当前位置： SCI文献检索 > SCHIZOPHRENIA RESEARCH期刊下所有文献 > Reduced fractional anisotropy and axial diffusivity in white matter in 22q11.2 deletion syndrome: a pilot study.

Reduced fractional anisotropy and axial diffusivity in white matter in 22q11.2 deletion syndrome: a pilot study.

Abstract：

:Individuals with 22q11.2 deletion syndrome (22q11.2DS) evince a 30% incidence of schizophrenia. We compared the white matter (WM) of 22q11.2DS patients without schizophrenia to a group of matched healthy controls using Tract-Based-Spatial-Statistics (TBSS). We found localized reduction of Fractional Anisotropy (FA) and Axial Diffusivity (AD; measure of axonal integrity) in WM underlying the left parietal lobe. No changes in Radial Diffusivity (RD; measure of myelin integrity) were observed. Of note, studies in chronic schizophrenia patients report reduced FA, no changes in AD, and increases in RD in WM. Our findings suggest different WM microstructural pathology in 22q11.2DS than in patients with schizophrenia.

journal_name

Schizophr Res

journal_title

Schizophrenia research

authors

Kikinis Z,Asami T,Bouix S,Finn CT,Ballinger T,Tworog-Dube E,Kucherlapati R,Kikinis R,Shenton ME,Kubicki M

doi

10.1016/j.schres.2012.06.032

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

35-9

issue

1

eissn

0920-9964

issn

1573-2509

pii

S0920-9964(12)00349-0

journal_volume

141

pub_type

杂志文章,多中心研究

相关文献

SCHIZOPHRENIA RESEARCH文献大全
  • Antipsychotic drug use in pregnancy: A multinational study from ten countries.

    abstract：AIM:To compare the prevalence and trends of antipsychotic drug use during pregnancy between countries across four continents. METHODS:Individually linked health data in Denmark (2000-2012), Finland (2005-2014), Iceland (2004-2017), Norway (2005-2015), Sweden (2006-2015), Germany (2006-2015), Australia (New South Wales...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2020.03.048

    authors： Reutfors J,Cesta CE,Cohen JM,Bateman BT,Brauer R,Einarsdóttir K,Engeland A,Furu K,Gissler M,Havard A,Hernandez-Diaz S,Huybrechts KF,Karlstad Ø,Leinonen MK,Li J,Man KKC,Pazzagli L,Schaffer A,Schink T,Wang Z,Yu Y,

    更新日期：2020-06-01 00:00:00

  • Remission in schizophrenia: applying recent consensus criteria to refine the concept.

    abstract：:Although the concept of remission has been widely accepted and utilized in depression and anxiety disorders, there has been much less emphasis on defining remission in schizophrenia. Recently, an expert consensus definition of remission in schizophrenia was proposed along specific operational criteria for the attainme...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2007.05.003

    authors： Lasser RA,Nasrallah H,Helldin L,Peuskens J,Kane J,Docherty J,Tronco AT

    更新日期：2007-11-01 00:00:00

  • Patterns of premorbid functioning in individuals at clinical high risk of psychosis.

    abstract：:In schizophrenia, four typical patterns of premorbid functioning have been observed: stable-good, stable-intermediate, poor-deteriorating and deteriorating. However, it is unknown whether similar patterns exist in those who are at clinical high risk (CHR) of psychosis. The aim of this study was to examine patterns of ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2015.11.004

    authors： Lyngberg K,Buchy L,Liu L,Perkins D,Woods S,Addington J

    更新日期：2015-12-01 00:00:00

  • Risk factors for completed suicide in schizophrenia and other chronic psychotic disorders: a case-control study.

    abstract：OBJECTIVE:Despite an increased risk for suicide among individuals diagnosed with psychotic disorders, risk factors for completed suicide remain largely unexamined in this population. Using a case-control design, this study aimed to investigate clinical and behavioural risk factors for suicide completion in schizophreni...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2006.02.025

    authors： McGirr A,Tousignant M,Routhier D,Pouliot L,Chawky N,Margolese HC,Turecki G

