizophrenia patients compared to...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2015.10.038

    authors： Tan Y,Li Y,Tan S,Wang Z,Yang FD,Cao B,Zunta-Soares GB,Soares JC,Zhang XY

    更新日期：2015-12-01 00:00:00

  • Executive functions in adolescents with schizotypal personality disorder.

    abstract：:Adolescents meeting diagnostic criteria for schizotypal personality disorder (SPD) are presumed to be at risk for developing schizophrenia in adulthood, making them an important group for exploring the developmental trajectory of the disease. Deficits in executive functioning have been documented in schizophrenia pati...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/s0920-9964(99)00119-x

    authors： Diforio D,Walker EF,Kestler LP

    更新日期：2000-04-07 00:00:00

  • Subjective quality of life in first-episode psychosis. A ten year follow-up study.

    abstract：UNLABELLED:Subjective quality of life (S-QoL) is an important outcome measure in first episode psychosis (FEP). The aims of this study were to describe S-QoL-development the first 10-years in FEP patients and to identify predictors of this development. METHODS:A representative sample of 272 patients with a first episo...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2016.02.034

    authors： Gardsjord ES,Romm KL,Friis S,Barder HE,Evensen J,Haahr U,ten Velden Hegelstad W,Joa I,Johannessen JO,Langeveld J,Larsen TK,Opjordsmoen S,Rund BR,Simonsen E,Vaglum P,McGlashan T,Melle I,Røssberg JI

    更新日期：2016-04-01 00:00:00

  • Deficits in language-mediated mental operations in patients with schizophrenia.

    abstract：:We found previously that a subgroup of schizophrenic patients who passed screening tests of attentional competence showed memory deficits on word memory tasks, but were comparable with controls on tone memory tasks. To better understand the nature of language-specific memory deficits in this subgroup of patients, the ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/s0920-9964(01)00194-3

    authors： Wexler BE,Donegan N,Stevens AA,Jacob SA

    更新日期：2002-01-15 00:00:00

  • Predictors of antipsychotic medication adherence in patients recovering from a first psychotic episode.

    abstract：BACKGROUND:Many patients recovering from a first psychotic episode will discontinue medication against medical advice, even before a 1-year treatment course is completed. Factors associated with treatment adherence in patients with chronic schizophrenia include beliefs about severity of illness and need for treatment, ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2005.10.016

    authors： Perkins DO,Johnson JL,Hamer RM,Zipursky RB,Keefe RS,Centorrhino F,Green AI,Glick IB,Kahn RS,Sharma T,Tohen M,McEvoy JP,Weiden PJ,Lieberman JA,HGDH Research Group.

    更新日期：2006-03-01 00:00:00

  • Reduced fractional anisotropy and axial diffusivity in white matter in 22q11.2 deletion syndrome: a pilot study.

    abstract：:Individuals with 22q11.2 deletion syndrome (22q11.2DS) evince a 30% incidence of schizophrenia. We compared the white matter (WM) of 22q11.2DS patients without schizophrenia to a group of matched healthy controls using Tract-Based-Spatial-Statistics (TBSS). We found localized reduction of Fractional Anisotropy (FA) an...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.schres.2012.06.032

    authors： Kikinis Z,Asami T,Bouix S,Finn CT,Ballinger T,Tworog-Dube E,Kucherlapati R,Kikinis R,Shenton ME,Kubicki M

    更新日期：2012-10-01 00:00:00

  • Spatial memory deficits in a virtual reality eight-arm radial maze in schizophrenia.

    abstract：:Learning and memory impairments are present in schizophrenia (SZ) throughout the illness course and predict psychosocial function. Abnormalities in prefrontal and hippocampal function are thought to contribute to SZ deficits. The radial arm maze (RAM) is a test of spatial learning and memory in rodents that relies on ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2011.11.014

    authors： Spieker EA,Astur RS,West JT,Griego JA,Rowland LM

    更新日期：2012-03-01 00:00:00

  • Pre-morbid fertility in psychosis: findings from the AESOP first episode study.

