Abstract：
:Structural abnormalities in the lateral prefrontal cortex (LPFC) are well-documented in schizophrenia and recent evidence suggests that these abnormalities relate to functional outcome. Cognitive control mechanisms, reliant on the LPFC, are impaired in schizophrenia and predict functional outcome, thus impaired cognitive control could mediate the relationship between neuroanatomical abnormalities in the LPFC and functional outcome. We used surface-based morphometry to investigate relationships between cortical surface characteristics, cognitive control, and measures of social and role functioning in 26 individuals with schizophrenia and 29 healthy controls. Results demonstrate that schizophrenia participants had thinner cortex in a region of the superior frontal gyrus (BA10). Across all participants, decreased cortical thickness in this region related to decreased cognitive control and decreased role functioning. Moreover, cognitive control fully mediated the relationship between cortical thickness in the superior frontal gyrus and role functioning, indicating that neuroanatomical abnormalities in the LPFC adversely impact role functioning via impaired cognitive control processes.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Tully LM,Lincoln SH,Liyanage-Don N,Hooker CIdoi
10.1016/j.schres.2013.12.005subject
Has Abstractpub_date
2014-02-01 00:00:00pages
358-64issue
2-3eissn
0920-9964issn
1573-2509pii
S0920-9964(13)00661-0journal_volume
152pub_type
杂志文章abstract：:Deficits in N-methyl-d-aspartate-type (NMDAR) function contribute to cognitive deficits in schizophrenia, particularly dysfunction in neuroplasticity, defined as reduced learning during training on exercises that place implicit, increasing demands on early sensory (auditory and visual) information processing. Auditory...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2018.02.003
更新日期：2019-05-01 00:00:00
abstract：:There is controversy over whether the incidence rates of schizophrenia and psychotic disorders have changed in recent decades. To detect deviations from trends in incidence, we analysed admission data of patients with an ICD-8/9/10 diagnosis of psychotic disorders in the Canton Zurich / Switzerland, for the period 197...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.06.001
更新日期：2007-09-01 00:00:00
abstract：:Schizophrenia is associated with structural brain abnormalities that are likely to be present before disease onset. It remains unclear to what extent these represent general vulnerability indicators or are associated with the developing clinical state itself. It also remains unclear whether such state or trait alterat...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.12.003
更新日期：2016-06-01 00:00:00
abstract：:Autoimmunity, gastrointestinal (GI) disorders and schizophrenia have been associated with one another for a long time. This paper reviews these connections and provides a context by which multiple risk factors for schizophrenia may be related. Epidemiological studies strongly link schizophrenia with autoimmune disorde...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2014.06.027
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:There is increased interest in the impact of new long-acting treatments on health-related quality of life (HRQoL) in patients with schizophrenia. The aim of this study was to evaluate the impact of treatment with subcutaneous injections of RBP-7000, a new sustained-release formulation of risperidone, compare...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.schres.2016.03.020
更新日期：2016-07-01 00:00:00
abstract：:While the long-term administration of antipsychotics is known to cause dopamine supersensitivity psychosis (DSP), recent studies revealed that DSP helps form the foundation of treatment resistance. Electroconvulsive shock (ES) is one of the more effective treatments for treatment-resistant schizophrenia. The objective...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2020.11.062
更新日期：2021-01-08 00:00:00
abstract：BACKGROUND:Verbal and visual memory deficits are prominent trait markers for schizophrenia, with impairments also observed in first-degree relatives [Snitz, B.E., Macdonald, A.W., 3rd, & Carter, C.S. (2006). Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of put...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2008.05.027
更新日期：2008-10-01 00:00:00
abstract：:Numerous studies have described attenuated event-related potential (ERP) component amplitudes in schizophrenia (e.g., P300, Mismatch Negativity (MMN), Error Negativity/Error-Related Negativity (Ne/ERN)). Functional magnetic resonance imaging (fMRI) studies have typically shown decreased recruitment of diverse brain ar...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.09.036
更新日期：2009-12-01 00:00:00
abstract：:The glutamatergic dysfunction hypothesis of schizophrenia implicates the genes involved in glutamatergic transmission as strong candidates for schizophrenia-susceptibility. Recent linkage and association studies have identified the glutamate receptor, ionotropic, delta 1 gene GRID1 on 10q22 as a strong candidate for s...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.03.007
更新日期：2007-07-01 00:00:00
abstract：BACKGROUND:A false sense of reality is a characteristic of schizophrenia spectrum disorders (SSD). Reality confusion may also emanate from posterior orbitofrontal cortex (OFC) lesions, as evident in confabulations that patients act upon and disorientation. This confusion can be measured by repeated runs of a continuous...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.07.036
更新日期：2019-02-01 00:00:00
abstract：:Several investigations suggest that complexin may be a schizophrenia-susceptibility factor. We conducted a genetic association analysis between complexin genes (CPLX1 and CPLX2) and schizophrenia in Japanese patients (377 cases and 341 controls). Ten and eleven haplotype-tagging (ht)SNPs in CPLX1 and CPLX2, respective...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2005.12.842
更新日期：2006-02-28 00:00:00
abstract：:Poor insight into the neurocognitive deficits in schizophrenia-spectrum disorders may have significant clinical implications for treatment. The purpose of this study was to replicate and extend the psychometric findings initially reported on the Measure of Insight into Cognition Clinician-Rated (MIC-CR) and Self-Repor...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2011.10.002
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:In schizophrenic psychoses, the normal sexual dimorphism of the brain has been shown to be disrupted or even reversed. Little is known, however, at what time point in emerging psychosis this occurs. We have therefore examined, if these alterations are already present in the at-risk mental state (ARMS) for ps...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.03.034
更新日期：2018-09-01 00:00:00