    更新日期：2006-05-01 00:00:00

  • DNA hypermethylation of serotonin transporter gene promoter in drug naïve patients with schizophrenia.

    abstract：INTRODUCTION:Dysfunctional serotonin signaling has been linked to the pathogenesis of autism, obsessive compulsive disorder, mood disorders and schizophrenia. While the hypo-activity of serotonin signaling is involved in the pathogenesis of depression, anxiety and obsessive compulsive disorder; LSD, an agonist of serot...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2013.12.007

    authors： Abdolmaleky HM,Nohesara S,Ghadirivasfi M,Lambert AW,Ahmadkhaniha H,Ozturk S,Wong CK,Shafa R,Mostafavi A,Thiagalingam S

    更新日期：2014-02-01 00:00:00

  • The Experience of Caregiving Inventory for first-episode psychosis caregivers: validation of the Brazilian version.

    abstract：:Family members of first-episode psychosis (FEP) patients are regarded as key components of the patient's evaluation, recovery and treatment. This paper aimed to investigate 75 FEP caregivers' appraisal, psychological morbidity and quality of life in the initial phase of treatment in a specialized FEP outpatient progra...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2012.03.014

    authors： Jorge Rde C,Chaves AC

    更新日期：2012-07-01 00:00:00

  • Reading deficits in schizophrenia and their relationship to developmental dyslexia: A review.

    abstract：:Although schizophrenia and developmental dyslexia are considered distinct disorders in terms of clinical presentation and functional outcome, they both involve disruption in the processes that support skilled reading, including language, auditory perception, visual perception, oculomotor control, and executive functio...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,评审

    doi：10.1016/j.schres.2017.06.049

    authors： Whitford V,O'Driscoll GA,Titone D

    更新日期：2018-03-01 00:00:00

  • Pathways between stigma and suicidal ideation among people at risk of psychosis.

    abstract：:Mental illness stigma may contribute to suicidality and is associated with social isolation and low self-esteem among young people at risk of psychosis. However, it is unclear whether mental illness stigma contributes to suicidality in this population. We therefore examined the associations of self-labeling and stigma...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2016.01.048

    authors： Xu Z,Müller M,Heekeren K,Theodoridou A,Metzler S,Dvorsky D,Oexle N,Walitza S,Rössler W,Rüsch N

    更新日期：2016-04-01 00:00:00

  • A confirmatory factor analytic evaluation of the pentagonal PANSS model.

    abstract：:The positive and negative syndrome scale (PANSS) is widely used in psychiatric research. Reflecting this common use, considerable attention has been applied to the psychometric properties of this instrument. However, despite the publication of numerous studies and analyses, it remains uncertain how best data from the ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/s0920-9964(02)00295-5

    authors： Fitzgerald PB,de Castella AR,Brewer K,Filia K,Collins J,Davey P,Rolfe T,Kulkarni J

    更新日期：2003-05-01 00:00:00

  • Psychological well-being and mental health recovery in the NIMH RAISE early treatment program.

    abstract：:Recovery-oriented practices that promote client-centered care, collaboration, and functional outcome have been recommended to improve treatment engagement, especially for individuals with serious mental illness (SMI). Psychological well-being (PWB) is related to recovery and refers to experiencing purpose and meaning ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2016.11.032

    authors： Browne J,Penn DL,Meyer-Kalos PS,Mueser KT,Estroff SE,Brunette MF,Correll CU,Robinson J,Rosenheck RA,Schooler N,Robinson DG,Addington J,Marcy P,Kane JM

    更新日期：2017-07-01 00:00:00

  • Prefrontal cortical sulcal widening associated with poor treatment response to clozapine.