    abstract：:Individuals with psychotic illnesses are known to have a reduced fertility. It is unclear whether this is due to biological or social factors. Most fertility studies have been conducted in chronic schizophrenia, where confounders like medication and hospitalisation make this difficult to elicit. A less severe reductio...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2014.04.007

    authors： Zimbron J,Stahl D,Hutchinson G,Dazzan P,Morgan K,Doody GA,Jones PB,Murray RM,Fearon P,Morgan C,MacCabe JH

    更新日期：2014-07-01 00:00:00

  • Nicotine consumption and schizotypy in first-degree relatives of individuals with schizophrenia and non-psychiatric controls.

    abstract：:Individuals with schizophrenia have very high rates of cigarette smoking, and much has been discovered about the influence of nicotine on brain functioning in schizophrenia. However, less is understood about the relationship between nicotine consumption and milder phenotypes related to schizophrenia, specifically schi...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2007.08.024

    authors： Esterberg ML,Jones EM,Compton MT,Walker EF

    更新日期：2007-12-01 00:00:00

  • Experimental validation of candidate schizophrenia gene ZNF804A as target for hsa-miR-137.

    abstract：:MicroRNAs (miRNAs) are small non-coding RNAs that mainly function as negative regulators of gene expression (Lai, 2002) and have been shown to be involved in schizophrenia etiology through genetic and expression studies (Burmistrova et al., 2007; Hansen et al., 2007a; Perkins et al., 2007; Beveridge et al., 2010; Kim ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2012.06.038

    authors： Kim AH,Parker EK,Williamson V,McMichael GO,Fanous AH,Vladimirov VI

    更新日期：2012-10-01 00:00:00

  • Deficits in GABAA receptor function and working memory in non-smokers with schizophrenia.

    abstract：BACKGROUND:Although altered gamma-aminobutyric acid (GABA) neurotransmission has been implicated in the pathophysiology of schizophrenia, it is unclear whether the influence of GABA on working memory processes is confounded by nicotine use in this population. It is therefore crucial to evaluate working memory and its u...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2016.01.008

    authors： Bridgman AC,Barr MS,Goodman MS,Chen R,Rajji TK,Daskalakis ZJ,George TP

    更新日期：2016-03-01 00:00:00

  • Gender differences in 542 Chinese inpatients with schizophrenia.

    abstract：OBJECTIVE:To investigate gender differences in the onset and other clinical features of Han Chinese inpatients with schizophrenia. METHODS:Five-hundred-and-forty-two Han Chinese inpatients with DSM-IV schizophrenia were assessed with the Positive and Negative Symptoms Scale (PANSS), the Brief Psychiatric Rating Scale ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2007.05.025

    authors： Tang YL,Gillespie CF,Epstein MP,Mao PX,Jiang F,Chen Q,Cai ZJ,Mitchell PB

    更新日期：2007-12-01 00:00:00

  • The Brief Assessment of Cognition in Schizophrenia: reliability, sensitivity, and comparison with a standard neurocognitive battery.

    abstract：:Studies of neurocognitive function in patients with schizophrenia use widely variable assessment techniques. Clinical trials assessing the cognitive enhancing effect of new medications have used neurocognitive assessment batteries that differed in content, length and administration procedures. The Brief Assessment of ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2003.09.011

    authors： Keefe RS,Goldberg TE,Harvey PD,Gold JM,Poe MP,Coughenour L

    更新日期：2004-06-01 00:00:00

  • Outcome after discharge from an early psychosis program.

    abstract：:Studies defining the course and outcome of individuals experiencing their first episode (FE) of psychosis generally report an improvement in symptoms and functioning. Today, many FE patients are treated in specialized early psychosis programs. Little is known what happens to these individuals after discharge from thes...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2008.08.032

    authors： Addington J,Addington D

    更新日期：2008-12-01 00:00:00

  • Spatial localization of retinal anomalies in regular cannabis users: The relevance of the multifocal electroretinogram.

