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Diminished modulation of motor cortical reactivity during context-based action observation in schizophrenia.

Abstract：

BACKGROUND:Deficient mirror neuron system (MNS)-activity is associated with social cognition deficits in schizophrenia. However, it is not known how socio-emotional contexts modulate the MNS-response. In a Transcranial Magnetic Stimulation (TMS)-experiment, we aimed to compare putative MNS-responses to action observation stimuli with and without a context, in patients with schizophrenia and healthy subjects. METHOD:TMS-evoked motor cortical reactivity was measured by single and paired [short interval intracortical inhibition (SICI) and facilitation (ICF)] pulse-paradigms in schizophrenia patients (n = 39) and healthy subjects (n = 28) while they observed three experimental-blocks: a static image, a neutral hand action (NA) and a context-based hand action (CA). The degree of cortical reactivity facilitation with the two action observation blocks, relative to the static block provided indirect measures of premotor MNS-activity. A subset of patients (n = 31) also underwent comprehensive social cognition assessments. RESULTS:RMANOVA demonstrated significantly higher cortical reactivity during the CA-block in both groups (all TMS-paradigms); albeit significantly less pronounced in patients (SICI and ICF paradigms). MNS-activity during the CA-block was significantly higher compared to that during the NA-block in both groups (all TMS-paradigms), but significantly less pronounced in patients (SICI and single-pulse paradigms). MNS-activity during the CA-block measured by the ICF paradigm was positively correlated with social cognition performance. CONCLUSION:Providing a context to the action modulates MNS-activity. This modulation is diminished in schizophrenia patients, suggestive of a diminished sensorimotor associative learning process. This novel, ecologically valid paradigm to tap into the MNS may serve as a neuro-marker of social cognition performance in schizophrenia.

journal_name

Schizophr Res

journal_title

Schizophrenia research

authors

Bagewadi VI,Mehta UM,Naik SS,Govindaraj R,Varambally S,Arumugham SS,Naveen Kumar C,Thirthalli J

doi

10.1016/j.schres.2018.07.043

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

222-229

eissn

0920-9964

issn

1573-2509

pii

S0920-9964(18)30489-4

journal_volume

204

pub_type

杂志文章

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