    abstract：:Increased sulcal widening in the prefrontal cortex of patients with schizophrenia may be associated with a poor treatment response to clozapine. To further evaluate this, we examined data from patients treated with clozapine in our center. Patients with the greatest degree of improvement (n=26) and those with no impro...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/s0920-9964(00)00130-4

    authors： Konicki PE,Kwon KY,Steele V,White J,Fuller M,Jurjus GJ,Jaskiw GE

    更新日期：2001-03-30 00:00:00

  • Psychiatric treatment following participation in the CapOpus randomized trial for patients with comorbid cannabis use disorder and psychosis.

    abstract：BACKGROUND:Randomized trials targeting cannabis use disorders in patients with psychosis have generally been unsuccessful. One of the largest such trials was the CapOpus trial, which had an impact on the number of monthly joints used, but not on the number of days with cannabis use or positive or negative symptoms. OB...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.schres.2013.10.014

    authors： Hjorthøj CR,Orlovska S,Fohlmann A,Nordentoft M

    更新日期：2013-12-01 00:00:00

  • Hippocampal and anterior cingulate morphology in subjects at ultra-high-risk for psychosis: the role of family history of psychotic illness.

    abstract：BACKGROUND:While structural brain imaging abnormalities have been identified in schizophrenia and related disorders, it is unclear when they arise. Some appear to predate the illness and may be genetic in origin, while others are associated with the onset of the disorder. METHODS:We examined the hippocampal volumes an...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2004.10.008

    authors： Wood SJ,Yücel M,Velakoulis D,Phillips LJ,Yung AR,Brewer W,McGorry PD,Pantelis C

    更新日期：2005-06-15 00:00:00

  • Olfactory identification deficit in relation to schizotypy.

    abstract：:Past studies have shown that schizophrenic men tend to be impaired on the olfactory identification task. We examined individual differences in the olfactory function in relation to schizotypy. Healthy individuals who might carry latent liability for schizophrenia participated in olfactory identification and acuity tas...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/s0920-9964(97)00045-5

    authors： Park S,Schoppe S

    更新日期：1997-08-29 00:00:00

  • A dimensional comparison between delusional disorder, schizophrenia and schizoaffective disorder.

    abstract：INTRODUCTION:Since the early description of paranoia, the nosology of delusional disorder has always been controversial. The old idea of unitary psychosis has now gained some renewed value from the dimensional continuum model of psychotic symptoms. AIMS:1. To study the psychopathological dimensions of the psychosis sp...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2015.10.039

    authors： Muñoz-Negro JE,Ibanez-Casas I,de Portugal E,Ochoa S,Dolz M,Haro JM,Ruiz-Veguilla M,de Dios Luna Del Castillo J,Cervilla JA

    更新日期：2015-12-01 00:00:00

  • Comparative efficacy between clozapine and other atypical antipsychotics on depressive symptoms in patients with schizophrenia: analysis of the CATIE phase 2E data.

    abstract：BACKGROUND:The comparative antidepressant effects of clozapine and other atypical antipsychotics for schizophrenia remain elusive, leading us to examine this question using the data from the Clinical Antipsychotic Trials of Intervention Effectiveness phase 2E. METHODS:Ninety-nine patients who discontinued treatment wi...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.schres.2014.12.024

    authors： Nakajima S,Takeuchi H,Fervaha G,Plitman E,Chung JK,Caravaggio F,Iwata Y,Mihashi Y,Gerretsen P,Remington G,Mulsant B,Graff-Guerrero A

    更新日期：2015-02-01 00:00:00

  • Spatial memory deficits in a virtual reality eight-arm radial maze in schizophrenia.

    abstract：:Learning and memory impairments are present in schizophrenia (SZ) throughout the illness course and predict psychosocial function. Abnormalities in prefrontal and hippocampal function are thought to contribute to SZ deficits. The radial arm maze (RAM) is a test of spatial learning and memory in rodents that relies on ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2011.11.014

    authors： Spieker EA,Astur RS,West JT,Griego JA,Rowland LM

    更新日期：2012-03-01 00:00:00

  • Subjective wellbeing under quetiapine treatment: effect of diagnosis, mood state, and anxiety.