    abstract：:Widely used in industrialized countries, cannabis is a neuromodulator substance. The cannabinoid system is present at critical stages of retinal processing. We have recently shown a delay in bipolar and ganglion cell responses in regular cannabis users, as observed using flash (fERG) and pattern (PERG) electroretinogr...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2019.01.013

    authors： Schwitzer T,Henrion ML,Sarre D,Albuisson E,Angioi-Duprez K,Giersch A,Lalanne L,Schwan R,Laprevote V

    更新日期：2020-05-01 00:00:00

  • Pharmacokinetic-pharmacodynamic modeling of antipsychotic drugs in patients with schizophrenia Part I: the use of PANSS total score and clinical utility.

    abstract：BACKGROUND:To develop a pharmacokinetic-pharmacodynamic (PK-PD) model using individual-level data of Positive and Negative Syndrome Scale (PANSS) total score to characterize the antipsychotic drug effect taking into account the placebo effect and dropout rate. In addition, a clinical utility (CU) criterion that describ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2013.02.011

    authors： Pilla Reddy V,Kozielska M,Suleiman AA,Johnson M,Vermeulen A,Liu J,de Greef R,Groothuis GM,Danhof M,Proost JH

    更新日期：2013-05-01 00:00:00

  • Reproducibility of fMRI activations during a story listening task in patients with schizophrenia.

    abstract：:A prerequisite to longitudinal fMRI studies in schizophrenia is the knowledge on fMRI signal reliability in schizophrenia patients. We assessed the reproducibility of activations elicited by two fMRI sessions, which were 21 months apart, of a story listening paradigm in 10 schizophrenia patients and 10 healthy subject...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2011.01.025

    authors： Maïza O,Mazoyer B,Hervé PY,Razafimandimby A,Dollfus S,Tzourio-Mazoyer N

    更新日期：2011-05-01 00:00:00

  • The Premorbid Adjustment Scale as a measure of developmental compromise in patients with schizophrenia and their healthy siblings.

    abstract：:Schizophrenia is associated with subtle developmental compromise, but the degree to which this is also associated with heritability and genetic risk is uncertain. The goal of the current study was to investigate the childhood, adolescent, and early adulthood social and academic function of patients with schizophrenia,...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2009.04.007

    authors： Shapiro DI,Marenco S,Spoor EH,Egan MF,Weinberger DR,Gold JM

    更新日期：2009-07-01 00:00:00

  • Behavioral effects of non-viral mediated RNA interference of synapsin II in the medial prefrontal cortex of the rat.

    abstract：:Synapsin II is a synaptic vesicle-associated phosphoprotein that has been implicated in the pathophysiology of schizophrenia. Researchers have demonstrated reductions in synapsin II mRNA and protein in post-mortem prefrontal cortex and hippocampus samples from patients with schizophrenia. Synapsin II protein expressio...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2012.01.029

    authors： Dyck BA,Tan ML,Daya RP,Basu D,Sookram CD,Thomas N,Mishra RK

    更新日期：2012-05-01 00:00:00

  • Effects of omega-3 PUFA on immune markers in adolescent individuals at ultra-high risk for psychosis - Results of the randomized controlled Vienna omega-3 study.

    abstract：:Alterations of immune function have been reported in ultra-high risk (UHR) for psychosis patients causing expectations in terms of predictive meaningfulness and benefits of anti-inflammatory agents. According to a RCT in UHR-patients supplementation of omega-3 polyunsaturated fatty acids (PUFA) was effective in reduci...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.schres.2017.01.026

    authors： Smesny S,Milleit B,Schaefer MR,Hesse J,Schlögelhofer M,Langbein K,Hipler UC,Berger M,Cotter DR,Sauer H,McGorry PD,Amminger GP