abstract：OBJECTIVE:Following encouraging results in the early detection of psychotic disorders, interest in the early detection of affective, especially bipolar disorders, has recently been renewed. However, the differentiation between affective disorders with and without psychotic features is often missing, although it has bee...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.04.001
更新日期：2012-07-01 00:00:00
abstract：:Genetic and environmental models of neuropsychiatric disease have grown exponentially over the last 20years. One measure that is often used to evaluate the translational relevance of these models to human neuropsychiatric disease is prepulse inhibition of startle (PPI), an operational measure of sensorimotor gating. D...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2017.10.009
更新日期：2018-08-01 00:00:00
abstract：:This is the first study to investigate whether positive family history (FH) of psychosis and affective disorders moderates the relationship between child diagnostic status and parent-reported social and behavioral problems on the Child Behavior Checklist (CBCL) in clinical high-risk adolescents. This longitudinal inve...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.04.027
更新日期：2015-08-01 00:00:00
abstract：:Schizophrenic delusions are important target symptoms for treatment. This study aims to identify predictors of delusion formation. Two samples of schizophrenic patients (total n = 131) are examined prospectively every second week during a period of 6 months. In one sample (n = 60) delusion formation (n = 27; 45%) is c...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(98)00033-4
更新日期：1998-06-22 00:00:00
abstract：:Diminished expression is a diagnostic feature of a range of schizophrenia-spectrum disorders/conditions and is often unresponsive to treatment, is present across premorbid, first episode and various clinical states, and is considered a poor prognostic indicator. Surprisingly, little is known about diminished expressio...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.05.003
更新日期：2013-08-01 00:00:00
abstract：BACKGROUND:Alterations in bone mineral density (BMD) in patients with psychotic disorder may reflect the effect of treatment (disease effect observed in patients but not their siblings) or, as an intermediate marker of cumulative endogenous estrogen exposure, alterations in the neuroprotective effect of estrogen in the...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.10.031
更新日期：2013-01-01 00:00:00
abstract：:Recent research on risk for psychosis has focused on youth who manifest subclinical signs that are often associated with the prodrome to psychosis. Standardized measures of prodromal symptoms have been shown to significantly enhance prediction of risk for conversion to an Axis I psychotic disorder. In the present stud...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2011.03.034
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:Some studies have suggested that antipsychotic-naïve patients with nonaffective psychosis (NAP) have glucose intolerance. AIMS:To conduct a systematic review and meta-analysis of fasting glucose (FG), two hour values in the oral glucose tolerance test (2HG), fasting insulin concentration (INS), and insulin ...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.schres.2016.09.026
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Higher liability to psychosis is associated with low self-esteem and increased sensitivity to social stress. Recently, we reported a positive relation between liability to psychosis and affective and psychotic responses to social stress. This study investigated how self-esteem moderates paranoia, peak subjec...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.06.042
更新日期：2018-12-01 00:00:00
abstract：:Past studies have demonstrated that the Brief Negative Symptom Scale (BNSS) has excellent psychometric properties in patients with schizophrenia. In the current study, we extended this literature by examining psychometric properties of the BNSS in outpatients diagnosed with bipolar disorder (n=46), outpatients with sc...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.12.014
更新日期：2016-02-01 00:00:00
abstract：:Alterations of immune function have been reported in ultra-high risk (UHR) for psychosis patients causing expectations in terms of predictive meaningfulness and benefits of anti-inflammatory agents. According to a RCT in UHR-patients supplementation of omega-3 polyunsaturated fatty acids (PUFA) was effective in reduci...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2017.01.026
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Alterations in the inhibitory circuitry of the dorsolateral prefrontal cortex (DLPFC) in schizophrenia include reduced expression of the messenger RNA (mRNA) for somatostatin (SST), a neuropeptide present in a subpopulation of gamma-aminobutyric acid (GABA) neurons. Neuropeptide Y (NPY) is expressed in a sub...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.09.014
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:We previously developed a novel method of identifying children aged 9-12 years who may be at elevated risk of developing schizophrenia and the spectrum disorders because they present a triad of putative antecedents of schizophrenia (ASz). The present study aimed to determine whether ASz children also present...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2010.05.034
更新日期：2010-08-01 00:00:00
abstract：:Motivational deficits in patients with schizophrenia adversely affect various domains of daily living. This symptom in everyday life situations manifests in a complex behavioral pattern whose root cannot be simplified to an impaired reward-motivation scheme. This study aimed to identify impairment of the salience netw...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.01.019
更新日期：2018-07-01 00:00:00
abstract：:Clinical improvement in psychotic symptoms is not immediate when neuroleptic treatment is commenced. Previous studies have demonstrated the development of biochemical tolerance to the effects of neuroleptics on the dopamine system. This study demonstrates a relationship between this biochemical change and the clinical...
journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0920-9964(90)90007-t
更新日期：1990-07-01 00:00:00
abstract：INTRODUCTION:This study investigates the effect of exposure to "The Troubles" (the period of civil unrest from 1968 onwards) in Northern Ireland on symptomatology in people with schizophrenia. METHOD:Eighty-two participants were assessed on a number of psychiatric rating scales and on measures of trauma, including an ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2008.02.012
更新日期：2008-07-01 00:00:00
abstract：BACKGROUND:Appropriate expression of emotions and correct perception of emotional expression in others are important social skills which may be impaired in schizophrenia and contribute to poor social adjustment. We examined the relationship between expression of emotions as measured by affective flattening and other ne...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(00)00093-1
更新日期：2001-12-01 00:00:00
