Abstract:
:The aim of this study was to test the validity of the CHR state by focusing on the course of psychosis spectrum symptoms, depression and global functioning in converters and non-converters. A total of 188 CHR-positive subjects (60.2% men) aged between 13 and 35years (mean=20.5) at study outset were assessed five times (t0-t4) over a total observation period of 36months. Conversion to manifest psychosis was defined according to ICD-10 criteria for schizophrenia (F20) or brief psychotic disorder (F23). Measures of positive and negative symptoms were assessed with the Structured Interview for Prodromal Syndromes (SIPS), depression with the Calgary Depression Scale (CDS), and global functioning with the Global Assessment of Functioning Scale (GAF). Converters scored higher over time on all SIPS scales apart from grandiosity (Cohen's d: 0.5-0.7; all p<0.001), higher on the CDS (d=0.43, p=0.001) and lower on the GAF (d=0.69, p<0.001) than did non-converters. Positive and negative symptoms as well as depression were most severe at study outset (t0) and then declined sharply following a linear function over the three-year observation period (t1-t4) across groups (all linear contrasts p<0.001). In conclusion, converters showed significantly more psychopathological symptoms and poorer functioning before crossing the diagnostic threshold for manifest psychosis. CHR-subjects who convert to manifest psychosis during follow-up appear to be recovering from illness rather than becoming ill. Major issues involve the poor discrimination of CHR state and psychosis as well as the dichotomous definition of both at-risk and disease states. Further examination in other CHR-samples is warranted.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Hengartner MP,Heekeren K,Dvorsky D,Walitza S,Rössler W,Theodoridou Adoi
10.1016/j.schres.2017.01.040subject
Has Abstractpub_date
2017-11-01 00:00:00pages
19-26eissn
0920-9964issn
1573-2509pii
S0920-9964(17)30053-1journal_volume
189pub_type
杂志文章abstract::Previous studies have demonstrated that patients with schizophrenia and individuals with schizotypy experience decreased anticipatory pleasure. However, it is unclear whether this decrease is contributed by altered reward processing at the proximal or distal future. In order to investigate the preference for receiving...
journal_title:Schizophrenia research
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journal_title:Schizophrenia research
pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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journal_title:Schizophrenia research
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更新日期:2015-02-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.01.007
更新日期:2018-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究
doi:10.1016/s0920-9964(03)00018-5
更新日期:2003-11-01 00:00:00
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journal_title:Schizophrenia research
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doi:10.1016/j.schres.2006.02.010
更新日期:2006-05-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/0920-9964(95)00069-0
更新日期:1996-05-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.04.024
更新日期:2018-09-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2014.03.026
更新日期:2014-06-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2011.11.019
更新日期:2012-03-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.04.025
更新日期:2018-02-01 00:00:00
abstract::Psychotic-like experiences (PLEs) are part of a continuum of psychosis. Previous longitudinal studies highlighted a relationship between peripheral inflammation during childhood and onset of PLEs in adulthood. In this study, we tested if this association is mediated by internalising and externalising symptoms experien...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2020.11.009
更新日期:2020-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.04.007
更新日期:2009-07-01 00:00:00
abstract::Atypical antipsychotic drugs (AAPDs) are widely used in children and adolescents to treat a variety of psychiatric disorders. However, little is known about the long-term effects of AAPD treatment before the brain is fully developed. Indeed, we and others have previously reported that treatment of adolescent rats with...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.10.034
更新日期:2015-02-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2016.10.020
更新日期:2017-04-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2012.02.004
更新日期:2012-05-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.12.036
更新日期:2010-05-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2006.01.022
更新日期:2006-06-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2012.04.001
更新日期:2012-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2020.05.013
更新日期:2020-08-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章
doi:10.1016/s0920-9964(99)00072-9
更新日期:1999-10-19 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2011.08.004
更新日期:2011-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2011.09.006
更新日期:2011-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2020.04.004
更新日期:2020-04-30 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2005.10.016
更新日期:2006-03-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.03.010
更新日期:2015-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2018.06.068
更新日期:2018-12-01 00:00:00
abstract::Verbal fluency deficits in schizophrenia are difficult to interpret because the tasks are multi-factorial and groups differ in total words generated. We manipulated retrieval and switching demands by requiring alternation between over-learned sequences in which retrieval is relatively automatic (OS) and semantic categ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.11.017
更新日期:2008-02-01 00:00:00