    更新日期：2017-10-01 00:00:00

  • Metacognitive deficits predict future levels of negative symptoms in schizophrenia controlling for neurocognition, affect recognition, and self-expectation of goal attainment.

    abstract：:The recalcitrance of negative symptoms in the face of pharmacologic treatment has spurred interest in understanding the psychological factors that contribute to their formation and persistence. Accordingly, this study investigated whether deficits in metacognition, or the ability to form integrated ideas about oneself...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.schres.2015.06.015

    authors： Lysaker PH,Kukla M,Dubreucq J,Gumley A,McLeod H,Vohs JL,Buck KD,Minor KS,Luther L,Leonhardt BL,Belanger EA,Popolo R,Dimaggio G

    更新日期：2015-10-01 00:00:00

  • Differential neuropsychological patterns of frontal- and temporal-lobe dysfunction in patients with schizophrenia.

    abstract：:The frontal and temporal lobes have been implicated as pathogenic sites for schizophrenia, although there is a marked heterogeneity of brain function and structure between individual patients. It is currently unclear whether some patients with schizophrenia exhibit primarily frontal lobe dysfunction, while others exhi...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/s0920-9964(00)00115-8

    authors： Allen DN,Goldstein G,Weiner C

    更新日期：2001-03-01 00:00:00

  • Delay discounting and affective priming in individuals with negative schizotypy.

    abstract：:Previous studies have demonstrated that patients with schizophrenia and individuals with schizotypy experience decreased anticipatory pleasure. However, it is unclear whether this decrease is contributed by altered reward processing at the proximal or distal future. In order to investigate the preference for receiving...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2018.12.040

    authors： Cai XL,Weigl M,Liu BH,Cheung EFC,Ding JH,Chan RCK

    更新日期：2019-08-01 00:00:00

  • Speech deficits in serious mental illness: a cognitive resource issue?

    abstract：:Speech deficits, notably those involved in psychomotor retardation, blunted affect, alogia and poverty of content of speech, are pronounced in a wide range of serious mental illnesses (e.g., schizophrenia, unipolar depression, bipolar disorders). The present project evaluated the degree to which these deficits manifes...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2014.10.032

    authors： Cohen AS,McGovern JE,Dinzeo TJ,Covington MA

    更新日期：2014-12-01 00:00:00

  • Wisconsin Card Sorting Test performance in schizophrenia: the role of working memory.

    abstract：:Schizophrenia typically results in reduced performance on the Wisconsin Card Sorting Test (WCST). In the current study, we used a variety of approaches to examine the role of working memory (WM) in this deficit. One approach was to examine patterns of perseverative and non-perseverative errors. A second approach invol...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/s0920-9964(02)00353-5

    authors： Hartman M,Steketee MC,Silva S,Lanning K,Andersson C

    更新日期：2003-10-01 00:00:00

  • Schizotypy and individual differences in the frequency of normal associations in verbal utterances.

    abstract：BACKGROUND:Recent empirical evidence [Maher, B.A., Manschreck, T.C., Linnert, J., Candela, S., 2005. Quantitative assessment of the frequency of normal associations in the utterances of schizophrenia patients and healthy controls. Schizophrenia Research 78, 219-224] shows that schizophrenia patients produce an elevated...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2007.06.009

    authors： Lenzenweger MF,Miller AB,Maher BA,Manschreck TC

    更新日期：2007-09-01 00:00:00

  • Impaired emotional learning and reduced amygdala size in schizophrenia: a 3-month follow-up.

    abstract：:Individuals with schizophrenia have difficulties in emotional information processing. A relationship between behavioral variables of emotional processing and structural amygdala alterations in schizophrenia has been proposed but not shown, yet. Morphological studies of amygdala size in schizophrenia have yielded incon...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2004.02.023

    authors： Exner C,Boucsein K,Degner D,Irle E,Weniger G

    更新日期：2004-12-01 00:00:00