Abstract:
:The purpose of this study was to determine if patients with schizophrenia or schizoaffective disorders and comorbid posttraumatic stress disorder (PTSD) are at higher risk for suicidality than patients without comorbid PTSD. Participants were 165 male veterans with primary diagnoses of schizophrenia or schizoaffective disorder. Those with comorbid PTSD reported higher rates of suicidal ideation and suicidal behaviors compared to those without comorbid PTSD. These findings suggest that patients with comorbid PTSD are at higher risk for suicidality. Enhanced screening and targeted interventions may be warranted to address comorbid PTSD and increased suicide risk in this population.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Strauss JL,Calhoun PS,Marx CE,Stechuchak KM,Oddone EZ,Swartz MS,Butterfield MIdoi
10.1016/j.schres.2006.02.010subject
Has Abstractpub_date
2006-05-01 00:00:00pages
165-9issue
1eissn
0920-9964issn
1573-2509pii
S0920-9964(06)00077-6journal_volume
84pub_type
杂志文章abstract:BACKGROUND:Deficient mirror neuron system (MNS)-activity is associated with social cognition deficits in schizophrenia. However, it is not known how socio-emotional contexts modulate the MNS-response. In a Transcranial Magnetic Stimulation (TMS)-experiment, we aimed to compare putative MNS-responses to action observati...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.07.043
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVES:The impact of cannabis use on the brain tissue is still unclear, both in the healthy developing brain and in people with schizophrenia. The focus of this review is on white matter, the primary connective infrastructure of the brain. METHODS:We systematically reviewed diffusion tensor imaging (DTI) studies o...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2014.04.026
更新日期:2014-07-01 00:00:00
abstract::Second generation antipsychotics cause derangements in glucose metabolism that are often interpreted as insulin resistance. In previous studies we have shown that this is not classical insulin resistance but the drugs were actually inducing a hyperglycaemic state associated with elevated hepatic glucose output (HGO) a...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.05.003
更新日期:2014-08-01 00:00:00
abstract:PURPOSE:The excitatory neurotransmitter glutamate has become an important area of focus for schizophrenia researchers. Polymorphisms in the type-three metabotropic glutamate receptor gene (GRM3) have been associated with the pathogenesis of schizophrenia. The purpose of this study was to determine whether a pharmacogen...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2005.04.001
更新日期:2005-09-15 00:00:00
abstract:BACKGROUND:The intrusion of associations into the utterances of schizophrenic individuals typically disrupts the coherence of the patient's utterances. Recent theoretical formulations of these phenomena have emphasized the hyperactivity) of associational networks in such language disturbance (e.g., Maher, B.A. 2003 Sch...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2005.05.017
更新日期:2005-10-15 00:00:00
abstract:BACKGROUND:Cognitive remediation therapy (CRT) has proven to be effective in treating cognitive deficits in schizophrenia. The current study aimed to assess the efficacy of CRT on psychotic symptoms and cognitive complaints. METHODS:We contrasted the changes in symptoms and cognitive complaints in patients with schizo...
journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2009.03.029
更新日期:2009-06-01 00:00:00
abstract::While the "clinical high-risk state" for psychosis has demonstrated good reliability and fair predictive validity for psychotic disorders, over 50% of identified subjects do not progress to psychosis. Despite the benefits that early detection and treatment might offer, debate concerning the official inclusion of a "ps...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.03.012
更新日期:2010-07-01 00:00:00
abstract::Around 1 in 5 children under 13 years old experience sub-clinical psychotic experiences (PEs) like hallucinations and delusions. While PEs in childhood are a significant risk factor for adult psychotic disorders, the majority of those experiencing childhood PEs do not develop a psychotic disorder. Individual differenc...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.08.022
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:Research participants must have adequate consent-related abilities to provide informed consent at the time of study enrollment. We sought to determine if research participants with schizophrenia maintain adequate consent-related abilities during a longitudinal study. If participants lose abilities during a tr...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.schres.2011.04.012
更新日期:2011-08-01 00:00:00
abstract::The recalcitrance of negative symptoms in the face of pharmacologic treatment has spurred interest in understanding the psychological factors that contribute to their formation and persistence. Accordingly, this study investigated whether deficits in metacognition, or the ability to form integrated ideas about oneself...
journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2015.06.015
更新日期:2015-10-01 00:00:00
abstract::Cortical thickness may be useful as a treatment response predictor in first-episode (FE) patients with schizophrenia, although this possibility has been scarcely assessed. In this study we assessed the possible relation between cortical thickness in regions of interest selected because of previously reported structura...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.06.042
更新日期:2014-09-01 00:00:00
abstract::The glutamatergic dysfunction hypothesis of schizophrenia implicates the genes involved in glutamatergic transmission as strong candidates for schizophrenia-susceptibility. Recent linkage and association studies have identified the glutamate receptor, ionotropic, delta 1 gene GRID1 on 10q22 as a strong candidate for s...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.03.007
更新日期:2007-07-01 00:00:00
abstract::The current study investigated whether a previously reported beneficial effect of methadone maintenance therapy (MMT) on antiretroviral adherence is also present in relation to antipsychotic treatment for schizophrenia. Administrative data were linked over a 17-year period for 1996 people who were dually diagnosed wit...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.05.031
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Although altered gamma-aminobutyric acid (GABA) neurotransmission has been implicated in the pathophysiology of schizophrenia, it is unclear whether the influence of GABA on working memory processes is confounded by nicotine use in this population. It is therefore crucial to evaluate working memory and its u...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2016.01.008
更新日期:2016-03-01 00:00:00
abstract::Long-stay patients constitute a small proportion of all patients with schizophrenia, but in both VA and state psychiatric systems these patients account for a majority of the costs associated with treatment of the illness. VA and state patients would be expected to differ in several respects, including age at onset an...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(99)00182-6
更新日期:2000-05-25 00:00:00
abstract::We investigated whether associations between area deprivation, urbanicity and elevated risk of severe mental illnesses (SMIs, including schizophrenia and bipolar disorder) is accounted for by social drift or social causation. We extracted primary and secondary care electronic health records from 2004 to 2015 from a po...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2020.03.044
更新日期:2020-06-01 00:00:00
abstract::Variable levels of essential polyunsaturated fatty acids (EPUFAs) reported in schizophrenia are likely due to differences in age, sex, ethnicity, diet, life style and treatments. The present study examined the EPUFAs levels in plasma, RBC and CSF in never-medicated first-episode psychotic patients and normal controls ...
journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.schres.2007.09.036
更新日期:2008-01-01 00:00:00
abstract::The aim of this study was to test the validity of the CHR state by focusing on the course of psychosis spectrum symptoms, depression and global functioning in converters and non-converters. A total of 188 CHR-positive subjects (60.2% men) aged between 13 and 35years (mean=20.5) at study outset were assessed five times...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.01.040
更新日期:2017-11-01 00:00:00
abstract::Assessment of depression in individuals who are considered to be at clinical high risk (CHR) for psychosis is important as high rates of depression have been reported in CHR individuals. The Calgary Depression Scale (CDSS) is the most widely used scale for assessing depression in schizophrenia. It has excellent psycho...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.12.014
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Verbal and visual memory deficits are prominent trait markers for schizophrenia, with impairments also observed in first-degree relatives [Snitz, B.E., Macdonald, A.W., 3rd, & Carter, C.S. (2006). Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of put...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.05.027
更新日期:2008-10-01 00:00:00
abstract::The study examined the psychometric properties, factor structure and validity of a recently developed measure of insight, the Beck Cognitive Insight Scale (BCIS) and tested the relationship between the BCIS and psychiatric symptoms in a sample of middle-aged and older patients with schizophrenia or schizoaffective dis...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2004.02.019
更新日期:2004-12-01 00:00:00
abstract::Insight and hopelessness have been reported to be associated with suicidality in schizophrenia. In addition, there is evidence that diminished insight is correlated with impairment in some domains of cognitive function in schizophrenia. The purpose of this study was to clarify the relative importance for suicidality i...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(02)00310-9
更新日期:2003-03-01 00:00:00
abstract::Structural abnormalities in the lateral prefrontal cortex (LPFC) are well-documented in schizophrenia and recent evidence suggests that these abnormalities relate to functional outcome. Cognitive control mechanisms, reliant on the LPFC, are impaired in schizophrenia and predict functional outcome, thus impaired cognit...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.12.005
更新日期:2014-02-01 00:00:00
abstract::Nondeclarative memory (NDM) has subtypes associated with different brain regions; learning of a probabilistic classification task is impaired by striatal damage and learning of a gambling task is impaired by ventromedial prefrontocortical damage. Typical and atypical antipsychotic medications differentially affect imm...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(02)00315-8
更新日期:2003-06-01 00:00:00
abstract::Psychotic disorders are characterized by auditory verbal hallucinations (AVHs), and research has shown that AVHs are linked to deficits in working memory. Our understanding of AVHs across the psychosis continuum is limited. To date, little research has tested whether hallucination proneness (HP) is linked with abnorma...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.10.031
更新日期:2018-05-01 00:00:00
abstract::The construct of Expressed Emotion (EE) is a reliable predictor of relapse in psychotic disorders globally. However, cultural differences in the level and manifestation of EE have been reported. This review was conducted in line with PRISMA guidelines to demonstrate the distribution of EE and its domains cross-cultura...
journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.schres.2019.03.020
更新日期:2019-06-01 00:00:00
abstract::A motivation is a telling hallmark of negative symptomatology in schizophrenia, and it impacts nearly every facet of behavior, including inclination to attempt the difficult cognitive tasks involved in cognitive remediation therapy. Experiences of external reward, reinforcement, and hedonic anticipatory enjoyment are ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.08.001
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Mismatch negativity (MNN) and P3a are event related potential (ERP) measures of early sensory information processing. These components are usually conceptualized as being "pre-attentive" and therefore immune to changes with variations in attentional functioning. This study aimed to determine whether manipula...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.01.035
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:A false sense of reality is a characteristic of schizophrenia spectrum disorders (SSD). Reality confusion may also emanate from posterior orbitofrontal cortex (OFC) lesions, as evident in confabulations that patients act upon and disorientation. This confusion can be measured by repeated runs of a continuous...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.07.036
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:The intersect and blurring of boundaries between schizophrenia spectrum disorders and autism spectrum disorder (ASD) has long been an area of confusion, in both nosology and clinical practice. Individuals with a comorbid presentation of the two spectra can present with a distinct phenomenological profile to ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.11.037
更新日期:2020-02-01 00:00:00