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Meta-analysis of glucose tolerance, insulin, and insulin resistance in antipsychotic-naïve patients with nonaffective psychosis.

Abstract：

BACKGROUND:Some studies have suggested that antipsychotic-naïve patients with nonaffective psychosis (NAP) have glucose intolerance. AIMS:To conduct a systematic review and meta-analysis of fasting glucose (FG), two hour values in the oral glucose tolerance test (2HG), fasting insulin concentration (INS), and insulin resistance (IR). METHOD:We identified possibly relevant studies, then selected studies, following usual guidelines, with two authors reviewing the manuscripts. We required studies to include subjects with nonaffective psychosis and control subjects. RESULTS:There were 911 patients and 870 control subjects in the analysis of FG; their average ages were respectively 28.7 and 29.5years. Significant differences were found for all four variables, with effect size estimates ranging from 0.21 to 0.58. CONCLUSIONS:As a group, at the time of first clinical contact for psychosis, people with NAP have a slight increase in FG, which most of them maintain in the normal range despite a small increase in IR by secreting additional INS. When faced with a physiological challenge such as a glucose tolerance test or antipsychotics, they are no longer able to maintain a normal glucose concentration.

journal_name

Schizophr Res

journal_title

Schizophrenia research

authors

Greenhalgh AM,Gonzalez-Blanco L,Garcia-Rizo C,Fernandez-Egea E,Miller B,Arroyo MB,Kirkpatrick B

doi

10.1016/j.schres.2016.09.026

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

57-63

eissn

0920-9964

issn

1573-2509

pii

S0920-9964(16)30435-2

journal_volume

179

pub_type

杂志文章,meta分析,评审

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