    abstract：OBJECTIVE:To examine the effect of diagnosis, mood state, and anxiety on subjective wellbeing in patients with affective and non-affective psychotic disorders treated with quetiapine IR. METHODS:2175 patients with schizophrenia-spectrum (SZ, n=1681), schizoaffective (SA, n=249), and bipolar disorder (BPD, n=245) were ...

    journal_title：Schizophrenia research

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.schres.2009.03.004

    authors： Lambert M,Naber D,Karow A,Huber CG,Köhler J,Heymann J,Schimmelmann BG

    更新日期：2009-05-01 00:00:00

  • Computerized cognitive remediation training for schizophrenia: an open label, multi-site, multinational methodology study.

    abstract：:A recent single-site study (Fisher et al., 2009. Am J Psychiatry. 166 (7) 805-11) showed that repeated training with the Brain Fitness Program (BFP) improved performance on a battery of neuropsychological tasks. If replicated these data suggest an important non-pharmacological method for ameliorating cognitive impairm...

    journal_title：Schizophrenia research

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.schres.2012.01.042

    authors： Murthy NV,Mahncke H,Wexler BE,Maruff P,Inamdar A,Zucchetto M,Lund J,Shabbir S,Shergill S,Keshavan M,Kapur S,Laruelle M,Alexander R

    更新日期：2012-08-01 00:00:00

  • Prevalence and correlates of depressive symptoms in a catchment-area based cohort of older community-living schizophrenia patients.

    abstract：BACKGROUND:Depressive symptoms frequently accompany schizophrenia. Older patients constitute the fastest growing segment of the schizophrenia population. With regard to the risk factors associated with depression, it is uncertain to which extent older schizophrenia patients differ from their age peers in the community....

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2014.05.002

    authors： Meesters PD,Comijs HC,Sonnenberg CM,Hoogendoorn AW,de Haan L,Eikelenboom P,Beekman AT,Stek ML

    更新日期：2014-08-01 00:00:00

  • Associations between spontaneous movement abnormalities and psychotic-like experiences in the general population.

    abstract：:An accumulating body of literature supports the notion that psychotic-like experiences (PLEs) may occur as a continuous phenotype. However, researchers are still working to determine if these events accompany an underlying continuum of neurobiological vulnerability as well. Within this context, it is notable that spon...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2011.06.028

    authors： Mittal VA,Dean DJ,Pelletier A,Caligiuri M

    更新日期：2011-11-01 00:00:00

  • Effect of retrieval effort and switching demand on fMRI activation during semantic word generation in schizophrenia.

    abstract：:Verbal fluency deficits in schizophrenia are difficult to interpret because the tasks are multi-factorial and groups differ in total words generated. We manipulated retrieval and switching demands by requiring alternation between over-learned sequences in which retrieval is relatively automatic (OS) and semantic categ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2007.11.017

    authors： Ragland JD,Moelter ST,Bhati MT,Valdez JN,Kohler CG,Siegel SJ,Gur RC,Gur RE

    更新日期：2008-02-01 00:00:00

  • Behavioral sequelae of astrocyte dysfunction: focus on animal models of schizophrenia.

    abstract：:Astrocytes regulate multiple processes in the brain ranging from trophic support of developing neurons to modulation of synaptic neurotransmission and neuroinflammation in adulthood. It is, therefore, understandable that pathogenesis and pathophysiology of major psychiatric disorders involve astrocyte dysfunctions. Un...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,评审

    doi：10.1016/j.schres.2014.10.044

    authors： Xia M,Abazyan S,Jouroukhin Y,Pletnikov M

    更新日期：2016-09-01 00:00:00

  • Motor abnormalities and cognitive impairment in first-episode psychosis patients, their unaffected siblings and healthy controls.

    abstract：:Motor abnormalities (MAs) may be already evidenced long before the beginning of illness and are highly prevalent in psychosis. However, the extent to which the whole range of MAs are related to cognitive impairment in psychosis remains understudied. This study aimed to examine comparatively the relationships between t...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2017.10.035

    authors： Cuesta MJ,Moreno-Izco L,Ribeiro M,López-Ilundain JM,Lecumberri P,Cabada T,Lorente-Omeñaca R,Sánchez-Torres AM,Gómez MS,Peralta V

    更新日期：2018-10-01 00:00:00

  • Clozapine-induced cardiomyopathy and myocarditis monitoring: A systematic review.

    abstract：:The use of clozapine requires monitoring the absolute neutrophil count because of the risk of agranulocytosis, but other potentially fatal adverse events associated with clozapine (specifically, myocarditis and cardiomyopathy) do not have mandatory procedures. We performed a systematic review of English-language artic...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2018.03.006

    authors： Knoph KN,Morgan RJ 3rd,Palmer BA,Schak KM,Owen AC,Leloux MR,Patel M,Leung JG

    更新日期：2018-09-01 00:00:00

  • Variations in differential gene expression patterns across multiple brain regions in schizophrenia.

    abstract：:Large-scale gene expression studies in schizophrenia (SZ) have generally focused on the dorsolateral prefrontal cortex. Despite a wealth of evidence implicating multiple other brain regions in the disease, studies of other brain regions have been less frequent and have rarely been performed in the same subjects. We an...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2005.03.020

    authors： Katsel P,Davis KL,Gorman JM,Haroutunian V

    更新日期：2005-09-15 00:00:00

  • Learning-related changes in brain activity following errors and performance feedback in schizophrenia.

    abstract：:In previous studies of self-monitoring in schizophrenia, patients have exhibited reductions in the amplitude of the error-related negativity (ERN), a component of the event-related brain potential (ERP) elicited most prominently immediately following the execution of incorrect responses. In the current study, we exami...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2007.08.027

    authors： Morris SE,Heerey EA,Gold JM,Holroyd CB

    更新日期：2008-02-01 00:00:00

  • A meta-analysis of emotion perception and functional outcomes in schizophrenia.

    abstract：INTRODUCTION:Emotion perception (EP) is impaired in schizophrenia, is stable across clinical state, resistant to antipsychotic treatment and linked to symptom severity. Given its pervasive nature, there is a need to quantitatively examine whether this dysfunction impacts functional outcomes. We used a meta-analytic str...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.schres.2012.01.023

    authors： Irani F,Seligman S,Kamath V,Kohler C,Gur RC

    更新日期：2012-05-01 00:00:00

  • Moral cognition and homicide amongst forensic patients with schizophrenia and schizoaffective disorder: A cross-sectional cohort study.

    abstract：:Forensic patients with schizophrenia who had carried out a homicide scored higher on a measure of moral cognition (MFQ-30) than other violent patients. Neurocognitive impairment was associated with homicide by mediation via higher scores for in-group loyalty. ...

    journal_title：Schizophrenia research

    pub_type： 信件

    doi：10.1016/j.schres.2017.07.026

    authors： O'Reilly K,O'Connell P,Corvin A,O'Sullivan D,Coyle C,Mullaney R,O'Flynn P,Grogan K,Richter M,Kennedy H

    更新日期：2018-03-01 00:00:00

  • Increasing mortality in schizophrenia: are women at particular risk? A follow-up of 1111 patients admitted during 1980-2006 in Northern Norway.

    abstract：:A study of mortality for all patients with schizophrenia admitted to the University Hospital of North Norway during 1980-2006 was performed, with a special focus on gender differences and changes in mortality during a period of transition from hospital-based to community-based care. A total of 1111 patients with schiz...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2011.07.021

    authors： Høye A,Jacobsen BK,Hansen V

    更新日期：2011-11-01 00:00:00